48 completed, 31 unknown, 14 not yet recruiting, 7 active not recruiting. 77 Not applicable, 14 Phase 2, 9 Phase 4, 6 Phase 3, 3 Phase 1.
Follow Irreversible Pulpitis: new trials by email Literature Review of Irreversible Pulpitis trials Research Report on Irreversible Pulpitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Effectiveness in the Management of Irreversible Pulpitis RCT, Pulpotomy - Irreversible Pulpitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 138 | 2027-06-01 | 2026-02-17 |
| The Effect of Bitewing Radiography on Outcomes and Costs of Treating Caries in Permanent Teeth Visual-tactile caries examination, Visual-tactile caries examination and bilateral bitewing radiography - Dental Caries, Teeth Loss | Not applicable | Not yet recruiting | Jukka Leinonen | 250 | 2027-03-01 | 2026-10-20 |
| Child's Behavior Using Single Rotary File System Versus Manual Instrumentation in Pulpectomy of Primary Molars Fanta AF F one rotary files 20 taper 4, Manual files (k files ,Mani, Inc., Japan). - Irreversible Pulpitis | Not applicable | Recruiting | Cairo University | 54 | 2026-07-25 | 2026-10-21 |
| Salvadora Persica-Zinc Oxide Versus MTA as Pulpotomy Agents in Mature Permanent Molars With Irreversible Pulpitis Mineral Trioxide Aggregate, Salvadora persica Extract + Zinc Oxide - Irreversible Pulpitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 78 | 2026-06-20 | 2026-06-05 |
| R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis MTA Pulpotomy, Rosemarinus officinalis extract pulpotomy - Irreversible Pulpitis, Pulpotomy | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 100 | 2026-06-01 | 2026-05-27 |
| Impact of Cross-Sectional Design in Single-File Rotary System on Apical Debris Extrusion AF One single-file rotary system - Postoperative Pain, Irreversible Pulpitis | Not applicable | Recruiting | Minia University | 30 | 2026-06-01 | 2026-09-09 |
| Pain Assessment Governing Partial or Full Pulpotomy of Immature Molars With Irreversible Pulpitis in Molar Incisor Hypomineralization pulpotomy for MIH affected immature PFMs, partial pulpotomy for MIH affected immature PFMs, pulpotomy for non-MIH affected immature PFMs - Molar Incisor Hypomineralisation, Irreversible Pulpitis | Not applicable | Active not recruiting | Alaa Khafagy | 132 | 2026-05-01 | 2026-10-01 |
| Postoperative Pain After Pulpectomy in Primary Molars Fanta AF F one rotary files 20 taper 4, Manual files (k files ,Mani, Inc., Japan). - Irreversible Pulpitis | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-04-10 | 2026-02-23 |
| To Evaluate Post Operative Pain Using Two Different Kind of Sealers in Obturation of Teeth With Symptomatic Irreversible Pulpitis During Second Visit When the Patient is Painless AH-Plus Epoxy Resin Sealer, bioceramic sealer - Post Operative Pain, Acute, Irreversible Pulpitis | Phase 2 / Phase 3 | Not yet recruiting | Jaweria Gul Keyani | 60 | 2026-04-01 | 2026-01-08 |
| Evaluation of Bacterial Reduction After Pulpectomy in Primary Molars Rotary Instrumentation, Manual Instrumentation - Irreversible Pulpitis | Not applicable | Not yet recruiting | Cairo University | 34 | 2026-04-01 | 2026-03-17 |
| Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000 - Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block | Phase 4 | Completed | Rehman Medical Institute - RMI | 50 | 2026-03-03 | 2026-10-09 |
| Comparison of Treatment Outcome of Pulpotomy With Versus Without Dental Operating Microscope in Carious Mature Permanent Teeth Dental operating microscope - Irreversible Pulpitis | Early Phase 1 | Not yet recruiting | Chulalongkorn University | 50 | 2026-02-21 | 2026-03-18 |
| Clinical and Radiographic Outcomes of Rotary Instrumentation in Primary Molars Rotary Instrumentation, Manual Instrumentation - Pulpectomy, Irreversible Pulpitis | Not applicable | Not yet recruiting | Anfal mohamed elmotaz almogtaba | 44 | 2026-02-01 | 2026-01-06 |
| Effect of Cryotherapy on Anesthetic Success and Pain in Irreversible Pulpitis infiltration anesthesia alone, mandibular anesthesia alone, infiltration anesthesia combined with cryotherapy - Irreversible Pulpitis, Cryotherapy | Not applicable | Not yet recruiting | TC Erciyes University | 100 | 2026-01-30 | 2026-02-11 |
| CGF Partial Pulpotomy Versus Endodontic Treatment Other treatment - Irreversible Pulpitis | Not applicable | Not yet recruiting | Minia University | 60 | 2026-01-20 | 2026-02-18 |
| Biomarkers for Differentiating Reversible and Irreversible Pulpitis Pulpal Blood Biomarker Analysis - Reversible Pulpitis, Irreversible Pulpitis | Completed | Safa | 90 | 2025-11-01 | 2026-07-31 | |
| Comparative Evaluation of Diclofenac Sodium and Ibuprofen for Post-Endodontic Pain Management Ibuprofen, Diclofenac sodium - Irreversible Pulpitis, Post-endodontic Pain | Phase 4 | Completed | Armed Forces Institute of Dentistry, Pakistan | 60 | 2025-10-01 | 2026-05-04 |
| Treatment Outcomes of Pulpotomy Versus Pulpectomy in Vital Primary Molars Diagnosed With Irreversible Pulpitis Pulpotomy, Pulpectomy - Irreversible Pulpitis | Not applicable | Recruiting | Qatar University | 80 | 2025-08-01 | 2026-08-13 |
| Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis Dexamathsone 4mg/ml associated with experimental arm, Normal saline injection - Irreversible Pulpitis | Not applicable | Active not recruiting | College of Physicians and Surgeons Pakistan | 44 | 2025-07-15 | 2025-11-18 |
| Clinical and Radiographic Outcomes of Pulpotomy Versus Pulpectomy in Primary Molars With Symptomatic Irreversible Pulpitis MTA pulp dressing material, Metapex - Irreversible Pulpitis | Not applicable | Active not recruiting | Minia University | 110 | 2025-07-15 | 2026-08-24 |
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Pain, Postoperative (13) · Pain (8) · Pulpitis (8) · Periapical Periodontitis (7) · Dental Pulp Necrosis (5) · Dental Pulp Diseases (4) · Dental Caries (3) · Diabetes Mellitus, Type 2 (2) · Agnosia (1) · Anodontia (1) · Bicuspid Aortic Valve Disease (1) · Disease (1) · Molar Hypomineralization (1) · Periapical Abscess (1)
Pathological Conditions, Signs and Symptoms (25) · Stomatognathic Diseases (24) · Neurologic Manifestations (20) · Signs and Symptoms (20) · Tooth Diseases (19) · Pathologic Processes (18) · Postoperative Complications (13) · Dental Pulp Diseases (12) · Pain (11) · Jaw Diseases (7) · Mouth Diseases (7) · Periapical Diseases (7) · Periodontal Diseases (7) · Periodontitis (7) · Necrosis (5)
Pulpotomy (16) · Ibuprofen (5) · Pemetrexed (5) · Diclofenac (4) · Epinephrine (4) · Ketorolac Tromethamine (4) · Lidocaine (4) · mineral trioxide aggregate (4) · tricalcium silicate (4) · Acetaminophen (3) · Carticaine (3) · Pulpectomy (3) · Root Canal Therapy (3) · Saline Solution (3) · Sodium Hypochlorite (3)
Cairo University (15) · Postgraduate Institute of Dental Sciences Rohtak (9) · Minia University (5) · Al-Azhar University (4) · Ain Shams University (3) · Altamash Institute of Dental Medicine (3) · Azad University of Medical Sciences (3) · Alexandria University (2) · Armed Forces Institute of Dentistry, Pakistan (2) · Dow University of Health Sciences (2) · Gulf Medical University (2) · Jordan University of Science and Technology (2) · Mansoura University (2) · Misr International University (2) · Qatar University (2)
Egypt (32) · Pakistan (14) · India (10) · Turkey (Türkiye) (6) · Iran (5) · United States (4) · Jordan (3) · Spain (3) · Qatar (2) · United Arab Emirates (2) · Brazil (1) · Bulgaria (1) · China (1) · Finland (1) · Hungary (1)
Suzan AW Amin, PhD (3) · Dr. Pankaj Sangwan, MDS (2) · Nahid Mohammadzadeh Akhlaghi, DDS,MDS (2) · Nebu Philip, PhD (2) · Alaa A. Eissa, Msc (1) · Alaina Tariq Mughal, BDS, FCPS (R) (1) · Amaury J Pozos-Guillen, PhD (1) · Araib AT Tahir, BDS (1) · Ashraf Fouad, DDS (1) · Aya A Gamal, MSc (1) · Bharat Suneja, MDS (1) · Choontawee Soponsakulkaew (1) · DR. Sanjay Tewari, MDS (1) · Dana Kesler Shvero, DMD (1) · Daniel Chavarria, PhD (1)
PMID 10613619, PMID 12148679, PMID 15230906, PMID 1574311, PMID 17185058, PMID 17437870, PMID 18498882, PMID 20171350, PMID 21831678, PMID 24702239, PMID 24862701, PMID 25770038, PMID 26831048, PMID 27080115, PMID 27788771, PMID 27939729, PMID 28190451, PMID 28857203, PMID 29061359, PMID 29397214, PMID 29709297, PMID 30314709, PMID 30638262, PMID 32676136, PMID 32976660, PMID 34383324, PMID 34854987, PMID 35160239, PMID 35887779, PMID 36856848, PMID 36965768, PMID 37080387, PMID 38233887, PMID 38807160, PMID 39479199, PMID 39935864, PMID 41026352, PMID 41027503, PMID 42614935, PMID 9272792, PMID 9431539, PMID 9594474, PMID 9693577
2009 (1)