82 completed, 31 unknown, 23 recruiting, 18 terminated. 180 Phase 2, 30 Phase 1, 27 Phase 3.
Follow Intracranial Hemorrhages: new trials by email Literature Review of Intracranial Hemorrhages trials Research Report on Intracranial Hemorrhages
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage Sirolimus (Rapamune®) - Post-hemorrhagic Hydrocephalus (PHH) | Phase 1 / Phase 2 | Not yet recruiting | Massachusetts General Hospital | 15 | 2027-01-01 | 2026-06-25 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-12-05 | 2026-11-04 |
| MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Lidocaine hydrochloride, Isotonic saline - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 90 | 2026-12-01 | 2026-09-11 |
| IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage Lidocaine hydrochloride, Methylprednisolone sodium succinate - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Recruiting | Daniel Raper, MBBS | 25 | 2026-06-23 | 2026-07-08 |
| GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial Semaglutide, 0.5 mg/mL - Intracerebral Hemorrhage | Phase 2 | Not yet recruiting | Chinese University of Hong Kong | 200 | 2026-06-15 | 2026-05-29 |
| Role of Neuroinflammation and Blood-Brain Barrier Breakdown in Intracerebral Hemorrhage. TEP with 18F-DPA-714 injection - Intracerebral Hemorrhage | Phase 2 | Not yet recruiting | University Hospital, Toulouse | 117 | 2026-06-01 | 2026-05-13 |
| Synergistic Minimally Invasive Surgery and Deferoxamine in ICH Minimally Invasive surgery (MIS), Deferoxamine, Standard Medical Care (SMD) - Intracerebral Hemorrhage, ICH - Intracerebral Hemorrhage | Phase 2 / Phase 3 | Not yet recruiting | University of Illinois at Chicago | 240 | 2026-03-01 | 2025-10-10 |
| Minocycline in Stroke Study at Maimonides Minocycline 200mg - Stroke, Ischemia Stroke | Phase 2 / Phase 3 | Recruiting | Joyce Chen | 1164 | 2026-02-02 | 2026-03-19 |
| Infusion of Lidocaine and Steroids in Middle Meningeal Artery for Pain in Subarachnoid Hemorrhage Lidocaine, Lidocaine and Dexamethasone - Subarachnoid Hemorrhage, Aneurysmal, Headache | Phase 2 | Recruiting | The University of Texas Medical Branch, Galveston | 15 | 2026-01-02 | 2026-11-03 |
| Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH) Tranexamic Acid (Cyklokapron) - Chronic Subdural Hematoma | Phase 2 / Phase 3 | Recruiting | St. Olavs Hospital | 274 | 2025-12-10 | 2026-07-17 |
| Clinical Study to Evaluate the Efficacy of Febuxostat in the Treatment of Conservatively Managed Intracranial Hemorrhage Patients Febuxostat 40 mg, Standard medical treatment - Intracranial Hemorrhage | Phase 2 | Recruiting | Tanta University | 46 | 2025-11-20 | 2026-07-15 |
| A Multicenter, Randomized, Double-blind, Placebo-controlled Trial on the Treatment of Hypertensive Intracerebral Hemorrhage With Naoxuekang Dropping Pills Naoxuekang Dropping Pills, Naoxuekang Matching Placebo - Hypertensive Intracerebral Hemorrhage, Cerebral Small Vessel Diseases | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 1950 | 2025-10-10 | 2025-10-01 |
| Tranexamic Acid Therapy For The Treatment of Subdural Hematomas Tranexamic Acid 650 MG, Placebo - Chronic Subdural Hematoma | Phase 2 | Not yet recruiting | Baylor College of Medicine | 240 | 2025-10-01 | 2025-05-14 |
| Efficacy of Daily IV Administration of Dornase Alfa up to 14 Days Post Subarachnoid Hemorrhage on Functional Independence at 6 Months Daily infusion of dornase alfa - Ruptured Aneurysm of Intracranial Artery, SAH (Subarachnoid Hemorrhage) | Phase 2 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 304 | 2025-09-26 | 2026-05-08 |
| Intra-Arterial Tenecteplase Following Endovascular Thrombectomy for Large Vessel Occlusion Stroke Intra-arterial Tenecteplase, Intra-arterial Saline - Acute Ischemic Stroke | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 40 | 2025-09-22 | 2026-09-25 |
| FLudrocortisone Administration in Aneurysmal Subarachnoid Haemorrhage Fludrocortisone, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 2 | Recruiting | The George Institute | 524 | 2025-08-13 | 2025-12-16 |
| Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage Colchicine 0.5mg, Matching placebo - Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage Lobar | Phase 2 | Recruiting | Huashan Hospital | 80 | 2025-06-18 | 2025-06-26 |
| Effect of Cilostazol in Promoting Hematoma Clearance After Intracerebral Hemorrhage Pletaal 100mg/tab, Conventional internal medicine treatment - ICH - Intracerebral Hemorrhage | Phase 2 | Recruiting | National Taiwan University Hospital | 100 | 2025-06-16 | 2026-03-09 |
| Stem Cell Therapy for Intracerebral Hemorrhage Device: Phase Ⅰ Dose Level 1, Device: Phase Ⅰ Dose Level 2, Device: Phase Ⅰ Dose Level 3 - Intracerebral Hemorrhage, Mesenchymal Stem Cell | Phase 1 / Phase 2 | Recruiting | Tang Zhouping | 39 | 2025-06-02 | 2026-10-20 |
| Effect of Xenon on Brain Injury After Aneurysmal Subarachnoid Hemorrhage Xenon, air/oxygen - Subarachnoid Hemorrhage, Aneurysmal, Cerebral Injury | Phase 2 | Recruiting | Turku University Hospital | 160 | 2025-04-22 | 2025-05-01 |
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Cerebral Hemorrhage (76) · Subarachnoid Hemorrhage (74) · Stroke (33) · Vasospasm, Intracranial (16) · Ischemic Stroke (13) · Hematoma, Subdural, Chronic (12) · Aneurysm (11) · Intracranial Aneurysm (9) · Hemorrhagic Stroke (8) · Brain Injuries, Traumatic (7) · Brain Ischemia (6) · Cerebrovascular Disorders (6) · Hemorrhage (6) · Headache (5)
Pathologic Processes (178) · Pathological Conditions, Signs and Symptoms (178) · Vascular Diseases (178) · Brain Diseases (177) · Cardiovascular Diseases (177) · Central Nervous System Diseases (177) · Nervous System Diseases (177) · Cerebrovascular Disorders (174) · Hemorrhage (172) · Wounds and Injuries (25) · Trauma, Nervous System (22) · Craniocerebral Trauma (21) · Signs and Symptoms (19) · Intracranial Hemorrhage, Traumatic (16)
Sodium Chloride (13) · Saline Solution (12) · Tranexamic Acid (12) · Deferoxamine (6) · Dexamethasone (5) · Tissue Plasminogen Activator (5) · Propofol (4) · Simvastatin (4) · Fentanyl (3) · Labetalol (3) · Lidocaine (3) · Magnesium Sulfate (3) · Minocycline (3) · Nimodipine (3) · Sirolimus (3)
Beijing Tiantan Hospital (5) · Novo Nordisk A/S (4) · Capital Medical University (3) · Chinese University of Hong Kong (3) · Johns Hopkins University (3) · Oslo University Hospital (3) · Tang-Du Hospital (3) · Thomas Jefferson University (3) · University Hospital Heidelberg (3) · University of Florida (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Beth Israel Deaconess Medical Center (2) · Henry Ford Health System (2) · Hope Biosciences LLC (2) · Hope Pharmaceuticals (2)
United States (63) · China (28) · Canada (24) · Germany (12) · Netherlands (10) · United Kingdom (10) · Finland (8) · Australia (6) · Egypt (5) · France (5) · Italy (5) · Switzerland (5) · Taiwan (4) · Denmark (3) · Norway (3)
Sven Poli, Dr. med. (3) · Charles S Cox, MD (2) · Dimitre Staykov, MD (2) · George KC Wong (2) · Magdy Selim, MD, PhD (2) · Michael D Hill, MD (2) · Michael Diringer, MD (2) · Peter J Kirkpatrick, FRCS(SN) (2) · Susanne Muehlschlegel, MD (2) · Adam Burgoyne, MD, PhD (1) · Aditya Pandey, MD (1) · Adrian Parry-Jones, PhD, MRCP (1) · Alejandro Rabinstein, MD (1) · Alex Nesbitt, MBBS (1)
PMID 37870112, PMID 31424491, PMID 36700520, PMID 41114449, PMID 11105983, PMID 11161595, PMID 11590206, PMID 14671250, PMID 15569871, PMID 15728810, PMID 16179504, PMID 16319269, PMID 16552014, PMID 16636233, PMID 16757825, PMID 17038942, PMID 17290026, PMID 17630481, PMID 18211362, PMID 18239180, PMID 18289410, PMID 18420953, PMID 18580208, PMID 18658043, PMID 18676556, PMID 19061352, PMID 19197830, PMID 19344224, PMID 19628806, PMID 19762703, PMID 20536619, PMID 20798370, PMID 21346218, PMID 21396235, PMID 21454813, PMID 21998061, PMID 22282887, PMID 22678087, PMID 22747768, PMID 22776958, PMID 23228346, PMID 23391776, PMID 23392270, PMID 23551657, PMID 23581590, PMID 23636409, PMID 23680226, PMID 23706046, PMID 23943316, PMID 23981692
2014 (2), 2017 (2), U01NS074425 (2), 2004 (1), 2005 (1), 2015 (1), 2019 (1), 2023 (1), 2025 (1), P50NS044227 (1), P50NS044283 (1), R01AG069930 (1), R01NS038484 (1), R01NS046309 (1), R44NS063485 (1)