77 terminated. 77 Phase 3, 20 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 77 | Terminated 77 |
| Phase 2 | 20 | Terminated 20 |
Follow Inflammation: new trials by email Literature Review of Inflammation trials Research Report on Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN) Metoprolol Injection, saline 0.9% - Acute Respiratory Distress Syndrome (ARDS) | Phase 3 | Terminated | Consorcio Centro de Investigación Biomédica en Red (CIBER) | 14 | 2024-07-10 | 2026-06-02 |
| A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole SCY-078, Fluconazole, Echinocandin - Candidiasis, Invasive, Candidemia | Phase 3 | Terminated | Scynexis, Inc. | 68 | 2022-08-03 | 2026-08-10 |
| A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction Lithium Carbonate, Placebo - Carotid Artery Diseases, Carotid Artery Stenosis | Phase 3 | Terminated | Negovsky Reanimatology Research Institute | 107 | 2021-11-20 | 2025-09-25 |
| Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Vitamin C, Placebo - Sepsis, Septic Shock | Phase 3 | Terminated | Hospital Sirio-Libanes | 71 | 2021-08-01 | 2024-01-30 |
| Best Available Therapy With or Without Meropenem for Bloodstream Infections by Enterobacterales With High Level of Resistance to Carbapenems Meropenem - Carbapenem-Resistant Enterobacteriaceae Infection, Bloodstream Infection | Phase 2 / Phase 3 | Terminated | Hospital de Clinicas de Porto Alegre | 13 | 2021-05-04 | 2022-08-03 |
| INB03 for the Treatment of Pulmonary Complications From COVID-19 INB03, Placebo - COVID-19 | Phase 2 / Phase 3 | Terminated | Inmune Bio, Inc. | 79 | 2020-10-21 | 2026-05-19 |
| Study of LAU-7b for the Treatment of Coronavirus Disease 2019 (COVID-19) Disease in Adults LAU-7b, Placebo oral capsule - COVID-19 Disease | Phase 2 / Phase 3 | Terminated | Laurent Pharmaceuticals Inc. | 351 | 2020-08-18 | 2025-11-13 |
| Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 Hyperbaric oxygen - SARS (Severe Acute Respiratory Syndrome), Cytokine Storm | Phase 2 / Phase 3 | Terminated | Karolinska Institutet | 34 | 2020-06-03 | 2023-01-09 |
| The Role of Resistant Starch in COVID-19 Infection Dietary Supplement containing resistant starch, Placebo Starch - COVID-19 | Phase 2 / Phase 3 | Terminated | Yale University | 226 | 2020-06-03 | 2022-10-05 |
| Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT) Placebo, Ruxolitinib - COVID-19 | Phase 3 | Terminated | Incyte Corporation | 211 | 2020-05-24 | 2022-01-19 |
| Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers Tocilizumab - COVID, SARS Pneumonia | Phase 3 | Terminated | Beneficência Portuguesa de São Paulo | 129 | 2020-05-08 | 2020-08-26 |
| MSCs in COVID-19 ARDS Remestemcel-L, Placebo - Mesenchymal Stromal Cells, Remestemcel-L | Phase 3 | Terminated | Icahn School of Medicine at Mount Sinai | 223 | 2020-04-30 | 2022-04-25 |
| The Vitamin D in Pediatric Crohn's Disease ( ViDiPeC-2 ) vitamin D3 - Crohn Disease | Phase 3 | Terminated | Jantchou Prevost | 55 | 2020-02-07 | 2026-10-21 |
| Effect of Albumin Administration in Hypoalbuminemic Hospitalized Patients With Community-acquired Pneumonia. Albumin Human - Community-acquired Pneumonia, Hypoalbuminemia | Phase 3 | Terminated | Jordi Carratala | 39 | 2019-10-31 | 2023-01-31 |
| Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock Dexmedetomidine 100 Mcg/mL Intravenous Solution, 5% glucose Infusion solution - Septic Shock, Vasopressor Resistance | Phase 3 | Terminated | Centre Hospitalier Universitaire Dijon | 32 | 2019-10-27 | 2026-02-04 |
| Albumin Replacement Therapy in Septic Shock Albutein® 200 g/L or Plasbumin® 20 - Septic Shock | Phase 3 | Terminated | Jena University Hospital | 440 | 2019-10-21 | 2024-10-28 |
| Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock Vitamin C, Normal saline - Septic Shock | Phase 3 | Terminated | New York Presbyterian Brooklyn Methodist Hospital | 3 | 2019-10-15 | 2020-02-10 |
| Local Compression Seroma DIminution Objective (CLODIS) Compression by chest bandage urgo K2®, punctures - Breast Cancer, Mastectomy | Phase 3 | Terminated | Centre Francois Baclesse | 60 | 2018-11-18 | 2025-10-06 |
| Midodrine Use in Septic Shock Midodrine Hydrochloride, placebo - Septic Shock | Phase 3 | Terminated | University of Virginia | 10 | 2018-11-05 | 2025-09-24 |
| Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock Triple therapy group - Septic Shock, Critical Illness | Phase 2 / Phase 3 | Terminated | Hamad Medical Corporation | 106 | 2018-03-17 | 2021-12-10 |
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Sepsis (24) · Shock, Septic (15) · Bacteremia (6) · Candidemia (5) · Cytokine Release Syndrome (5) · Respiratory Distress Syndrome (5) · COVID-19 (4) · Critical Illness (4) · Abscess (3) · Acute Kidney Injury (3) · Candidiasis (3) · Candidiasis, Invasive (3) · Fibrosis (3) · Mycoses (3)
Pathological Conditions, Signs and Symptoms (77) · Pathologic Processes (76) · Infections (57) · Systemic Inflammatory Response Syndrome (49) · Shock (22) · Sepsis (21) · Respiratory Tract Diseases (16) · Bacterial Infections and Mycoses (13) · Lung Diseases (11) · Cardiovascular Diseases (10) · Respiratory Tract Infections (9) · Urogenital Diseases (9) · Vascular Diseases (9) · Female Urogenital Diseases and Pregnancy Complications (8)
Sodium Chloride (8) · Saline Solution (5) · Hydrocortisone (4) · Ascorbic Acid (3) · Daptomycin (3) · Thiamine (3) · Vancomycin (3) · Albumins (2) · Anidulafungin (2) · Fluconazole (2) · Glutamine (2) · Meropenem (2) · Micafungin (2) · Serum Albumin, Human (2) · Sugars (2)
Pfizer (5) · Assistance Publique - Hôpitaux de Paris (2) · Centre Hospitalier Universitaire Dijon (2) · Emory University (2) · University of Versailles (2) · ANRS, Emerging Infectious Diseases (1) · Astellas Pharma Global Development, Inc. (1) · Bausch & Lomb Incorporated (1) · Baystate Medical Center (1) · Beneficência Portuguesa de São Paulo (1) · Centre Francois Baclesse (1) · Centre Hospitalier Régional d'Orléans (1) · Centre Hospitalier Universitaire de Besancon (1) · Centre Hospitalier Universitaire de Nīmes (1) · Christiana Care Health Services (1)
United States (30) · France (16) · Canada (11) · Italy (8) · Spain (8) · Brazil (7) · Germany (7) · Greece (5) · Israel (5) · Netherlands (5) · Belgium (4) · Bulgaria (4) · Denmark (4) · Russia (4) · Colombia (3)
Abbot R. Laptook, MD (1) · Adham Mohamed, PharmD (1) · Alexander Rombauts (1) · Alexander Wilmer, MD, PhD (1) · Alexandra Kadl, MD (1) · Amanda Conti, MD (1) · Anders Kjellberg, MD (1) · Annetine C Gelijns, PhD (1) · Arlene A Stecenko, MD (1) · Bairbre Connolly, MD (1) · Borja Ibanez, MD PhD FESC (1)
PMID 28459966, PMID 28597967, PMID 33891293, PMID 10722036, PMID 1138591, PMID 11502226, PMID 12454520, PMID 12545007, PMID 12700374, PMID 16000352, PMID 1607900, PMID 16570523, PMID 17443204, PMID 17517240, PMID 17586184, PMID 18337740, PMID 18353115, PMID 19067285, PMID 20332511, PMID 20459801, PMID 20591191, PMID 20646908, PMID 20844049, PMID 20946227, PMID 21988742, PMID 22059409, PMID 22079954, PMID 22120766, PMID 227054, PMID 23525934, PMID 23549582, PMID 24484547, PMID 24835849, PMID 24838355, PMID 25463545, PMID 25466837, PMID 26631058, PMID 26771781, PMID 26832963, PMID 26903338, PMID 26936876, PMID 27162802, PMID 27585969, PMID 27695824, PMID 27940189, PMID 28098591, PMID 28732314, PMID 29247809, PMID 29325753, PMID 29388815
2014 (2), 2018 (2), M01RR000032 (1), M01RR000044 (1), M01RR000070 (1), M01RR000633 (1), M01RR000750 (1), M01RR006022 (1), M01RR007122 (1), M01RR008084 (1), M01RR016587 (1), N01HR056179 (1), U10HD021373 (1), U10HD021385 (1), U10HD021397 (1)