73 completed, 12 terminated, 7 unknown, 5 recruiting. 25 Phase 3, 15 Phase 2, 13 Phase 4, 9 Not applicable, 5 Phase 1.
Follow Candidiasis, Invasive: new trials by email Literature Review of Candidiasis, Invasive trials Research Report on Candidiasis, Invasive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Shortening Treatment Duration in Uncomplicated Candidemia: the CanTEN Trial Caspofungin only within the study, Caspofungin for 3 days within the study, Placebo only within the study - Candidemia, Invasive Candidiasis | Phase 4 | Not yet recruiting | Oliver Cornely, MD | 420 | 2026-09-01 | 2026-09-01 |
| A Randomized Study of a Short Duration Therapy for Candidemia Standard of Care (SOC), Shortened duration of antifungal therapy - CANDIDEMIA | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 362 | 2025-07-01 | 2025-03-05 |
| A Study Comparing Short-course Antifungal Therapy (SCAT) 7 Day vs Standard 14 Day Antifungal Therapy for Uncomplicated Candidemia Antifungal treatment - Candidemia | Not yet recruiting | Augusta University | 150 | 2025-05-01 | 2025-04-04 | |
| Performance Evaluation of the Fujifilm Wako Beta-D-glucan Technique in the Diagnosis of Major Invasive Fungal Infections (IFI) Beta-1,3/1,6-D-Glucan - Candidemia, Aspergillosis Invasive | Completed | Central Hospital, Nancy, France | 280 | 2024-12-17 | 2025-12-09 | |
| A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis. Fosmanogepix, Caspofungin, Fluconazole - Candidemia, Candidiasis, Invasive | Phase 3 | Recruiting | Basilea Pharmaceutica | 450 | 2024-12-11 | 2026-10-19 |
| Invasive Candidiasis in Critical Care Invasive candidiasis test, Urine sample collection for future research - Invasive Candidiasis | Recruiting | University Hospital Ostrava | 100 | 2024-04-11 | 2025-06-05 | |
| Clinical Study to Evaluate the Efficacy of an Anti-Fungal Supplement CanXida Remove (Formula RMV), Placebo - Candida Systemic, Candida Albicans Infection | Not applicable | Completed | CanXida | 60 | 2023-11-30 | 2024-08-22 |
| Comparison of Uncomplicated Candidemia Therapy Duration in Children therapy duration - Invasive Candidiasis | Not applicable | Recruiting | Arkansas Children's Hospital Research Institute | 420 | 2023-09-08 | 2026-04-17 |
| A Study of ABCD for Injection in Subjects With Invasive Candidiasis and Invasive Aspergillus Amphotericin B cholesteryl Sulfate Complex for Injection - Invasive Candidiasis, Invasive Aspergillosis | Phase 3 | Completed | CSPC Ouyi Pharmaceutical Co., Ltd. | 31 | 2023-03-30 | 2025-04-09 |
| Phylogenetic Characteristics of Different Candida Species and Their Impact on the Clinical Picture of Patients With Invasive Candidiasis. What Has Changed During the COVID Pandemic? Candida, Candida Systemic | Withdrawn | Fondazione IRCCS Policlinico San Matteo di Pavia | 2023-03-01 | 2026-02-19 | ||
| A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole SCY-078, Fluconazole, Echinocandin - Candidiasis, Invasive, Candidemia | Phase 3 | Terminated | Scynexis, Inc. | 68 | 2022-08-03 | 2026-08-10 |
| Candida PCR Diagnosis Strategy in Patients From Intensive Care Units Diagnosis strategy based on C. glabrata / krusei PCR - Candida | Not applicable | Completed | University Hospital, Toulouse | 48 | 2022-05-19 | 2026-08-11 |
| Safety and Efficacy of Interferon-Gamma 1b in Patients With Candidemia Interferon Gamma-1B - Candidemia | Phase 2 | Completed | Radboud University Medical Center | 65 | 2022-03-31 | 2026-06-22 |
| Early Identification of Candida in Intra-abdominal Candidiasis calscreener, Metabolic profile, optical microscopy - Candida Sepsis, Candidiasis, Invasive | Completed | Central Hospital, Nancy, France | 40 | 2022-02-17 | 2023-07-17 | |
| Evaluate Bioequivalence of Micafungin (50mg/Vial) Micafungin - Invasive Candidiasis | Phase 4 | Completed | Yung Shin Pharm. Ind. Co., Ltd. | 14 | 2022-01-06 | 2022-08-11 |
| Efficacy of Prophylactic Fluconazole Therapy in Preterm and Very Low Birth Weight Neonates in Preventing Invasive Fungal Infection. Fluconazole, Saline - Invasive Candidiases | Phase 3 | Completed | Services Institute of Medical Sciences, Pakistan | 110 | 2021-05-01 | 2023-05-08 |
| Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation Rezafungin for Injection, Posaconazole, Fluconazole - Candidemia, Mycoses | Phase 3 | Completed | Mundipharma Research Limited | 602 | 2020-05-11 | 2026-04-13 |
| Peritoneal 1.3-ß-D-glucan for the Diagnosis of Intra-abdominal Candidiasis in Critically Ill Patients (pBDG2) 1.3 BETA D GLUCAN - Intra Abdominal Infections, Candidiasis, Invasive | Completed | Central Hospital, Nancy, France | 200 | 2020-01-20 | 2023-02-09 | |
| Amphotericin B Cholesteryl Sulfate Complex for Injection(ABCD) in the Treatment of Invasive Candidiasis and Invasive Aspergillosis Amphotericin B cholesteryl sulfate complex for injection(ABCD) - Invasive Candidiasis, Invasive Aspergillosis | Phase 2 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 60 | 2020-01-01 | 2020-01-13 |
| An Open-label Study of APX001 for Treatment of Patients With Candidemia/Invasive Candidiasis Caused by Candida Auris APX001 - Candidemia, Invasive Candidiases | Phase 2 | Completed | Basilea Pharmaceutica | 9 | 2019-12-13 | 2025-09-16 |
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Candidemia (68) · Candidiasis (26) · Torulopsis (17) · Mycoses (14) · Invasive Fungal Infections (8) · Fungemia (7) · Aspergillosis (6) · Sepsis (6) · Critical Illness (5) · Bacteremia (2) · Intraabdominal Infections (2) · Pathologic Processes (2) · Pneumonia, Pneumocystis (2) · Systemic Inflammatory Response Syndrome (2)
Bacterial Infections and Mycoses (104) · Infections (103) · Invasive Fungal Infections (96) · Mycoses (90) · Candidiasis (78) · Pathological Conditions, Signs and Symptoms (74) · Pathologic Processes (72) · Inflammation (67) · Systemic Inflammatory Response Syndrome (66) · Sepsis (62) · Fungemia (61) · Disease Attributes (8) · Respiratory Tract Diseases (4) · Respiratory Tract Infections (4)
Micafungin (18) · Anidulafungin (14) · Caspofungin (14) · Fluconazole (14) · Voriconazole (7) · Injections (5) · ibrexafungerp (4) · Amphotericin B (3) · Rezafungin (2) · Saline Solution (2) · amphotericin B, deoxycholate drug combination (2) · liposomal amphotericin B (2) · Blood Specimen Collection (1) · Duration of Therapy (1) · Echinocandins (1)
Pfizer (15) · Astellas Pharma Inc (7) · Merck Sharp & Dohme LLC (5) · Scynexis, Inc. (4) · Basilea Pharmaceutica (3) · Central Hospital, Nancy, France (3) · T2 Biosystems (3) · University Medical Center Groningen (3) · Assistance Publique - Hôpitaux de Paris (2) · Astellas Pharma Global Development, Inc. (2) · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · Duke University (2) · Medical University of Graz (2) · Radboud University Medical Center (2) · University Hospital, Lille (2)
United States (39) · France (21) · Italy (16) · Germany (15) · Spain (13) · Canada (11) · Netherlands (11) · Belgium (10) · Austria (9) · Greece (9) · Brazil (7) · China (7) · South Africa (7) · South Korea (7) · Taiwan (7)
David Angulo, MD (3) · Marc Engelhardt (2) · Peter Pappas, MD (2) · Robert Krause, MD (2) · William J Steinbach, MD (2) · Alexandra Hill, MD (1) · Anahita Rouze, MD (1) · Arunaloke Chakrabarti, MD (1) · Baodong Ye (1) · Barbara D Alexander, MD (1) · Brian Fisher, DO (1)
PMID 28459966, PMID 28597967, PMID 33891293, PMID 31280481, PMID 21147825, PMID 23315320, PMID 33438477, PMID 38008099, PMID 38502709, PMID 39468640, PMID 39529079, PMID 41940006, PMID 16127033, PMID 17568028, PMID 17719934, PMID 19804626, PMID 22018278, PMID 22879929, PMID 23676114, PMID 23710653, PMID 24165173, PMID 24261608, PMID 24550378, PMID 24559321, PMID 24669841, PMID 24906361, PMID 25097069, PMID 25149761, PMID 25487797, PMID 25586686, PMID 25678411, PMID 25701307, PMID 25902926, PMID 27287231, PMID 27706483, PMID 27872072, PMID 28971861, PMID 29367293, PMID 29438475, PMID 29596222, PMID 29628014, PMID 29991219, PMID 30289478, PMID 30418357, PMID 31586424, PMID 32032174, PMID 32955088, PMID 33361296, PMID 33558294, PMID 35134165
2017 (3), 2009 (2), 2008 (1), 2014 (1), 2015 (1), R01AI170385 (1), U01CK000692 (1)