28 completed. 28 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 28 | Completed 28 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model Synthetic interstitial fluid (SIF) / SIF neutral pH, Synthetic interstitial fluid (SIF) / SIF acidic pH, Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM - Pain | Early Phase 1 | Completed | Stefan Heber | 42 | 2025-06-17 | 2025-07-29 |
| Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease Colchicine, Placebo - Peripheral Artery Disease | Early Phase 1 | Completed | University of Pennsylvania | 24 | 2024-09-25 | 2026-04-02 |
| Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Inflammation Dapagliflozin (DAPA) - Inflammation | Early Phase 1 | Completed | Washington University School of Medicine | 6 | 2024-05-08 | 2026-01-07 |
| Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity GLY-LOW - Insulin Resistance, Obesity | Early Phase 1 | Completed | Hoskinson Health and Wellness Clinic | 13 | 2023-07-27 | 2025-06-10 |
| The Effect of Albumin Supplementation on the Inflammatory and Oxidative Stress Markers in Septic Patients Human albumin - Albumin Supplementation, Albumin Therapy | Early Phase 1 | Completed | University of Pecs | 40 | 2023-03-04 | 2026-08-17 |
| WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study Inulin, Maltodextrin, Ty21a Typhoid Fever Vaccine - Inflammation, Vaccine | Early Phase 1 | Completed | USDA, Western Human Nutrition Research Center | 60 | 2022-09-27 | 2025-12-17 |
| Inflammation and Daily Life Study Naproxen, Placebos - Inflammation | Early Phase 1 | Completed | University of California, Los Angeles | 144 | 2022-02-09 | 2025-02-25 |
| Stress, Inflammation and Immune Response Pilot Study- Aim 3 App based mindfulness program (ABMP) - Systemic Lupus Erythematosus, Inflammation | Early Phase 1 | Completed | University of Wisconsin, Madison | 3 | 2022-02-02 | 2024-05-16 |
| Zinc Effect on Inflammation and Cardiovascular Risk in HIV Zinc Gluconate, Placebo - Inflammation, Cardiovascular Diseases | Early Phase 1 | Completed | University Hospitals Cleveland Medical Center | 95 | 2020-01-22 | 2025-06-12 |
| Aspirin Effects on Emotional Reactions Aspirin 500 MG, Placebo - Healthy Adults | Early Phase 1 | Completed | Ohio State University | 268 | 2019-10-08 | 2024-06-03 |
| Brain Imaging to Understand the Role of Inflammation in N-Acetyl Cysteine (NAC) Treatment of Bipolar Depression N-acetyl cysteine (NAC) - Bipolar Disorder, Depression | Early Phase 1 | Completed | Martin Lan | 3 | 2018-11-01 | 2021-08-05 |
| Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia Salsalate Oral Tablet, Placebo Oral Tablet - Preeclampsia | Early Phase 1 | Completed | University of Iowa | 24 | 2018-08-26 | 2025-06-03 |
| Acute Effects of E-Cigarette Aerosol Inhalation Electronic Cigarette Aerosol - Endothelial Dysfunction, Biochemical Markers | Early Phase 1 | Completed | University of Pennsylvania | 31 | 2018-05-22 | 2024-05-08 |
| Effects of Cyproterone Compound-spironolactone, Metformin and Pioglitazone on Inflammatory Markers in PCOS Cyproterone compound + Spironolactone, Metformin, Pioglitazone - Polycystic Ovary Syndrome | Early Phase 1 | Completed | Shiraz University of Medical Sciences | 90 | 2018-02-01 | 2019-11-12 |
| Cognitive, Emotional, and Neural Responses to Acute Inflammation Typhoid Vi Polysaccharide Vaccine, Placebo - Healthy | Early Phase 1 | Completed | University of California, San Francisco | 24 | 2018-01-01 | 2019-06-25 |
| Safety and Efficacy of Oral Bovine Lactoferrin Lactoferrin, Placebos - Neonatal SEPSIS | Early Phase 1 | Completed | Cairo University | 200 | 2018-01-01 | 2019-09-19 |
| Effect of Supplementation of Fluoride on Maternal Periodontal Health, Preterm Delivery, and Perinatal Well-Being Prenatal vitamin-mineral containing 3 mg fluoride, Prenatal vitamin-mineral containing 0 mg fluoride - Preterm Birth, Preterm Labor | Early Phase 1 | Completed | Johns Hopkins University | 43 | 2015-10-01 | 2019-11-05 |
| the Influence of Remote Ischemic Preconditioning on Inflammation During Human Endotoxemia Multiple-dose Remote Ischemic Preconditioning, Single-dose Remote Ischemic Preconditioning, LPS infusion - Autoimmune Diseases, Infection | Early Phase 1 | Completed | Radboud University Medical Center | 30 | 2015-10-01 | 2016-04-04 |
| Brain Inflammation and Function in Alcoholism connectivity, neuroinflammation, neurofunction - Alcohol Use Disorder (AUD) | Early Phase 1 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 74 | 2015-02-19 | 2026-10-13 |
| Preventing the Inflammatory Response to Experimentally-induced Insomnia Symptoms Aspirin, Placebo - Insomnia | Early Phase 1 | Completed | Beth Israel Deaconess Medical Center | 8 | 2014-10-01 | 2017-03-15 |
Showing 20 of 28. Sign in to see all of them.
Depression (3) · Cardiovascular Diseases (2) · Insulin Resistance (2) · Obesity (2) · Pain (2) · Sepsis (2) · Adenoma (1) · Alcoholism (1) · Atherosclerosis (1) · Autoimmune Diseases (1) · Bacteremia (1) · Bipolar Disorder (1) · Cognitive Dysfunction (1) · Colonic Neoplasms (1)
Pathologic Processes (28) · Pathological Conditions, Signs and Symptoms (28) · Infections (6) · Behavior (5) · Mental Disorders (4) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Signs and Symptoms (4) · Systemic Inflammatory Response Syndrome (4) · Behavioral Symptoms (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Glucose Metabolism Disorders (3) · Urogenital Diseases (3) · Bacterial Infections (2)
Aspirin (2) · Endotoxins (2) · Acetylcysteine (1) · Anthocyanins (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Arginine (1) · Cholecalciferol (1) · Colchicine (1) · Exercise (1) · Fluorides (1) · Gentamicins (1) · Inulin (1) · Lactoferrin (1) · Lipopolysaccharides (1) · Meropenem (1)
University of California, Los Angeles (2) · University of Pennsylvania (2) · Beth Israel Deaconess Medical Center (1) · Bispebjerg Hospital (1) · Boston University (1) · Cairo University (1) · Copenhagen University Hospital, Rigshospitalet (1) · Hoskinson Health and Wellness Clinic (1) · Johns Hopkins University (1) · Maastricht University Medical Center (1) · Martin Lan (1) · National Cancer Institute (NCI) (1) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (1) · Ohio State University (1) · Radboud University Medical Center (1)
United States (18) · Denmark (2) · Austria (1) · China (1) · Egypt (1) · Hungary (1) · Iran (1) · Netherlands (1)
Anna Stanhewicz, PhD (1) · Aoife S O'Donovan, PhD (1) · Bess Caswell, PhD (1) · Danielle Lemay, PhD (1) · Dardo G Tomasi, Ph.D. (1) · David Beebe, PhD (1) · Felix W. Wehrli, PhD (1) · Gholamhossein R Omrani, MD (1) · Grace A McComsey, MD, FIDSA (1) · Irina Burd, M.D., Ph.D. (1) · Jelle Zwaag, MSc (1) · Kristian H Mikkelsen, MD (1) · Mary Kable, PhD (1) · Matthew R Young, Ph.D. (1)
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K01MH109871 (1), R01HL139358 (1), R01MH091352 (1), R21AG058893 (1), R21AT003714 (1), R21AT009153 (1)