1199 completed, 417 unknown, 260 recruiting, 216 terminated. 676 Not applicable, 601 Phase 2, 431 Phase 1, 237 Phase 3, 38 Phase 4.
Follow Colonic Neoplasms: new trials by email Literature Review of Colonic Neoplasms trials Research Report on Colonic Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cancer Awareness Among Syrian Migrants PMT-Based Cancer Screening Educational Intervention, PMT-Based Cancer Screening Education Program - Breast Cancer Screening, Cervical Cancer Screening | Not applicable | Not yet recruiting | Toros University | 30 | 2027-03-09 | 2026-10-15 |
| Collagenase Biobank Study Colorectal (Colon or Rectal) Cancer | Not yet recruiting | University of Chicago | 107 | 2026-12-01 | 2026-10-13 | |
| This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid Tumors LTZ-232 - Colorectal Cancer, Advanced/Metastatic Solid Tumor | Phase 1 | Recruiting | LTZ Therapeutics, Inc. | 152 | 2026-12-01 | 2026-10-20 |
| ctDNA and TEP Levels in Colon Cancer Additional Peripheral Venous Blood Sampling for ctDNA and TEP Biomarker Analysis - Colon Cancer | Not applicable | Not yet recruiting | Institute of Oncology Ljubljana | 80 | 2026-11-01 | 2026-10-07 |
| A Study to Evaluate INCA33890 in the Treatment of Circulating Tumor DNA-Positive Stage II/III Microsatellite Stable Colorectal Cancer After Curative Resection and Chemotherapy INCA33890 - CRC (Colorectal Cancer) | Phase 2 | Not yet recruiting | Incyte Corporation | 40 | 2026-10-26 | 2026-09-22 |
| Chemotherapy Combined With or Without Short-Course Radiotherapy Versus Chemotherapy Alone as Neoadjuvant Therapy for High-Risk Locally Advanced Colon Cancer With pMMR/MSS short-course radiotherapy, Serplulimab, CapOx(Capecitabine+ Oxaliplatin) - Locally Advanced Colon Cancer, pMMR | Phase 3 | Not yet recruiting | Fudan University | 480 | 2026-10-15 | 2026-10-16 |
| Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry Proton Transfer Reaction Mass Spectrometry Analysis - Pancreas Cancer, Hepatocellular Carcinoma | Not yet recruiting | University of Oklahoma | 2000 | 2026-10-01 | 2026-07-29 | |
| Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer Cemiplimab + Fianlimab [Fixed Dose Combination (FDC)] - Colon Cancer | Phase 2 | Not yet recruiting | John Strickler, M.D. | 24 | 2026-10-01 | 2026-08-27 |
| A Phase 1 Study of DEM301 in Participants With Metastatic Colorectal Cancer DEM301 - Metastatic Colorectal Cancer, Colon Cancer | Phase 1 | Recruiting | DEM BioPharma, Inc. | 60 | 2026-10-01 | 2026-10-15 |
| Impact of Probiotics on Neuropathy Induced by Adjuvant Chemotherapy in Patients With Colon Cancer. PROBIOTIC SUPPLEMENTATION BY OXXYSLAB®, PLACEBO supplementation - Colon Adenocarcinoma, Neuropathic Pain | Not applicable | Not yet recruiting | Centre Francois Baclesse | 130 | 2026-10-01 | 2026-07-30 |
| mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer cmFOLFOXIRI plus PD-1 inhibitor, mFOLFOX6 - Colon Cancer (Stage II &Amp;Amp; III) | Phase 2 | Not yet recruiting | Sun Yat-sen University | 138 | 2026-10-01 | 2026-05-22 |
| A Study of Trastuzumab Deruxtecan (T-DXd) and Cetuximab in People With Colorectal Cancer Fam-Trastuzumab Deruxtecan-Nxki - Colorectal Cancer, Adenocarcinoma of the Colon | Phase 2 | Not yet recruiting | Memorial Sloan Kettering Cancer Center | 27 | 2026-10-01 | 2026-10-01 |
| Improving Colorectal Cancer Screening Uptake Through Education and Stool-Based Testing Outreach Colorectal Cancer Education Materials, Cologuard test kit, Fecal immunochemical test kit - Colorectal Cancer (CRC) Screening, CRC Screening | Not applicable | Not yet recruiting | Washington University School of Medicine | 200 | 2026-09-30 | 2026-08-24 |
| Neoadjuvant Pembrolizumab and Porustobart in Resectable pMMR/MSS Colon Cancer Pembrolizumab, Porustobart - Colon Cancer | Phase 2 | Recruiting | Solstice Oncology, Inc. | 100 | 2026-09-30 | 2026-10-22 |
| NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients Nurse-led Geriatric Assessment - Colo-rectal Cancer | Not applicable | Not yet recruiting | Helse Stavanger HF | 50 | 2026-09-28 | 2026-10-14 |
| Tafolecimab Combined With Chemoimmunotherapy as Neoadjuvant Treatment for pMMR/MSS Locally Advanced Colon Cancer Tafolecimab, Sintilimab - Colon Cancer, PCSK9 Inhibitor | Phase 2 | Recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 70 | 2026-09-20 | 2026-09-25 |
| ctDNA-Guided Immunotherapy for dMMR/MSI-H Colon Cancer PD-1 inhibitor, CTLA-4 inhibitor, ctDNA/MRD testing - Colon Cancer, Deficient Mismatch Repair | Phase 2 | Recruiting | Fudan University | 23 | 2026-09-14 | 2026-09-25 |
| Innovative and Cooperative Pathway Integrating Oncogeriatric, Pharmaceutical and Pharmacological Follow-up in Elderly Patients. Experimental - Elderly, Breast Cancer | Phase 4 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 794 | 2026-09-01 | 2026-09-03 |
| Radiogenomic Profiling of Dendritic Cells and Macrophages to Predict Recurrence in Colorectal Liver Metastasis Radiogenomic and Immune Profiling, Prospective Radiogenomic and ctDNA Profiling - Colo-rectal Cancer, Liver Metastases | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 210 | 2026-09-01 | 2026-08-06 | |
| Multicenter Prospective Study Protocol for Validating Surgical Quality Standards in D3 Lymphadenectomy for Oncological Right Hemicolectomy Right Colectomy & D3 Lymphadenectomy - Colon Neoplasms, Right Colon Tumors | Not yet recruiting | Fundació d'investigació Sanitària de les Illes Balears | 120 | 2026-09-01 | 2026-10-02 |
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Rectal Neoplasms (834) · Colorectal Neoplasms (828) · Breast Neoplasms (330) · Pancreatic Neoplasms (252) · Lung Neoplasms (220) · Neoplasms (216) · Stomach Neoplasms (199) · Carcinoma, Non-Small-Cell Lung (150) · Neoplasm Metastasis (143) · Prostatic Neoplasms (139) · Ovarian Neoplasms (126) · Esophageal Neoplasms (123) · Melanoma (87) · Carcinoma, Hepatocellular (78)
Digestive System Diseases (2384) · Intestinal Diseases (2384) · Gastrointestinal Diseases (2381) · Neoplasms by Site (2381) · Digestive System Neoplasms (2377) · Intestinal Neoplasms (2374) · Colonic Diseases (2365) · Gastrointestinal Neoplasms (2334) · Neoplasms (2177) · Colorectal Neoplasms (1565) · Rectal Diseases (1147) · Pathological Conditions, Signs and Symptoms (493) · Skin and Connective Tissue Diseases (362) · Skin Diseases (361) · Neoplasms by Histologic Type (359)
Fluorouracil (219) · Leucovorin (202) · Oxaliplatin (192) · Irinotecan (151) · Bevacizumab (111) · Capecitabine (94) · Cetuximab (92) · Folfox protocol (54) · Chemotherapy, Adjuvant (36) · Colonoscopy (30) · Panitumumab (30) · pembrolizumab (26) · Drug Therapy (24) · Magnetic Resonance Spectroscopy (23) · Nivolumab (22)
National Cancer Institute (NCI) (114) · Memorial Sloan Kettering Cancer Center (52) · Alliance for Clinical Trials in Oncology (40) · M.D. Anderson Cancer Center (33) · City of Hope Medical Center (30) · Case Comprehensive Cancer Center (18) · GERCOR - Multidisciplinary Oncology Cooperative Group (18) · Roswell Park Cancer Institute (17) · Assistance Publique - Hôpitaux de Paris (16) · Stanford University (16) · Amgen (15) · European Organisation for Research and Treatment of Cancer - EORTC (15) · Fudan University (15) · Sun Yat-sen University (15) · Fox Chase Cancer Center (14)
United States (1105) · France (210) · China (192) · Italy (131) · Spain (119) · Canada (114) · United Kingdom (107) · Germany (91) · South Korea (84) · Netherlands (68) · Denmark (64) · Belgium (62) · Australia (47) · Taiwan (40) · Israel (37)
Norman Wolmark, MD (12) · Leonard B. Saltz, MD (7) · Shivan Mehta, MD (7) · Nancy E. Kemeny, MD (6) · Aimery de Gramont, MD (5) · Ajay Goel, PhD (5) · Hedy L. Kindler, MD (5) · Howard S. Hochster, MD (5) · Marwan Fakih, MD (5) · Sydney Welt, MD (5)
PMID 36306483, PMID 31268130, PMID 33356421, PMID 21997132, PMID 32085892, PMID 35588252, PMID 36657089, PMID 37162250, PMID 37934000, PMID 38564700, PMID 15273542, PMID 15758907, PMID 15894098, PMID 19755046, PMID 22070868, PMID 25071111, PMID 25952085, PMID 26049686, PMID 26348120, PMID 26438146, PMID 27432417, PMID 27986363, PMID 28006055, PMID 28712102, PMID 30466310, PMID 31631858, PMID 31811950, PMID 32702383, PMID 33074326, PMID 33439695, PMID 33538338, PMID 36657661, PMID 37590355, PMID 38315963, PMID 40056080, PMID 40215447, PMID 42100890, PMID 10400410, PMID 10493478, PMID 10496568, PMID 10536559, PMID 10550154, PMID 10615079, PMID 10744089, PMID 11098486, PMID 11114689, PMID 11167863, PMID 11171826, PMID 11247898, PMID 11256129
P30CA033572 (14), P30CA015083 (13), P30CA068485 (12), U10CA031946 (11), P30CA043703 (9), 2019 (8), 2023 (8), 2025 (8), P30CA072720 (7), U10CA032102 (7), 2017 (6), P30CA016672 (6), U10CA012027 (6), U10CA021115 (6), P30CA014089 (5)