28 completed, 10 recruiting, 6 not yet recruiting, 5 active not recruiting. 56 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 56 | Completed 28, Recruiting 10, Not yet recruiting 6, Active not recruiting 5, Terminated 3, Unknown 2, Enrolling by invitation 1, Withdrawn 1 |
Follow Inflammation: new trials by email Literature Review of Inflammation trials Research Report on Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Metformin and ACLR Muscle Recovery Metformin, Placebo - Atrophy, Inflammation | Early Phase 1 | Not yet recruiting | University of Utah | 40 | 2026-11-01 | 2026-07-13 |
| 25BT056: Basket Study of Viral Cytotoxic T Lymphocytes Virus-Specific Cytotoxic T Lymphocytes (vCTLs) - EBV Viremia, CMV Viremia | Early Phase 1 | Not yet recruiting | Children's Hospital of Philadelphia | 35 | 2026-11-01 | 2026-10-22 |
| SMART 2D: Study of Montelukast's Effects on Renal and Cardiovascular Health in Adolescents and Young Adults With Type 2 Diabetes Montelukast, Montelukast Placebo - Type 2 Diabetes | Early Phase 1 | Recruiting | University of Colorado, Denver | 50 | 2026-10-12 | 2026-10-06 |
| Prednisone in Adults With an Immune-Mediated Subtype of Autism Spectrum Disorder Prednisone, Placebo - Autism Spectrum Disorder, Autism Spectrum Disorders | Early Phase 1 | Recruiting | Christopher John McDougle, M.D. | 32 | 2026-08-01 | 2026-08-19 |
| LpD3.5 Intervention Study in Older Adults- LISA-I Trial LpD3.5, Placebo - Mild Cognitive Impairment (MCI), Cognition | Early Phase 1 | Recruiting | University of South Florida | 15 | 2026-03-03 | 2026-08-31 |
| The Role of Acetazolamide in Mitigating Inflammation and Innate Immune Activation at High Altitude ACETAZOLAMIDE oral capsule, Placebo Arm - Hypoxemia, Acute Mountain Sickness (AMS) | Early Phase 1 | Active not recruiting | University of California, Riverside | 19 | 2025-09-17 | 2026-04-08 |
| Impact of T Cells on Age-related Vascular Dysfunction: A Translational Approach Placebo, Abatacept 10 mg/kg - Cardiovascular Diseases, Inflammation | Early Phase 1 | Withdrawn | University of Utah | 2025-09-01 | 2026-01-12 | |
| Safety, Virological and Immunological Assessment of the Controlled Dengue Human Infection Model in Dengue-Immune Participants in Thailand (DHIT-Immune) rDEN2Δ30-7169 - Safety Issues, Dengue | Early Phase 1 | Not yet recruiting | Mahidol University | 12 | 2025-09-01 | 2025-04-03 |
| Short-Term Outcomes of Early Administration of Colchicine in Non-ST Segment Elevation Myocardial Infarction Patients Treated With Drug-Eluting Stents. Colchicine, Placebo - Non ST-Segment Elevation Myocardial Infarction | Early Phase 1 | Recruiting | Assiut University | 140 | 2025-08-10 | 2025-08-27 |
| Chronic Intervention With Sulforaphane-Smart® in Overweight and Obese Adults Sulforaphan-Smart® formula, Control (placebo) group - Obesity and Overweight | Early Phase 1 | Not yet recruiting | Mª Jesús Periago | 40 | 2025-07-01 | 2025-05-09 |
| Mechanisms of Pain Hypersensitivity in a Human Skin Inflammation Model Synthetic interstitial fluid (SIF) / SIF neutral pH, Synthetic interstitial fluid (SIF) / SIF acidic pH, Synthetic interstitial fluid (SIF) / SIF acidic pH + BCTC 1 µM - Pain | Early Phase 1 | Completed | Stefan Heber | 42 | 2025-06-17 | 2025-07-29 |
| Human Umbilical Cord Mesenchymal Stem Cells Treatment in Sepsis CD83-positive MSC, regulatory MSC, control solution - Sepsis | Early Phase 1 | Recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 180 | 2025-05-22 | 2025-05-25 |
| Mechanistic Studies of Psilocybin in Headache Disorders Psilocybin, Placebo - Migraine | Early Phase 1 | Recruiting | Yale University | 50 | 2025-05-19 | 2026-07-13 |
| Lipid Mediators & Cancer: Montelukast, SPM, and Almonds No Interventions, Sports Pro Resolve 4 g, Double Wood SPM 4 g - Colorectal Cancer, Sarcoma | Early Phase 1 | Not yet recruiting | University of South Florida | 56 | 2025-03-01 | 2025-03-20 |
| Tofacitinib in Patients With Amyotrophic Lateral Sclerosis Tofacitinib tablets - Amyotrophic Lateral Sclerosis | Early Phase 1 | Not yet recruiting | Beijing Tiantan Hospital | 12 | 2024-12-01 | 2024-11-15 |
| Comparison of Angiotensin II to Standard Dose Vasopressors on Change in Arterial Elastance Giapreza - Septic Shock, Cirrhosis | Early Phase 1 | Active not recruiting | The Cleveland Clinic | 30 | 2024-11-15 | 2026-05-05 |
| Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures GLP-1, Placebo - Longevity, Quality of Life | Early Phase 1 | Enrolling by invitation | AgelessRx | 150 | 2024-11-01 | 2025-07-30 |
| Mechanistic Clinical Trial of Colchicine in Patients With Peripheral Artery Disease Colchicine, Placebo - Peripheral Artery Disease | Early Phase 1 | Completed | University of Pennsylvania | 24 | 2024-09-25 | 2026-04-02 |
| Role of Inflammation in Vascular Phenotype Associated With E-cigarette Use Placebo, Salsalate 750 MG Oral Tablet [DISALCID] - Electronic Cigarette Use, Endothelial Dysfunction | Early Phase 1 | Recruiting | University of Iowa | 24 | 2024-08-15 | 2026-10-29 |
| Evidence-based Evaluation and Mechanism of Shenhuang Granules in the Treatment of Sepsis shenhuang granule, placebo - Sepsis | Early Phase 1 | Recruiting | The First Affiliated Hospital of Zhejiang Chinese Medical University | 410 | 2024-07-01 | 2025-08-22 |
Showing 20 of 56. Sign in to see all of them.
Sepsis (4) · Cardiovascular Diseases (3) · Depression (3) · Obesity (3) · Atherosclerosis (2) · Autoimmune Diseases (2) · Cognitive Dysfunction (2) · Colorectal Neoplasms (2) · Diabetes Mellitus (2) · Hypoxia (2) · Insulin Resistance (2) · Motor Activity (2) · Neonatal Sepsis (2) · Neuroinflammatory Diseases (2)
Pathologic Processes (56) · Pathological Conditions, Signs and Symptoms (56) · Infections (14) · Systemic Inflammatory Response Syndrome (11) · Signs and Symptoms (10) · Nervous System Diseases (9) · Nutritional and Metabolic Diseases (8) · Behavior (7) · Female Urogenital Diseases and Pregnancy Complications (7) · Mental Disorders (7) · Metabolic Diseases (7) · Urogenital Diseases (7) · Neurologic Manifestations (6) · Sepsis (6)
Aspirin (4) · salicylsalicylic acid (3) · Anti-Inflammatory Agents, Non-Steroidal (2) · Colchicine (2) · Endotoxins (2) · Exercise (2) · Lactoferrin (2) · Metformin (2) · Sodium Chloride (2) · Tablets (2) · montelukast (2) · Abatacept (1) · Acetates (1) · Acetazolamide (1) · Acetylcysteine (1)
University of Pennsylvania (3) · Beth Israel Deaconess Medical Center (2) · USDA, Western Human Nutrition Research Center (2) · University of California, Los Angeles (2) · University of Iowa (2) · University of South Florida (2) · University of Utah (2) · AgelessRx (1) · Assiut University (1) · Baylor College of Medicine (1) · Beijing Tiantan Hospital (1) · Bispebjerg Hospital (1) · Boston University (1) · Cairo University (1) · Children's Hospital of Philadelphia (1)
United States (35) · China (4) · Egypt (3) · Denmark (2) · United Kingdom (2) · Austria (1) · Hungary (1) · Iran (1) · Netherlands (1) · Spain (1)
Danielle Lemay, PhD (2) · Monika Haack, PhD (2) · Amrita Ahluwalia, BSc PhD (1) · Amy C Arnold, PhD (1) · Anna Stanhewicz, PhD (1) · Aoife S O'Donovan, PhD (1) · Bess Caswell, PhD (1) · Caitlin Elgarten, MD, MSCE (1) · Christopher J McDougle, M.D. (1) · Dardo G Tomasi, Ph.D. (1) · David Beebe, PhD (1) · Felix W. Wehrli, PhD (1) · Feng DanDan, master (1) · Gholamhossein R Omrani, MD (1) · Grace A McComsey, MD, FIDSA (1)
PMID 10191237, PMID 10685584, PMID 18299127, PMID 19098906, PMID 19358906, PMID 20562702, PMID 20573305, PMID 20594330, PMID 21270403, PMID 22225756, PMID 22273282, PMID 22292553, PMID 22370776, PMID 22542159, PMID 22895665, PMID 24005862, PMID 25770082, PMID 25948052, PMID 25948673, PMID 25997043, PMID 26360770, PMID 26442449, PMID 26562532, PMID 27763627, PMID 27893465, PMID 28062311, PMID 28709450, PMID 29282327, PMID 29352570, PMID 29682542, PMID 29749279, PMID 30031863, PMID 30044959, PMID 30165617, PMID 30782041, PMID 31042077, PMID 31084985, PMID 31103547, PMID 31429679, PMID 31632316, PMID 31733140, PMID 31814084, PMID 32107360, PMID 32129462, PMID 32302292, PMID 32445625, PMID 32528311, PMID 32538283, PMID 32865380, PMID 33216614
K01MH109871 (1), R01AG060395 (1), R01HL139358 (1), R01MH091352 (1), R21AG058893 (1), R21AT003714 (1), R21AT009153 (1)