41 completed, 15 unknown, 10 recruiting, 7 not yet recruiting. 31 Not applicable, 11 Phase 1, 10 Phase 2, 6 Phase 3, 2 Early Phase 1.
Follow Hypoxic-Ischemic Encephalopathy: new trials by email Literature Review of Hypoxic-Ischemic Encephalopathy trials Research Report on Hypoxic-Ischemic Encephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cell-Based Therapy for White Matter Repair in Periventricular Leukomalacia Investigational Combination Product - Periventricular Leukomalacia, White Matter Disease | Early Phase 1 | Withdrawn | MGAM LLC | 2027-01-01 | 2025-07-22 | |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| EEG-Based Decision-Support Algorithm for Hypoxic-Ischemic Encephalopathy in Term Newborns Hypoxic-Ischemic Encephalopathy, Perinatal Asphyxia | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 310 | 2026-09-16 | 2026-08-13 | |
| Neonatal Neurological Observation With Video AI Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring - Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy | Recruiting | Artemis AI Labs | 200 | 2026-07-13 | 2026-07-15 | |
| Hydrogen In Neonatal Encephalopathy (HIE) Trial Hydrogen Gas (H2) - HIE, Hypoxic-Ischemic Encephalopathy | Phase 1 | Not yet recruiting | Boston Children's Hospital | 54 | 2026-03-01 | 2026-02-17 |
| A Study of a Blood Marker in Newborns With Brain Injury Caused by Lack of Oxygen at Birth Hypoxic-Ischemic Encephalopathy | Not yet recruiting | Mustafa Gürkan | 20 | 2025-12-15 | 2025-12-18 | |
| Evaluating a Wireless NIRS Device in the Neonatal Intensive Care Unit Wireless NIRS - Hypoxic-Ischemic Encephalopathy, Congenital Heart Disease | Not applicable | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 20 | 2025-11-15 | 2026-07-28 |
| A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury Metformin - Hypoxic-Ischemic Encephalopathy, HIE | Phase 1 | Enrolling by invitation | Boston Children's Hospital | 30 | 2025-10-01 | 2026-02-17 |
| Nephroprotection Following Perinatal Asphyxia: Randomized Controlled Trial Pentoxifylline, placebo distilled water - Hypoxic-Ischemic Encephalopathy, Neonatal Encephalopathy | Not applicable | Not yet recruiting | Alexandria University | 30 | 2025-07-30 | 2025-07-28 |
| Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period Motor Disorders, Neurodevelopmental Disorders | Not yet recruiting | Karolinska Institutet | 2900 | 2025-01-01 | 2024-10-17 | |
| The Effect of Maternal Scent and Knitted Octopus Application on Pain in Infants Diagnosed With Neonatal Asphyxia and Receiving Therapeutic Hypothermia Treatment scent - Hypoxic-Ischemic Encephalopathy, Pain | Not applicable | Completed | Alev Sivasli | 45 | 2024-12-30 | 2026-04-13 |
| Dose Optimization of Caffeine for HIE Caffeine citrate 20 mg/kg, Caffeine citrate 30 mg/kg - Hypoxic-Ischemic Encephalopathy | Phase 1 | Active not recruiting | University of North Carolina, Chapel Hill | 16 | 2024-07-26 | 2026-08-14 |
| Monitoring After Cardiac Arrest: Electroencephalogram and Cerebral Oximetry in Predicting Outcome Cardiac Arrest, EEG With Periodic Abnormalities | Completed | Haseki Training and Research Hospital | 44 | 2024-06-15 | 2025-03-19 | |
| PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia Caffeine citrate - Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy | Phase 1 | Withdrawn | University of Arkansas | 2024-05-08 | 2024-05-10 | |
| Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest Post-Resuscitation Syndrome, Critical Illness | Completed | Ahmet Düzgün | 168 | 2024-05-01 | 2026-05-08 | |
| Functional Imaging of Baby Brains Diffuse Optical Tomography - Hypoxia Ischemia, Cerebral, Hypoxia-Ischemia, Brain | Unknown | Hamilton Health Sciences Corporation | 25 | 2024-03-15 | 2024-10-23 | |
| School-aged Outcomes Post Hypoxic Ischaemic Encephalopathy Hypoxic-Ischemic Encephalopathy | Enrolling by invitation | University College Cork | 196 | 2024-03-09 | 2026-08-18 | |
| Umbilical Cord Abnormalities in the Prediction of Adverse Pregnancy Outcomes Umbilical cord measurements & observations - Small for Gestational Age at Delivery, Hypoxic-Ischemic Encephalopathy | Unknown | Medway NHS Foundation Trust | 5000 | 2023-10-03 | 2024-03-12 | |
| Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy Normal Saline along with standard treatment, Sovateltide along with standard treatment - Hypoxic-Ischemic Encephalopathy, Neonatal Asphyxia | Phase 2 | Recruiting | Pharmazz, Inc. | 40 | 2023-09-06 | 2025-12-31 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia RLS-0071, Placebo - Hypoxic-Ischemic Encephalopathy | Phase 2 | Recruiting | ReAlta Life Sciences, Inc. | 70 | 2023-07-27 | 2026-04-13 |
Showing 20 of 89. Sign in to see all of them.
Hypoxia-Ischemia, Brain (89) · Asphyxia Neonatorum (12) · Hypothermia (8) · Brain Injuries (7) · Asphyxia (5) · Cerebral Palsy (5) · Heart Arrest (5) · Leukomalacia, Periventricular (4) · Premature Birth (4) · Stroke (4) · Brain Diseases (3) · Fetofetal Transfusion (3) · Hypoglycemia (3) · Hypoxia, Brain (3) · Intracranial Hemorrhages (3)
Brain Ischemia (89) · Cardiovascular Diseases (89) · Central Nervous System Diseases (89) · Cerebrovascular Disorders (89) · Hypoxia (89) · Pathological Conditions, Signs and Symptoms (89) · Signs and Symptoms (89) · Signs and Symptoms, Respiratory (89) · Vascular Diseases (89) · Nervous System Diseases (88) · Brain Diseases (86) · Hypoxia, Brain (86) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (24) · Infant, Newborn, Diseases (20) · Pathologic Processes (16)
Umbilical Cord Clamping (5) · Epoetin Alfa (3) · Erythropoietin (3) · Saline Solution (3) · caffeine citrate (3) · Dexmedetomidine (2) · Hydrocortisone (2) · Magnetic Resonance Imaging (2) · hydrocortisone hemisuccinate (2) · Cytidine Diphosphate Choline (1) · Diagnostic Imaging (1) · Electroretinography (1) · Hyperbaric Oxygenation (1) · Intercellular Signaling Peptides and Proteins (1) · Levetiracetam (1)
University of California, San Francisco (4) · Boston Children's Hospital (3) · McGill University Health Centre/Research Institute of the McGill University Health Centre (3) · NICHD Neonatal Research Network (3) · Nemours Children's Clinic (3) · Assistance Publique - Hôpitaux de Paris (2) · Children's Hospital of Fudan University (2) · Semmelweis University (2) · The Hospital for Sick Children (2) · University of Florida (2) · University of North Carolina, Chapel Hill (2) · University of Oulu (2) · Zhengzhou University (2) · Agah Bahadır Öztürk,MD (1) · Ahmet Düzgün (1)
United States (33) · China (10) · Turkey (Türkiye) (9) · Canada (6) · India (6) · United Kingdom (5) · Finland (2) · France (2) · Hungary (2) · Italy (2) · New Zealand (2) · Australia (1) · Brazil (1) · Egypt (1) · Germany (1)
Seetha Shankaran, MD (4) · Abhik Das, PhD (3) · Brian Kalish, MD (3) · Abbot R Laptook, MD (2) · Anup Katheria, MD (2) · Barbara J. Stoll, MD (2) · Barbara Schmidt, MD, MSc (2) · Brenda B. Poindexter, MD MS (2) · Carl D'Angio, MD (2) · Changlian Zhu, MD, PhD (2) · Edward F. Bell, MD (2) · Jukka Kortelainen, MD, PhD (2) · Kathleen A. Kennedy, MD MPH (2) · Krisa P. Van Meurs, MD (2) · Kristi L. Watterberg, MD (2)
PMID 24524452, PMID 35835616, PMID 41250198, PMID 10763759, PMID 11703564, PMID 14977901, PMID 1622910, PMID 17695343, PMID 18784420, PMID 20207600, PMID 20695757, PMID 20847327, PMID 22348528, PMID 23008465, PMID 23149172, PMID 23440789, PMID 23629670, PMID 24012586, PMID 24136687, PMID 24366463, PMID 24473179, PMID 25123212, PMID 25393080, PMID 25439577, PMID 25536254, PMID 25616519, PMID 25631390, PMID 25644966, PMID 25782975, PMID 25827279, PMID 26063194, PMID 26169430, PMID 26291387, PMID 26828941, PMID 26857710, PMID 27126393, PMID 27450203, PMID 27524449, PMID 27614933, PMID 27733184, PMID 28065781, PMID 28389438, PMID 28672318, PMID 29031859, PMID 29067428, PMID 29095433, PMID 29408249, PMID 29463417, PMID 29496329, PMID 29681183
U10HD021364 (3), U10HD021373 (3), U10HD021385 (3), U10HD027851 (3), U10HD027853 (3), U10HD027856 (3), U10HD027880 (3), U10HD027904 (3), U10HD034216 (3), U10HD036790 (3), U10HD040492 (3), U10HD040689 (3), U10HD053109 (3), U10HD068244 (3), U10HD068263 (3)