16 completed, 7 unknown, 3 recruiting, 3 terminated. 12 Not applicable, 9 Phase 2, 9 Phase 3, 5 Phase 4, 1 Early Phase 1.
Follow Intercellular Signaling Peptides and Proteins: new trials by email Literature Review of Intercellular Signaling Peptides and Proteins trials Research Report on Intercellular Signaling Peptides and Proteins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Plasma Rich in Growth Factors (PRGF) in the Treatment of Foot Ulcers in Diabetic Patients With Peripheral Arterial Disease Topical application of Plasma Rich in Growth Factors (PRGF), Conventional treatment (conventional treatment with adequate offloading and metabolic control, +/- antibiotic). - Foot Ulcers, Diabetic | Phase 4 | Recruiting | Biotechnology Institute IMASD | 38 | 2025-11-01 | 2025-09-11 |
| Open, Non-comparative Pilot Study to Evaluate the Safety and Efficacy of Intraovarian Plasma Rich in Growth Factors (PRGF) in Patients With Low Ovarian Reserve Plasma Rich in Growth Factors (PRGF) - Low Ovarian Reserve | Not applicable | Recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 50 | 2025-05-30 | 2025-06-12 |
| Role of Plasma Rich Growth Factor in Repair Primary Cleft Palate Plasma Rich in Growth Factors (PRGF), Placebo - Cleft Palate, Plasma Rich in Growth Factors | Not applicable | Not yet recruiting | Cairo University | 36 | 2025-04-01 | 2025-03-21 |
| PRGF-ENDORET® Infiltrations in the Treatment of Low Back Pain. Plasma Rich in Growth Factors (PRGF), Corticosteroid solution (Celestone Cronodose suspension for injection) in saline solution. - Diseases [C] - Musculoskeletal Diseases [C05 | Phase 4 | Recruiting | Biotechnology Institute IMASD | 48 | 2025-01-23 | 2025-02-06 |
| Effect of PRF & Fractional CO2 Laser in Postburn Hypertrophic Scars Plasma rich in growth factors (PRGF-Endoret), Fractional CO2 laser assisted PDT - Hypertrophic Scars, Burn Scar Patients | Early Phase 1 | Not yet recruiting | Assiut University | 30 | 2024-11-01 | 2024-10-29 |
| Guided Bone Regeneration Combined With PRGF for Atrophic Edentulous Maxilla Guided Bone Regeneration Combined With Plasma Rich in Growth Factors - Alveolar Bone Loss, Edentulous Maxilla, Atrophic | Not applicable | Completed | Universidade do Porto | 11 | 2023-03-01 | 2026-09-09 |
| Evaluation of Treatment of Osteoarthritis of the Knee in the Form of Chondromalacia of the Articular Cartilage Treated in the Arthroscopic Technique With the Use of:Autogenous Transplantation of Fragmented Adipose Tissue,PRP GF,Mesenchymal Cells,Hyaluronic Acid-low Molecular Weight and Cross-linked Autogenous transplant of fragmented adipose tissue taken from abdominal integuments, PRP GF (platelet-rich plasma with growth factors), Mesenchymal cells centrifuged from bone marrow cells taken from the iliac crest - Osteoarthritis, Knee, Chondral Defect | Not applicable | Completed | eMKa MED Medical Center | 150 | 2022-12-12 | 2025-08-07 |
| Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors Plasma rich in growth factors ( PRGF ) - Macular Holes | Phase 2 | Unknown | Minia University | 40 | 2022-06-01 | 2023-11-02 |
| Comparison of Two Different Types of Platelet Concentrate to Augment Bone Around Immediate Dental Implant Drug: Growth Factors (CGF), Drug: Growth Factors (PRGF), Surgery: Dental Implant surgery - Dental Implant Failure Nos | Not applicable | Completed | Minia University | 20 | 2022-02-01 | 2026-06-09 |
| Influence of PRGF (Plasma Rich in Growth Factors) Puncture in Ovaries With Low Follicular Reservetechniques Growth Factors - Low Ovarian Reserve | Phase 3 | Terminated | IVI Bilbao | 51 | 2021-06-29 | 2025-05-02 |
| Clinical and Comparative Evaluation of the Treatment Results of Arthroscopic Reconstruction of Cartilage Defects in the Knee Joint With the Use of Autogenous Cartilage Graft With PRP GF (Platelet-rich Plasma With Growth Factors) Arthroscopic reconstruction of cartilage defects in the knee joint with the use of autogenous cartilage transplant with PRP GF (platelet plasma with growth factor), Arthroscopic reconstruction of the cartilage defects of the knee joint using the microfracture method - Cartilage Damage, Cartilage Injury | Not applicable | Unknown | eMKa MED Medical Center | 60 | 2021-06-22 | 2022-04-14 |
| Efficacy of PRGF Supplementation After TMJ Arthrocentesis in Patients With TMJ Osteoarthritis Plasma Rich in Growth Factor (PRGF) Supplementation, Triamcinolone Acetonide - TMJ, Osteoarthritis | Phase 4 | Terminated | University of Florida | 5 | 2021-03-30 | 2025-02-21 |
| Effectiveness of Lyophilized Growth Factors for Subacromial Impingement Growth factors, Saline - Shoulder Impingement Syndrome | Not applicable | Unknown | Alexandria University | 60 | 2020-09-01 | 2020-07-09 |
| A Trial to Evaluate the Combination Efficacy of Artificial Dermis and Growth Factor in Chronic Wounds Ulcer artificial dermis, growth factor - Chronic Wound | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 64 | 2020-03-01 | 2019-10-21 |
| Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium Plasma rich in growth factors (PRGF-Endoret) - Infertility, Infertility, Female | Phase 2 | Completed | Sara Rafael Fernandez | 13 | 2019-05-27 | 2022-09-08 |
| Efficacy of Intralesional Injection of Platelet Rich Plasma in the Treatment of Patients With Erosive Oral Lichen Planus Platelet rich plasma, Triamcinolone Acetonide - Erosive Oral Lichen Planus | Phase 2 | Completed | Cairo University | 20 | 2018-01-01 | 2023-02-09 |
| Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone Culture with progesterone, Culture without progesterone, Culture with growth factors - Obstetric Labor, Premature | Not applicable | Completed | Hillel Yaffe Medical Center | 115 | 2017-07-15 | 2022-06-23 |
| Socket Augmentation Using Atorvastatin With Or Without PRGF (Clinical and Histomorphometric Study) PRGF/ATV, ATV gel - Socket Preservation | Phase 4 | Completed | Ain Shams University | 30 | 2016-03-01 | 2018-09-24 |
| Improving Embryogenesis by Adding Growth Factors to In Vitro Human Culture Media Growth Factors and Cytokine adding to embryo culture media, No Intervention - In Vitro Human Embryo Development | Not applicable | Completed | Ibn Sina Hospital | 426 | 2015-05-01 | 2018-10-02 |
| Growth Factors Release of PRF and PRGF group 1 bio-oss bone xenograft, group 2 platelet rich in growth factor (autogenous platelet rich in growth factor), group 3 platelet rich fibrin (autogenous platelet rich fibrin) - Periodontitis | Phase 3 | Completed | Al-Azhar University | 30 | 2014-09-01 | 2015-05-19 |
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Osteoarthritis (4) · Osteoarthritis, Knee (4) · Alveolar Bone Loss (1) · Atrophic Maxilla (1) · Bone Cysts (1) · Cartilage Diseases (1) · Cicatrix, Hypertrophic (1) · Cleft Palate (1) · Foot Ulcer (1) · Hypoxia-Ischemia, Brain (1) · Infertility (1) · Infertility, Female (1) · Knee Injuries (1) · Lichen Planus (1) · Obstetric Labor, Premature (1)
Meir Medical Center (6) · Biotechnology Institute IMASD (2) · Cairo University (2) · Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias (2) · Minia University (2) · eMKa MED Medical Center (2) · Ain Shams University (1) · Al-Azhar University (1) · Alexandria University (1) · Assiut University (1) · Emory University (1) · Hillel Yaffe Medical Center (1) · IVI Bilbao (1) · Ibn Sina Hospital (1) · Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (1)
Egypt (8) · Spain (7) · Israel (6) · Poland (2) · United States (2) · China (1) · Iran (1) · Portugal (1)
Omer Mei Dan, Dr (3) · Adriano M Almeida, MD (1) · Ahmed Ali, Assistant Proffesor (1) · Ahmed Y Gamal, PhD (1) · Arnaldo J Hernandez, MD, PhD (1) · Charles G. Widmer, DDS (1) · Edmund Waller, MD (1) · Jailan Noureldin (1) · Khaled A Ghaffar, Professor (1) · Lior Laver, MD (1) · Mohamed Makboul, Professor (1) · Nasibeh Zare, DDS (1) · Ola M Ezzatt, Lecturer (1) · Reza Tabrizi, DMD (1)