6 completed, 3 recruiting, 1 not yet recruiting. 10 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 6, Recruiting 3, Not yet recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 1 | Completed 1 |
Follow Hypoxic-Ischemic Encephalopathy: new trials by email Literature Review of Hypoxic-Ischemic Encephalopathy trials Research Report on Hypoxic-Ischemic Encephalopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy Normal Saline along with standard treatment, Sovateltide along with standard treatment - Hypoxic-Ischemic Encephalopathy, Neonatal Asphyxia | Phase 2 | Recruiting | Pharmazz, Inc. | 40 | 2023-09-06 | 2025-12-31 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia RLS-0071, Placebo - Hypoxic-Ischemic Encephalopathy | Phase 2 | Recruiting | ReAlta Life Sciences, Inc. | 70 | 2023-07-27 | 2026-04-13 |
| A Dose Escalation Study of Levetiracetam in the Treatment of Neonatal Seizures Levetiracetam Injection, Phenobarbital Sodium Injection - Neonatal Seizure, Neonatal Encephalopathy | Phase 2 | Recruiting | University of California, San Diego | 133 | 2023-03-24 | 2026-10-15 |
| Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) Dexmedetomidine Hydrochloride, Morphine Sulfate - Hypoxic-Ischemic Encephalopathy, Pain | Phase 2 | Completed | University of Utah | 50 | 2022-06-20 | 2026-03-06 |
| Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Hydrocortisone, Placebo - Hypoxic-Ischemic Encephalopathy, Asphyxia | Phase 2 / Phase 3 | Completed | Semmelweis University | 32 | 2016-02-01 | 2023-04-21 |
| Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Erythropoietin, Normal saline - Hypoxic-ischemic Encephalopathy, Neonatal Encephalopathy | Phase 1 / Phase 2 | Completed | University of California, San Francisco | 50 | 2013-09-01 | 2020-07-13 |
| Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy Cerebrolysin® - Hypoxic-Ischemic Encephalopathy | Phase 2 | Completed | Sahar M.A. Hassanein, MD | 40 | 2011-03-01 | 2013-09-13 |
| Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy recombinant human erythropoietin - Hypoxic-Ischemic Encephalopathy | Phase 1 / Phase 2 | Completed | Zhengzhou University | 167 | 2003-08-01 | 2008-12-16 |
| Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy hypothermia - Hypoxic-Ischemic Encephalopathy | Phase 1 / Phase 2 | Completed | Zhengzhou University | 100 | 2002-07-01 | 2009-01-06 |
Hypoxia-Ischemia, Brain (10) · Asphyxia (3) · Asphyxia Neonatorum (3) · Cerebral Palsy (1) · Hereditary Sensory and Autonomic Neuropathies (1) · Hypothermia (1) · Pain (1) · Shock (1)
Brain Diseases (10) · Brain Ischemia (10) · Cardiovascular Diseases (10) · Central Nervous System Diseases (10) · Cerebrovascular Disorders (10) · Hypoxia (10) · Hypoxia, Brain (10) · Nervous System Diseases (10) · Pathological Conditions, Signs and Symptoms (10) · Signs and Symptoms (10) · Signs and Symptoms, Respiratory (10) · Vascular Diseases (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Death (3) · Infant, Newborn, Diseases (3)
Dexmedetomidine (1) · Epoetin Alfa (1) · Erythropoietin (1) · Hydrocortisone (1) · Levetiracetam (1) · Morphine (1) · Nerve Growth Factor (1) · Phenobarbital (1) · RLS-0071 (1) · Saline Solution (1) · Sildenafil Citrate (1) · Sodium Chloride (1) · cerebrolysin (1) · hydrocortisone hemisuccinate (1)
Zhengzhou University (2) · Assistance Publique - Hôpitaux de Paris (1) · Pharmazz, Inc. (1) · ReAlta Life Sciences, Inc. (1) · Sahar M.A. Hassanein, MD (1) · Semmelweis University (1) · University of California, San Diego (1) · University of California, San Francisco (1) · University of Utah (1)
United States (4) · China (2) · Egypt (1) · France (1) · Hungary (1) · India (1) · New Zealand (1)
Changlian Zhu, MD, PhD (2) · Anil Gulati (1) · Cynthia M Sharpe, M.D. (1) · Jeff J Gold, M.D. PhD (1) · Mariana Baserga, MD (1) · Richard H Haas, MBBChir (1) · Sahar MA Hassanein, MD (1) · Sonya G Wang, M.D. (1) · Yvonne W Wu, MD, MPH (1)
PMID 24473179, PMID 27126393, PMID 27614933, PMID 30661082, PMID 31155392, PMID 31261373, PMID 34764335, PMID 40983658
2023 (1)