243 completed. 243 Phase 3, 49 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 243 | Completed 243 |
| Phase 2 | 49 | Completed 49 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Oral Iron for the Management of Iron Deficiency Anemia in SGLT2i-Treated Heart Failure Patients Oral iron supplementation - Heart Failure, Anemia | Phase 3 | Completed | Universidade do Porto | 55 | 2025-09-20 | 2026-07-16 |
| A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography - Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic | Phase 2 / Phase 3 | Completed | University of Leicester | 66 | 2023-12-05 | 2026-07-22 |
| A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study sacubitril/valsartan - Heart Failure | Phase 3 | Completed | Novartis Pharmaceuticals | 8 | 2023-12-04 | 2025-10-14 |
| The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients SmartHF application - Heart Failure | Phase 3 | Completed | University of Michigan | 225 | 2023-07-21 | 2026-01-16 |
| Sodium Chloride vs. Glucose Solute as a Volume Replacement Therapy During Decongestion in Acute Heart Failure Furosemide intravenous infusion, Continous intravenous infusion of 0.9% Sodium Chloride solution, Continous intravenous infusion of 5% Glucose solution - Acute Heart Failure, Congestion | Phase 3 | Completed | Wroclaw Medical University | 50 | 2022-02-01 | 2024-06-21 |
| Impact of DApagliflozin on Cardiac Function Following Anterior Myocardial Infarction in Non-Diabetic Patients Dapagliflozin 10mg, Glucose Tab - Anterior MI | Phase 2 / Phase 3 | Completed | Omar Younis | 100 | 2021-10-01 | 2024-11-19 |
| MSCs for Prevention of MI-induced HF Umbilical Cord-Derived Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs), Conventional Treatment - Myocardial Infarction, Acute, Myocardial Infarction First | Phase 3 | Completed | Shiraz University of Medical Sciences | 420 | 2021-09-15 | 2024-11-04 |
| Study to Evaluate the Efficacy and Safety of AZD4831 in Participants With Heart Failure With Left Ventricular Ejection Fraction > 40% AZD4831, Placebo - Heart Failure With Preserved Ejection Fraction | Phase 2 / Phase 3 | Completed | AstraZeneca | 711 | 2021-06-30 | 2025-08-27 |
| The Re-Prosper HF Study probenecid, Placebo - Heart Failure | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 125 | 2021-06-09 | 2026-09-14 |
| Impact on Atrial Remodeling of Dapaglifozin in Patients With Heart Failure . Dapagliflozin - Heart Failure | Phase 3 | Completed | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 162 | 2021-02-08 | 2023-07-12 |
| Randomized Double-blind Trial to Study the Benefit of Colchicine in Patients With Acutely Decompensated Heart Failure Colchicine 0.5 MG, Placebo - HEART FAILURE | Phase 3 | Completed | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | 279 | 2021-02-08 | 2024-05-22 |
| Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure Furosemide, Torsemide - Heart Failure | Phase 3 | Completed | Yale University | 47 | 2021-02-08 | 2024-10-15 |
| Hypertonic Saline Therapy in Ambulatory Heart Failure Unit. Hypertonic saline solution plus intravenous furosemide, Intravenous furosemide - Heart Failure | Phase 3 | Completed | Puerta de Hierro University Hospital | 167 | 2021-01-01 | 2023-11-09 |
| Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack. Dapagliflozin, Placebo - Acute Myocardial Infarction, Heart Failure | Phase 3 | Completed | AstraZeneca | 4017 | 2020-12-22 | 2025-03-07 |
| The CASCADE HF Soft Launch and Calibration Phase I and II Non-Invasive Continuous Remote Patient Monitoring, Affective Analysis of Participant Response to Continuous Remote Patient Monitoring - Heart Failure | Phase 2 / Phase 3 | Completed | Endeavor Health | 20 | 2020-12-14 | 2023-10-03 |
| Intravenous Thyroxine for Heart-Eligible Organ Donors Thyroxine, Saline - Brain Death, Heart Failure | Phase 3 | Completed | Washington University School of Medicine | 838 | 2020-12-01 | 2024-01-10 |
| Furoscix Real-World Evaluation for Decreasing Hospital Admissions in Heart Failure Furoscix Infusor - Heart Failure | Phase 3 | Completed | scPharmaceuticals, Inc. | 27 | 2020-11-12 | 2023-02-24 |
| Treatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS Device Sacubitril / Valsartan Oral Tablet [Entresto] - Pulmonary Hypertension | Phase 3 | Completed | Germans Trias i Pujol Hospital | 14 | 2020-10-29 | 2021-09-28 |
| Reduced Anticoagulation Targets in ECLS (RATE) Heparin, LMWH - Heart Failure, Respiratory Failure | Phase 3 | Completed | University Medical Center Groningen | 330 | 2020-10-01 | 2025-05-02 |
| Micophenolate Mofetil Versus Azathioprine in Myocarditis mycophenolate mofetil 2 g per day, azathioprine of 150 [75; 150] mg per day - Lymphocytic Myocarditis (Disorder), Heart Failure | Phase 3 | Completed | I.M. Sechenov First Moscow State Medical University | 50 | 2020-10-01 | 2025-07-15 |
Showing 20 of 243. Sign in to see all of them.
Heart Diseases (19) · Cardiovascular Diseases (18) · Myocardial Infarction (16) · Renal Insufficiency (15) · Cardiomyopathies (13) · Hypertension (9) · Heart Failure, Diastolic (8) · Heart Failure, Systolic (7) · Atrial Fibrillation (6) · Cardiomyopathy, Dilated (6) · Coronary Artery Disease (6) · Inflammation (6) · Myocardial Ischemia (6) · Coronary Disease (5)
Cardiovascular Diseases (225) · Heart Diseases (224) · Pathological Conditions, Signs and Symptoms (63) · Pathologic Processes (50) · Vascular Diseases (39) · Male Urogenital Diseases (21) · Urogenital Diseases (21) · Female Urogenital Diseases (20) · Female Urogenital Diseases and Pregnancy Complications (20) · Myocardial Ischemia (20) · Respiratory Tract Diseases (20) · Urologic Diseases (20) · Kidney Diseases (19) · Infarction (18) · Ischemia (18)
Tolvaptan (11) · sacubitril and valsartan sodium hydrate drug combination (10) · Natriuretic Peptide, Brain (9) · Sildenafil Citrate (8) · Enalapril (7) · Furosemide (7) · empagliflozin (7) · Spironolactone (6) · Valsartan (6) · Carvedilol (5) · Rosuvastatin Calcium (5) · dapagliflozin (5) · Cardiac Resynchronization Therapy (4) · candesartan (4) · candesartan cilexetil (4)
AstraZeneca (10) · National Heart, Lung, and Blood Institute (NHLBI) (10) · Novartis Pharmaceuticals (9) · Boston Scientific Corporation (8) · Duke University (8) · Scios, Inc. (7) · Boehringer Ingelheim (6) · Otsuka Pharmaceutical Co., Ltd. (6) · Columbia University (4) · Abbott Medical Devices (3) · Hebei Medical University (3) · Janssen Research & Development, LLC (3) · LivaNova (3) · NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3) · University Medical Center Groningen (3)
United States (104) · Canada (53) · Germany (42) · Spain (38) · Italy (36) · Poland (34) · Netherlands (32) · United Kingdom (32) · France (29) · Czechia (27) · Australia (26) · Brazil (26) · Russia (26) · Argentina (25) · Sweden (25)
Barry Massie, MD (3) · Christopher O'Connor, MD (3) · Katsuhisa Saito (3) · Kerry L. Lee, PhD (3) · Benjamin W Van Tassell, PharmD (2) · Eric Velazquez, MD (2) · Eugene Braunwald, MD (2) · Kerry Lee (2) · Kunshen Liu, MD (2) · Marc J Semigran, MD (2)
PMID 37366061, PMID 31081589, PMID 36632831, PMID 19196892, PMID 25326006, PMID 29431256, PMID 31370950, PMID 33301080, PMID 34465123, PMID 35603667, PMID 38770818, PMID 42669134, PMID 10400005, PMID 18926433, PMID 20188504, PMID 20925544, PMID 21193691, PMID 21545947, PMID 21900185, PMID 22339573, PMID 22740508, PMID 24281134, PMID 24281137, PMID 25543972, PMID 26041600, PMID 26666380, PMID 26927285, PMID 27266853, PMID 27448534, PMID 27514751, PMID 27658757, PMID 29094152, PMID 29748350, PMID 30871349, PMID 31218819, PMID 31535829, PMID 32865377, PMID 33107592, PMID 34397263, PMID 34693515, PMID 34861151, PMID 35331406, PMID 35687107, PMID 35867859, PMID 36017745, PMID 36129693, PMID 36791280, PMID 37350280, PMID 37621153, PMID 38037709
2016 (9), 2017 (4), U01HL084904 (3), 2014 (2), 2018 (2), 2019 (2), 2005 (1), 2009 (1), I01CX001968 (1), P20RR011104 (1), R01AG018915 (1), R01AT002454 (1), R01HL065547 (1), R01HL083176 (1), R01HL105853 (1)