32 completed, 3 terminated, 2 withdrawn. 15 Phase 2, 9 Phase 3, 5 Phase 1, 5 Phase 4, 3 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 13, Terminated 2 |
| Phase 3 | 9 | Completed 8, Withdrawn 1 |
| Phase 1 | 5 | Completed 5 |
| Phase 4 | 5 | Completed 3, Terminated 1, Withdrawn 1 |
| Not applicable | 3 | Completed 3 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function. BNP (nesiritide), Placebo - Left Ventricular Diastolic Dysfunction | Phase 1 / Phase 2 | Completed | Mayo Clinic | 41 | 2008-03-01 | 2015-07-01 |
| Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal EF Nesiritide - Heart Failure, Congestive, Dyspnea | Phase 4 | Withdrawn | University of Medicine and Dentistry of New Jersey | 2007-08-01 | 2015-11-11 | |
| A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure Nesiritide, Placebo - Heart Decompensation | Phase 3 | Completed | Scios, Inc. | 7141 | 2007-05-01 | 2013-03-08 |
| BNP Therapy Observation Unit Outcomes STudy (BOOST) Nesiritide - Congestive Heart Failure | Phase 4 | Terminated | Emory University | 17 | 2007-03-01 | 2015-02-09 |
| Natrecor (Nesiritide) in Transplant-Eligible Management of Congestive Heart Failure-TMAC Natrecor (nesiritide)+Standard Care+dobutamine or milrinone, Placebo+Standard Care+dobutamine or milrinone - Congestive Heart Failure, Cardiac Transplantation | Phase 2 | Terminated | Scios, Inc. | 16 | 2006-09-01 | 2014-12-08 |
| SCIO-469: Open-Label Study for Patients With Myelodysplastic Syndromes. SCIO-469 - Bone Marrow Diseases, Myelodysplastic Syndromes | Phase 2 | Completed | Scios, Inc. | 62 | 2005-05-01 | 2013-11-07 |
| Heart and Blood Pressure Study: The Effect of Aortic Impedance on Myocardial Relaxation oral hydralazine and intravenous nesiritide - High Blood Pressure | Not applicable | Completed | University of Wisconsin, Madison | 17 | 2005-05-01 | 2019-02-08 |
| Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure nesiritide - Heart Failure, Congestive | Not applicable | Completed | University of Wisconsin, Madison | 15 | 2005-02-01 | 2019-02-08 |
| Extension Study of the Efficacy and Safety of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma SCIO-469, SCIO-469 and bortezomib - Multiple Myeloma | Phase 2 | Completed | Scios, Inc. | 30 | 2004-11-01 | 2010-10-22 |
| Registry for Acute Decompensated Heart Failure Patients Admitted to the ER Acute Decompensated Heart Failure - Heart Failure, Congestive, Heart Decompensation | Completed | Scios, Inc. | 18920 | 2004-07-01 | 2010-04-28 | |
| SPRiNG: SCIO-469 Patients With Rheumatoid Arthritis Not Receiving Methotrexate SCIO-469, Placebo - Arthritis, Rheumatoid | Phase 2 | Completed | Scios, Inc. | 302 | 2004-07-01 | 2010-10-18 |
| Study of Oral SCIO-469 in Relapsed, Refractory Patients With Multiple Myeloma SCIO-469, SCIO-469 and bortezomib - Multiple Myeloma | Phase 2 | Completed | Scios, Inc. | 62 | 2004-06-01 | 2010-10-18 |
| A Study of the Safety and Efficacy of Follow-up Serial Infusions of Natrecor(Nesiritide) for the Management of Patients With Heart Failure Nesiritide - Heart Failure, Congestive | Phase 2 | Completed | Scios, Inc. | 920 | 2004-04-01 | 2011-05-20 |
| Clinical Study to Evaluate Nesiritide in Patients Undergoing Coronary Artery Bypass Graft (CABG) Surgery A014 / NAPA Nesiritide - Coronary Artery Bypass Surgery, Coronary Heart Disease | Phase 2 | Completed | Scios, Inc. | 305 | 2004-03-01 | 2011-05-19 |
| BNP for Cardio-Renal Decompensation Syndrome (BNP-CARDS) Natrecor, a recombinant form of B-type Natriuretic Peptide, made by Scios, Inc. vs. placebo - Congestive Heart Failure Exacerbation, Renal Insufficiency | Phase 4 | Completed | Stanford University | 100 | 2004-03-01 | 2015-04-28 |
| Impact of Nesiritide Infusion for Decompensated Heart Failure in the Emergency Department recombinant B-type, natriuretic peptide, placebo - Heart Failure, Congestive, Cardiomyopathy | Phase 4 | Completed | University of Texas Southwestern Medical Center | 104 | 2003-12-01 | 2007-11-16 |
| Nesiritide - Dilated Cardiomyopathy Nesiritide, 5% Dextrose - Dilated Cardiomyopathy | Not applicable | Completed | University of California, Los Angeles | 20 | 2003-12-01 | 2008-07-03 |
| Nesiritide in Chronic Heart Failure nesiritide, continuous infusion - Heart Failure | Phase 2 | Terminated | University of Chicago | 20 | 2003-08-01 | 2013-10-08 |
| Nesiritide and Vo2 Max in Heart Failure Patients nesiritide (Natrecor(TM)) - Heart Failure | Phase 2 | Completed | University of Rochester | 20 | 2003-07-01 | 2013-06-19 |
| Nesiritide Infusion for the Treatment of Decompensated Heart Failure and Renal Dysfunction Nesiritide - Congestive Heart Failure, Renal Insufficiency | Phase 2 | Completed | Brigham and Women's Hospital | 34 | 2003-04-01 | 2013-09-12 |
Showing 20 of 37. Sign in to see all of them.
Heart Failure (26) · Renal Insufficiency (11) · Cardiomyopathies (8) · Dyspnea (6) · Arthritis, Rheumatoid (3) · Coronary Disease (2) · Dyspnea, Paroxysmal (2) · Multiple Myeloma (2) · Myocardial Ischemia (2) · Acute Kidney Injury (1) · Aneurysm (1) · Bone Marrow Diseases (1) · Bone Marrow Neoplasms (1) · Cardiomyopathy, Dilated (1) · Cardiovascular Diseases (1)
Natriuretic Peptide, Brain (25) · SCIO-469 (6) · Bortezomib (2) · Furosemide (1) · Glucose (1) · Hydralazine (1) · Milrinone (1) · Natriuretic Peptides (1)
United States (16) · Argentina (1) · Australia (1) · Brazil (1) · Bulgaria (1) · Canada (1) · Chile (1) · China (1) · Colombia (1) · France (1) · Germany (1) · Greece (1) · India (1) · Israel (1) · Lithuania (1)
Horng H. Chen, M.D. (3) · Adam H Miller (1) · Allen Anderson, MD (1) · Anju Nohria, MD (1) · Daniel Wu, MD (1) · Douglas Ander, MD (1) · Leway Chen, MD (1) · Marc J S, MD (1) · Marc Klapholz, MD (1) · Margaret M. Redfield, M.D. (1) · Michael B Fowler, MB (1) · Nancy K Sweitzer, MD PhD (1) · Nancy K Sweitzer, MD, PhD (1) · Ronald Witteles, MD (1)
PMID 10400005, PMID 11911755, PMID 12486437, PMID 15342289, PMID 15846257, PMID 16183441, PMID 17498579, PMID 17923600, PMID 17980248, PMID 18178412, PMID 18480204, PMID 18541822, PMID 18687247, PMID 19808265, PMID 21095276, PMID 21732835, PMID 22157521, PMID 22497823, PMID 23032196, PMID 23122795, PMID 23537892, PMID 23770519, PMID 23899930, PMID 24054337, PMID 24464687, PMID 24622005, PMID 25074507, PMID 25281655, PMID 26304935, PMID 26874387, PMID 26988350, PMID 27623769, PMID 28641792, PMID 29431103, PMID 29781109, PMID 30354576, PMID 31606362, PMID 33775110, PMID 36314126, PMID 37725680, PMID 39878152
P01HL076611 (2), UL1RR024150 (2), R01HL036634 (1), R01HL084155 (1)