210 completed, 90 unknown, 65 recruiting, 30 terminated. 93 Not applicable, 73 Phase 2, 48 Phase 4, 42 Phase 3, 30 Phase 1.
Follow Cardiomegaly: new trials by email Literature Review of Cardiomegaly trials Research Report on Cardiomegaly
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| BAG3-DCM Natural History Study Dilated Cardiomyopathy (DCM), Cardiovascular Diseases | Not yet recruiting | Rocket Pharmaceuticals Inc. | 30 | 2026-12-01 | 2026-10-19 | |
| Therapeutic Implications of CMR Low Native T1 in Non-treated Non-hypertrophic Females With Fabry Disease (FD) Decision tree for initiating treatment - Fabry Disease | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 60 | 2026-11-01 | 2026-10-14 |
| An AAV Gene Therapy Trial of AFTX-201 in Adults With BAG3-Associated Dilated Cardiomyopathy (DCM) AFTX-201 - Dilated Cardiomyopathy (DCM), BAG3 Mutation Associated Dilated Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Affinia Therapeutics | 22 | 2026-10-01 | 2026-10-21 |
| Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular Hypertrophy Cardiac amyloidosis screening during CIED implantation - Cardiac Amyloidosis, Left Ventricular Hypertrophy | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 242 | 2026-09-01 | 2026-07-29 |
| Can Exercise Electrocardiography Discriminate Hypertensive Heart Disease From Obstructive Coronary Artery Disease? A Multimodality Imaging Study Obstructive Coronary Artery Disease, Left Ventricular Hypertrophy | Recruiting | University of Pisa | 30 | 2026-09-01 | 2026-09-29 | |
| Observational Study of Natural History of BAG3 Gene Mutation-Associated Dilated Cardiomyopathy in Chinese Adults Observational, None intervention - Dilated Cardiomyopathy | Recruiting | AstraZeneca | 10 | 2026-08-18 | 2026-10-22 | |
| Angiotensin Receptor Blocker After TAVR in Severe Aortic Stenosis With Left Ventricular Hypertrophy (ARBITAR) Angiotensin Receptor Blocker (ARB) - Transcatheter Aortic Valve Replacement (TAVR), Left Ventricular Hypertrophy | Phase 4 | Not yet recruiting | Seoul National University Hospital | 632 | 2026-08-15 | 2026-07-29 |
| AI-based Echocardiography for Detection of Cardiac Amyloidosis AI-based echocardiogram - Cardiac Amyloidosis, Heart Failure With Preserved Ejection Fraction (HFPEF) | Not applicable | Not yet recruiting | Germans Trias i Pujol Hospital | 200 | 2026-07-01 | 2026-06-12 |
| Study of LX2006 Gene Therapy in Friedreich Ataxia Cardiomyopathy LX2006, Usual Care - Friedreich Ataxia, Cardiomyopathy, Secondary | Phase 2 | Recruiting | Lexeo Therapeutics | 26 | 2026-06-25 | 2026-09-02 |
| RHYthm and Myocardial Function Relationship Evaluation in Heart Diseases speckle tracking echocardiography - Arrhythmia, Cardiomyopathy, Dilated | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 253 | 2026-06-23 | 2026-09-10 | |
| A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA) NVC-001 - Low Dose, NVC-001 - Intermediate Dose, NVC-001 - High Dose - LMNA-Related Dilated Cardiomyopathy | Phase 1 / Phase 2 | Recruiting | Nuevocor Pte. Ltd. | 21 | 2026-06-16 | 2026-08-07 |
| Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy FAP immunosuppressive CAR-DC - Dilated Cardiomyopathy (DCM), Heart Failure | Phase 1 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 5 | 2026-05-11 | 2026-07-02 |
| Effect of Sildenafil on Left Ventricular Function in Pediatric With Primary Dilated Cardiomyopathy Cardiomyopathy, Dilated | Not yet recruiting | Assiut University | 70 | 2026-05-10 | 2026-04-17 | |
| A Phase 1 AAV Gene Therapy Trial Evaluating Safety and Preliminary Efficacy of RP-A701 in Subjects With BAG3 Dilated Cardiomyopathy RP-A701 is a recombinant viral vector composed of an AAV serotype rh.74 (AAVrh.74) capsid encapsulating the transgene, BCL2-associated Athanogene 3 (BAG3) - Dilated Cardiomyopathy (DCM) | Phase 1 | Recruiting | Rocket Pharmaceuticals Inc. | 8 | 2026-04-17 | 2026-10-01 |
| Mainstreaming Genetic Testing for Non-Ischemic Cardiomyopathy in Western Canada Health service delivery change - Nonischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM) | Not applicable | Enrolling by invitation | Thomas Roston | 300 | 2026-02-02 | 2026-05-08 |
| Endocardial Delivery for Myocardial Regeneration Using Allogeneic iPSC-derived Cardiomyocyte Spheroids for HF With Systolic Dysfunction (EMERALD Study) HS-005 - Heart Failure, Ischemic Heart Failure | Phase 1 / Phase 2 | Recruiting | Heartseed Inc. | 14 | 2026-01-19 | 2026-10-22 |
| Left Ventricular Hypertrophy in CKD Patients transthoracic echocardiography - Left Ventricular Hypertrophy | Not yet recruiting | Sohag University | 100 | 2026-01-15 | 2026-02-02 | |
| Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy coronary angiography - Dilated Cardiomyopathy (DCM) | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 330 | 2026-01-06 | 2025-12-19 | |
| Evaluation of the Efficacy of Diagnostic Support Algorithms in Chest X-rays- LuAna Trial App LuAna - Consolidation, Lung Injury | Not applicable | Recruiting | Hospital Israelita Albert Einstein | 2400 | 2026-01-05 | 2026-09-16 |
| A Study of AZD4063 in PLN R14del Dilated Cardiomyopathy AZD4063 - Dilated Cardiomyopathy | Phase 1 | Recruiting | AstraZeneca | 23 | 2025-12-01 | 2026-09-04 |
Showing 20 of 438. Sign in to see all of them.
Cardiomyopathy, Dilated (242) · Hypertrophy, Left Ventricular (162) · Heart Failure (116) · Cardiomyopathy, Hypertrophic (57) · Hypertension (53) · Cardiomyopathies (49) · Cardiovascular Diseases (30) · Heart Diseases (22) · Aortic Valve Stenosis (19) · Cardiomyopathy, Restrictive (14) · Death, Sudden, Cardiac (14) · Kidney Failure, Chronic (14) · Arrhythmogenic Right Ventricular Dysplasia (13) · Myocardial Infarction (13)
Heart Diseases (416) · Cardiovascular Diseases (408) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (270) · Genetic Diseases, Inborn (258) · Pathological Conditions, Signs and Symptoms (244) · Laminopathies (238) · Cardiomyopathies (226) · Pathological Conditions, Anatomical (204) · Hypertrophy (185) · Vascular Diseases (109) · Pathologic Processes (85) · Heart Valve Diseases (77) · Aortic Valve Disease (75) · Aortic Stenosis, Subvalvular (57)
Valsartan (10) · Blood Specimen Collection (6) · Allopurinol (5) · Amlodipine (5) · Echocardiography (5) · Eplerenone (5) · Losartan (5) · dapagliflozin (5) · Standard of Care (4) · Tadalafil (4) · paricalcitol (4) · ARRY-371797 (3) · Adrenergic beta-Antagonists (3) · Atenolol (3) · Cardiac Resynchronization Therapy (3)
National Heart, Lung, and Blood Institute (NHLBI) (13) · Imperial College London (9) · University Medical Centre Ljubljana (6) · AstraZeneca (5) · Johns Hopkins University (5) · University Hospital, Bordeaux (5) · Assistance Publique - Hôpitaux de Paris (4) · Assiut University (4) · LoneStar Heart, Inc. (4) · Massachusetts General Hospital (4) · McGill University Health Centre/Research Institute of the McGill University Health Centre (4) · Novartis Pharmaceuticals (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · University of Colorado, Denver (4) · University of Dundee (4)
United States (111) · United Kingdom (46) · Germany (38) · China (36) · France (36) · Italy (30) · Canada (26) · Spain (21) · Denmark (16) · Poland (16) · Netherlands (14) · Brazil (12) · Sweden (11) · Turkey (Türkiye) (11) · Belgium (10)
Ercan Ok, MD (3) · James Ware (3) · Andrew M South, MD MS (2) · Andrew T Yan, MD (2) · Barry Greenberg, MD (2) · Bojan Vrtovec, MD, PhD (2) · Elisa Giannetta, MD - Phd (2) · Franz Schaefer, MD (2) · Ida Jovanovic, Prof,MD,PhD (2) · Javier Bermejo Thomas, MD, PhD (2) · Jianjun Mu, doctor (2)
PMID 36718638, PMID 38979608, PMID 17582361, PMID 18591942, PMID 22651868, PMID 22936827, PMID 23362308, PMID 24414062, PMID 25142002, PMID 26680013, PMID 28917683, PMID 37010012, PMID 42669063, PMID 10028970, PMID 10030657, PMID 10199738, PMID 10213344, PMID 10368877, PMID 10450601, PMID 10556226, PMID 10594802, PMID 10598732, PMID 10678860, PMID 10802712, PMID 10830164, PMID 10908222, PMID 10940788, PMID 10952828, PMID 11055975, PMID 11057898, PMID 11208620, PMID 11250334, PMID 11403367, PMID 11422885, PMID 11514367, PMID 11710893, PMID 11803349, PMID 12088775, PMID 12106931, PMID 12172314, PMID 12356407, PMID 12423712, PMID 12457625, PMID 12555153, PMID 12652219, PMID 12668503, PMID 12714020, PMID 12738602, PMID 12742978, PMID 12906982
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