47 completed, 28 recruiting, 12 active not recruiting, 6 unknown. 42 Not applicable, 41 Phase 2, 17 Phase 1, 5 Early Phase 1, 4 Phase 3.
Follow nicotinamide-beta-riboside: new trials by email Literature Review of nicotinamide-beta-riboside trials Research Report on nicotinamide-beta-riboside
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The NICE-PAD II Trial Nicotinamide Riboside (NR), Placebo - Peripheral Artery Disease (PAD) | Phase 3 | Not yet recruiting | Northwestern University | 250 | 2026-12-01 | 2026-08-24 |
| Nicotinamide Riboside Supplementation in Chronic Kidney Disease Nicotinamide Riboside (NR), Matched Placebo (Capsules) - Chronic Kidney Disease | Phase 2 | Not yet recruiting | University of California, San Diego | 30 | 2026-10-01 | 2026-07-15 |
| N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease Nicotinamide Riboside (NR), Palacebo - Alzheimer Disease (AD) | Phase 2 | Recruiting | Haukeland University Hospital | 270 | 2026-08-26 | 2026-08-20 |
| Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants Nicotinamide Riboside (NR), Placebo - Preterm Birth, Inadequate Milk Production | Phase 2 / Phase 3 | Recruiting | University of California, Davis | 40 | 2026-08-19 | 2026-09-14 |
| Efficacy of Topical Niacinamide Riboside on the Signs of Facial Skin Aging Topical niacinamide riboside, Placebo - Skin Aging on Face, Skin Care Dermocosmetics | Not applicable | Recruiting | ChromaDex, Inc. | 140 | 2026-08-17 | 2026-08-21 |
| NAD Supplementation in Parkinson's Disease Nicotinamide Riboside (NR), Oral placebo capsules - Parkinson's Disease | Not applicable | Enrolling by invitation | University of Oklahoma | 40 | 2026-08-10 | 2026-08-12 |
| Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism Niagen® - Healthy Adult | Not applicable | Recruiting | Massachusetts General Hospital | 50 | 2026-06-01 | 2026-06-17 |
| Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial) Nicotinamide Riboside, Pterostilbene - Clonal Cytopenia of Undetermined Significance, Myelodysplastic Syndrome | Phase 2 | Recruiting | University of Colorado, Denver | 10 | 2026-05-20 | 2026-06-03 |
| Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension Nicotinamide Riboside (NR), Placebo - Pulmonary Hypertension | Not applicable | Recruiting | Vanderbilt University Medical Center | 10 | 2026-04-09 | 2026-05-04 |
| NR and Exercise for Blood Pressure Brisk walking, Nicotinamide Riboside 1000 mg, Placebo - Hypertension (HTN) | Not applicable | Not yet recruiting | ZHANG Jiaqi | 112 | 2026-04-01 | 2026-03-18 |
| Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training Nicotinamide Riboside (NR) - Health Adult Subjects | Not applicable | Recruiting | ZHANG Jiaqi | 16 | 2026-01-06 | 2026-03-18 |
| Effects of Single-Dose Nicotinamide Riboside (NR) on Sleep Nicotinamide Riboside (NR), Placebo - Healthy Volunteers | Not applicable | Completed | Eye & ENT Hospital of Fudan University | 28 | 2025-12-17 | 2026-09-16 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) Acetylcysteine, EH301, Riluzole - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogipuzkoa Health Research Institute | 90 | 2025-11-25 | 2026-02-17 |
| Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis Zinc, Placebos for zinc and nicotinamide riboside, Nicotinamide riboside - Idiopathic Pulmonary Fibrosis | Phase 2 | Recruiting | Cedars-Sinai Medical Center | 60 | 2025-11-03 | 2025-11-10 |
| NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals Nicotinamide Riboside (NR), Placebo - Sleep | Phase 2 | Recruiting | Haukeland University Hospital | 16 | 2025-10-13 | 2025-09-15 |
| Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment Nicotinamide Riboside, Placebo, Vitrectomy and Gas tamponade - Retinal Detachment | Phase 4 | Recruiting | Center for Eye Research Australia | 144 | 2025-09-19 | 2026-03-23 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| ACEs, SIRT1, and Premature Vascular Aging in Humans Nicotinamide Riboside, Placebo - Adverse Childhood Experiences, Endothelial Dysfunction | Not applicable | Recruiting | University of Wisconsin, Madison | 30 | 2025-03-27 | 2026-08-19 |
| The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease Nicotinamide Riboside (NR), Placebo - Huntington Disease | Phase 2 | Recruiting | Oslo University Hospital | 120 | 2025-03-18 | 2025-03-19 |
| The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging Nicotinamide Riboside (NR), Placebo - Frailty, Frail Elderly Syndrome | Phase 2 | Recruiting | Haukeland University Hospital | 100 | 2025-01-01 | 2025-01-20 |
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Cognitive Dysfunction (6) · Obesity (6) · Parkinson Disease (6) · Acute Kidney Injury (4) · Hypertension (4) · Amyotrophic Lateral Sclerosis (3) · Ataxia Telangiectasia (3) · Frailty (3) · Heart Failure (3) · Peripheral Arterial Disease (3) · Renal Insufficiency, Chronic (3) · Sarcopenia (3) · Alzheimer Disease (2) · Atherosclerosis (2) · COVID-19 (2)
Haukeland University Hospital (13) · National Heart, Lung, and Blood Institute (NHLBI) (5) · University of Washington (5) · Massachusetts General Hospital (3) · Mayo Clinic (3) · University Hospital, Akershus (3) · University of Copenhagen (3) · University of Oklahoma (3) · Aarhus University Hospital (2) · Children's Hospital of Philadelphia (2) · ChromaDex, Inc. (2) · Donna Hammond, PhD (2) · Maastricht University Medical Center (2) · Mclean Hospital (2) · Northwestern University (2)
United States (57) · Norway (18) · Denmark (7) · Netherlands (3) · Australia (2) · China (2) · United Kingdom (2) · Canada (1) · Chile (1) · Germany (1) · Hong Kong (1) · Mexico (1) · South Africa (1) · Spain (1) · Switzerland (1)
Charalampos Tzoulis, PhD (5) · Charalampos Tzoulis, MD, PhD (4) · Andriy Yabluchanskiy, MD, PhD (3) · Kevin D O'Brien, MD (3) · Christopher R Martens, Ph.D. (2) · Kristoffer Haugarvoll, MD, PhD (2) · Michael N Sack, M.D. (2) · Rachael J Klein, M.D. (2) · Ahmet Hoke (1) · Alexandra Thomas, MD (1) · Amanpreet Cheema, PhD (1) · Armin Ahmadi, PhD (1) · Baback Roshanravan, MD (1)
PMID 42063312, PMID 29599478, PMID 29992272, PMID 32791973, PMID 41264372, PMID 10693811, PMID 20008425, PMID 21110941, PMID 21651395, PMID 23782899, PMID 25386668, PMID 27127236, PMID 27721479, PMID 28869251, PMID 29211728, PMID 29469929, PMID 30127395, PMID 30673618, PMID 30797625, PMID 31035376, PMID 31278280, PMID 31390002, PMID 31673160, PMID 31710095, PMID 32320006, PMID 32421208, PMID 32790648, PMID 33393613, PMID 33524145, PMID 33769844, PMID 34084879, PMID 34292494, PMID 34871486, PMID 35025762, PMID 35235774, PMID 35620522, PMID 35854224, PMID 35998039, PMID 36588397, PMID 36644285, PMID 37159264, PMID 37478182, PMID 37586364, PMID 37994989, PMID 38016950, PMID 38987585, PMID 39548320, PMID 39847432, PMID 4060272, PMID 40739200
2023 (3), R21HL126209 (2), 2025 (1), 3UH3DK114920-04S2 (1), K01AG054731 (1), K01DK147652 (1), P30CA033572 (1), R01AG066670 (1), R01AG090846 (1), R01CA254955 (1), R01DK101509 (1), R01DK121516 (1), R01HL144937 (1), R01HL149722 (1), R01HL163960 (1)