260 completed, 128 recruiting, 81 unknown, 45 terminated. 153 Phase 2, 100 Not applicable, 95 Phase 1, 74 Phase 3, 12 Early Phase 1.
Follow Amyloidosis: new trials by email Literature Review of Amyloidosis trials Research Report on Amyloidosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With Daratumumab With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) in Newly Diagnosed Systemic AL Amyloidosis NXC-201, Dara-CyBorD - Light Chain (AL) Amyloidosis | Phase 3 | Not yet recruiting | Nexcella Inc. | 260 | 2027-01-01 | 2026-07-16 |
| Linvoseltamab Versus Daratumumab, Bortezomib, Cyclophosphamide, and Dexamethasone (Dara-Vcd) in Adult Participants With Newly Diagnosed Systemic Light Chain Amyloidosis Linvoseltamab, Daratumumab, Bortezomib - Newly Diagnosed Amyloidosis, Amyloidosis Stage I-IIIA | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 382 | 2026-12-18 | 2026-10-28 |
| Study to Evaluate Change in Disease Activity and Adverse Events of Subcutaneous Etentamig Compared With Daratumumab Plus Cyclophosphamide Plus Bortezomib Plus Dexamethasone (Dara-CyBorD) in Adults With Amyloid Light Chain (AL) Amyloidosis Etentamig, Daratumumab, Cyclophosphamide - Amyloid Light Chain (AL) Amyloidosis | Phase 3 | Not yet recruiting | AbbVie | 370 | 2026-11-29 | 2026-08-28 |
| PET/CT Imaging in Carriers of TTR Mutations Iodine-124 Evuzamitide (I-124E) - ATTR, ATTR Gene Mutation | Not yet recruiting | University of Texas Southwestern Medical Center | 80 | 2026-11-14 | 2026-10-29 | |
| To Evaluate the Long-term Safety and Tolerability of Acoramidis in Participants With Newly Diagnosed ATTR-CM (ACT-EARLY OLE) Acoramidis (AG10) - Amyloidosis in Transthyretin (TTR), Amyloidosis, Familial | Phase 3 | Not yet recruiting | Eidos Therapeutics, a BridgeBio company | 250 | 2026-11-01 | 2026-08-11 |
| Phase 1a/b Study of GPRC5D CART Therapy in Relapsed/Refractory Multiple Myeloma and Light-chain Amyloidosis GPRC5D CART - Relapsed/Refractory Multiple Myeloma (RRMM), Light-Chain Amyloidosis | Phase 1 | Not yet recruiting | Hadassah Medical Organization | 160 | 2026-11-01 | 2026-10-20 |
| Prospective Evaluation of Subcutaneous Administration of Daratumumab by the FreedomEDGE® Infusion System Subcutaneous Daratumumab Administration Using FreedomEDGE® - Multiple Myeloma or Amyloidosis | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 100 | 2026-10-01 | 2026-07-23 |
| Right Ventricular Septal Biopsy to Detect Cardiac Amyloidosis ATTR-CM (Transthyretin Amyloid Cardiomyopathy), Heart Failure | Not yet recruiting | Geisinger Clinic | 70 | 2026-10-01 | 2026-08-25 | |
| Early Detection of Amyloidosis in Monoclonal Gammopathy Using Nuclear Medicine Imaging ¹⁸F-florbetaben - Monoclonal Gammopathy, Monoclonal Gammopathy of Undetermined Significance (MGUS) | Not applicable | Not yet recruiting | University of Zurich | 50 | 2026-10-01 | 2026-06-03 |
| Safety and Efficacy Study of GEB-101 Injection in Subjects With TGFBI-related Corneal Dystrophy GEB-101 Injection - Hereditary Corneal Dystrophy, Corneal Abnormality | Phase 1 / Phase 2 | Not yet recruiting | GenEditBio Limited | 30 | 2026-10-01 | 2026-09-10 |
| Application of Digital Twins' Technology in Patients Who Had a Stroke, With Moyamoya Disease and With Cerebral Amyloid Angiopathy (CAA) During the Secondary Prevention Phase: A Proof of Concept Using a Randomized Control Trial (Clinical Study 6, STRATIF-AI Project) AI, healthy dialogue - Stroke, Moyamoya Disease | Not applicable | Recruiting | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | 20 | 2026-10-01 | 2026-08-28 |
| PET Imaging Study Using Evuzamitide to Detect Cardiac Amyloidosis in Patients With Inconclusive Nuclear Scans and Elevated TAD1 Levels Evuzamitide - Amyloidogenic Transthyretin (ATTR) Amyloidosis, Cardiac Amyloidosis | Not yet recruiting | Lorena Saelices | 25 | 2026-10-01 | 2026-10-22 | |
| Impact of a Cardiac Rehabilitation Program on Patients With Cardiac Amyloidosis Cardiac Rehabilitation Program - Amyloidosis | Not applicable | Recruiting | University Hospital, Montpellier | 40 | 2026-09-23 | 2026-10-08 |
| Individualized Exercise Training in Cardiac Amyloidosis Exercise Intervention, Physical Activity Handout - Cardiac Amyloidosis | Not applicable | Not yet recruiting | Oregon Health and Science University | 60 | 2026-09-15 | 2026-09-23 |
| Prevalence of Cardiac Thrombi in Cardiac Amyloidosis Cardiac CT scan with contrast - Cardiac Amyloidosis | Not applicable | Recruiting | Centre Hospitalier Universitaire Dijon | 200 | 2026-09-07 | 2026-09-17 |
| Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry Registry - Amyloidosis, Hereditary | Not yet recruiting | Virginia Commonwealth University | 1000 | 2026-09-01 | 2026-08-12 | |
| Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA) Cardiac Amyloidosis, Transthyretin Amyloidosis | Not yet recruiting | University Hospital, Lille | 57 | 2026-09-01 | 2026-05-15 | |
| Detection of Cardiac Amyloidosis Using Right Ventricular Sensing Amplitude in Patients With Left Ventricular Hypertrophy Cardiac amyloidosis screening during CIED implantation - Cardiac Amyloidosis, Left Ventricular Hypertrophy | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 242 | 2026-09-01 | 2026-07-29 |
| A Pilot Study of Anselamimab in Patients With AL Amyloidoma and Measurable Tissue Involvement Anselamimab - AL Amyloidosis | Early Phase 1 | Not yet recruiting | Stanford University | 5 | 2026-09-01 | 2026-10-27 |
| SMS-Based Remote Symptom Monitoring for Patients With Plasma Cell Disorders Non-Interventional Study - AL Amyloidosis, Multiple Myeloma | Recruiting | Mayo Clinic | 150 | 2026-08-25 | 2026-09-30 |
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Immunoglobulin Light-chain Amyloidosis (237) · Amyloid Neuropathies, Familial (186) · Multiple Myeloma (125) · Neoplasms, Plasma Cell (68) · Leukemia, Lymphocytic, Chronic, B-Cell (66) · Lymphoma, Non-Hodgkin (63) · Hodgkin Disease (61) · Lymphoma, Follicular (61) · Lymphoma, Large B-Cell, Diffuse (61) · Lymphoma, Mantle-Cell (61) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (61) · Burkitt Lymphoma (60) · Lymphoma, Large-Cell, Immunoblastic (59) · Lymphoma, B-Cell, Marginal Zone (57)
Nutritional and Metabolic Diseases (619) · Metabolic Diseases (617) · Proteostasis Deficiencies (617) · Immune System Diseases (273) · Nervous System Diseases (272) · Neoplasms by Histologic Type (265) · Immunoproliferative Disorders (264) · Cardiovascular Diseases (261) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (256) · Neoplasms (256) · Paraproteinemias (252) · Lymphoproliferative Disorders (246) · Genetic Diseases, Inborn (218) · Neurodegenerative Diseases (206)
Dexamethasone (71) · Bortezomib (36) · Cyclophosphamide (35) · Melphalan (34) · Calcium Dobesilate (25) · daratumumab (24) · Filgrastim (18) · Lenalidomide (16) · Peripheral Blood Stem Cell Transplantation (16) · pomalidomide (13) · dexamethasone acetate (10) · Thalidomide (9) · ixazomib (9) · patisiran (9) · tafamidis (9)
Mayo Clinic (21) · Alnylam Pharmaceuticals (20) · Fondazione IRCCS Policlinico San Matteo di Pavia (16) · Boston Medical Center (12) · Pfizer (12) · Brigham and Women's Hospital (10) · Eidos Therapeutics, a BridgeBio company (10) · GlaxoSmithKline (9) · Memorial Sloan Kettering Cancer Center (9) · Ionis Pharmaceuticals, Inc. (8) · National Cancer Institute (NCI) (8) · Barbara Ann Karmanos Cancer Institute (7) · Centre Hospitalier Universitaire de Nīmes (7) · Prothena Biosciences Ltd. (7) · The Cleveland Clinic (7)
United States (291) · France (101) · Italy (96) · Germany (73) · United Kingdom (67) · Spain (64) · China (55) · Netherlands (44) · Canada (40) · Belgium (35) · Sweden (34) · Brazil (33) · Australia (32) · Greece (30) · Portugal (30)
Vaishali Sanchorawala, MD (11) · Morie A. Gertz, MD (4) · Raymond Comenzo, MD (4) · Heather Landau, MD (3) · Jin Lu (3) · John A. Glaspy, MD, MPH (3) · Mazen A Hanna, MD (3) · Sharmila Dorbala, MD (3) · Alan Solomon, MD (2)
PMID 31353964, PMID 40226119, PMID 25803389, PMID 32107748, PMID 38065307, PMID 42389794, PMID 21732836, PMID 27494299, PMID 28550039, PMID 29115008, PMID 29972753, PMID 29972757, PMID 30558645, PMID 32499241, PMID 32524297, PMID 33070419, PMID 33825853, PMID 34355354, PMID 34396169, PMID 34923848, PMID 35799473, PMID 36715498, PMID 37366170, PMID 37434378, PMID 37943223, PMID 38548524, PMID 38932583, PMID 39213194, PMID 40488446, PMID 41100731, PMID 41205147, PMID 41913562, PMID 41937511, PMID 42212672, PMID 42658465, PMID 42658466, PMID 42669063, PMID 42669065, PMID 42693367, PMID 42728504, PMID 12000194, PMID 15044325, PMID 15156165, PMID 15308571, PMID 15365071, PMID 15459300, PMID 16710026, PMID 17397698, PMID 17554116, PMID 17855669
2023 (8), 2019 (7), P30CA015083 (7), 2018 (6), 2016 (4), 2025 (4), P30CA022453 (4), U10CA032102 (4), 2015 (3), 2017 (3), P30CA015704 (3), P30CA072720 (3), 2014 (2), P30CA006973 (2), P30CA016086 (2)