28 completed, 10 unknown, 7 recruiting, 4 terminated. 20 Phase 2, 10 Not applicable, 7 Phase 4, 6 Phase 1, 6 Phase 3.
Follow Milrinone: new trials by email Literature Review of Milrinone trials Research Report on Milrinone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Milrinone and Epinephrine on TAPSE Epinephrine, Milrinone Injection - Cardiac Anaesthesia, Cardiopulmonary Bypass | Not applicable | Recruiting | Mansoura University | 102 | 2026-03-01 | 2026-10-13 |
| Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation Combined Epoprostenol Sodium & Milrinone, Normal saline - Right Heart Failure, Right Ventricular Dysfunction | Phase 2 | Recruiting | Montreal Heart Institute | 141 | 2025-12-10 | 2026-06-25 |
| Milrinone on Cardiac Performance During Off-pump Coronary Artery Bypass Surgery Milrinone Injection - Ischemic Heart Disease | Unknown | Konkuk University Medical Center | 20 | 2024-09-01 | 2023-09-28 | |
| Efficacy of Milrinone With Sildenafil in Persistent Pulmonary Hypertension in Children Sildenafil, Milrinone - Persistent Pulmonary Hypertension of the Newborn | Not applicable | Completed | Muhammad Aamir Latif | 42 | 2023-12-01 | 2024-08-26 |
| Milrinone on Right Ventricular Strain in Cardiac Surgery Milrinone - Ischemic Heart Disease, Valvular Heart Disease | Unknown | Konkuk University Medical Center | 41 | 2023-11-03 | 2024-01-19 | |
| Dobutamine Versus Milrinone in Management of Critically Ill Low Cardiac Output Pediatric Patients at Cairo University Children's Hospital Dobutamine - Dobutamine, Milrinone , Pediatrics , Low Cardiac Output | Not applicable | Unknown | Cairo University | 40 | 2023-10-01 | 2023-08-21 |
| Cardiac Power Output in Cardiogenic Shock Patients 1:1 Randomization to receive milrinone - Heart Failure, Cardiogenic Shock | Early Phase 1 | Recruiting | University of Chicago | 5 | 2023-07-06 | 2026-08-06 |
| Inhaled and Intravenous Milrinone in Patients With Severe Pulmonary Hypertension Milrinone inhalation, Milrinone infusion - Pulmonary Hypertension Due to Left Heart Disease | Phase 4 | Recruiting | Zagazig University | 38 | 2023-05-20 | 2025-04-30 |
| Inhaled Versus Intravenous Milrinone for Patients Undergoing Mitral Valve Replacement Surgery Inhaled Milrinone, IV Milrinone - Mitral Valve Replacement, Pulmonary Hypertension | Phase 2 / Phase 3 | Completed | Menoufia University | 60 | 2023-04-01 | 2025-02-11 |
| Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function Levosimendan, Dobutamine, Milrinone - Acute Decompensated Heart Failure (ADHF), Cardiorenal Syndrome (CRS) | Phase 4 | Completed | Ain Shams University | 60 | 2022-06-01 | 2026-09-21 |
| CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock Dobutamine, Milrinone, Normal Saline - Shock, Cardiogenic | Phase 4 | Recruiting | Ottawa Heart Institute Research Corporation | 346 | 2022-03-05 | 2026-05-01 |
| Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow The topical application of a vasodilator on the LIMA graft - Internal Mammary Artery Syndrome, Vasodilation | Phase 3 | Completed | Damascus University | 46 | 2022-01-01 | 2026-03-19 |
| Milrinone Versus Placebo in Patients With Septic Shock Milrinone - Septic Shock, Cardiac Output | Phase 2 | Unknown | Mahidol University | 64 | 2021-12-01 | 2022-09-15 |
| Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy nimodipine, Oral Nimodipine and milrinone - Oral Nimodipine, Milrinone | Phase 2 | Completed | Zagazig University | 30 | 2021-11-24 | 2022-05-25 |
| Effect of Nebulized Milrinone on Right Ventricular Hemodynamics in Adult Cardiac Surgery Milrinone, Normal saline - Anesthesia | Phase 4 | Unknown | Ain Shams University | 70 | 2021-10-17 | 2022-07-20 |
| Opportunistic PK/PD Trial in Critically Ill Children (OPTIC) The OPTIC study is collecting PK data on children prescribed understudied drugs of interest per standard of care. - Cardiac Disease, Critically Ill | Recruiting | Duke University | 2000 | 2021-10-05 | 2026-10-16 | |
| Cerebral Hemodynamic Optimization by Milrinone to Prevent Delayed Cerebral Ischemia Milrinone Injection, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 2 | Unknown | University Hospital, Toulouse | 234 | 2021-07-25 | 2024-09-25 |
| Milrinone Infusion for VAsospam Treatment in Subarachnoid hemoRrhage Milrinone 1 Mg/mL Solution for Injection, Saline solution for injection - Vasospasm | Phase 3 | Completed | University Hospital, Angers | 370 | 2020-08-10 | 2026-03-09 |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| Levosimendan Versus Milrinone in Off Pump CABG Surgery Levosimendan, Milrinone - Hemodynamics | Phase 4 | Unknown | Assiut University | 60 | 2019-03-06 | 2019-03-07 |
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Cardiac Output, Low (7) · Heart Failure (7) · Hypertension, Pulmonary (6) · Heart Defects, Congenital (4) · Myocardial Ischemia (3) · Persistent Fetal Circulation Syndrome (3) · Shock, Cardiogenic (3) · Acute Kidney Injury (2) · Cardio-Renal Syndrome (2) · Renal Insufficiency (2) · Shock, Septic (2) · Sprains and Strains (2) · Subarachnoid Hemorrhage (2) · Ventricular Dysfunction, Right (2) · Acute Coronary Syndrome (1)
Konkuk University Medical Center (3) · Sahlgrenska University Hospital (3) · Ain Shams University (2) · Assiut University (2) · Duke University (2) · Montreal Heart Institute (2) · Ottawa Heart Institute Research Corporation (2) · The Alfred (2) · Zagazig University (2) · Andre Denault (1) · Cairo University (1) · Children's Hospital of Philadelphia (1) · Chulalongkorn University (1) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (1) · Coram Clinical Trials (1)
United States (13) · Egypt (8) · Canada (7) · Sweden (4) · South Korea (3) · Australia (2) · France (2) · Thailand (2) · Austria (1) · Belgium (1) · China (1) · Finland (1) · Pakistan (1) · Singapore (1) · Spain (1)
Sven-Erik Ricksten, Professor (2) · Abdur Rehman, FCPS (1) · Adelina Pellicer, PhD (1) · Albert Castellheim, MD, PhD (1) · Anna Hofer, MD (1) · Belaid BB Bouhemad, PU-PH (1) · Benjamin BC Chousterman, PH (1) · Benjamin M Hibbert, MD, PhD (1) · Birgitta Romlin, MD, PhD (1) · Carlos Labrandero, MD (1) · Chi Hornik (1) · Christoph P Hornik, MD, PhD, MPH (1)
PMID 11082382, PMID 11606352, PMID 12456409, PMID 14639158, PMID 15261929, PMID 15329162, PMID 15999045, PMID 16236968, PMID 16547439, PMID 17400468, PMID 17470271, PMID 17566702, PMID 18378625, PMID 19559822, PMID 19794327, PMID 22578975, PMID 24906491, PMID 27378592, PMID 27470232, PMID 28526144, PMID 28598920, PMID 29209510, PMID 29673370, PMID 31585674, PMID 31919012, PMID 32682511, PMID 33739957, PMID 33781988, PMID 34347952, PMID 34376218, PMID 34713704, PMID 35261289, PMID 35881893, PMID 36416787, PMID 37485397, PMID 40138463, PMID 41151960, PMID 7574953, PMID 8103681, PMID 9201062, PMID 9288373
2019 (1), U10HD036790 (1), UG1HD021364 (1), UG1HD027851 (1), UG1HD027853 (1), UG1HD027880 (1), UG1HD027904 (1), UG1HD034216 (1), UG1HD040492 (1), UG1HD040689 (1), UG1HD053089 (1), UG1HD053109 (1), UG1HD068244 (1), UG1HD068263 (1), UG1HD068278 (1)