58 completed, 18 recruiting, 13 unknown, 5 not yet recruiting. 35 Phase 2, 29 Not applicable, 18 Phase 3, 17 Phase 1, 8 Early Phase 1.
Follow Niacinamide: new trials by email Literature Review of Niacinamide trials Research Report on Niacinamide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial) Nicotinamide, Standard Glaucoma Therapy - Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG) | Phase 2 | Not yet recruiting | University of Chicago | 96 | 2027-06-01 | 2026-10-13 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury Nicotinamide (NAM), Placebo control - Acute Kidney Injury | Not applicable | Not yet recruiting | Beth Israel Deaconess Medical Center | 20 | 2026-09-01 | 2026-07-31 |
| Multi Interventional Approaches to Mitigate HIV Reservoirs for the Sustained HIV Remission Without Antiretrovirals Maraviroc, Dolutegravir, Dendritic Cell Vaccine - Hiv, HIV I Infection | Phase 2 | Recruiting | Federal University of São Paulo | 70 | 2026-07-15 | 2026-08-19 |
| Stimulating Fat Tissue Storage With Niacin to Reduce Fat Accumulation in the Liver. Niacin (250mg), Placebo Oral Tablet - Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Liver Fibrosis/NASH | Not applicable | Recruiting | Université de Sherbrooke | 36 | 2026-06-22 | 2026-07-02 |
| Comparative Evaluation of Nicotine Analogs Biospecimen Collection, Nicotine, 6-Methyl Nicotine - Tobacco-Related Carcinoma, Addiction | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 70 | 2026-05-29 | 2026-06-26 |
| A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients Topical niacinamide 5% cream, Sunscreen - Skin Cancer, Cutaneous Squamous Cell Carcinoma (CSCC) | Early Phase 1 | Recruiting | Marissa Lobl | 20 | 2026-05-01 | 2026-06-05 |
| Bactericidal Activity and Safety of Nicotinamide in Combination With Bedaquiline, Pretomanid, and Linezolid in Drug-susceptible Pulmonary Tuberculosis Bedaquiline, pretomanid, linezolid, Nicotinamide (NAM) - Drug Susceptible Pulmonary Tuberculosis | Phase 2 | Suspended | Gates Medical Research Institute | 165 | 2026-04-17 | 2026-08-10 |
| Efficacy and Safety of Oral Nicotinamide as an Adjunctive Therapy in Patients With Sepsis Nicotinamide 1000 mg - Sepsis - to Reduce Mortality in the Intensive Care Unit | Phase 4 | Completed | Ain Shams University | 60 | 2026-03-28 | 2026-10-20 |
| Study on the Functional Impact of Cosmetics on Improving Self-Esteem and Quality of Life in Black Women Niacinamide and Bioceramide-Based Skincare Regimen - Post-inflammatory Hyperpigmentation | Not applicable | Recruiting | Hospital Israelita Albert Einstein | 60 | 2026-03-19 | 2026-06-04 |
| The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response Vitamin B3 - Heat Strain, Healthy Volunteer Study | Early Phase 1 | Recruiting | Beth Israel Deaconess Medical Center | 28 | 2026-01-26 | 2026-02-05 |
| Unravelling the Effects of Nicotinamide/Pyrroloquinolone Quinone /Citicoline/Homotaurine Fixed Combination on Contrast Sensitivity, Quality of Life, and Reading Performance in Glaucoma Citicoline 500 MG (Optigen) for 4 months, citicoline 500 mg + nicotinamide 54 mg + PQQ 5 mg + Homotaurine 50 mg fixed combination tablet (Neuprozin mito) - Glaucoma | Not applicable | Completed | Università degli Studi 'G. d'Annunzio' Chieti e Pescara | 44 | 2025-11-01 | 2026-10-06 |
| Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP) Nicotinamide Tablet - Glaucoma | Not applicable | Not yet recruiting | Università degli Studi 'G. d'Annunzio' Chieti e Pescara | 360 | 2025-10-01 | 2025-06-05 |
| Efficacy and Safety of a Combined Serum Containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES a combination serum containing Melasyl™, 10% Niacinamide, Hyaluronic Acid, and HEPES, 2% hydroquinone cream - Melasma, Post-acne Hyperpigmentation | Not applicable | Not yet recruiting | Dr.dr.Irma Bernadette, SpKK (K) | 68 | 2025-09-15 | 2025-08-13 |
| Clinical Trial on the Protective Role of Vitamin B3 in Enhancing Immunotherapy for Bladder Cancer Patients Tislelizumab, Cisplatin, Gemcitabine and Vitamin B3 - Bladder (Urothelial, Transitional Cell) Cancer | Phase 1 | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 12 | 2025-08-01 | 2026-06-30 |
| Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients Nicotinamide Riboside, Nicotinamide, Nicotinamide Mononucleotide - Glaucoma | Phase 2 | Recruiting | Christopher Kai Shun Leung | 138 | 2025-05-19 | 2025-06-26 |
| Tracing the Metabolic Flux of Orally Administered NAD+ Precursors Nicotinamide Mononucleotide (NMN), Nicotinamide (NAM) - Healthy Adults | Phase 1 | Recruiting | Metro International Biotech, LLC | 32 | 2025-04-28 | 2025-05-06 |
| Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls Nicotinamide, Placebo - Frailty, Fall | Phase 2 | Unknown | University of Chile | 60 | 2024-05-21 | 2024-06-20 |
| Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB) Nicotinamide, Placebo - Fatty Liver, Obesity | Phase 2 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 30 | 2024-04-23 | 2025-11-18 |
| Nicotinamide Supplementation in Glaucoma Nicotinamide Tablet, Nicotinamide Placebo - Glaucoma | Phase 3 | Enrolling by invitation | Singapore Eye Research Institute | 520 | 2024-03-12 | 2024-12-12 |
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Glaucoma (7) · Acute Kidney Injury (4) · COVID-19 (3) · Carcinoma, Basal Cell (3) · Cognitive Dysfunction (3) · Hyperphosphatemia (3) · Keratosis, Actinic (3) · Kidney Failure, Chronic (3) · Melanosis (3) · Neoplasms (3) · Alzheimer Disease (2) · Anxiety Disorders (2) · Brain Injuries, Traumatic (2) · Carcinoma, Squamous Cell (2) · Chronic Kidney Disease-Mineral and Bone Disorder (2)
POLYSAN Scientific & Technological Pharmaceutical Company (8) · Ain Shams University (3) · Beth Israel Deaconess Medical Center (3) · Columbia University (2) · Federal University of São Paulo (2) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (2) · Rhode Island Hospital (2) · Umeå University (2) · Universidad Autonoma de San Luis Potosí (2) · University of California, Irvine (2) · University of Chile (2) · University of North Carolina, Chapel Hill (2) · Università degli Studi 'G. d'Annunzio' Chieti e Pescara (2) · VA Office of Research and Development (2) · Washington University School of Medicine (2)
United States (39) · Russia (8) · Brazil (6) · Canada (6) · Egypt (4) · France (4) · Germany (4) · Italy (4) · China (3) · Pakistan (3) · Spain (3) · United Kingdom (3) · Chile (2) · Sweden (2) · Australia (1)
Chandramohan Wakade, MBBS (2) · Estomih Mduma (2) · Mikhail S. Bogomolov, MD, PhD (2) · Adeline Divoux, PhD (1) · Ahmed Hassan Nouh, MD (1) · Alan S Yu, MB, BChir (1) · Alan Yu, M.B., B.Chir (1) · Alexander V Savello, Prof (1) · Alexey Shmonin, Prof (1) · Ameer Muhammad, MSc (1) · An-Wen Chan (1) · An-Wen Chan, MD DPhil (1) · Andrei C Sposito, PhD (1)
PMID 40576086, PMID 18385391, PMID 18992952, PMID 19776051, PMID 20819978, PMID 23276366, PMID 23740194, PMID 23913470, PMID 24768191, PMID 24794816, PMID 25293882, PMID 25592338, PMID 27043866, PMID 28881921, PMID 29256113, PMID 29282426, PMID 29982218, PMID 30374901, PMID 31085679, PMID 31092901, PMID 31394172, PMID 32345747, PMID 33324899, PMID 33539743, PMID 33902087, PMID 33993135, PMID 34582462, PMID 34792559, PMID 34980232, PMID 35022035, PMID 35222903, PMID 35680173, PMID 36316932, PMID 36881769, PMID 36963502, PMID 37651119, PMID 37702300, PMID 38570905, PMID 38593249, PMID 38689404, PMID 39032770, PMID 39356039, PMID 39499526, PMID 39549554, PMID 39671543, PMID 40069789, PMID 40557242, PMID 41232946, PMID 41313494, PMID 41357333
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