111 completed, 32 unknown, 21 recruiting, 20 terminated. 74 Not applicable, 26 Phase 4, 20 Phase 1, 15 Phase 3, 12 Phase 2.
Follow GERD: new trials by email Literature Review of GERD trials Research Report on GERD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endoscopic Band Ligation for Treating Reflux Disease Band Ligation - GERD | Not applicable | Not yet recruiting | El Katib Hospital | 10 | 2027-01-01 | 2026-09-10 |
| PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients Bravo pH monitoring sessions - GERD | Not applicable | Not yet recruiting | University of Chicago | 80 | 2026-12-01 | 2026-10-13 |
| Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia | Not applicable | Not yet recruiting | McMaster University | 96 | 2026-10-01 | 2026-08-10 |
| Sedation Depth and EGJ Endoscopic Grading: A Randomized Controlled Trial Upper gastrointestinal endoscopy - Gerd, Esophagogastric Junction | Not applicable | Completed | Mohamed Abd El-Raouf Tawfik | 192 | 2026-06-01 | 2026-10-23 |
| Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy GERD | Enrolling by invitation | Prof Urs Zingg | 100 | 2026-04-21 | 2026-06-11 | |
| Thread-Embedding Acupuncture as an Adjunct to Proton Pump Inhibitor Therapy for Gastroesophageal Reflux Disease Thread-Embedding Acupuncture - GERD, Gastroesophageal Reflux Disease | Not applicable | Recruiting | University of Science Ho Chi Minh City | 50 | 2026-04-15 | 2026-09-01 |
| PRospective Registry of Esophageal Motility No intervention - Esophageal Diseases, Achalasia | Recruiting | IRCCS San Raffaele | 10000 | 2026-03-09 | 2026-04-02 | |
| Diaphragmatic Training on GERD Volume-oriented incentive spirometry, Diaphragmatic breathing exercise, Usual Care Group - GERD, Diaphragmatic Training | Not applicable | Recruiting | Changhua Christian Hospital | 42 | 2026-03-04 | 2026-04-22 |
| A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 414 | 2025-12-20 | 2026-03-06 |
| Utility of Mucosal Impedance Device in Chronic Esophageal Disorders: MuVI Esophageal mucosal impedance testing - Gerd, Eosinophilic Esophagitis | Recruiting | Medical College of Wisconsin | 50 | 2025-11-20 | 2026-07-27 | |
| Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers. Trimedat® - Irritable Bowel Syndrome, Gallstone Disease | Phase 1 | Recruiting | Valenta Pharm JSC | 36 | 2025-11-06 | 2026-02-19 |
| Heartburn, Gastroesophageal Reflux Disease Zastaprazan, Esomeprazole - GERD | Phase 4 | Recruiting | Incheon St.Mary's Hospital | 160 | 2025-07-07 | 2025-12-23 |
| Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 300 | 2025-04-30 | 2026-04-27 |
| Alginate vs Sucralfate for GERD Symptomatic Relief Alginate, Sucralfate - GERD | Phase 2 / Phase 3 | Completed | CMH Lahore Medical College and Institute of Dentistry | 140 | 2025-04-01 | 2026-07-15 |
| Anti-Reflux Endoscopic Therapy Using Argon Plasma Coagulation (AREA) in Gastroesophageal Reflux Disease (GERD) Patients: A Single Center, Randomized, Sham, Controlled Trial (The AREA Study) Anti reflux endoscopic theraphy, Endoscopy - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 18 | 2024-02-10 | 2025-02-12 |
| Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD) GERD | Unknown | Assiut University | 100 | 2024-01-01 | 2024-06-13 | |
| Efficacy and Safety of Combined Thread Embedding Acupuncture With Auricular Acupuncture for GERD Thread Embedding Acupuncture, Auricular acupuncture, Standard treatment - GERD | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 66 | 2023-12-06 | 2024-03-20 |
| Famotidine and Antacids for Treatment of Dyspepsia Intravenous Famotidine, Oral Maalox/ Mylanta - Dyspepsia, GERD | Phase 4 | Recruiting | Stony Brook University | 80 | 2023-11-09 | 2026-06-02 |
| A Study to Compare Pharmacokinetics, Pharmacodynamics and Safety of UI059 and UIC202201 in Healthy Subjects UI059, UIC202201 - GERD | Phase 1 | Completed | Korea United Pharm. Inc. | 8 | 2023-10-08 | 2023-11-21 |
| Prospective Evaluation of PH-impedance Tracings According to the Wingate Consensus, and Influence on GERD Classification According to the Lyon Consensus Questionnaires - GERD | Recruiting | Universitair Ziekenhuis Brussel | 120 | 2023-09-29 | 2025-03-19 |
Showing 20 of 204. Sign in to see all of them.
Gastroesophageal Reflux (204) · Heartburn (14) · Barrett Esophagus (13) · Obesity (12) · Hernia, Hiatal (8) · Obesity, Morbid (7) · Esophagitis (6) · Deglutition Disorders (5) · Esophageal Achalasia (5) · Esophagitis, Peptic (5) · Gastroparesis (5) · Non-Erosive Reflux Disease (5) · Cough (4) · Eosinophilic Esophagitis (4) · Dyspepsia (3)
Esophageal Motility Disorders (204) · Digestive System Diseases (203) · Gastrointestinal Diseases (203) · Esophageal Diseases (202) · Deglutition Disorders (199) · Pathological Conditions, Signs and Symptoms (56) · Signs and Symptoms (48) · Nutritional and Metabolic Diseases (21) · Nutrition Disorders (18) · Overnutrition (18) · Signs and Symptoms, Digestive (18) · Body Weight (17) · Overweight (17) · Gastroenteritis (15) · Stomach Diseases (15)
Esomeprazole (28) · Omeprazole (7) · Pantoprazole (7) · Endoscopy (6) · Rabeprazole (6) · Domperidone (5) · Lansoprazole (5) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (3) · Gastroscopy (3) · Antacids (2) · Baclofen (2) · Citalopram (2) · Endoscopy, Digestive System (2) · Manometry (2) · Acoustic Impedance Tests (1)
AstraZeneca (25) · Mayo Clinic (8) · Asian Institute of Gastroenterology, India (7) · Chong Kun Dang Pharmaceutical (6) · Johns Hopkins University (4) · McMaster University (3) · NDO Surgical, Inc. (3) · Takeda (3) · Torax Medical Incorporated (3) · University of North Carolina, Chapel Hill (3) · Assiut University (2) · Baylor Research Institute (2) · Capital Medical University (2) · Children's Mercy Hospital Kansas City (2) · Cinclus Pharma Holding AB (2)
United States (76) · South Korea (14) · Germany (10) · Belgium (9) · France (9) · Italy (9) · Canada (7) · India (7) · Switzerland (6) · United Kingdom (6) · Denmark (5) · Hungary (5) · Austria (4) · Egypt (4) · Netherlands (4)
Nicholas Shaheen, MD, MPH (3) · Chuan Zhang, MD (2) · Mohan Dr Ramchandani, MD DM (2) · N van den Berk (2) · Sergey Morozov, MD, PhD (2) · A Sellink (1) · A Sellink, MD (1) · Adam M Tritsch, MD (1) · Alain Castaigne, Medical Director (1) · Aleksandar Nagorni, Prof. Dr (1) · Amanda Cafaro, BSN (1) · Amy Foxx-Orenstein, D.O. (1) · Andres Maldonado, M.D. (1) · Andrew Batey, M.D. (1)
PMID 11275880, PMID 12872107, PMID 14595322, PMID 14745387, PMID 15647177, PMID 15855966, PMID 15855987, PMID 16542276, PMID 17116123, PMID 17391505, PMID 18443855, PMID 19601705, PMID 20110554, PMID 20578215, PMID 21083590, PMID 21083673, PMID 21242557, PMID 21347742, PMID 21586712, PMID 21952699, PMID 22111863, PMID 22642956, PMID 22759841, PMID 23560727, PMID 23622977, PMID 23800403, PMID 23840119, PMID 23919738, PMID 24018760, PMID 24151377, PMID 24299323, PMID 24976710, PMID 25171881, PMID 25304129, PMID 25330784, PMID 25448923, PMID 25858519, PMID 26559637, PMID 27712711, PMID 28119763, PMID 28567114, PMID 28607547, PMID 28894571, PMID 29248733, PMID 29739175, PMID 30257076, PMID 30504527, PMID 30625462, PMID 30711626, PMID 31564831
K23AT009218 (2), 2025 (1), K23DK115827 (1), R21DK077678 (1), R21DK097529 (1)