17 completed, 4 unknown, 2 recruiting, 2 withdrawn. 26 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 26 | Completed 17, Unknown 4, Recruiting 2, Withdrawn 2, Terminated 1 |
Follow GERD: new trials by email Literature Review of GERD trials Research Report on GERD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Heartburn, Gastroesophageal Reflux Disease Zastaprazan, Esomeprazole - GERD | Phase 4 | Recruiting | Incheon St.Mary's Hospital | 160 | 2025-07-07 | 2025-12-23 |
| Famotidine and Antacids for Treatment of Dyspepsia Intravenous Famotidine, Oral Maalox/ Mylanta - Dyspepsia, GERD | Phase 4 | Recruiting | Stony Brook University | 80 | 2023-11-09 | 2026-06-02 |
| Citalopram for Reflux Hypersensitivity and Functional Heartburn Citalopram 20mg, Placebo Oral Tablet - GERD | Phase 4 | Unknown | Universitaire Ziekenhuizen KU Leuven | 100 | 2019-05-27 | 2019-12-05 |
| Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features Vonoprazan, Omeprazole - GERD, Gastro Esophageal Reflux | Phase 4 | Terminated | St. Luke's Medical Center, Philippines | 82 | 2019-05-26 | 2023-11-22 |
| Prucalopride Treatment for Refractory Gastro-esophageal Reflux Disease Prucalopride, Placebo Oral Tablet - GERD | Phase 4 | Unknown | Universitaire Ziekenhuizen KU Leuven | 60 | 2019-02-18 | 2019-12-05 |
| Effect of Obesity on Proton Pump Inhibitors Lansoprazole, Pantoprazole, Midazolam - Pediatric Obesity, NAFLD | Phase 4 | Completed | Children's Mercy Hospital Kansas City | 76 | 2018-07-03 | 2026-06-04 |
| Cardiac Safety of Lansoprazole and Domperidon Combination Lansoprazole/Domperidone, Lansoprazole - GERD, Cardiac Event | Phase 4 | Withdrawn | Neutec Ar-Ge San ve Tic A.Ş | 2018-03-01 | 2023-01-05 | |
| Efficacy and Safety Evaluation of Neobianacid® in GERD and EPS Neobianacid®, Omeprazole 20mg, Neobianacid® placebo - GERD, EPS | Phase 4 | Completed | Aboca Spa Societa' Agricola | 275 | 2017-09-12 | 2022-11-21 |
| An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of Ramadan Dexlansoprazole 60 MG - GERD, Proton Pump Inhibitor | Phase 4 | Completed | American University of Beirut Medical Center | 33 | 2017-02-27 | 2017-09-15 |
| The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate lansoprazole, placebo - Rhinitis, Nasal Obstruction | Phase 4 | Unknown | McGill University Health Centre/Research Institute of the McGill University Health Centre | 98 | 2015-01-01 | 2014-10-29 |
| Research of Efficient Use of Omeprazole in Combination With Domperidone in Gastroesophageal Reflux Disease of Mild to Moderate Severity omeprazole+domperidone SR, omeprazole - GERD | Phase 4 | Unknown | Belarusian Medical Academy of Post-Graduate Education | 60 | 2013-12-01 | 2014-05-16 |
| Efficacy and Saafety of Omez Iin Patients With H.Pylori Associated Diseases OMEZ 40, OMEZ 80 - GERD | Phase 4 | Completed | Dr. Reddy's Laboratories Limited | 120 | 2013-01-01 | 2016-10-04 |
| To Assess the Efficacy of Esomeprazole 20mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole esomeprazole 20 mg - Gastroesophageal Reflux Disease, GERD | Phase 4 | Completed | AstraZeneca | 107 | 2011-08-01 | 2013-02-21 |
| Placebo Controlled Study of Baclofen for GERD in Children With Cerebral Palsy Baclofen, placebo - Cerebral Palsy, GERD | Phase 4 | Withdrawn | Boston Children's Hospital | 2009-04-01 | 2017-08-29 | |
| Does Omeprazole Decrease Intestinal Calcium Absorption? Omeprazole - Osteoporosis, Achlorhydria | Phase 4 | Completed | University of Wisconsin, Madison | 23 | 2008-01-01 | 2013-02-15 |
| Nexium (Esomeprazole) in Symptom Adapted Therapy in GERD Patients esomeprazole (Nexium®), Xolaam® - GERD | Phase 4 | Completed | AstraZeneca | 3029 | 2007-03-01 | 2012-12-11 |
| Nexium RESPONSE Trial Esomeprazole - GERD | Phase 4 | Completed | AstraZeneca | 1000 | 2006-05-01 | 2009-01-26 |
| Nexium 40mg Once Daily vs Prevacid 30mg Twice a Day for Control of Severe GERD Antacids - GERD | Phase 4 | Completed | Digestive & Liver Disease Specialists | 50 | 2005-10-01 | 2009-02-25 |
| An Open-Label Study of Once-Daily Oral Administration of Esomeprazole 40 mg in Patients With Symptoms of Gastroesophageal Reflux Disease (GERD) Esomeprazole - GERD | Phase 4 | Completed | AstraZeneca | 350 | 2005-10-01 | 2009-03-06 |
| The Utility of Nexium in Chronic Cough and Reflux Disease Esomeprazole, Placebo - Cough, GERD | Phase 4 | Completed | University of North Carolina, Chapel Hill | 40 | 2005-09-01 | 2012-01-10 |
Showing 20 of 26. Sign in to see all of them.
Gastroesophageal Reflux (26) · Heartburn (3) · Achlorhydria (1) · Cardiovascular Diseases (1) · Cerebral Palsy (1) · Cough (1) · Dyspepsia (1) · Esophagitis (1) · Esophagitis, Peptic (1) · Hip Fractures (1) · Nasal Obstruction (1) · Non-alcoholic Fatty Liver Disease (1) · Osteoporosis (1) · Parasomnias (1) · Pediatric Obesity (1)
Deglutition Disorders (26) · Digestive System Diseases (26) · Esophageal Diseases (26) · Esophageal Motility Disorders (26) · Gastrointestinal Diseases (26) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (6) · Signs and Symptoms, Digestive (4) · Gastroenteritis (2) · Nervous System Diseases (2) · Nutritional and Metabolic Diseases (2) · Respiration Disorders (2) · Respiratory Tract Diseases (2) · Stomach Diseases (2) · Acid-Base Imbalance (1)
Esomeprazole (9) · Omeprazole (5) · Lansoprazole (3) · Antacids (2) · Pantoprazole (2) · Rabeprazole (2) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (1) · Ambulatory Care Facilities (1) · Baclofen (1) · Citalopram (1) · Dexlansoprazole (1) · Domperidone (1) · Histamine H2 Antagonists (1) · Midazolam (1) · aluminum hydroxide, magnesium hydroxide, drug combination (1)
AstraZeneca (7) · Universitaire Ziekenhuizen KU Leuven (2) · Aboca Spa Societa' Agricola (1) · American University of Beirut Medical Center (1) · Belarusian Medical Academy of Post-Graduate Education (1) · Boston Children's Hospital (1) · Children's Mercy Hospital Kansas City (1) · Digestive & Liver Disease Specialists (1) · Dr. Reddy's Laboratories Limited (1) · Incheon St.Mary's Hospital (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · National Taiwan University Hospital (1) · Neutec Ar-Ge San ve Tic A.Ş (1) · St. Luke's Medical Center, Philippines (1) · Stony Brook University (1)
United States (8) · Belgium (2) · Belarus (1) · Denmark (1) · France (1) · Italy (1) · Lebanon (1) · Netherlands (1) · Philippines (1) · South Korea (1) · Taiwan (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Nicholas Shaheen, MD, MPH (2) · David A Johnson, MD (1) · Karen E Hansen, MD (1) · Kathryn Kyler, MD, MS (1) · Makiko Abe (1) · Masataka Date (1) · Ming-Shiang Wu, PHD (1) · Nicodemus L Ong, MD (1) · Paula Fernstrom (1) · Samuel Nurko, MD (1) · Serhat Bor, Prof Dr (1)
PMID 19601705, PMID 20578215, PMID 21083590, PMID 21083673, PMID 21347742, PMID 22759841, PMID 26559637, PMID 28119763, PMID 28567114, PMID 28607547, PMID 28894571, PMID 29739175, PMID 30504527, PMID 30625462, PMID 37307528, PMID 42226497
K23DK115827 (1), R21DK077678 (1)