8560 completed, 1670 unknown, 1356 recruiting, 614 active not recruiting. 8078 Not applicable, 972 Phase 2, 796 Phase 1, 677 Phase 3, 588 Phase 4.
Follow Overweight: new trials by email Literature Review of Overweight trials Research Report on Overweight
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Metabolic Effects of Polylactose: A Novel Prebiotic Polylactose, Placebo - Obesity, Adolescent, Obesity, Childhood | Not applicable | Withdrawn | University of Minnesota | 2028-05-01 | 2025-07-11 | |
| A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults Body positioning - Healthy Volunteers Only | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 20 | 2028-01-01 | 2025-06-18 |
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| Community Active and Healthy Families Pragmatic Trial Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment - Child Obesity | Phase 4 | Not yet recruiting | University of Colorado, Denver | 416 | 2028-01-01 | 2026-10-09 |
| Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients Tirzepatide + Standard Therapy (Intervention Group), Standard Oral Antidiabetic Drugs (OADs) - Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight | Not applicable | Not yet recruiting | Akhtar Saeed Medical and Dental College | 52 | 2027-12-12 | 2026-10-29 |
| AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH AI-informed behavioral intervention, Standard behavioral intervention, Health Education - Obesity (Disorder) | Not applicable | Not yet recruiting | Aikaterini Karaivazoglou | 840 | 2027-09-01 | 2026-04-14 |
| Modifying Diet to Improve Gut Microbiome DASH diet, standard American diet - Obesity | Not applicable | Not yet recruiting | H. Lee Moffitt Cancer Center and Research Institute | 28 | 2027-07-01 | 2026-09-17 |
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Simplifying Diet Tracking in a Digital Weight Loss Intervention Simplified Dietary Self-Monitoring, Detailed Dietary Self-Monitoring, Core Behavioral Weight Loss Intervention - Overweight, Obesity | Not applicable | Not yet recruiting | Stanford University | 328 | 2027-05-01 | 2026-05-28 |
| Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D) ESG with OverStitch - Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30) | Not applicable | Not yet recruiting | Boston Scientific Corporation | 50 | 2027-04-01 | 2026-11-06 |
| Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? NutriAct plus, Rescue VLCD - Obesity & Overweight, Weight Loss Maintenance | Not applicable | Not yet recruiting | Knut Mai | 292 | 2027-03-01 | 2026-07-20 |
| Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose Pecan, Control - Nutrition, Healthy, Dyslipidemia | Not applicable | Not yet recruiting | University of Georgia | 90 | 2027-03-01 | 2026-08-11 |
| Semaglutide for Weight Management During Hormone Therapy for Early Breast Cancer Semaglutide (Wegovy®) - Breast Cancer (Early Breast Cancer), Obesity | Phase 2 | Not yet recruiting | Aarhus University Hospital | 32 | 2027-03-01 | 2026-11-02 |
| Brain and Obesity Longitudinal Development: Neurobiological Mechanisms of Semaglutide Treatment of Adolescent Obesity Semaglutide - Pediatric Obesity, Obesity | Not yet recruiting | Erin Mauney | 12 | 2027-03-01 | 2026-11-02 | |
| Puerto Rican Obesity Intervention for Men TeleSalud Healthy Eating- Physical Activity/Sedentary Behavior (HE-PA/SB), TeleSalud General Health Intervention - Obesity | Not applicable | Not yet recruiting | Medical College of Wisconsin | 48 | 2027-03-01 | 2026-10-30 |
| Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults LUM-201, Placebo, Semagludtide - Obesity & Overweight | Phase 2 | Not yet recruiting | Lumos Pharma | 202 | 2027-02-15 | 2026-08-10 |
| BRE-13: Mediterranean Diet Explore the effect of MedDiet vs. Usual Diet on Fatty Acid Profile, Explore the effect of MedDiet vs. Usual Diet on Breast Tumor Tissue, Explore the effect of MedDiet vs. Usual Diet on Lipids - Dietary Assessment, Dietary and Lifestyle Behaviour Change | Not applicable | Not yet recruiting | University of Illinois at Chicago | 30 | 2027-02-15 | 2026-10-09 |
| Effects of Tirzepatide on Gut Microbiota and Gastrointestinal Function After Drug Withdrawal in Obese Patients Tirzepatide - Obesity / Overweight | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 80 | 2027-02-01 | 2026-10-15 | |
| Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 250 | 2027-02-01 | 2026-07-28 |
| EMBodied psychOsocial Impacts of Weight Stigma During Pregnancy (EMBODY): A Prospective Cohort Study Weight Stigma, Pregnancy Outcomes | Not yet recruiting | Monash University | 800 | 2027-02-01 | 2026-10-16 |
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Obesity (11397) · Weight Loss (1204) · Motor Activity (1154) · Diabetes Mellitus, Type 2 (1124) · Pediatric Obesity (1122) · Obesity, Morbid (934) · Diabetes Mellitus (827) · Insulin Resistance (790) · Metabolic Syndrome (733) · Hypertension (589) · Cardiovascular Diseases (482) · Inflammation (325) · Body Weight (297) · Obesity, Abdominal (292)
Nutritional and Metabolic Diseases (13706) · Overnutrition (13686) · Nutrition Disorders (13624) · Pathological Conditions, Signs and Symptoms (13605) · Signs and Symptoms (13570) · Body Weight (13262) · Metabolic Diseases (3293) · Glucose Metabolism Disorders (3102) · Endocrine System Diseases (2253) · Behavior (2109) · Obesity (1844) · Hyperinsulinism (1369) · Body Weight Changes (1341) · Diabetes Mellitus (1242)
Exercise (496) · Diet (238) · semaglutide (226) · Bariatric Surgery (164) · Tirzepatide (150) · Liraglutide (127) · Metformin (125) · Gastric Bypass (117) · Caloric Restriction (109) · Nutrition Assessment (99) · Control Groups (90) · Resistance Training (85) · Diet Therapy (81) · Standard of Care (73) · Sodium Chloride (72)
Novo Nordisk A/S (205) · University of Colorado, Denver (119) · Eli Lilly and Company (118) · Mayo Clinic (113) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (104) · Washington University School of Medicine (95) · Pennington Biomedical Research Center (91) · The Miriam Hospital (91) · Maastricht University Medical Center (89) · University of Copenhagen (89) · Massachusetts General Hospital (87) · University of Alabama at Birmingham (84) · Yale University (82) · Duke University (80) · University of Pennsylvania (79)
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