10342 completed, 2156 unknown, 1544 recruiting, 681 active not recruiting. 9436 Not applicable, 1178 Phase 2, 873 Phase 3, 872 Phase 1, 783 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating the Metabolic Effects of Polylactose: A Novel Prebiotic Polylactose, Placebo - Obesity, Adolescent, Obesity, Childhood | Not applicable | Withdrawn | University of Minnesota | 2028-05-01 | 2025-07-11 | |
| A Study of Body Fat Distribution and Airway Mechanics in Healthy Adults Body positioning - Healthy Volunteers Only | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 20 | 2028-01-01 | 2025-06-18 |
| Adiposity Distribution in Acute Respiratory Failure PEEP Titration Using Electrical Impedance Tomography (EIT), Body Positioning: Supine and Prone - Acute Hypoxemic Respiratory Failure, Obesity | Not applicable | Not yet recruiting | Maurizio F. Cereda, MD | 80 | 2028-01-01 | 2025-06-13 |
| Community Active and Healthy Families Pragmatic Trial Community Active and Healthy Families Intensive Health Behavior and Lifestyle Treatment - Child Obesity | Phase 4 | Not yet recruiting | University of Colorado, Denver | 416 | 2028-01-01 | 2026-10-09 |
| Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients Tirzepatide + Standard Therapy (Intervention Group), Standard Oral Antidiabetic Drugs (OADs) - Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight | Not applicable | Not yet recruiting | Akhtar Saeed Medical and Dental College | 52 | 2027-12-12 | 2026-10-29 |
| AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH AI-informed behavioral intervention, Standard behavioral intervention, Health Education - Obesity (Disorder) | Not applicable | Not yet recruiting | Aikaterini Karaivazoglou | 840 | 2027-09-01 | 2026-04-14 |
| Modifying Diet to Improve Gut Microbiome DASH diet, standard American diet - Obesity | Not applicable | Not yet recruiting | H. Lee Moffitt Cancer Center and Research Institute | 28 | 2027-07-01 | 2026-09-17 |
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| Simplifying Diet Tracking in a Digital Weight Loss Intervention Simplified Dietary Self-Monitoring, Detailed Dietary Self-Monitoring, Core Behavioral Weight Loss Intervention - Overweight, Obesity | Not applicable | Not yet recruiting | Stanford University | 328 | 2027-05-01 | 2026-05-28 |
| The Effect of Oral Iron Supplements on Insulin and Glucose Metabolism in Overweight and Obese Women 195 mg iron daily, 15 mg iron daily - Overweight and Obese Women | Not applicable | Recruiting | Nicole Stoffel | 70 | 2027-05-01 | 2026-11-13 |
| Reflux Disease After Gastric Bypass Versus Sleeve Gastrectomy in Morbid Obese Patients: an Italian Study Roux-en-Y-Gastric bypass, Sleeve gastrectomy, SG - Gastroesophageal Reflux Disease, Obesity | Not applicable | Not yet recruiting | Niguarda Hospital | 128 | 2027-05-01 | 2026-11-12 |
| Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D) ESG with OverStitch - Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30) | Not applicable | Not yet recruiting | Boston Scientific Corporation | 50 | 2027-04-01 | 2026-11-06 |
| Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity? NutriAct plus, Rescue VLCD - Obesity & Overweight, Weight Loss Maintenance | Not applicable | Not yet recruiting | Knut Mai | 292 | 2027-03-01 | 2026-07-20 |
| Cardiometabolic Effects of the Recommended Daily Pecan Intake Dose Pecan, Control - Nutrition, Healthy, Dyslipidemia | Not applicable | Not yet recruiting | University of Georgia | 90 | 2027-03-01 | 2026-08-11 |
| Semaglutide for Weight Management During Hormone Therapy for Early Breast Cancer Semaglutide (Wegovy®) - Breast Cancer (Early Breast Cancer), Obesity | Phase 2 | Not yet recruiting | Aarhus University Hospital | 32 | 2027-03-01 | 2026-11-02 |
| Brain and Obesity Longitudinal Development: Neurobiological Mechanisms of Semaglutide Treatment of Adolescent Obesity Semaglutide - Pediatric Obesity, Obesity | Not yet recruiting | Erin Mauney | 12 | 2027-03-01 | 2026-11-02 | |
| Puerto Rican Obesity Intervention for Men TeleSalud Healthy Eating- Physical Activity/Sedentary Behavior (HE-PA/SB), TeleSalud General Health Intervention - Obesity | Not applicable | Not yet recruiting | Medical College of Wisconsin | 48 | 2027-03-01 | 2026-10-30 |
| A Randomized Controlled Trial of Prepared vs. Unprepared Food Prepared meals, Unprepared Pantry/Produce box - Pregnant Patients at Risk of Gestational Diabetes | Not applicable | Not yet recruiting | University of Michigan | 40 | 2027-03-01 | 2026-11-12 |
| Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults LUM-201, Placebo, Semagludtide - Obesity & Overweight | Phase 2 | Not yet recruiting | Lumos Pharma | 202 | 2027-02-15 | 2026-08-10 |
| BRE-13: Mediterranean Diet Explore the effect of MedDiet vs. Usual Diet on Fatty Acid Profile, Explore the effect of MedDiet vs. Usual Diet on Breast Tumor Tissue, Explore the effect of MedDiet vs. Usual Diet on Lipids - Dietary Assessment, Dietary and Lifestyle Behaviour Change | Not applicable | Not yet recruiting | University of Illinois at Chicago | 30 | 2027-02-15 | 2026-10-09 |
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Obesity (11411) · Overweight (3576) · Weight Loss (1238) · Malnutrition (1228) · Motor Activity (1192) · Diabetes Mellitus, Type 2 (1155) · Pediatric Obesity (1124) · Obesity, Morbid (934) · Diabetes Mellitus (863) · Insulin Resistance (825) · Vitamin D Deficiency (797) · Metabolic Syndrome (741) · Hypertension (613) · Cardiovascular Diseases (506) · Inflammation (381)
Nutritional and Metabolic Diseases (16501) · Pathological Conditions, Signs and Symptoms (14438) · Signs and Symptoms (13988) · Overnutrition (13703) · Body Weight (13398) · Overweight (10166) · Metabolic Diseases (3766) · Glucose Metabolism Disorders (3210) · Endocrine System Diseases (2483) · Behavior (2296) · Obesity (1844) · Pathologic Processes (1450) · Body Weight Changes (1441) · Hyperinsulinism (1411)
Exercise (517) · Cholecalciferol (340) · Diet (250) · semaglutide (226) · Vitamin D (203) · Bariatric Surgery (164) · Tirzepatide (153) · Nutrition Assessment (137) · Metformin (131) · Liraglutide (127) · Gastric Bypass (117) · Caloric Restriction (112) · Control Groups (110) · Diet Therapy (95) · Standard of Care (94)
Novo Nordisk A/S (206) · University of Colorado, Denver (130) · Washington University School of Medicine (125) · Mayo Clinic (123) · Eli Lilly and Company (118) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (112) · University of Copenhagen (103) · Massachusetts General Hospital (100) · Maastricht University Medical Center (96) · Pennington Biomedical Research Center (95) · University of Alabama at Birmingham (92) · The Miriam Hospital (91) · Yale University (90) · Duke University (85) · University of Pennsylvania (84)
United States (6120) · China (774) · Canada (736) · France (721) · United Kingdom (641) · Spain (570) · Turkey (Türkiye) (547) · Italy (488) · Denmark (482) · Germany (447) · Brazil (362) · Netherlands (333) · Egypt (292) · Mexico (281) · Sweden (265)
Samuel Klein, MD (22) · Jack A Yanovski, M.D. (20)
PMID 38375882, PMID 33512717, PMID 33305842, PMID 29718281, PMID 38376518, PMID 39077939, PMID 39151033, PMID 26210388, PMID 26708836, PMID 30122305, PMID 30230252, PMID 33238176, PMID 40839263, PMID 41029405, PMID 28386912, PMID 28950422, PMID 30651576, PMID 33782940, PMID 38271099, PMID 42014131, PMID 22085317, PMID 23987123, PMID 24500151, PMID 24570244, PMID 26529632, PMID 26599819, PMID 27474016, PMID 27482610, PMID 27817208, PMID 28473337, PMID 28978680, PMID 31004409, PMID 32002540, PMID 32909523, PMID 33567185, PMID 37652841, PMID 38698650, PMID 39226070, PMID 39952695, PMID 40576086, PMID 40705619, PMID 11832527, PMID 14688154, PMID 15479938, PMID 17715408, PMID 18673303, PMID 19858703, PMID 20573639, PMID 20798995, PMID 21646368
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