121 completed, 35 recruiting, 21 unknown, 17 active not recruiting. 50 Phase 2, 49 Not applicable, 28 Phase 3, 15 Phase 1, 11 Phase 4.
Follow Eosinophilic Esophagitis: new trials by email Literature Review of Eosinophilic Esophagitis trials Research Report on Eosinophilic Esophagitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States Esophageal string test - Dysphagia, Eosinophilic Esophagitis | Not applicable | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 70 | 2026-11-01 | 2026-10-27 |
| A Trial of Upadacitinib for Non-responsive Eosinophilic Esophagitis Upadacitinib 30mg Dose, Upadacitinib Matching Placebo - EoE, Eosinophilic Esophagitis | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 52 | 2026-09-30 | 2026-10-06 |
| Impact of Body Positioning on EndoFLIP Measurements: A Comparative Study of Supine and Left Lateral Decubitus Positions EndoFlip - Dysphagia, Esophageal Stricture | Not applicable | Recruiting | Johns Hopkins University | 25 | 2026-07-24 | 2026-08-24 |
| Elimination Diet Strategies and Histologic Remission in Children With Eosinophilic Gastrointestinal Disorders Elimination Diet - Eosinophilic Gastrointestinal Disorders (EGID) | Recruiting | Cukurova University | 34 | 2026-07-01 | 2026-08-21 | |
| The DiNAM-EoE-C Study: Esophageal Distensibility and Novel Assessment of Motility in Eosinophilic Esophagitis Eosinophilic Esophagitis (EoE), Dysphagia, Esophageal | Enrolling by invitation | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 25 | 2026-05-01 | 2026-07-29 | |
| Trial of Partial Enteral Nutrition With Dairy Free Diet in Eosinophilic Esophagitis Partial enteral nutrition (PEN) with dairy elimination, Dairy elimination alone - Eosinophilic Esophagitis (EoE) | Not applicable | Recruiting | Kate Farms Inc | 36 | 2026-03-18 | 2026-04-16 |
| PRospective Registry of Esophageal Motility No intervention - Esophageal Diseases, Achalasia | Recruiting | IRCCS San Raffaele | 10000 | 2026-03-09 | 2026-04-02 | |
| Comparison of Eohilia With Dupixent on Esophagus Diameter in Patients With Eosinophilic Esophagitis. Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT], budesonide oral suspension - Eosinophilic Esophagitis (EoE) | Early Phase 1 | Enrolling by invitation | Mayo Clinic | 60 | 2026-02-04 | 2026-05-04 |
| Utility of Mucosal Impedance Device in Chronic Esophageal Disorders: MuVI Esophageal mucosal impedance testing - Gerd, Eosinophilic Esophagitis | Recruiting | Medical College of Wisconsin | 50 | 2025-11-20 | 2026-07-27 | |
| A Study of Dupilumab in Small Children With an Allergic Condition of the Esophagus (Food Pipe): Eosinophilic Esophagitis dupilumab - Eosinophilic Esophagitis (EoE) | Phase 3 | Recruiting | Regeneron Pharmaceuticals | 20 | 2025-11-10 | 2026-09-29 |
| A Study in Adult Participants With EoE to Evaluate Vonoprazan 20 mg Compared to Placebo After 12 Weeks and to Evaluate Vonoprazan 20 mg Up to 24 Weeks Vonoprazan, Placebo - Eosinophilic Esophagitis | Phase 2 | Active not recruiting | Phathom Pharmaceuticals, Inc. | 95 | 2025-10-30 | 2026-10-13 |
| Natural History of Eosinophilic Esophagitis in Adult and Pediatric Population Eosinophilic Esophagitis (EoE) | Recruiting | Fondazione IRCCS Policlinico San Matteo di Pavia | 200 | 2025-09-01 | 2026-06-29 | |
| Surface EMG Testing on Swallowing in EoE Patients Surface Electromyography, Fiberoptic Endoscopic Evaluation of Swallowing - Eosinophilic Esophagitis (EoE) | Active not recruiting | Mayo Clinic | 30 | 2025-08-04 | 2026-07-17 | |
| Trans-Cervical and Trans-abdominal Ultrasound for Monitoring Esophageal Thickness in Eosinophilic Esophagitis Trans cervical or abdominal ultrasound - Eosinophilic Esophagitis (EoE) | Not applicable | Not yet recruiting | Sheba Medical Center | 100 | 2025-08-01 | 2025-07-29 |
| BURDEN OF ESOPHAGEAL CANCER IN EOSINOPHILIC ESOPHAGITIS (ESCAPE STUDY) Eosinophilic Esophagitis (EoE) | Completed | IRCCS San Raffaele | 100000 | 2025-07-23 | 2026-03-11 | |
| Local Clinical and Immunological Responses in Eosinophilic Esophagitis (EoE) Patients, Role of Mucosal Barrier Function and Type II Inflammation Eosinophilic Esophagitis (EoE) | Recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 56 | 2025-07-01 | 2025-06-10 | |
| Prevalence and Description of FIRE (Food Induced Immediate Response of the Esophagus) in the Pediatric Population With Eosinophilic Esophagitis Eosinophilic Esophagitis | Recruiting | University Hospital, Angers | 40 | 2025-07-01 | 2026-06-15 | |
| Comparing the Availability of AQ280 in the Body After Single Oral Doses of a Capsule Formulation Versus a Tablet for Oral Suspension Formulation AQ280 Capsule, AQ280 Tablet for Oral Suspension, Placebo Capsule - Eosinophilic Esophagitis | Phase 1 | Completed | AQILION AB | 9 | 2025-06-13 | 2026-06-01 |
| Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study Umbilical Cord Blood Infusion (Autologous and Allogeneic) - Autism Spectrum Disorder, Eosinophilic Gastrointestinal Disorders | Not applicable | Not yet recruiting | Bundang CHA Hospital | 1 | 2025-06-01 | 2025-05-29 |
| A Non-interventional Observational Study to Assess Long-term Efficacy and Safety of Dupilumab for the Treatment of Patients (>= 12 Years) With Eosinophilic Esophagitis Under Real-world-conditions in Germany Dupilumab - Eosinophilic Esophagitis | Recruiting | Sanofi | 150 | 2025-05-28 | 2026-09-17 |
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Esophagitis (24) · Deglutition Disorders (18) · Eosinophilic enteropathy (18) · Gastroesophageal Reflux (16) · Esophageal Diseases (13) · Eosinophilia (11) · Hypersensitivity (11) · Food Hypersensitivity (10) · Gastrointestinal Diseases (10) · Gastroenteritis (8) · Digestive System Diseases (6) · Hematologic Diseases (5) · Immune System Diseases (5) · Leukocyte Disorders (5)
Hemic and Lymphatic Diseases (234) · Hypersensitivity, Immediate (230) · Hematologic Diseases (229) · Immune System Diseases (229) · Leukocyte Disorders (229) · Digestive System Diseases (228) · Gastroenteritis (226) · Gastrointestinal Diseases (224) · Eosinophilia (223) · Hypersensitivity (223) · Esophageal Diseases (221) · Esophagitis (210) · Otorhinolaryngologic Diseases (22) · Pathological Conditions, Signs and Symptoms (19) · Pharyngeal Diseases (18)
Fluticasone (17) · dupilumab (15) · Budesonide (12) · Endoscopy, Digestive System (7) · AK002 (6) · APT-1011 (5) · BID protein, human (4) · cendakimab (4) · Endoscopy (3) · Esomeprazole (3) · Omeprazole (3) · Sodium Chloride (3) · montelukast (3) · Blood Specimen Collection (2) · Dexlansoprazole (2)
Mayo Clinic (24) · Children's Hospital Medical Center, Cincinnati (13) · University of North Carolina, Chapel Hill (9) · University of Colorado, Denver (8) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Regeneron Pharmaceuticals (7) · Allakos Inc. (6) · Ann & Robert H Lurie Children's Hospital of Chicago (6) · Dr. Falk Pharma GmbH (5) · IRCCS San Raffaele (5) · Shire (5) · Celgene (4) · Children's Hospital of Philadelphia (4) · Ellodi Pharmaceuticals, LP (4) · Massachusetts General Hospital (4)
United States (164) · Italy (21) · Canada (17) · Germany (17) · Switzerland (15) · Spain (13) · United Kingdom (12) · Australia (11) · Netherlands (11) · Belgium (10) · Israel (9) · Poland (8) · France (7) · Japan (5) · Austria (4)
Evan S Dellon, MD, MPH (8) · Craig Paterson, MD (5) · Joshua B Wechsler, MD (5) · Marc E Rothenberg, MD, PhD (5) · David Katzka, MD (4) · Karthik Ravi, MD (4) · Marc E. Rothenberg, M.D., Ph.D. (4) · Calies Menard-Katcher, MD (3) · Evan Dellon, MD, MPH (3) · Ralph Mueller, PhD (3) · Calman P Prussin, M.D. (2)
PMID 42031097, PMID 28809387, PMID 34182150, PMID 36574003, PMID 37718471, PMID 39735351, PMID 41711386, PMID 41749054, PMID 10049409, PMID 16329022, PMID 17919504, PMID 19935783, PMID 20457157, PMID 20920599, PMID 22111863, PMID 22206777, PMID 22561055, PMID 22895393, PMID 23567357, PMID 24177377, PMID 24314292, PMID 24768678, PMID 24907494, PMID 24907502, PMID 24997328, PMID 25017104, PMID 25226850, PMID 25789989, PMID 25792708, PMID 26142551, PMID 26184697, PMID 26247167, PMID 26426817, PMID 26513622, PMID 26685124, PMID 27035377, PMID 27101536, PMID 27650328, PMID 27889574, PMID 28676207, PMID 29248733, PMID 29544738, PMID 29902649, PMID 30009819, PMID 30145316, PMID 30395812, PMID 30476587, PMID 30502508, PMID 30614939, PMID 30708107
U54AI117804 (4), 2014 (3), 2019 (2), UL1TR001082 (2), 2009 (1), 2016 (1), 2018 (1), K23DK090073 (1), K23DK129784 (1), R01CA103769 (1), R01DK091923 (1), R01DK101856 (1), R01DK114457 (1), R01DK132001 (1), R01DK135692 (1)