587 completed. 587 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 587 | Completed 587 |
Follow Gastrointestinal Diseases: new trials by email Literature Review of Gastrointestinal Diseases trials Research Report on Gastrointestinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vonoprazan-based Versus Esomeprazole-based Triple Therapy for Helicobacter Pylori Eradication vonoprazan-based triple therapy (VAL regimen), Esomeprazole-based triple therapy (EAL regimen) - Helicobacter Pylori Infection, Dyspepsia | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 80 | 2026-04-15 | 2026-10-26 |
| Effect of Ondansetron on Patient Tolerance, Efficacy and Endoscopist Workload in Unsedated Endoscopy for Upper Gastrointestinal Bleeding intravenous ondansetron, Placebo - Esophagogastroduodenoscopy, Upper Gastrointestinal Bleeding (UGIB) | Phase 4 | Completed | Peking Union Medical College Hospital | 80 | 2026-02-16 | 2026-09-16 |
| Efficacy and Safety of GTN vs. Nifedipine in Acute Anal Fissure: A Clinical Trial Glyceryl Trinitrate (GTN) 0.2% Ointment, Glyceryl Trinitrate (GTN) 0.4% Ointment, Nifedipine 0.2% Ointment - Acute Anal Fissure, Anal Pain | Phase 4 | Completed | Hafiz Muhammad Hamza | 110 | 2025-03-17 | 2025-05-14 |
| Evaluation of the Effectiveness of a Topical Medical Device in Wound Healing and Symptom Relief in the Postoperative Period of Open Excisional Hemorrhoidectomy (The Emor Study) Gel containing a Propionibacterium extract, Hyaluronic acid and silver sulfadiazine - Anus Diseases, Gastrointestinal Diseases | Phase 4 | Completed | University of Cagliari | 114 | 2025-03-04 | 2025-07-02 |
| Helicobacter Pylori Screening and Treatment in the At-risk South Florida Community-AIM 2 PYTEST® 14C-Urea Capsule Breath Test (at Home), PYTEST® 14C-Urea Capsule Breath Test (Standard Retesting In-Person) - H. Pylori Infection, Gastric Cancer | Phase 4 | Completed | University of Miami | 50 | 2024-11-06 | 2026-10-16 |
| Evaluation of Efficacy of Skål Pro Powder on Symptoms of Irritable Bowel Syndrome Skal Pro, Placebo - Irritable Bowel Syndrome, Gastrointestinal Diseases | Phase 4 | Completed | EP Plus Group Sdn Bhd | 57 | 2024-10-17 | 2026-09-11 |
| Therapeutic Effect of Vonoprazan Versus Dexlansoprazole in Treatment of Gastroesophageal Reflux Disease Dexlansoprazole 60 mg, Vonoprazan 20 mg bid - Vonoprazan, Proton Pump Inhibitor | Phase 4 | Completed | Ayman Magd Eldin Mohammad Sadek | 136 | 2024-10-01 | 2025-02-27 |
| Evaluation the of Role of Vitamin D Supplement on Tumor Response, Inflammation and Apoptosis in Patients With Stage II or III Colorectal Cancer Receiving Chemotherapy. Vitamin D - Vitamin D on Tumor Response and Inflammatory Markers, Colo-rectal Cancer | Phase 4 | Completed | Tanta University | 44 | 2024-07-31 | 2025-11-21 |
| Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy GLP-1 medication - Diabetes Mellitus, Type 2, Obesity | Phase 4 | Completed | The Cleveland Clinic | 69 | 2024-07-31 | 2025-12-05 |
| Association Between Effectiveness of Mirikizumab and UC Patients With High Neutrophilic Infiltration in Epithelium of the Colonic Mucosa Mirikizumab, Vedolizumab - Ulcerative Colitis | Phase 4 | Completed | Showa Inan General Hospital | 100 | 2024-07-20 | 2025-10-20 |
| Bowel Preparation in Colonoscopy: Lactulose vs Polyethyleneglycol, Randomized Double-blind Comparative Clinical Trial, Multicenter Study. Bowel preparation before colonoscopy - Colorectal Cancer Screening | Phase 4 | Completed | Hospital Civil de Guadalajara | 449 | 2024-07-20 | 2026-07-28 |
| Effect of Bioflor on Gut Microbiota in Proton-Pump Inhibitor Users Saccharomyces Boulardii 250 MG, Proton Pump Inhibitors (PPI) - Dysbiosis, Gastroesophageal Reflux Disease (GERD) | Phase 4 | Completed | Seoul National University Hospital | 80 | 2024-07-18 | 2026-10-01 |
| A Study to Assess the Concentrations of Risankizumab in the Breast Milk of Adult Lactating Women With Inflammatory Bowel Disease Breast Milk Sampling, Risankizumab - Inflammatory Bowel Disease | Phase 4 | Completed | AbbVie | 10 | 2024-04-24 | 2026-04-20 |
| Neuromuscular Blockade Comparison for GI-2 Recovery After Bowel Resection Neostigmine Injectable Solution, Sugammadex injection - Intestinal Disease | Phase 4 | Completed | University of California, Irvine | 132 | 2024-04-17 | 2026-08-25 |
| Effect of Tenapanor on the Metagenomics and Metabolomics of Patients With Irritable Bowel Syndrome With Constipation Tenapanor - IBS, IBS - Irritable Bowel Syndrome | Phase 4 | Completed | Kyle Staller, MD, MPH | 36 | 2024-02-06 | 2026-03-12 |
| Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer Pentoxifylline, FOLFOX, XELOX - Metastatic Colorectal Carcinoma | Phase 4 | Completed | Tanta University | 44 | 2024-02-01 | 2026-10-21 |
| The Impact of Sugammadex on Ileus After Abdominal Wall Reconstruction Neostigmine / Glycopyrrolate, Sugammadex - Hernia, Ventral, Ileus | Phase 4 | Completed | Clayton Petro | 184 | 2024-01-15 | 2025-11-21 |
| Comparative Effectiveness of Triple Versus Quadruple Therapy in the Treatment of Helicobacter Pylori Induced Gastritis Triple Therapy, Quadruple Therapy - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Completed | Azfar Farogh | 752 | 2024-01-05 | 2025-12-31 |
| Comparison of Probiotic Effects on the Outcomes of Patients After Colorectal Cancer Surgery Lactobacillus casei Shirota, Lactobacillus acidophilus - Colorectal Cancer | Phase 4 | Completed | Dharmais National Cancer Center Hospital | 90 | 2024-01-01 | 2025-08-27 |
| Randomized Control Trial of Micronized Purified Flavonoid Fraction for Post Operative Treatment in Anal Fistula Surgery Micronized purified flavonoid fraction(Daflon 1000mg), Placebo - Anal Fistula | Phase 4 | Completed | Taipei Medical University Shuang Ho Hospital | 106 | 2023-12-13 | 2025-05-16 |
Showing 20 of 587. Sign in to see all of them.
Gastroesophageal Reflux (70) · Crohn Disease (63) · Colitis, Ulcerative (56) · Colorectal Neoplasms (53) · Inflammatory Bowel Diseases (40) · Irritable Bowel Syndrome (38) · Stomach Neoplasms (26) · Peptic Ulcer (25) · Colonic Neoplasms (23) · Gastrointestinal Hemorrhage (23) · Appendicitis (19) · Diarrhea (17) · Heartburn (14) · Dyspepsia (13) · Gastritis (13)
Digestive System Diseases (583) · Intestinal Diseases (362) · Gastroenteritis (192) · Pathological Conditions, Signs and Symptoms (175) · Colonic Diseases (167) · Neoplasms (133) · Esophageal Diseases (126) · Neoplasms by Site (125) · Digestive System Neoplasms (124) · Gastrointestinal Neoplasms (119) · Pathologic Processes (94) · Signs and Symptoms (91) · Rectal Diseases (84) · Inflammatory Bowel Diseases (79)
Esomeprazole (47) · Infliximab (20) · Lansoprazole (18) · Omeprazole (17) · Rabeprazole (17) · Amoxicillin (16) · Metronidazole (15) · vedolizumab (15) · Pantoprazole (12) · Bismuth (10) · Clarithromycin (10) · Mesalamine (10) · Adalimumab (9) · Sodium Chloride (9) · Capecitabine (8)
AstraZeneca (27) · Takeda (14) · Xijing Hospital of Digestive Diseases (10) · Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives (9) · Hoffmann-La Roche (7) · Mayo Clinic (7) · Universitaire Ziekenhuizen KU Leuven (7) · Chinese University of Hong Kong (6) · Kaohsiung Veterans General Hospital. (6) · Novartis Pharmaceuticals (5) · GlaxoSmithKline (4) · Herlev Hospital (4) · Medical University of Warsaw (4) · Region Örebro County (4) · Yonsei University (4)
United States (144) · China (50) · France (40) · South Korea (33) · Italy (31) · Canada (29) · Denmark (29) · Spain (25) · Taiwan (25) · Belgium (24) · United Kingdom (24) · Netherlands (23) · Germany (18) · Poland (15) · Sweden (14)
Paula Fernstrom (8) · Arie Levine, MD (4) · Yongquan Shi, Ph. D (4) · Andrew J Clarke, PhD (2) · Arnulf Ferlitsch, MD (2) · Ayman Sadek, MD (2) · Bor-Shyang Sheu, MD (2) · Brian G Feagan, MD (2)
PMID 25478944, PMID 40013523, PMID 10343249, PMID 10395629, PMID 10403850, PMID 10536559, PMID 10896917, PMID 11156645, PMID 11256129, PMID 11822956, PMID 11857360, PMID 12127688, PMID 12170403, PMID 12432298, PMID 1305308, PMID 14570648, PMID 14644354, PMID 14762782, PMID 1479177, PMID 1499440, PMID 15044883, PMID 15058524, PMID 15094271, PMID 15168373, PMID 15488052, PMID 15519198, PMID 15555725, PMID 15645403, PMID 15738894, PMID 15793647, PMID 15818423, PMID 15838899, PMID 15843939, PMID 15888773, PMID 15901026, PMID 15915027, PMID 16116317, PMID 16266222, PMID 16279893, PMID 16393226, PMID 16393228, PMID 16500392, PMID 16611269, PMID 16612915, PMID 1669678, PMID 16882832, PMID 16927929, PMID 16937471, PMID 17058158, PMID 17058159
2014 (9), 2015 (4), 2008 (3), 2009 (3), 2017 (3), 2019 (2), 2005 (1), 2016 (1), 2018 (1), K23DK115827 (1), K23DK124567 (1), K24DK078228 (1), R01CA091912 (1), R01DK059961 (1), R01DK101856 (1)