239 completed, 71 unknown, 27 recruiting, 20 terminated. 176 Not applicable, 31 Phase 4, 17 Phase 3, 16 Phase 2, 6 Phase 1.
Follow Appendicitis: new trials by email Literature Review of Appendicitis trials Research Report on Appendicitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis Piperacillin/Tazobactam, Ceftriaxone + Metronidazole - Appendicitis Perforated, Appendectomy, Laparoscopic | Phase 3 | Not yet recruiting | McMaster Children's Hospital | 180 | 2027-04-01 | 2026-10-09 |
| Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study Irrigation with PVI, Usual care - Acute, Perforated Appendicitis | Phase 4 | Not yet recruiting | The University of Texas Health Science Center, Houston | 1750 | 2027-03-01 | 2025-02-10 |
| Perforated Appendicitis and Postoperative Antibiotics Pilot Trial Postoperative antibiotico-prophylaxis, No postoperative antibiotics - Perforated Appendicitis | Not applicable | Not yet recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2027-01-01 | 2026-09-17 |
| Comparative Study Between Laparoscopic and Open Appendectomy of Complicated Appendicitis Laparoscopic Appendectomy, Open Appendectomy - Appendicitis, Perforated Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-11-01 | 2026-10-16 |
| Laparoscopic vs Open Appendectomy in Obese Patients Open Appendectomy, Laparoscopic Appendectomy - Acute Appendicitis, Appendicitis (Diagnosis) | Not applicable | Not yet recruiting | University of Health Sciences Lahore | 166 | 2026-10-02 | 2026-09-16 |
| Patient Choice Between Antibiotics and Appendectomy in Uncomplicated Appendicitis (FRENCH 47 - ALACARTE) Shared decision-making, amoxicillin-clavulanate, Appendectomy - Acute Appendicitis | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 560 | 2026-10-01 | 2026-10-05 |
| Immediate Laparoscopic Appendectomy Versus Interval Laparoscopic Appendectomy for Early Appendicular Mass Immediate Laparoscopic Appendectomy, Interval Laparoscopic Appendectomy - Appendicular Mass, Acute Appendicitis | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-23 |
| Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy Laparoscopic appendectomy - Appendicitis, Acute, Appendectomy | Recruiting | Ahmet Burak Doğan, MD | 80 | 2026-09-01 | 2026-09-04 | |
| Prospective Comparison of Pro-Adrenomedullin, C-Reactive Protein, and Neutrophil-to-Lymphocyte Ratio for Diagnosing Acute Appendicitis Serum Pro-Adrenomedullin Measurement - Acute Appendicitis | Recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 400 | 2026-08-01 | 2026-10-26 | |
| Laparoscopic Appendectomy: Outcomes of 10 mmHg Versus 15 mmHg Intra-abdominal Pressure Laparoscopic appendectomy with 10 mmHg pneumoperitoneum, Laparoscopic appendectomy with 15 mmHg pneumoperitoneum - Appendectomy, Laparoscopic, Intra Abdominal Pressure | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 150 | 2026-07-27 | 2026-07-27 |
| Primary Versus Delayed Wound Closure in Complicated Appendectomy (The HIEDI-Yemen Trial) Primary Closure with HIEDI, Delayed Primary Closure with HIEDI - Appendicitis, Surgical Wound Infection | Not applicable | Not yet recruiting | Sana'a University | 200 | 2026-07-01 | 2026-07-07 |
| Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy Pressure Transducer, Traditional Palpation Method - Appendicitis Acute, Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Recruiting | Ankara Etlik City Hospital | 60 | 2026-06-30 | 2026-07-07 |
| Feasibility and Safety of a Pediatric ERAS Protocol for Laparoscopic Appendectomy Comprehensive 20-Item Pediatric ERAS Protocol - Appendectomy, Laparoscopic, Acute Appendicitis | Not applicable | Recruiting | Ahmet Burak Doğan, MD | 100 | 2026-06-15 | 2026-10-15 |
| TACTILE : Validation of a Teleconsultation-Based Predictive Score for the Diagnosis of Acute Appendicitis in Children Using Artificial Intelligence Methods Score-based appendicitis risk classification in teleconsultation - Acute Appendicitis | Not applicable | Not yet recruiting | University Hospital, Angers | 1500 | 2026-06-01 | 2026-03-18 |
| Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy Port-site local anesthesia infiltration, Port-Site Saline Infiltration (Placebo) - Appendectomy, Laparoscopic, Appendicitis Acute | Not applicable | Recruiting | YUNUS YÜKSEL | 300 | 2026-04-24 | 2026-09-17 |
| Diagnosis of Abdominal Pain Using RNA Levels: The NATURAL Study TruNAV, an RNA-based blood test for host immune activation by infections - Intra Abdominal Infections, Appendicitis Acute | Recruiting | True Bearing Diagnostics, Inc. | 1000 | 2026-04-17 | 2026-05-12 | |
| Comparative Study on the Diagnostic Validity of the Alvarado Score, Appendicitis Inflammatory Response (AIR), and Adult Appendicitis Score (AAS) in Acute Appendicitis at East Lancashire Hospitals NHS Trust (ELHT) Acute Appendicitis | Completed | East Lancashire Hospitals NHS Trust | 300 | 2026-04-13 | 2026-09-04 | |
| First Appendectomy Using Revolve Surgical Robotic Arm Revolve Surgical System - RSS - Appendicitis Acute | Not applicable | Not yet recruiting | Unity Health Toronto | 3 | 2026-04-01 | 2026-03-06 |
| Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis Acute Appendicitis | Recruiting | Sanliurfa Education and Research Hospital | 200 | 2026-03-18 | 2026-04-01 | |
| Laparoscopic vs Open Appendectomy Laparoscopic appendectomy, Open Appendectomy - Acute Appendicitis, Superficial SSI | Not applicable | Completed | Quaid-e-Azam Medical College | 276 | 2026-01-24 | 2026-09-25 |
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Abdominal Pain (14) · Disease (13) · Pain (12) · Pain, Postoperative (12) · Agnosia (11) · Peritonitis (11) · COVID-19 (10) · Abdomen, Acute (9) · Cholecystitis (9) · Abdominal Abscess (8) · Surgical Wound Infection (8) · Intraabdominal Infections (7) · Pancreatitis (7) · Diverticulitis (6)
Cecal Diseases (399) · Digestive System Diseases (399) · Gastroenteritis (398) · Intestinal Diseases (398) · Gastrointestinal Diseases (397) · Infections (394) · Intraabdominal Infections (393) · Pathological Conditions, Signs and Symptoms (101) · Pathologic Processes (58) · Signs and Symptoms (54) · Neurologic Manifestations (51) · Pain (32) · Signs and Symptoms, Digestive (23) · Biliary Tract Diseases (22) · Postoperative Complications (20)
Appendectomy (47) · Metronidazole (25) · Amoxicillin-Potassium Clavulanate Combination (8) · Anti-Bacterial Agents (8) · Ceftriaxone (8) · Ertapenem (7) · Piperacillin, Tazobactam Drug Combination (7) · Surgical Procedures, Operative (7) · Laparoscopy (6) · Saline Solution (6) · Levofloxacin (5) · Observation (5) · Blood Specimen Collection (4) · Bupivacaine (4) · Ciprofloxacin (4)
Assiut University (9) · Children's Mercy Hospital Kansas City (8) · Turku University Hospital (7) · Helsinki University Central Hospital (5) · Mansoura University (5) · Cirujanos la Serena (4) · Fatih Sultan Mehmet Training and Research Hospital (4) · Herlev Hospital (4) · National Taiwan University Hospital (4) · University of Washington (4) · Zagazig University (4) · Ankara City Hospital Bilkent (3) · Chinese University of Hong Kong (3) · Duke University (3) · HaEmek Medical Center, Israel (3)
United States (77) · Turkey (Türkiye) (41) · Egypt (18) · Finland (16) · United Kingdom (16) · China (15) · France (15) · South Korea (13) · Canada (12) · Denmark (12) · Spain (10) · Italy (9) · Croatia (8) · Germany (7) · Netherlands (7)
Paulina Salminen, MD, PhD (5) · Shawn D St. Peter, MD (4) · David R Flum, MD, MPH (3) · Ewen M Harrison, FRCS, PhD (3) · Santiago Horgan, MD (3) · Benno Mann, PD Dr. med. (2) · Kyoung Ho Lee, MD (2) · Kyuseok Kim, MD (2) · Marcelo A Beltran, M.D. (2) · Michael Sand, Dr. med. (2) · Mohamed Eltorki, MBChB (2) · Peter C Minneci, MD (2)
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