5922 completed, 3110 unknown, 2202 recruiting, 1079 terminated. 4434 Phase 2, 3555 Not applicable, 2343 Phase 1, 1328 Phase 3, 254 Phase 4.
Follow Gastrointestinal Neoplasms: new trials by email Literature Review of Gastrointestinal Neoplasms trials Research Report on Gastrointestinal Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Neoadjuvant Therapy for Esophageal Cancer Neoadjuvant concurrent chemoradiotherapy - Esophageal Carcinoma, Neoadjuvant Therapy | Not applicable | Enrolling by invitation | Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center | 43 | 2028-03-01 | 2025-05-25 |
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Shared Decision Making using a Patient Decision Aid. - Shared Decision Making, Colonic Polyp | Phase 2 | Not yet recruiting | Vejle Hospital | 110 | 2028-02-01 | 2026-04-30 |
| CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Metastatic Colorectal Cancer CA102N, TAS-102, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Suspended | Holy Stone Healthcare Co., Ltd | 100 | 2027-12-01 | 2026-09-18 |
| Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer intravoxel incoherent motion magnetic resonance imaging - Rectal Neoplasms, Prognosis | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 400 | 2027-11-01 | 2025-12-08 | |
| Combination of Osemitamab (TST001), Pembrolizumab and Chemotherapy as First-line Therapy in Advanced or Metastatic GC/GEJ Adenocarcinoma Pembrolizumab and either Capcecitabine + Oxaliplatin or Oxaliplatin+Leucovorin + 5-fluorouracil - Gastric Cancer, Gastroesophageal-junction Cancer | Phase 3 | Not yet recruiting | Transcenta Therapeutics (Hangzhou) Co., Ltd. | 820 | 2027-06-30 | 2026-09-29 |
| Immunotherapy Treating GI Cancer engineered immune cells - Cancer | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 100 | 2027-06-01 | 2026-08-26 |
| Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial Balstilimab, Biopsy Procedure, Biospecimen Collection - Colorectal Adenocarcinoma, Stage II Colorectal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 20 | 2027-05-25 | 2026-09-29 |
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 260 | 2027-04-01 | 2026-09-10 |
| Cancer Awareness Among Syrian Migrants PMT-Based Cancer Screening Educational Intervention, PMT-Based Cancer Screening Education Program - Breast Cancer Screening, Cervical Cancer Screening | Not applicable | Not yet recruiting | Toros University | 30 | 2027-03-09 | 2026-10-15 |
| Life Expectancy-informed Colorectal Cancer Screening Decision Tool - Colorectal Cancer Control and Prevention | Not applicable | Not yet recruiting | Kathryn Martinez | 15000 | 2027-03-01 | 2026-10-20 |
| Autologous Tumor Infiltrating Lymphocytes With Interleukin-2 for the Treatment of Locally Advanced, Recurrent or Metastatic Gastrointestinal Stromal Tumors Aldesleukin, Biospecimen Collection, Chest Radiography - Locally Advanced Gastrointestinal Stromal Tumor, Metastatic Gastrointestinal Stromal Tumor | Phase 2 | Not yet recruiting | Joal Beane | 59 | 2027-02-15 | 2026-10-13 |
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| A Trial of ONO-4578 Versus Placebo in Combination With Nivolumab and Chemotherapy in Participants With Gastric Cancer, Esophagogastric Junction Cancer, or Esophageal Adenocarcinoma ONO-4578, Placebo, Nivolumab - Gastric Cancer, Esophagogastric Junction Cancer | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 600 | 2027-02-01 | 2026-09-14 |
| Combination of CT and Ultrasound Radiomics Combined With Liquid Biopsy to Predict Neoadjuvant Chemotherapy Response in Patients With Locally Advanced Gastric Cancer Gastric Cancer | Not yet recruiting | Liu Yang | 300 | 2027-02-01 | 2026-07-13 | |
| OLE Study Subsequent to Parent Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLC Rilogrotug - Cachexia; Cancer, Cachexia | Phase 2 / Phase 3 | Not yet recruiting | AVEO Pharmaceuticals, Inc. | 400 | 2027-02-01 | 2026-10-22 |
| OSCAR II STUDY - The ONCObind CTC Removal Study ONCObind (Onco-Seraph) 100 Filter, Matched Controls - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Colorectal Carcinoma (mCRC) | Not applicable | Not yet recruiting | ExThera Medical Corporation | 120 | 2027-01-15 | 2026-04-17 |
| A Safety Study of ST316 in Participants With Familial Adenomatous Polyposis (FAP). ST316 IV - Familial Adenomatous Polyposis (FAP) | Phase 1 | Not yet recruiting | Sapience Therapeutics | 40 | 2027-01-04 | 2026-08-12 |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
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Colorectal Neoplasms (6107) · Stomach Neoplasms (3164) · Colonic Neoplasms (2376) · Rectal Neoplasms (2236) · Esophageal Neoplasms (1840) · Breast Neoplasms (1009) · Neoplasms (880) · Pancreatic Neoplasms (800) · Carcinoma, Non-Small-Cell Lung (719) · Lung Neoplasms (687) · Neoplasm Metastasis (649) · Esophageal Squamous Cell Carcinoma (622) · Ovarian Neoplasms (551) · Prostatic Neoplasms (438)
Digestive System Diseases (14358) · Gastrointestinal Diseases (14339) · Digestive System Neoplasms (14324) · Neoplasms by Site (14117) · Neoplasms (13540) · Intestinal Diseases (9424) · Intestinal Neoplasms (9327) · Rectal Diseases (7899) · Colonic Diseases (7836) · Colorectal Neoplasms (3227) · Stomach Diseases (3177) · Neoplasms by Histologic Type (2541) · Head and Neck Neoplasms (2371) · Esophageal Diseases (2315)
Oxaliplatin (1007) · Fluorouracil (960) · Capecitabine (782) · Leucovorin (688) · Irinotecan (632) · Bevacizumab (599) · Cetuximab (424) · Cisplatin (417) · Radiotherapy (383) · Paclitaxel (320) · pembrolizumab (302) · Drug Therapy (247) · Docetaxel (219) · Folfox protocol (194) · Nivolumab (193)
National Cancer Institute (NCI) (316) · Fudan University (256) · Sun Yat-sen University (208) · M.D. Anderson Cancer Center (181) · Memorial Sloan Kettering Cancer Center (167) · Hoffmann-La Roche (118) · Yonsei University (99) · National Taiwan University Hospital (89) · City of Hope Medical Center (85) · Tianjin Medical University Cancer Institute and Hospital (80) · Sixth Affiliated Hospital, Sun Yat-sen University (79) · Pfizer (78) · Samsung Medical Center (74) · Alliance for Clinical Trials in Oncology (73) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (71)
United States (4345) · China (3331) · France (1064) · South Korea (934) · Spain (786) · Italy (768) · United Kingdom (742) · Germany (671) · Canada (653) · Netherlands (496) · Taiwan (451) · Japan (449) · Belgium (435) · Australia (383) · Denmark (327)
Norman Wolmark, MD (21) · Lin Shen, MD (18) · Ajay Goel, PhD (17)
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