3852 completed, 1677 unknown, 1275 recruiting, 702 terminated. 2454 Not applicable, 2433 Phase 2, 1500 Phase 1, 740 Phase 3, 169 Phase 4.
Follow this condition Literature Review of Rectal Diseases trials Research Report on Rectal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Clinic Delivery of HIV-related Anal Health Services PEACHES 2.0 Implementation Strategies - HIV, Gonorrhea | Not applicable | Not yet recruiting | Albert Einstein College of Medicine | 8 | 2028-02-01 | 2026-10-13 |
| The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp Shared Decision Making using a Patient Decision Aid. - Shared Decision Making, Colonic Polyp | Phase 2 | Not yet recruiting | Vejle Hospital | 110 | 2028-02-01 | 2026-04-30 |
| CA102N Combined With TAS-102 Compared to Bevacizumab Combined With TAS-102 in Subjects With Metastatic Colorectal Cancer CA102N, TAS-102, Bevacizumab - Metastatic Colorectal Cancer | Phase 2 | Suspended | Holy Stone Healthcare Co., Ltd | 100 | 2027-12-01 | 2026-09-18 |
| Application of Multimodal MRI in Histological Grading and Prognostic Assessment of Rectal Cancer intravoxel incoherent motion magnetic resonance imaging - Rectal Neoplasms, Prognosis | Not yet recruiting | Sichuan Cancer Hospital and Research Institute | 400 | 2027-11-01 | 2025-12-08 | |
| Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial Balstilimab, Biopsy Procedure, Biospecimen Collection - Colorectal Adenocarcinoma, Stage II Colorectal Cancer AJCC v8 | Phase 2 | Recruiting | National Cancer Institute (NCI) | 20 | 2027-05-25 | 2026-09-29 |
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 260 | 2027-04-01 | 2026-09-10 |
| Life Expectancy-informed Colorectal Cancer Screening Decision Tool - Colorectal Cancer Control and Prevention | Not applicable | Not yet recruiting | Kathryn Martinez | 15000 | 2027-03-01 | 2026-10-20 |
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| OSCAR II STUDY - The ONCObind CTC Removal Study ONCObind (Onco-Seraph) 100 Filter, Matched Controls - Pancreatic Ductal Adenocarcinoma (mPDAC), Metastatic Colorectal Carcinoma (mCRC) | Not applicable | Not yet recruiting | ExThera Medical Corporation | 120 | 2027-01-15 | 2026-04-17 |
| Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer Aerobic Exercise, Biopsy Procedure, Biospecimen Collection - Colon Polyp, Colorectal Carcinoma | Not applicable | Recruiting | City of Hope Medical Center | 30 | 2026-12-16 | 2026-08-28 |
| A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC) DES-1357 - Metastatic Colorectal Cancer (CRC) | Phase 1 / Phase 2 | Not yet recruiting | D. E. Shaw Research, LLC | 88 | 2026-12-03 | 2026-09-08 |
| COQ10 and Vitamin E for Off-Target Radiation Toxicity Coenzyme Q10 Cap/Tab, Vitamin E Cap/Tab - Prostate Cancer, Uterine Cancer | Phase 1 / Phase 2 | Not yet recruiting | University of Nebraska | 200 | 2026-12-01 | 2026-10-08 |
| Preventing Early-Onset Colorectal Cancer in the VA Patient intervention, PCP intervention - Colorectal Neoplasms, Mass Screening | Not applicable | Not yet recruiting | VA Office of Research and Development | 536 | 2026-12-01 | 2026-10-02 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| A Study of LG00313112 in Participants With Advanced Solid Malignancies Harboring a TP53 Y220C Mutation LG00313112 - Ovarian Cancer, Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | LG Chem | 250 | 2026-12-01 | 2026-08-07 |
| Reducing Neoplasia Recurrence After Non-thermal Endoscopic Resection of Large Colorectal Polyps Adjuvant thermal ablation, No adjuvant thermal ablation - Colorectal Cancer, Polyp of Colon | Not applicable | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 752 | 2026-12-01 | 2026-08-14 |
| A Multicenter Randomized Open-Label Trial Evaluating ctDNA-Guided Interruption Versus Standard of Care Immune-Checkpoint Inhibitor (ICI) Therapy In Patients With Advanced / Metastatic Solid Tumors. Signatera Genome ultra-sensitive ctDNA blood test - NSCLC (Advanced Non-small Cell Lung Cancer), NSCLC (Non-small Cell Lung Cancer) | Not applicable | Not yet recruiting | Natera, Inc. | 920 | 2026-12-01 | 2026-08-04 |
| A Prospective Study to Evaluate the Diagnostic Accuracy of Computer-aided Diagnosis (CADx) System in Real-time Characterization of Colorectal Neoplasia CADx - Colorectal Neoplasms | Not yet recruiting | Chinese University of Hong Kong | 510 | 2026-12-01 | 2026-09-22 | |
| TCR1188-ABC Cells in KRAS-mutated Cancers TCR1188-ABC cells, Fludarabine + Cyclophosphamide combination, Tocilizumab - Cholangiocarcinoma, Colorectal Cancer | Phase 1 | Recruiting | University of Pennsylvania | 30 | 2026-12-01 | 2026-10-14 |
Showing 20 of 8753. Sign in to see all of them.
Colorectal Neoplasms (6102) · Rectal Neoplasms (2234) · Colonic Neoplasms (1146) · Breast Neoplasms (620) · Neoplasms (527) · Pancreatic Neoplasms (520) · Carcinoma, Non-Small-Cell Lung (487) · Stomach Neoplasms (460) · Neoplasm Metastasis (458) · Lung Neoplasms (369) · Ovarian Neoplasms (339) · Prostatic Neoplasms (311) · Anus Neoplasms (294) · Fecal Incontinence (278) · Melanoma (263)
Digestive System Diseases (8707) · Gastrointestinal Diseases (8696) · Intestinal Diseases (8692) · Neoplasms by Site (7895) · Digestive System Neoplasms (7871) · Intestinal Neoplasms (7866) · Gastrointestinal Neoplasms (7760) · Neoplasms (7418) · Colonic Diseases (6502) · Colorectal Neoplasms (1829) · Pathological Conditions, Signs and Symptoms (1821) · Pathologic Processes (1133) · Urogenital Diseases (1018) · Neoplasms by Histologic Type (1000)
Fluorouracil (644) · Oxaliplatin (610) · Bevacizumab (542) · Leucovorin (522) · Capecitabine (503) · Irinotecan (468) · Cetuximab (368) · Radiotherapy (182) · pembrolizumab (164) · Folfox protocol (151) · Panitumumab (127) · Drug Therapy (120) · regorafenib (114) · Nivolumab (95) · Colonoscopy (93)
National Cancer Institute (NCI) (179) · Fudan University (135) · Sun Yat-sen University (115) · M.D. Anderson Cancer Center (112) · Memorial Sloan Kettering Cancer Center (90) · Hoffmann-La Roche (86) · Sixth Affiliated Hospital, Sun Yat-sen University (69) · City of Hope Medical Center (59) · Pfizer (51) · Alliance for Clinical Trials in Oncology (50) · Chinese University of Hong Kong (43) · Assistance Publique - Hôpitaux de Paris (41) · Massachusetts General Hospital (41) · Amgen (40) · Eli Lilly and Company (39)
United States (2907) · China (1395) · France (717) · Spain (546) · Italy (507) · United Kingdom (479) · Canada (436) · Germany (409) · South Korea (332) · Belgium (299) · Netherlands (296) · Australia (256) · Denmark (247) · Sweden (205) · Taiwan (194)
Norman Wolmark, MD (19) · Ajay Goel, PhD (12) · Marwan Fakih, MD (9)
PMID 36306483, PMID 15496622, PMID 35588252, PMID 37162250, PMID 26049686, PMID 26187751, PMID 30679026, PMID 31378656, PMID 32816630, PMID 15933795, PMID 19269519, PMID 21596621, PMID 22070868, PMID 26808342, PMID 28712102, PMID 33657038, PMID 36748942, PMID 37310167, PMID 42681563, PMID 16971718, PMID 17976611, PMID 18316791, PMID 19339720, PMID 20106720, PMID 22067400, PMID 22529255, PMID 23008301, PMID 23395398, PMID 23493136, PMID 23578724, PMID 26156652, PMID 27432930, PMID 27602924, PMID 28223062, PMID 29627309, PMID 30025745, PMID 30207593, PMID 30451751, PMID 30936547, PMID 31268130, PMID 31401903, PMID 33439695, PMID 33538338, PMID 34213592, PMID 36064325, PMID 36410913, PMID 36606664, PMID 37934000, PMID 38592721, PMID 38861286
2023 (48), 2025 (44), 2017 (32), 2016 (30), 2009 (29), P30CA033572 (29), 2019 (28), 2015 (24), 2018 (24), P30CA015083 (22), 2008 (19), P30CA014089 (19), 2014 (17), P30CA016672 (15), P30CA068485 (14)