Colitis, Ulcerative: Clinical Trials

824 completed, 252 unknown, 247 recruiting, 180 terminated. 415 Not applicable, 345 Phase 2, 223 Phase 3, 183 Phase 1, 127 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	415	Completed 173, Unknown 78, Recruiting 65, Not yet recruiting 34, Terminated 34, Active not recruiting 13, Withdrawn 9, Enrolling by invitation 6, Suspended 3
Phase 2	345	Completed 153, Terminated 61, Recruiting 50, Unknown 33, Active not recruiting 19, Withdrawn 15, Not yet recruiting 11, Enrolling by invitation 3
Phase 3	223	Completed 123, Terminated 30, Unknown 23, Active not recruiting 18, Recruiting 18, Withdrawn 6, Not yet recruiting 4, Enrolling by invitation 1
Phase 1	183	Completed 98, Terminated 25, Unknown 18, Not yet recruiting 14, Recruiting 14, Withdrawn 6, Active not recruiting 5, Enrolling by invitation 3
Phase 4	127	Completed 56, Unknown 16, Not yet recruiting 15, Recruiting 15, Terminated 14, Withdrawn 6, Active not recruiting 3, Enrolling by invitation 2
Early Phase 1	19	Unknown 7, Not yet recruiting 4, Recruiting 2, Terminated 2, Withdrawn 2, Completed 1, Enrolling by invitation 1

Follow Colitis, Ulcerative: new trials by email Literature Review of Colitis, Ulcerative trials Research Report on Colitis, Ulcerative

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Dose Ranging Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Budesonide Rectal Foam in Pediatric Patients Aged 5 to 17 Years With Active, Mild to Moderate Distal Ulcerative Colitis High dose budesonide rectal foam, Low dose budesonide rectal foam, Matching placebo rectal foam - Ulcerative Colitis	Phase 4	Not yet recruiting	Bausch Health Americas, Inc.	100	2029-06-01	2026-10-06
ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease	Not applicable	Not yet recruiting	VA Office of Research and Development	50	2028-01-01	2026-02-09
A Mindfulness-based Stress Reduction Program for IBD Mindfulness based stress reduction, Active Control - Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)	Not applicable	Not yet recruiting	Nova Scotia Health Authority	70	2027-09-01	2026-09-08
Digital Mind Body Intervention Among Black and Hispanic Patients Living With Inflammatory Bowel Disease Digital Mind Body Intervention mobile application - Crohn's Disease, Ulcerative Colitis	Not applicable	Not yet recruiting	Montefiore Medical Center	40	2027-07-01	2026-09-14
Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission Adapted Physical Activity, Usual Care - Inflammatory Bowel Diseases (IBD), Fatigue	Not applicable	Not yet recruiting	University Hospital, Grenoble	120	2027-06-01	2026-09-11
ASAPP Study - Topical 5-ASA as Prophylaxis for Pouchitis in Ulcerative Colitis Patients After Pelvic Pouch Surgery 5-ASA, Placebo - Ulcerative Colitis (UC), Pouchitis	Phase 4	Not yet recruiting	University Hospital, Linkoeping	110	2027-04-01	2026-08-19
LMT503 First-in-human SAD, MAD, and FE Study LMT503, Placebo - Inflammatory Bowel Disease, Colitis, Ulcerative	Phase 1	Not yet recruiting	Lmito Therapeutics Inc.	72	2027-03-01	2026-09-01
Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria	Phase 2	Not yet recruiting	Wuhan Kangfude Urolithiasis Research Institute Co., Ltd.	30	2027-03-01	2026-10-13
Nitazoxanide as Adjunct Therapy in Mild-to-Moderate Ulcerative Colitis Nitazoxanide (NTZ) - Ulcerative Colitis (UC)	Phase 2 / Phase 3	Not yet recruiting	Tanta University	44	2027-01-01	2026-09-15
Safety and Efficacy of a STOPping Strategy Versus Classical Maintenance Dose of JAK Inhibitors in Deep Remission Patients With Ulcerative Colitis treatment withdrawal - Ulcerative Colitis in Remission	Phase 4	Not yet recruiting	Assistance Publique Hopitaux De Marseille	224	2027-01-01	2026-07-22
Oral Aeromonas sp. MTB Phage Therapy for Pouchitis in Patients With Ulcerative Colitis (UC) MTB-targeted phage therapy - Pouchitis, UC - Ulcerative Colitis	Early Phase 1	Not yet recruiting	Jinling Hospital, China	12	2027-01-01	2026-10-22
Safety, Tolerability and PK of ATTO 1091 in Healthy Adult Volunteers and Patients With Ulcerative Colitis ATTO-1091, Placebo - Ulcerative Colitis (UC)	Phase 1	Not yet recruiting	Attovia Therapeutics Inc	96	2026-12-14	2026-09-15
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares elemental diet (ED) - Inflammatory Bowel Disease	Not applicable	Not yet recruiting	Wake Forest University Health Sciences	42	2026-12-01	2026-09-28
FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial 1: infliximab 2: filgotinib 3: ustekinumab 4: vedolizumab, 1: ustekinumab 2: vedolizumab 3: infliximab 4: filgotinib, 1: vedolizumab 2: infliximab 3: filgotinib 4: ustekinumab - Ulcerative Colitis (UC)	Phase 4	Not yet recruiting	University Hospital, Clermont-Ferrand	240	2026-12-01	2026-10-21
Efficacy of Upadacitinib Re-induction Therapy in Patients With Ulcerative Colitis Who Lost Response to 30 mg Maintenance Dose Upadacitinib - Ulcerative Colitis (UC)	Phase 4	Not yet recruiting	Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives	100	2026-11-15	2026-10-29
A Real-World Study of Guselkumab Persistence and Effectiveness in Participants With Crohn's Disease or Ulcerative Colitis Colitis, Ulcerative, Crohn Disease		Not yet recruiting	Janssen-Cilag, S.A.	200	2026-11-15	2026-11-03
A Study of Continued Use of Guselkumab in Participants With Crohn's Disease and Ulcerative Colitis in Real World Setting Crohn Disease, Colitis, Ulcerative		Not yet recruiting	Janssen Sciences Ireland UC	35	2026-11-12	2026-11-03
Microbiome-targeted Diet Therapy in Ulcerative Colitis High Protein, High Fiber (HPHF) Diet - Ulcerative Colitis	Not applicable	Recruiting	University of Minnesota	40	2026-11-09	2026-10-20
Longitudinal Immunophenotyping of Patients With Inflammatory Bowel Disease Inflammatory Bowel Disease, Crohn's Disease		Recruiting	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	100	2026-11-09	2026-11-04
Objective Disease Control and Treatment Strategies in Ulcerative Colitis Routine Clinical Care - Ulcerative Colitis (Disorder)		Not yet recruiting	First Affiliated Hospital, Sun Yat-Sen University	1000	2026-11-01	2026-10-26

Showing 20 of 1796. Sign in to see all of them.

Narrower conditions

Crohn Disease (664)  ·  Inflammatory Bowel Diseases (619)  ·  Colitis (55)  ·  Arthritis, Rheumatoid (41)  ·  Irritable Bowel Syndrome (38)  ·  Arthritis, Psoriatic (34)  ·  Spondylitis, Ankylosing (28)  ·  Psoriasis (27)  ·  Gastrointestinal Diseases (24)  ·  Ulcer (23)  ·  Colorectal Neoplasms (22)  ·  Pouchitis (22)  ·  Depression (21)  ·  Anxiety Disorders (20)

Broader conditions

Gastroenteritis (1788)  ·  Colonic Diseases (1784)  ·  Digestive System Diseases (1779)  ·  Intestinal Diseases (1779)  ·  Gastrointestinal Diseases (1772)  ·  Colitis (1741)  ·  Inflammatory Bowel Diseases (1177)  ·  Pathological Conditions, Signs and Symptoms (150)  ·  Pathologic Processes (97)  ·  Immune System Diseases (80)  ·  Musculoskeletal Diseases (69)  ·  Skin and Connective Tissue Diseases (66)  ·  Joint Diseases (62)  ·  Neoplasms (60)  ·  Arthritis (57)

Interventions

Mesalamine (83)  ·  vedolizumab (61)  ·  Infliximab (58)  ·  Fecal Microbiota Transplantation (52)  ·  Adalimumab (41)  ·  golimumab (25)  ·  Ustekinumab (19)  ·  Blood Specimen Collection (18)  ·  tofacitinib (18)  ·  etrasimod (17)  ·  mirikizumab (17)  ·  Azathioprine (15)  ·  ozanimod (15)  ·  Standard of Care (14)  ·  upadacitinib (13)

Sponsors

Takeda (48)  ·  AbbVie (40)  ·  Pfizer (37)  ·  Janssen Research & Development, LLC (23)  ·  Bausch Health Americas, Inc. (18)  ·  Ferring Pharmaceuticals (18)  ·  Bristol-Myers Squibb (17)  ·  Assiut University (16)  ·  Mayo Clinic (16)  ·  Shire (16)  ·  Eli Lilly and Company (14)  ·  GlaxoSmithKline (14)  ·  Chinese University of Hong Kong (12)  ·  Merck Sharp & Dohme LLC (12)  ·  Universitaire Ziekenhuizen KU Leuven (12)

Countries

United States (601)  ·  Canada (258)  ·  Germany (237)  ·  France (233)  ·  Poland (216)  ·  United Kingdom (206)  ·  Italy (203)  ·  Belgium (183)  ·  China (163)  ·  Netherlands (162)  ·  Hungary (160)  ·  Israel (156)  ·  Spain (151)  ·  Czechia (148)  ·  South Korea (136)

Results publications

PMID 40243391, PMID 40013523, PMID 32445184, PMID 35648151, PMID 36124702, PMID 29850873, PMID 30476584, PMID 31077827, PMID 31599001, PMID 32816215, PMID 33684552, PMID 35792493, PMID 36342120, PMID 36526796, PMID 36931693, PMID 38425446, PMID 39778975, PMID 26893500, PMID 32766762, PMID 32870265, PMID 33127596, PMID 33324993, PMID 33513294, PMID 34614208, PMID 35380664, PMID 35380740, PMID 36336750, PMID 37402275, PMID 37560161, PMID 38778549, PMID 42248437, PMID 16339095, PMID 19596014, PMID 25173754, PMID 25857665, PMID 26363929, PMID 26563167, PMID 28467869, PMID 29028981, PMID 29380251, PMID 29743836, PMID 30721964, PMID 31982148, PMID 33359090, PMID 34035832, PMID 34165201, PMID 35644166, PMID 35934286, PMID 36271912, PMID 36506749

NIH funding

2023 (29), 2017 (24), 2016 (19), 2018 (18), 2025 (17), 2015 (12), 2019 (11), 2014 (8), 2004 (5), 2009 (4), 2008 (3), P30CA060553 (2), U01DK062423 (2), U01DK062431 (2), 1IK2RD000689-01A2 (1)