66 completed, 14 terminated, 12 unknown, 7 withdrawn. 107 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 107 | Completed 66, Terminated 14, Unknown 12, Withdrawn 7, Not yet recruiting 4, Recruiting 4 |
Follow Emergencies: new trials by email Literature Review of Emergencies trials Research Report on Emergencies
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Starting HIV Prevention Medicine (PrEP) During an Emergency Department Visit With a Peer Navigator RAPID Response peer navigation, Emtricitabine/tenofovir disoproxil fumarate (F/TDF) - HIV Prevention, Pre-Exposure Prophylaxis (PrEP) | Phase 4 | Not yet recruiting | University of South Florida | 50 | 2026-11-01 | 2026-10-28 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| A Bundled Intervention to End Opioid Overdoses Bundled intervention (Experimental), control group, Buprenorphine (Experimental) - Opioid Use Disorder, Opioid Overdose | Phase 4 | Recruiting | University of Alabama at Birmingham | 160 | 2026-09-07 | 2026-10-02 |
| Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department Adrenaline, 0.9 % sodium chloride - Peri-intubation Hypotension | Phase 4 | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 128 | 2026-06-01 | 2026-06-10 |
| 45th Multicenter Airway Research Collaboration Airsupra - Asthma Acute, Asthma Exacerbation | Phase 4 | Recruiting | Massachusetts General Hospital | 1860 | 2025-11-07 | 2026-04-17 |
| Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis Ringer's Lactate, Normal Saline (0.9% Sodium Chloride) - Sepsis | Phase 4 | Not yet recruiting | Egemen Yildiz | 88 | 2025-11-01 | 2025-11-21 |
| Acute Migraine Treatment in the ED With Gepants Rimegepant, Zavegepant - Migraine Headaches | Phase 4 | Terminated | Icahn School of Medicine at Mount Sinai | 9 | 2025-06-05 | 2026-04-29 |
| Systemic Oral Glucocorticoids for the Treatment of Acute Osteoarthritis Pain in the Emergency Department Prednisone, Dexamethasone, Placebo - Osteoarthritis, Osteoarthritis (OA) of the Knee | Phase 4 | Recruiting | WellSpan Health | 192 | 2025-02-24 | 2026-08-19 |
| A Bundled Intervention a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth - Opioid Use Disorder, Opioid Overdose | Phase 4 | Completed | University of Alabama at Birmingham | 30 | 2025-02-13 | 2026-10-28 |
| Ibuprofen Versus Dexketoprofen in Rib Fractures Ibuprofen 800 mg, Dexketoprofen 50 mg - Rib Fracture | Phase 4 | Completed | Ankara City Hospital Bilkent | 128 | 2024-01-01 | 2026-10-06 |
| Evaluation of the Effects of Ketorolac Dose on Duration of Analgesia in Emergency Department (ED) Renal Colic Patients Ketorolac - Renal Colic, Flank Pain | Phase 4 | Completed | Hackensack Meridian Health | 86 | 2023-12-21 | 2026-08-14 |
| Evaluation of Blood Sampling From a Pre-existed Peripheral Intravenous Catheter Line Normal saline - Emergencies | Phase 4 | Unknown | Imam Abdulrahman Bin Faisal University | 150 | 2023-09-01 | 2023-10-16 |
| Comparing in Dexmedetomidine With po/pr Midazolam for Procedural Sedation in the Pediatric Emergency Department Dexmedetomidine, Midazolam - Procedural Anxiety, Emergencies | Phase 4 | Withdrawn | Insel Gruppe AG, University Hospital Bern | 2023-08-01 | 2022-09-30 | |
| Oral Essential Oils Efficacy in Acute Respiratory Symptoms essential oils of eucalyptus, thyme, cinnamon, lavender, winter savory, tea tree, camphor tree, placebo of the essential oil capsule - Respiratory Inflammation | Phase 4 | Completed | University of Sfax | 105 | 2023-03-01 | 2026-04-08 |
| RCT aiTriage Chest Pain Risk Stratification aiTriage risk score - Chest Pain, Emergencies | Phase 4 | Completed | Singapore General Hospital | 1120 | 2022-11-11 | 2026-01-08 |
| Fast-track Blood Test for Suspected Fever by Deficiency of a Kind of White Blood Cells As Main Defense Against Infection Meropenem Injection, Levofloxacin, Amoxicillin Clavulanate - Neutropenic Fever | Phase 4 | Unknown | The University of Hong Kong | 344 | 2022-10-24 | 2022-12-06 |
| Oral Penicillin Challenge and Allergy De-labeling in Children Amoxicillin 500mg - Penicillin Allergy | Phase 4 | Terminated | Phoenix Children's Hospital | 31 | 2022-09-26 | 2024-06-14 |
| Low-dose KETamine as an Adjunct to MOrphine for Acute Pain in the ED low dose ketamine, Placebo (saline) - Acute Pain, Opioid Use | Phase 4 | Terminated | University of Aarhus | 116 | 2022-05-31 | 2023-09-26 |
| Trigger Point Injections Versus Lidocaine Patch for Myofascial Pain in the Emergency Department Trigger point injection with 1% lidocaine, Lidocaine patch 5% - Myofascial Trigger Point Pain, Myofacial Pain | Phase 4 | Withdrawn | University of California, Irvine | 2021-11-01 | 2026-02-13 | |
| RAFF4 Trial: Vernakalant vs. Procainamide for Acute Atrial Fibrillation in the Emergency Department Vernakalant, Procainamide - Atrial Fibrillation | Phase 4 | Completed | Ottawa Hospital Research Institute | 350 | 2021-06-17 | 2025-04-10 |
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Agnosia (14) · Pain (14) · Asthma (9) · Migraine Disorders (8) · Acute Pain (5) · Low Back Pain (4) · Musculoskeletal Pain (4) · Dyspepsia (3) · Headache (3) · Opioid-Related Disorders (3) · Renal Colic (3) · Sepsis (3) · Wounds and Injuries (3) · Alcoholism (2)
Disease Attributes (107) · Pathologic Processes (107) · Pathological Conditions, Signs and Symptoms (107) · Signs and Symptoms (50) · Neurologic Manifestations (46) · Nervous System Diseases (25) · Pain (23) · Neurobehavioral Manifestations (16) · Perceptual Disorders (14) · Respiratory Tract Diseases (13) · Hypersensitivity, Immediate (10) · Immune System Diseases (10) · Lung Diseases (10) · Lung Diseases, Obstructive (10) · Brain Diseases (9)
Saline Solution (15) · Acetaminophen (14) · Ketamine (9) · dexketoprofen trometamol (8) · Hydromorphone (7) · Fentanyl (6) · Ibuprofen (6) · Morphine (6) · Propofol (6) · Ketorolac (5) · Sodium Chloride (5) · Metoclopramide (4) · Midazolam (4) · Budesonide (3) · Bupivacaine (3)
Pamukkale University (9) · Montefiore Medical Center (7) · Akdeniz University (6) · University of Alabama at Birmingham (4) · Phoenix Children's Hospital (3) · The University of Hong Kong (3) · Assistance Publique - Hôpitaux de Paris (2) · Emory University (2) · Hennepin Healthcare Research Institute (2) · Kecioren Education and Training Hospital (2) · Kocaeli University (2) · NYU Langone Health (2) · University Hospital, Clermont-Ferrand (2) · University of Alberta (2) · University of California, Irvine (2)
United States (50) · Turkey (Türkiye) (22) · Canada (7) · France (6) · Hong Kong (3) · Belgium (2) · Denmark (2) · Iran (1) · Ireland (1) · Israel (1) · Netherlands (1) · Oman (1) · Saudi Arabia (1) · Singapore (1) · Thailand (1)
Mustafa Serinken, MD (3) · Atakan Yilmaz, MD (2) · Li Li, MD;PhD (2) · Adaira Landry, B.A. (1) · Adnan Iqbal, MD (1) · Alexandra Schick (1) · Amit P Shah, MD FCFP(EM) (1) · Andrew Herring, MD (1) · Andrew K Chang, MD, MS (1) · Anita Srivastava, MD (1) · Arun Nagdev, MD (1) · Ashraf Fathy Elshehry, FRCEM-UK (1) · Asma Zainab, MD (1) · Basmah Safdar, MD (1) · Benjamin W Friedman, MD (1)
PMID 1015603, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 11555797, PMID 12411815, PMID 12487041, PMID 12548273, PMID 12560416, PMID 14622770, PMID 17138203, PMID 17413915, PMID 18090011, PMID 18686750, PMID 18762870, PMID 18826731, PMID 19157368, PMID 19174373, PMID 19388915, PMID 19647342, PMID 19690943, PMID 20802165, PMID 21063553, PMID 21197290, PMID 21707983, PMID 22186009, PMID 22427403, PMID 22463973, PMID 22506940, PMID 23406078, PMID 23484827, PMID 23535700, PMID 23569691, PMID 23788067, PMID 23846749, PMID 23878064, PMID 24394884, PMID 24852952, PMID 25141250, PMID 25441247, PMID 2589650, PMID 26330019, PMID 26759680, PMID 27618681, PMID 27714758, PMID 27787895, PMID 2803357, PMID 28081848, PMID 29645317
2016 (2), 2018 (1), K23AA022989 (1), R33DA062351 (1), R61DA062351 (1)