203 completed. 203 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 203 | Completed 203 |
Follow Dyssomnias: new trials by email Literature Review of Dyssomnias trials Research Report on Dyssomnias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EFFECT OF ZOLPIDEM ON SLEEP QUALITY AND OPIOID CONSUMPTION FOLLOWING PRIMARY TOTAL KNEE ARTHROPLASTY: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL Zolpidem 10 mg tablets, Avocado-soybean unsaponifiables 300 mg - Postoperative Pain Management in Total Knee Arthroplasty | Phase 4 | Completed | Sanatorio Allende | 54 | 2025-08-05 | 2026-09-03 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| f Adding Ketamine to Propofol For Drug-induced Sleep Endoscopy in Adult Patients With Obstructive Sleep Apnea Ketamine + propofol, propofol - Sleep Apnea Syndromes | Phase 4 | Completed | Zagazig University | 30 | 2024-07-30 | 2026-09-10 |
| HighCycle Study: Effect of Acetazolamide on Sleep Disordered Breathing in Women Compared to Men Acetazolamide, Placebo - Sleep-Disordered Breathing | Phase 4 | Completed | University of Zurich | 303 | 2024-07-15 | 2026-06-05 |
| Muscle Relaxation for Pediatric Adenotonsillectomy Rocuronium, Sugammadex, Anesthesia without neuromuscular blockade - Tonsillectomy | Phase 4 | Completed | University of Texas Southwestern Medical Center | 172 | 2024-04-10 | 2025-07-28 |
| Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality Dexmedetomidine, Esketamine, Normal saline - Old Age, Knee Replacement Surgery | Phase 4 | Completed | Peking University First Hospital | 154 | 2024-01-03 | 2026-07-06 |
| Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients Dexmedetomidine-esketamine, Routine sedation and analgesia - Intensive Care Unit, Mechanical Ventilation | Phase 4 | Completed | Peking University First Hospital | 174 | 2023-11-01 | 2025-12-05 |
| An Open-label Trial to Evaluate the Safety and Efficacy of Chloral Hydrate in Patients with Severe Insomnia Chloral Hydrate - Insomnia, Insomnia Chronic | Phase 4 | Completed | Pharmanovia | 100 | 2023-09-01 | 2024-11-07 |
| Effect of Eszopiclone on Adherence to CPAP and Severity of Insomnia in Patients With COMISA Eszopiclone 3 mg, Placebo - Obstructive Sleep Apnea, Insomnia | Phase 4 | Completed | University of Sao Paulo General Hospital | 60 | 2023-08-24 | 2026-05-29 |
| Solriamfetol and CBT-I in Patients With Insomnia Disorder Solriamfetol 75 MG, Cognitive Behavioral Therapy for Insomnia (CBT-I), Monitoring - Insomnia | Phase 4 | Completed | University of Pennsylvania | 115 | 2023-07-31 | 2026-05-12 |
| A Study to Investigate the Effect of XYWAV on Sleepiness, Polysomnography, and Functional Outcomes in Participants With Idiopathic Hypersomnia or Narcolepsy JZP258 (XYWAV) - Idiopathic Hypersomnia, Narcolepsy | Phase 4 | Completed | Jazz Pharmaceuticals | 199 | 2023-07-27 | 2026-08-27 |
| A Switch Study From High-Sodium Oxybate to Xywav to Evaluate Changes in Blood Pressure in Participants With Narcolepsy JZP258 - Narcolepsy | Phase 4 | Completed | Jazz Pharmaceuticals | 155 | 2023-06-26 | 2026-04-24 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality Dexmedetomidine, Esketamine, Normal saline - Breast Cancer, Perioperative Period | Phase 4 | Completed | Peking University First Hospital | 180 | 2023-05-22 | 2025-07-31 |
| Efficacy of Suvorexant on Post-operative Sleep Disturbance Suvorexant, Placebo - Postoperative Insomnia, Postoperative Delirium | Phase 4 | Completed | Columbia University | 100 | 2023-05-01 | 2026-07-23 |
| Feasibility Study on the Use of Redormin®500 on Day-time Cognition Valerian-Hop Extract, Placebo - Sleep Disorders, Circadian Rhythm, Cognitive Dysfunction | Phase 4 | Completed | Max Zeller Soehne AG | 40 | 2023-03-01 | 2026-06-11 |
| A Study to Find Out if Daridorexant is Safe and Efficacious in Patients With Insomnia and Comorbid Nocturia Daridorexant, Placebo - Insomnia Disorder, Nocturia | Phase 4 | Completed | Idorsia Pharmaceuticals Ltd. | 60 | 2023-02-16 | 2025-04-18 |
| Treating Insomnia and Improving Metabolic Health in Midlife Women With Insomnia Suvorexant, Placebo - Insomnia, Metabolic Health | Phase 4 | Completed | Brigham and Women's Hospital | 31 | 2023-01-06 | 2026-04-16 |
| Melatonin and DNA Damage Study Melatonin, Placebo - Sleep Quality, DNA Damage Repair Deficiency | Phase 4 | Completed | University of British Columbia | 40 | 2022-06-01 | 2024-08-28 |
| Lemborexant Shift Work Treatment Study Lemborexant, Placebo - Shift-Work Related Sleep Disturbance | Phase 4 | Completed | University of California, San Francisco | 29 | 2022-03-10 | 2026-02-04 |
| CBT-I or Zolpidem/Trazodone for Insomnia Zolpidem, Internet Cognitive Behavioral Therapy for Insomnia (CBT-I), Trazodone - Chronic Insomnia | Phase 4 | Completed | California Pacific Medical Center Research Institute | 155 | 2022-02-25 | 2025-02-24 |
Showing 20 of 203. Sign in to see all of them.
Sleep Initiation and Maintenance Disorders (81) · Sleep Apnea, Obstructive (52) · Sleep Apnea Syndromes (41) · Restless Legs Syndrome (17) · Sleep Wake Disorders (15) · Disorders of Excessive Somnolence (12) · Sleep Deprivation (10) · Depression (9) · Hypertension (9) · Heart Failure (5) · Hypoxia (5) · Sleep Disorders, Circadian Rhythm (5) · Anxiety Disorders (4) · Apnea (4) · Cardiovascular Diseases (4)
Nervous System Diseases (203) · Sleep Disorders, Intrinsic (190) · Sleep Wake Disorders (188) · Mental Disorders (130) · Respiratory Tract Diseases (88) · Respiration Disorders (84) · Apnea (80) · Pathological Conditions, Signs and Symptoms (61) · Signs and Symptoms (54) · Sleep Apnea Syndromes (43) · Neurologic Manifestations (36) · Cardiovascular Diseases (19) · Parasomnias (17) · Pathologic Processes (15)
Zolpidem (22) · Eszopiclone (16) · Continuous Positive Airway Pressure (14) · suvorexant (14) · ramelteon (10) · Dexmedetomidine (9) · Modafinil (6) · Pramipexole (6) · Saline Solution (6) · Acetazolamide (5) · Propofol (5) · Cognitive Behavioral Therapy (4) · Sugammadex (4) · 1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid (3) · Donepezil (3)
Peking University First Hospital (7) · Astellas Pharma Inc (6) · Hospital Universitario La Paz (6) · Takeda (6) · University of Zurich (6) · Sanofi (5) · Boehringer Ingelheim (4) · China Medical University, China (4) · Duke University (4) · Jazz Pharmaceuticals (4) · University of California, San Diego (4) · University of Sao Paulo (4) · Brigham and Women's Hospital (3) · Centre Hospitalier Universitaire Vaudois (3) · Cephalon (3)
United States (88) · Spain (16) · Canada (15) · Brazil (12) · Switzerland (12) · China (11) · Germany (10) · France (9) · Italy (8) · Japan (8) · United Kingdom (6) · Belgium (5) · Norway (5) · Sweden (5) · Taiwan (5)
Dong-Xin Wang, MD, PhD (4) · Francisco Garcia-Rio, MD (4) · Konrad E Bloch, MD (4) · Phyllis Diener (3) · Andrew D Krystal, MD (2) · Andrew Krystal, MD (2) · Christopher J Lettieri, MD (2) · Daniel J. Buysse, MD (2) · David L Steward, MD (2)
PMID 21256799, PMID 34739082, PMID 38862381, PMID 10450601, PMID 10678860, PMID 10908222, PMID 10940788, PMID 11208620, PMID 11422885, PMID 14500166, PMID 16376782, PMID 16494088, PMID 16579514, PMID 16804151, PMID 17068990, PMID 17452537, PMID 17494787, PMID 17556718, PMID 17921053, PMID 17925431, PMID 17936040, PMID 17975198, PMID 1798888, PMID 18198262, PMID 18347202, PMID 18404673, PMID 18413499, PMID 18417099, PMID 18452788, PMID 18458174, PMID 18458207, PMID 18539753, PMID 18584016, PMID 18584227, PMID 18595959, PMID 18627623, PMID 18663661, PMID 18710420, PMID 18788656, PMID 18971479, PMID 19101028, PMID 19249441, PMID 19317379, PMID 19357147, PMID 19454639, PMID 19567493, PMID 19920270, PMID 20007932, PMID 20016520, PMID 20051221
2015 (2), K23MH066978 (1), P50AG016574 (1), R01AG015866 (1), R01AG028769 (1), R01AG053838 (1), R01AG054521 (1), R01HL130552 (1), R01MH024652 (1), R01MH060413 (1), R01MH095776 (1), R34MH070821 (1), R34MH091338 (1)