166 completed, 25 unknown, 21 recruiting, 13 terminated. 79 Not applicable, 46 Phase 2, 44 Phase 3, 30 Phase 4, 14 Phase 1.
Follow Restless Legs Syndrome: new trials by email Literature Review of Restless Legs Syndrome trials Research Report on Restless Legs Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neuromodulation to Overcome Severe Restless Legs Syndrome Spinal Cord Stimulation - Restless Leg Syndrome (RLS), Spinal Cord Stimulation (SCS) | Not applicable | Not yet recruiting | Marshall Holland | 15 | 2027-10-01 | 2026-10-09 |
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| Tolerability and Efficacy of CBD Extract for RLS Treatment BRC-002, Placecbo - Restless Leg Syndrome | Phase 2 | Not yet recruiting | University of Colorado, Denver | 60 | 2026-11-01 | 2026-10-08 |
| Efficacy and Safety of Super High-Flux Hemodialysis in Maintenance Dialysis Patients. SHINE-RLS (Super High-flux Dialysis Improves Neuro-symptoms and Efficacy in Restless Legs Syndrome) Super High-Flux HD - End Stage Renal Failure, Hemodialysis, Restless Leg Syndrome (RLS) | Not applicable | Not yet recruiting | Far Eastern Memorial Hospital | 40 | 2026-10-01 | 2026-08-31 |
| Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI Ferric Carboxymaltose Injection [Ferinject], Randomization, Questionnaire and Physical Exam - Restless Legs Syndrome (RLS) | Phase 2 | Not yet recruiting | University Hospital, Montpellier | 66 | 2026-10-01 | 2026-09-16 |
| The Effect of Acupressure on Restless Legs Syndrome and Pruritus in Patients Undergoing Hemodialysis Vibration Assisted Acupressure - Restless Leg Syndrome (RLS) | Not applicable | Not yet recruiting | University of Baghdad | 70 | 2026-09-01 | 2026-09-11 |
| Optimizing Extended-Duration (XD-) TOMAC Therapy for Restless Legs Syndrome (RLS) Investigational Extended Duration (XD-) TOMAC Therapy, Tonic Motor Activation (TOMAC) Therapy - Restless Legs Syndrome (RLS) | Not applicable | Recruiting | Noctrix Health, Inc. | 20 | 2026-06-08 | 2026-06-30 |
| Study on the Efficacy of Spinal Cord Stimulation in Patients With Severe Refractory Primary or Secondary RLS Spinal cord stimulation (SCS), Sham stimulation - Restless Leg Syndrome (RLS) | Not applicable | Not yet recruiting | Clinica ARS Medica | 15 | 2026-06-01 | 2026-05-06 |
| Tonic Motor Activation (TOMAC) Therapy in Patients With Restless Legs Syndrome and Dopaminergic Augmentation Tonic Motor Activation (TOMAC) Device - Restless Legs Syndrome | Not applicable | Not yet recruiting | Noctrix Health, Inc. | 50 | 2026-04-01 | 2026-02-09 |
| Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety Crisugabalin - Restless Leg Syndrome (RLS), Variant Restless Legs Syndrome | Phase 1 | Recruiting | Beijing Friendship Hospital | 20 | 2026-03-10 | 2026-03-06 |
| EXPLORATORY STUDY OF THE POTENTIAL OF THERAPEUTIC EXERCISE IN THE TREATMENT OF WILLIS-EKBOM DISEASE Myofascial Self-Stretching Exercise Program, Buerger-Allen Exercise Program - Willis-Ekbom Disease, Restless Legs Syndrome (RLS) | Not applicable | Completed | Universidad Pontificia Comillas | 27 | 2026-03-03 | 2026-09-09 |
| Study on the Mechanism of Gut Microbiota Mediating Restless Legs Syndrome Through Iron Metabolism Not applicable- observational study - Restless Legs Syndrome (RLS) | Not yet recruiting | Wenxia Jiang | 100 | 2025-12-15 | 2026-01-02 | |
| Effect of Autogenic Training on Hemodialysis Patients Autogenic training, conventional physical therapy and hemodialysis care - Hemodialysis Patient, Restless Leg Syndrome (RLS) | Not applicable | Not yet recruiting | Cairo University | 54 | 2025-12-15 | 2025-12-22 |
| Combined Effects of Near-Infrared Light and Vibration on Diabetic Patients With Restless Leg Syndrome Near-Infrared Light Therapy, Vibration, Conventional Physical Therapy - Restless Leg Syndrome (RLS) | Not applicable | Not yet recruiting | Lahore University of Biological and Applied Sciences | 42 | 2025-12-14 | 2025-12-29 |
| Peroneal Electrical Nerve Stimulation in Pregnancy for Restless Legs Syndrome Peroneal Nerve Stimulation (PNS) Device - Restless Leg Disorder, Restless Leg Syndrome (RLS) | Not applicable | Recruiting | Rhode Island Hospital | 15 | 2025-10-15 | 2025-11-12 |
| Stellate Ganglion Stimulation for Restless Leg Syndrome in Hemodialysis Patients transcutaneous electrical nerve stimulation (TENS), Sham transcutaneous electrical nerve stimulation - Restless Leg Syndrome (RLS), Hemodialysis | Not applicable | Completed | Cairo University | 36 | 2025-10-10 | 2026-06-22 |
| Comparative Effects of Aerobic and Muscle Relaxation Exercises in Pregnant Women With Restless Leg Syndrome aerobic exercises, progressive muscle relaxation - Restless Leg Syndrome in Pregnancy | Not applicable | Recruiting | Riphah International University | 40 | 2025-10-01 | 2026-06-05 |
| The Suggested Immobilization Test With Exploratory Heart Rate Variability Analysis for Diagnosis of Restless Legs Syndrome A suggested immobilization test (SIT) - Restless Leg Syndrome | Not applicable | Recruiting | Siriraj Hospital | 52 | 2025-10-01 | 2026-02-13 |
| A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole Dipyridamole 50mg tid - Restless Leg Syndrome Due to Uraemia | Phase 2 / Phase 3 | Recruiting | Yunfeng Xia | 80 | 2025-09-20 | 2026-04-22 |
| Functional Connectivity of the Interoceptive Network in RLS Clinical assessment, auto-questionnaires (PSQI, ISI, ESS and HADS), Ecological Momentary Assessment (EMA) - Restless Legs Syndrome | Not applicable | Recruiting | University Hospital, Bordeaux | 30 | 2025-09-16 | 2026-09-25 |
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Sleep Initiation and Maintenance Disorders (22) · Sleep Wake Disorders (17) · Kidney Failure, Chronic (12) · Sleep Apnea, Obstructive (9) · Fatigue (8) · Parasomnias (7) · Parkinson Disease (7) · Sleep Apnea Syndromes (7) · Stroke (6) · Anemia, Iron-Deficiency (5) · Motor Activity (5) · Multiple Sclerosis (5) · Narcolepsy (5) · Sleep Disorders, Circadian Rhythm (5)
Dyssomnias (251) · Mental Disorders (251) · Nervous System Diseases (251) · Sleep Disorders, Intrinsic (251) · Parasomnias (244) · Sleep Wake Disorders (234) · Pathological Conditions, Signs and Symptoms (52) · Signs and Symptoms (39) · Neurologic Manifestations (35) · Female Urogenital Diseases and Pregnancy Complications (18) · Urogenital Diseases (18) · Pathologic Processes (17) · Disease Attributes (16) · Female Urogenital Diseases (16) · Kidney Diseases (16)
Pramipexole (20) · 1-(((alpha-isobutanoyloxyethoxy)carbonyl)aminomethyl)-1-cyclohexaneacetic acid (18) · rotigotine (16) · ropinirole (15) · Gabapentin (9) · ferric carboxymaltose (7) · Exercise (5) · Pregabalin (5) · Sugars (4) · Therapeutics (4) · ferrous sulfate (4) · Ascorbic Acid (3) · Dopamine Agonists (3) · Levodopa (3) · Mass Screening (3)
Boehringer Ingelheim (20) · GlaxoSmithKline (16) · XenoPort, Inc. (14) · UCB Pharma (10) · Noctrix Health, Inc. (9) · University Hospital, Montpellier (7) · TC Erciyes University (6) · American Regent, Inc. (5) · Astellas Pharma Inc (5) · Brigham and Women's Hospital (5) · Cairo University (4) · Massachusetts General Hospital (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (3) · Riphah International University (3)
United States (106) · Germany (26) · France (17) · Turkey (Türkiye) (17) · Austria (10) · Spain (10) · Switzerland (10) · Japan (9) · Canada (7) · Italy (7) · Finland (6) · Pakistan (6) · Sweden (6) · China (5) · Egypt (5)
Jonathan D Charlesworth, PhD (7) · John W Winkelman, MD, PhD (3) · Steven Caras, MD (3) · Alison E Pritchard, PhD (2) · Marshall Holland, MD (2) · Richard Larouche, M.D. (2)
PMID 26788345, PMID 27067343, PMID 27288210, PMID 21256799, PMID 21527006, PMID 26446245, PMID 12804680, PMID 14592339, PMID 14592341, PMID 14592342, PMID 17275473, PMID 18166705, PMID 18515185, PMID 18753003, PMID 19017878, PMID 19414938, PMID 19480225, PMID 20463578, PMID 20466589, PMID 20629075, PMID 20813583, PMID 20817595, PMID 20920156, PMID 21060282, PMID 21677899, PMID 21705273, PMID 22101745, PMID 22664749, PMID 23009552, PMID 23063302, PMID 23121149, PMID 23256574, PMID 23668924, PMID 23910574, PMID 23929523, PMID 23938061, PMID 23964267, PMID 24024727, PMID 24246378, PMID 24290737, PMID 24899755, PMID 25023924, PMID 25467190, PMID 26262586, PMID 26411693, PMID 26569149, PMID 26835466, PMID 26896370, PMID 27105763, PMID 27367949
2005 (2), R44NS117294 (2), 1UG3NS145980-01 (1), 2009 (1), 2014 (1), P01AG021190 (1), R01AG059613 (1), R21DA052861 (1)