364 completed, 73 unknown, 35 recruiting, 28 not yet recruiting. 228 Not applicable, 107 Phase 4, 72 Phase 2, 48 Phase 3, 26 Phase 1.
Follow Dry Eye: new trials by email Literature Review of Dry Eye trials Research Report on Dry Eye
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study of RCI001 Ophthalmic Solution in Participants With Dry Eye Disease RCI001 Ophthalmic Solution, Placebo Ophthalmic Solution - Dry Eye | Phase 2 | Not yet recruiting | Rudacure | 200 | 2027-09-01 | 2026-06-04 |
| Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome | Not yet recruiting | University of Pennsylvania | 220 | 2027-01-01 | 2026-03-02 | |
| Cooling Eyedrops for Dry Eye TRYPTYR Eye Drops, Purilens Plus Non-Preserved Saline Eye Drops - Dry Eye | Phase 4 | Not yet recruiting | University of California, Berkeley | 50 | 2026-11-01 | 2026-10-26 |
| Evaporative Dry Eye acoltremon 0.003%. - Dry Eye, Evaporative Dry Eye | Phase 4 | Not yet recruiting | Southern College of Optometry | 41 | 2026-10-26 | 2026-10-28 |
| Contact Lens-Wearing Dry Eye Subjects Who Are Treated With Acoltremon 0.003% acoltremon 0.003% - Dry Eye, Contact Lens Discomfort | Phase 4 | Not yet recruiting | Eye Research Associates, LLC | 50 | 2026-10-10 | 2026-10-08 |
| Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS preservative free ZOLYMBUS™ 0.01%. - Eye Drops Self-instillation, Glaucoma | Phase 4 | Not yet recruiting | Southern College of Optometry | 40 | 2026-10-05 | 2026-09-28 |
| Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain acoltremon ophthalmic solution 0.003% - Ocular Pain, Dry Eye | Phase 4 | Not yet recruiting | University of South Florida | 28 | 2026-10-01 | 2026-10-06 |
| Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Severe Dry Eye CAM-101, Vehicle Control - Dry Eye Disease, Dry Eye | Phase 3 | Not yet recruiting | Cambium Bio Limited | 475 | 2026-10-01 | 2026-06-12 |
| Ocular Surface Disease in Glaucoma Patients on Long-Term Therapy Glaucoma, Ocular Surface Disease | Not yet recruiting | Assiut University | 55 | 2026-09-26 | 2026-09-28 | |
| A Study of Full-Spectrum Screen Lighting for Reducing Screen-Related Eye Fatigue and Dry Eye Full-spectrum screen bar light, Brightness-matched screen task without screen bar lighting - Visual Fatigue, Dry Eye | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 112 | 2026-09-22 | 2026-09-18 |
| Temporary Tear Duct Filling With Hyaluronic Acid Gel and Assessment of Dry Eye Disease (DED) After Bilateral Cataract Surgery LACRIFILL® Canalicular Gel administration, Sham lacrimal canalicular procedure - Dry Eye, Dry Eye Disease (DED) | Phase 4 | Not yet recruiting | Medical University of Vienna | 25 | 2026-09-15 | 2026-09-09 |
| Evaluation of Lacrifill Lacrifill, Saline - Dry Eye, Ocular Surface Disease | Phase 4 | Recruiting | Eye Research Associates, LLC | 40 | 2026-09-02 | 2026-09-25 |
| a Novel siRNA Eyedrops for DED Treatment Low dose Arm, High dose Arm, Placebo Arm - Dry Eye | Early Phase 1 | Not yet recruiting | Eye & ENT Hospital of Fudan University | 30 | 2026-09-01 | 2026-11-02 |
| Phase III Study of OT202 in Treating Moderate to Severe Dry Eye OT202 conc 1%, Placebo - Dry Eye | Phase 3 | Recruiting | Ocumension Therapeutics (Suzhou) Co., Ltd | 842 | 2026-08-25 | 2026-10-15 |
| Long-term Effects of Acoltremon vs. Control in Dry Eye Disease Acoltremon 0.003%, Refresh classic preservative free - Dry Eye | Recruiting | The Eye Care Institute | 60 | 2026-08-18 | 2026-08-20 | |
| BL-RX01-TFSTAB-1402 Determine the ability of the iTrace™, BOSA™, OPD-Scan III, and IDRA to detect tear film stability utilizing Miebo® - Dry Eye | Phase 4 | Recruiting | Vance Thompson Vision | 20 | 2026-08-01 | 2026-08-27 |
| Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg Tyrvaya - Dry Eye | Not applicable | Recruiting | Ocular Aesthetics, LLC dba Ocular Clinical Trials | 50 | 2026-07-28 | 2026-07-30 |
| Autologous Serum Tears With Hyaluronate vs Balanced Salt Solution for Moderate-to-Severe Dry Eye Autologous Serum Tears (50% Autologous Serum Tears + 0.2% Sodium Hyaluronate), Biological - Autologous Serum Tears (50% Autologous Serum Tears + Balanced Saline Solution (BSS), Standard of Care (SOC) Treatment - Dry Eye, Eye Diseases | Phase 2 | Recruiting | University of Miami | 20 | 2026-07-21 | 2026-07-24 |
| Lacrima VR for Dry Eye Disease and Meibomian Gland Dysfunction Lacrima VR System - Dry Eye, Dry Eye Syndromes | Not applicable | Not yet recruiting | Demaod Ltd | 20 | 2026-07-20 | 2026-05-12 |
| Study of Proteomic Factors in Patients With Severe Dry Eye Syndrome Treated With Autologous Serum Eye Drops. Autologous serum eye drops, Collecting data from the medical record - Dry Eye Syndrome (DES), Dry Eye | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 68 | 2026-07-07 | 2026-07-09 |
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Dry Eye Syndromes (545) · Meibomian Gland Dysfunction (38) · Sjogren's Syndrome (18) · Cataract (13) · Keratoconjunctivitis Sicca (12) · Asthenopia (11) · Eye Diseases (8) · Corneal Diseases (6) · Glaucoma (6) · Xerophthalmia (6) · Lacerations (5) · Blepharitis (4) · Eye Pain (4) · Inflammation (4) · Conjunctival Diseases (3)
Lacrimal Apparatus Diseases (544) · Eye Diseases (537) · Eyelid Diseases (40) · Immune System Diseases (28) · Skin and Connective Tissue Diseases (28) · Musculoskeletal Diseases (22) · Pathological Conditions, Signs and Symptoms (22) · Connective Tissue Diseases (21) · Mouth Diseases (21) · Stomatognathic Diseases (21) · Joint Diseases (20) · Rheumatic Diseases (20) · Arthritis (19) · Autoimmune Diseases (18) · Conjunctival Diseases (18)
Lubricant Eye Drops (22) · Ophthalmic Solutions (22) · Cyclosporins (15) · Hyaluronic Acid (13) · lifitegrast (12) · Cyclosporine (8) · Propylene Glycol (8) · Sodium Chloride (7) · Carboxymethylcellulose Sodium (6) · Calcium Dobesilate (5) · Loteprednol Etabonate (5) · Therapeutics (5) · Insulin (4) · Intense Pulsed Light Therapy (4) · Polyethylene Glycols (4)
Alcon Research (50) · Singapore National Eye Centre (14) · Innovative Medical (11) · He Eye Hospital (10) · University of Alabama at Birmingham (9) · Bausch & Lomb Incorporated (8) · Peking University Third Hospital (8) · Southern College of Optometry (8) · University of Waterloo (8) · C.O.C. Farmaceutici S.r.l. (7) · Laboratorios Sophia S.A de C.V. (7) · Aldeyra Therapeutics, Inc. (6) · Toyos Clinic (6) · Allergan (5) · Beijing Tongren Hospital (5)
United States (210) · China (57) · Canada (27) · Italy (18) · Singapore (16) · Mexico (14) · Spain (13) · France (12) · United Kingdom (12) · Taiwan (11) · Egypt (10) · South Korea (9) · Turkey (Türkiye) (9) · Australia (6) · Austria (6)
Gail Torkildsen, MD (8) · Louis Tong, PhD (8) · John Hovanesian, MD (5) · Sandeep Jain, MD (5) · Lyndon Jones, PhD, FCOptom (4) · Mike Christensen (3) · Pedram Hamrah, MD (3) · Ali MA Ismail, lecturer (2) · Barbara Burgos Blasco, MD, PhD (2) · David Pei-Cheng Lin, PhD (2)
PMID 28736340, PMID 11879137, PMID 12649304, PMID 12823990, PMID 14508260, PMID 17216085, PMID 18848318, PMID 20735287, PMID 21750611, PMID 25179431, PMID 28736335, PMID 28777385, PMID 28797892, PMID 29055358, PMID 32280196, PMID 32836200, PMID 34707360, PMID 42803882, PMID 9778415, PMID 12140209, PMID 12160808, PMID 12561039, PMID 14723108, PMID 15090417, PMID 15499517, PMID 15604871, PMID 15767073, PMID 15948994, PMID 15976462, PMID 16021174, PMID 16371776, PMID 16900272, PMID 16973668, PMID 17043506, PMID 17054241, PMID 17066482, PMID 17102664, PMID 17172891, PMID 17199193, PMID 17317488, PMID 17324465, PMID 17394642, PMID 17508121, PMID 18691081, PMID 19034126, PMID 19757354, PMID 21078194, PMID 21438701, PMID 21450919, PMID 21479340
2018 (1), R01EY024966 (1), U10EY022879 (1), U10EY022881 (1)