13 completed, 6 unknown, 4 not yet recruiting, 3 recruiting. 12 Not applicable, 5 Phase 2, 2 Phase 1, 2 Phase 3, 2 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease DFL24498, Vehicle - Dry Eye Disease (DED) | Phase 2 | Recruiting | Dompé Farmaceutici S.p.A | 417 | 2026-05-12 | 2026-10-22 |
| Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren Disease Tofacitinib - Sjogren's Syndrome | Phase 2 | Recruiting | National Institute of Dental and Craniofacial Research (NIDCR) | 60 | 2025-12-18 | 2026-10-19 |
| Low-level Light Therapy Versus Intense Pulsed Light to Prevent Iatrogenic Dry Eye Disease After Cataract Surgery LLLT, IPL - Cataract Surgery, Eye Dryness | Not applicable | Not yet recruiting | Clinique Trenel | 60 | 2025-09-30 | 2025-07-08 |
| Clinical Trial for the Evaluation of Safety and Efficacy of Drop 0.4% Multidose mosturizing solution DROP 0.4%, Multidose mosturizing solution Avizor Eye Drops 0.2% Preserved - Eye Dryness | Phase 3 | Not yet recruiting | Avizor SA | 79 | 2025-07-01 | 2025-07-09 |
| Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome acupuncture GB20 or GB20 plus BL2, Chinese herbal tea TBDESJS - Dry Eye Syndrome (DES), Sjogren's Syndrome | Recruiting | Taipei Veterans General Hospital, Taiwan | 220 | 2025-01-16 | 2025-01-17 | |
| Efficacy of 0.28% Sodium Hyaluronate Eye Drops in Patient With Moderate to Severe Dry Eye 0.28% Sodium Hyaluronate , preservative free eye drops, 0.18% Sodium Hyaluronate , preservative free eye drops - Dry Eye Disease (DED), Tear Break-Up Time | Phase 4 | Enrolling by invitation | Department of Medical Services Ministry of Public Health of Thailand | 84 | 2024-09-01 | 2025-03-06 |
| Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops NCP112, NCP112 Placebo - Xerophthalmia | Phase 1 | Unknown | Huons Co., Ltd. | 60 | 2024-07-11 | 2024-10-01 |
| Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome TBDESJS, Acupuncture - Dry Eye Syndrome, Sjogren's Syndrome | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 220 | 2024-07-01 | 2024-06-26 | |
| A Clinical Trial to Evaluate the Efficacy of an Oral Supplement in Supporting Vision and Eye Health Eye Empower - Inflammation Symptoms, Eye Dryness | Not applicable | Completed | Bio Nature Health | 40 | 2024-04-22 | 2024-07-23 |
| A Prospective Study of the Dry Eye Drink That Evaluates Hydration and Subject's Assessment on Eye Dryness Dry Eye Drink - Dry Eye | Not applicable | Completed | Bruder Healthcare | 60 | 2023-08-01 | 2025-03-26 |
| VGH-DESJS-1 in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome and Sjögren's Syndrome Chinese herbal tea VGH-DESJS-1 - Dry Eye Syndrome, Sjogren's Syndrome | Not applicable | Completed | Taipei Veterans General Hospital, Taiwan | 100 | 2023-04-01 | 2024-01-26 |
| To Evaluate the Short-term and Long Term Efficacy of Acupuncture in Ocular and Oral Dryness Symptoms of Dry Eye Syndrome Acupuncture, Oral microbiota, Schirmer's test - Dry Eye Syndrome, Xerophthalmia | Not applicable | Unknown | Taipei Veterans General Hospital, Taiwan | 120 | 2022-12-06 | 2022-12-13 |
| Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank Whole-genome genotyping, Whole-genome sequencing, TCM pattern - Dry Eye Syndrome, Sjogren's Syndrome | Not yet recruiting | Taipei Veterans General Hospital, Taiwan | 100000 | 2022-10-01 | 2022-08-11 | |
| Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients S95011 concentrate for solution for infusion, Placebo concentrate for solution for infusion - Primary Sjögren's Syndrome | Phase 2 | Completed | Institut de Recherches Internationales Servier | 48 | 2021-08-03 | 2024-04-23 |
| A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease ECF843, ECF843 vehicle - Dry Eye | Phase 2 | Completed | Novartis Pharmaceuticals | 718 | 2020-10-06 | 2025-01-28 |
| Effect of Meibomian Gland Related Therapy on the Morphology of Meibomian Gland Intense pulsed light therapy, Hot compress massage - Xerophthalmia | Not applicable | Withdrawn | Yune Zhao | 2020-09-01 | 2020-11-19 | |
| Effects of Acupuncture on Sjögren's Syndrome Acupuncture, Sham acupuncture - Sjogren's Syndrome | Not applicable | Completed | Ana Carolina Fragoso Motta, DDS, PhD | 50 | 2019-02-18 | 2023-03-14 |
| DRy Eye Outcome and Prescription Study Artificial tears (classified by MHRA as a medical device) - Dry Eye, Dry Eye Syndrome | Unknown | Guy's and St Thomas' NHS Foundation Trust | 635 | 2018-08-23 | 2018-08-31 | |
| Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy Tear Film Imager, Restasis - Dry Eye Syndrome, Tear Film Insufficiency | Not applicable | Unknown | Meir Medical Center | 40 | 2018-01-30 | 2018-01-18 |
| Lifitegrast 5% Ophthalmic Solution and Contact Lens Dryness Lifitegrast - Contact Lens, Contact Lens Discomfort | Phase 4 | Completed | EV Clinical Trials | 21 | 2016-12-16 | 2018-09-28 |
Showing 20 of 29. Sign in to see all of them.
Dry Eye Syndromes (17) · Sjogren's Syndrome (8) · Keratoconjunctivitis Sicca (4) · Xerostomia (3) · Blepharitis (2) · Cataract (2) · Inflammation (2) · Amaurosis Fugax (1) · Amblyopia (1) · Arthritis (1) · Astigmatism (1) · Autoimmune Diseases (1) · Blindness (1) · Chorioretinitis (1)
Conjunctival Diseases (29) · Lacrimal Apparatus Diseases (29) · Eye Diseases (28) · Dry Eye Syndromes (12) · Arthritis, Rheumatoid (8) · Connective Tissue Diseases (8) · Immune System Diseases (8) · Mouth Diseases (8) · Musculoskeletal Diseases (8) · Rheumatic Diseases (8) · Skin and Connective Tissue Diseases (8) · Stomatognathic Diseases (8) · Arthritis (7) · Autoimmune Diseases (7) · Joint Diseases (7)
Acupuncture Therapy (3) · Intense Pulsed Light Therapy (2) · Blood Cell Count (1) · Blood Specimen Collection (1) · Cyclosporins (1) · Histocompatibility Testing (1) · Hyaluronic Acid (1) · Low-Level Light Therapy (1) · Medical History Taking (1) · Microbiota (1) · Nutritional Status (1) · Phototherapy (1) · Polyethylene Glycols (1) · Preservation, Biological (1) · Solutions (1)
Taipei Veterans General Hospital, Taiwan (5) · Dompé Farmaceutici S.p.A (2) · Abbott Medical Optics (1) · Ana Carolina Fragoso Motta, DDS, PhD (1) · Avizor SA (1) · Bio Nature Health (1) · Bruder Healthcare (1) · Clinique Trenel (1) · Department of Medical Services Ministry of Public Health of Thailand (1) · EV Clinical Trials (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Huons Co., Ltd. (1) · Institut de Recherches Internationales Servier (1) · Jin Yuan (1) · Johnson & Johnson Vision Care, Inc. (1)
United States (7) · Taiwan (5) · United Kingdom (3) · China (2) · France (2) · Singapore (2) · Australia (1) · Brazil (1) · Germany (1) · Haiti (1) · Hungary (1) · Italy (1) · South Korea (1) · Spain (1) · Thailand (1)
Ching-Mao Chang, M.D., Ph.D. (4) · Louis Tong, FRCS, MD (2) · Antoine Sylvestre-Bouchard (1) · Blake M Warner, D.D.S. (1) · Chang Ching-Mao, M.D., Ph.D. (1) · Christelle Doyon, MD (1) · Eduardo Melani Rocha, DDS, PhD (1) · Eric Donnenfeld, M.D. (1) · Fabiola R Oliveira, DDS, PhD (1) · Fani Segev, M.D. (1) · Flavio Mantelli, MD (1) · Heng Joo Ng (1) · Jaciara M Gomes-Silva, DDS, PhD (1) · Janet Pope, MD (1)
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