74 completed, 5 withdrawn, 4 unknown, 1 not yet recruiting. 26 Phase 2, 23 Phase 3, 20 Not applicable, 11 Phase 4, 5 Phase 1.
Follow Keratoconjunctivitis Sicca: new trials by email Literature Review of Keratoconjunctivitis Sicca trials Research Report on Keratoconjunctivitis Sicca
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease BRM421 Ophthalmic Solution, 0.03%, Artificial Tear, BRM421 Ophthalmic Solution, 0.06% - Dry Eye Disease (DED), Keratoconjunctivitis Sicca | Phase 2 | Not yet recruiting | BRIM Biotechnology Inc. | 99 | 2025-12-01 | 2025-10-20 |
| Tolerability and Efficacy Study of Reinnerva/Lubristil+G vs Vismed Reinnerva/Lubristil +G sterile eye drops (artificial tears), Vismed sterile eye drops (artificial tears) - Keratoconjunctivitis Sicca | Not applicable | Completed | Medivis SRL | 40 | 2025-06-09 | 2026-02-19 |
| Study of INV-102 Ophthalmic Solution in Adults With Moderate to Severe Dry Eye Disease INV-102, Vehicle - Dry Eye Disease | Phase 2 | Completed | Invirsa, Inc. | 109 | 2024-03-27 | 2026-09-18 |
| Vizol S DIGI EYE Efficacy and Safety Study in Patients With Dry Eye Vizol S DIGI EYE eye drops, 0,9% saline solution, eye drops - Dry Eye Disease (DED) | Phase 3 | Completed | Jadran Galenski laboratorij d.d. | 86 | 2024-03-20 | 2025-07-03 |
| Medical vs Acupuncture for Dry Eye Artificial tears, Traditional Chinese Medicine Acupuncture - Dry Eye, Acupuncture | Not applicable | Completed | Nadide Koca | 90 | 2024-01-15 | 2025-09-22 |
| Phase 4 Study Evaluating the Safety of the Nasal Guide With Tyrvaya Nasal Guide - Dry Eye, Keratoconjunctivitis Sicca | Phase 4 | Completed | Oyster Point Pharma, Inc. | 30 | 2023-06-14 | 2025-05-06 |
| Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B punctum plug insertion, Eye Drops, Lubricant - Dry Eye, Keratoconjunctivitis Sicca | Phase 1 | Unknown | Eximore Ltd. | 20 | 2022-09-29 | 2023-09-07 |
| Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease INV-102, Vehicle - Dry Eye Disease | Phase 1 / Phase 2 | Completed | Invirsa, Inc. | 84 | 2022-08-30 | 2026-09-18 |
| Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye Vizol S LIPID BALANCE eye drops, ophthalmic saline eye drops - Dry Eye Disease | Phase 3 | Completed | Jadran Galenski laboratorij d.d. | 64 | 2022-06-01 | 2024-03-21 |
| Safety Study of Tivanisiran to Treat Dry Eye Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution - Dry Eye Disease | Phase 3 | Completed | Sylentis, S.A. | 301 | 2022-03-24 | 2026-09-09 |
| Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness Osteopathic protocol of Sphenopalatine Ganglion Stimulation - Dry Eye Disease, Xerostomia | Not applicable | Completed | Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA | 30 | 2022-01-15 | 2024-11-01 |
| Levocarnitine for Dry Eye in Sjogren's Syndrome Levocarnitine, Placebo - Sjogren's Syndrome, Keratoconjunctivitis Sicca | Phase 2 | Completed | Vanderbilt University Medical Center | 15 | 2021-11-17 | 2025-12-04 |
| Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome Tivanisiran sodium ophthalmic solution, Vehicle ophthalmic solution - Dry Eye Disease, Sjögren Syndrome | Phase 3 | Completed | Sylentis, S.A. | 203 | 2021-05-25 | 2024-02-20 |
| Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy Study Pro-ocular™ Topical Gel, Placebo Topical Gel - Dry Eye Syndrome, Keratoconjunctivitis Sicca | Phase 2 | Unknown | PharmaDax Inc. | 80 | 2021-05-20 | 2021-05-14 |
| Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye Questionnaires, Tear fluid sampling, Impression Cytology - Keratoconjunctivitis Sicca, Dry Eye Syndromes | Completed | Johns Hopkins University | 92 | 2021-01-11 | 2023-01-05 | |
| Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fitting Ocular surface optical coherence tomography - Keratoconus, Ocular Surface Disease | Not applicable | Completed | Boston Sight | 11 | 2020-12-15 | 2023-10-27 |
| Mesenchymal Stem Cell Therapy of Dry Eye Disease in Patients With Sjögren's Syndrome ASCs, Cryostor CS10 - Keratoconjunctivitis Sicca, in Sjogren's Syndrome | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 40 | 2020-11-03 | 2023-03-08 |
| A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye Disease ECF843, ECF843 vehicle - Dry Eye | Phase 2 | Completed | Novartis Pharmaceuticals | 718 | 2020-10-06 | 2025-01-28 |
| A Randomized Study of Smile Exercise for Dry Eye smile exercise, 0.1% sodium hyaluronate eye drop - Dry Eye, Keratoconjunctivitis Sicca | Not applicable | Completed | Zhongshan Ophthalmic Center, Sun Yat-sen University | 299 | 2020-07-02 | 2024-05-14 |
| Effect of Cequa™ in Subjects With Dry Eye Disease CequaTM (Cyclosporine 0.09%) ophthalmic solution - Dry Eye Disease | Phase 4 | Completed | Sun Pharmaceutical Industries Limited | 135 | 2020-06-29 | 2024-02-06 |
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Dry Eye Syndromes (67) · Sjogren's Syndrome (9) · Xerophthalmia (4) · Corneal Diseases (3) · Hyperemia (3) · Keratitis (3) · Pain (3) · Xerostomia (3) · Conjunctival Diseases (2) · Eye Diseases (2) · Fatigue (2) · Keratoconjunctivitis (2) · Lacrimal Apparatus Diseases (2) · Amaurosis Fugax (1)
Conjunctivitis (84) · Conjunctival Diseases (83) · Eye Diseases (83) · Keratoconjunctivitis (83) · Lacrimal Apparatus Diseases (83) · Corneal Diseases (82) · Keratitis (82) · Dry Eye Syndromes (18) · Mouth Diseases (11) · Salivary Gland Diseases (11) · Stomatognathic Diseases (11) · Immune System Diseases (10) · Arthritis (9) · Connective Tissue Diseases (9) · Joint Diseases (9)
Lubricant Eye Drops (6) · Loteprednol Etabonate (5) · Cyclosporins (4) · rebamipide (4) · Cyclosporine (3) · Ophthalmic Solutions (3) · lifitegrast (3) · CF101 (2) · Carboxymethylcellulose Sodium (2) · Glycerol (2) · Hyaluronic Acid (2) · Sodium Chloride (2) · Acupuncture Therapy (1) · Adrenal Cortex Hormones (1) · Carnitine (1)
Allergan (4) · Oculeve, Inc. (4) · Sun Pharmaceutical Industries Limited (4) · Kala Pharmaceuticals, Inc. (3) · Mimetogen Pharmaceuticals USA, Inc. (3) · Rigel Pharmaceuticals (3) · Can-Fite BioPharma (2) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (2) · Invirsa, Inc. (2) · Jadran Galenski laboratorij d.d. (2) · Kubota Vision Inc. (2) · Ohio State University (2) · Otsuka Pharmaceutical Development & Commercialization, Inc. (2) · Sylentis, S.A. (2) · University of Alabama at Birmingham (2)
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Gail Torkildsen, MD (4) · Garth Cumberlidge, PhD (2) · Gary Foulks, MD (2) · Robert Shalwitz, MD (2) · Anne Marie Lynge Pedersen, PhD, DDS (1) · Christine Shieh, MD (1) · Daniel B Rootman, MD, MSc (1) · Daniel Brocks, MD (1) · Daniel Magilavy, MD (1) · David Evans, OD (1) · Edward Holland, MD (1) · Esen Akpek, MD (1)
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R34EY017626 (1)