27 completed, 6 withdrawn, 2 not yet recruiting, 1 recruiting. 13 Not applicable, 12 Phase 4, 9 Phase 2, 5 Phase 1, 4 Phase 3.
Follow Carboxymethylcellulose Sodium: new trials by email Literature Review of Carboxymethylcellulose Sodium trials Research Report on Carboxymethylcellulose Sodium
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5% - Dry Eye Disease (DED) | Phase 4 | Recruiting | Andover Research Eye Institute | 60 | 2026-06-03 | 2026-06-30 |
| Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection Hypoallergenic Eyelid Taping, Hypoallergenic Eyelid Taping With Lubricant Eye Drops - Corneal Injury, Exposure Keratopathy | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 200 | 2026-06-01 | 2026-05-07 |
| Dimensional Changes of Peri-implant Tissues Following Jumping Gap Grafting Using Erythropoietin Gel Mixed With Xenograft. Erythropoetin gel mixed with xenogenic bone graft, Xenogenic bone with gelling aget CMC ( carboxymethyl cellulose) - Peri-implant Bone and Soft Tissues | Phase 4 | Not yet recruiting | Ain Shams University | 26 | 2026-04-12 | 2026-04-15 |
| Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD) L-citrulline, Carboxymethyl cellulose, High Intensity Intervals Training - Metabolic Dysfunction-Associated Fatty Liver Disease, Obesity, Adolescent | Not applicable | Completed | Universidad de Guanajuato | 43 | 2023-03-14 | 2024-12-20 |
| Retentive Strength of Denture Adhesives on Various RR Ridges polymyxin b/trimethoprim ophthalmic, Carboxymethyl cellulose - Retentive Strength of Denture Adhesives | Phase 1 | Completed | Altamash Institute of Dental Medicine | 24 | 2022-08-18 | 2024-04-09 |
| Effects of Carboxymethylcellulose Artificial Tears on the Eye Microbiome Carboxymethylcellulose (CMC) Artificial Tears, Preservative-free, CMC-free Artificial Tears (control) - Dry Eye Syndromes | Phase 4 | Completed | University of Florida | 80 | 2022-04-22 | 2023-04-20 |
| Effects of Stulln and Accommodative Training Stulln Eyedrops, Thera Tears - Accommodation Disorder, Visual Fatigue | Phase 1 / Phase 2 | Withdrawn | Pacific University | 2021-03-15 | 2024-05-21 | |
| PRF Based Dressing Versus AQUACEL® for Local Treatment of Skin Graft Donor Site Half of the harvested area will be dressed with PRF dressing, and half with Aquacel®. - Treatment of Skin Graft Donor Site | Not applicable | Withdrawn | Rambam Health Care Campus | 2021-01-01 | 2021-09-24 | |
| Scarring At Donor Sites After Split-Thickness Skin Graft. Allevyn, Aquacel and Tegaderm, Mediskin - Donor Site Complication | Completed | University Hospital, Linkoeping | 17 | 2018-06-15 | 2020-07-29 | |
| Functional Research of Emulsifiers in Humans Emulsifier-containing diet - Healthy | Not applicable | Completed | University of Pennsylvania | 29 | 2018-04-06 | 2021-10-19 |
| Oral Glucose Intervention for Children With Gastroenteritis and Ketosis Oral Glucose Gel, Placebo - Gastrointestinal Infections, Ketosis | Withdrawn | University of Florida | 2018-01-01 | 2018-01-29 | ||
| Dry Eye Disease Study With Brimonidine Brimonidine, Brimonidine Mono Therapy, sodium carboxymethylcellulose - Dry Eye | Phase 2 | Completed | Ocugen | 84 | 2017-09-06 | 2022-07-06 |
| Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial Gabapentin 600mg, Placebo oral capsule, acetaminophen/codeine and ibuprofen - Abortion, Induced, Cervical Preparation | Phase 4 | Completed | University of California, Davis | 121 | 2017-03-20 | 2020-04-14 |
| Efficacy and Safety of Iota-Carrageenan Eye Drops (NCX-4240) Iota-Carrageenan, Carmellose - Adenoviral Conjunctivitis | Phase 2 | Withdrawn | NicOx | 2017-01-01 | 2017-05-10 | |
| Echothiophate Iodide for the Prevention of Progression of Myopia Echothiophate Iodide 0.03% Ophthalmic Solution, Carboxymethylcellulose Sodium (0.5%) - Myopia | Phase 4 | Withdrawn | Danbury Eye Physicians & Surgeons, PC | 2016-06-01 | 2025-02-07 | |
| Dry Eye Treatment With Artificial Tears Hypromellose 0.15%, Hypromellose 0.4%, Carboxymethylcellulose - Dry Eye | Not applicable | Completed | Aston University | 50 | 2015-04-01 | 2019-01-10 |
| Healing of Persistent Epithelial Defects carboxymethylcellulose sodium, Acuvue Oasys Bandage Contact Lens, Ambiodisk - Cornea | Not applicable | Withdrawn | Milton S. Hershey Medical Center | 2015-03-01 | 2019-02-05 | |
| A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease Refresh Optive® Gel Drops, REFRESH LIQUIGEL® - Dry Eye Syndromes | Phase 3 | Completed | Allergan | 188 | 2014-11-13 | 2019-04-16 |
| A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry Eye carboxymethylcellulose 0.5%/glycerin 0.9%, sodium hyaluronate 0.18% - Dry Eye Syndromes, Keratoconjunctivitis Sicca | Phase 4 | Completed | Allergan | 80 | 2014-05-14 | 2019-04-18 |
| Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme SL-701; poly-ICLC (polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethyl cellulose), Bevacizumab, SL-701 + GM-CSF - Adult Brain Glioblastoma, Glioblastoma Multiforme | Phase 1 / Phase 2 | Completed | Stemline Therapeutics, Inc. | 74 | 2014-05-01 | 2025-02-03 |
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Dry Eye Syndromes (16) · Corneal Diseases (3) · Corneal Neovascularization (2) · Keratoconjunctivitis Sicca (2) · Refractive Errors (2) · Asthenopia (1) · Cataract (1) · Conjunctivitis, Viral (1) · Corneal Injuries (1) · Fecal Incontinence (1) · Gastroenteritis (1) · Glaucoma (1) · Glaucoma, Open-Angle (1) · Glioblastoma (1) · Ketosis (1)
Allergan (9) · Alcon Research (2) · Reza Dana, MD (2) · University of Florida (2) · Ain Shams University (1) · Altamash Institute of Dental Medicine (1) · Andover Research Eye Institute (1) · Aston University (1) · Chulalongkorn University (1) · Danbury Eye Physicians & Surgeons, PC (1) · Fatih Sultan Mehmet Training and Research Hospital (1) · Fundação Altino Ventura (1) · Milton S. Hershey Medical Center (1) · Moses Murandu (1) · NicOx (1)
United States (19) · United Kingdom (3) · Brazil (2) · France (2) · China (1) · Egypt (1) · Germany (1) · Israel (1) · Mexico (1) · Pakistan (1) · Spain (1) · Sweden (1) · Thailand (1) · Turkey (Türkiye) (1)
Reza Dana, MD, MPH, MSc (2) · Alan Arturo Rodriguez-Carrillo, Bachelor (1) · Brigitte Duquesroix (1) · David J Schanzlin, MD (1) · Donna Z Bliss, phD (1) · Fred R Guyer, MD (1) · James S Wolffsohn, BSc PhD (1) · Jim Lewis, MD, MSCE (1) · Ma. Eugenia Garay-Sevilla, PhD (1) · Malcolm Simms, MBBSFRCS (1) · Malik Y. Kahook, MD (1) · Mark Curtis, O.D. (1)
PMID 24403819, PMID 25880685, PMID 34774538, PMID 37555738, PMID 39940261, PMID 40127129, PMID 41767362
R01NR007756 (1), R21DK115180 (1)