56 completed, 13 unknown, 10 not yet recruiting, 10 recruiting. 107 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 107 | Completed 56, Unknown 13, Not yet recruiting 10, Recruiting 10, Terminated 9, Withdrawn 4, Active not recruiting 3, Enrolling by invitation 2 |
Follow Dry Eye: new trials by email Literature Review of Dry Eye trials Research Report on Dry Eye
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cooling Eyedrops for Dry Eye TRYPTYR Eye Drops, Purilens Plus Non-Preserved Saline Eye Drops - Dry Eye | Phase 4 | Not yet recruiting | University of California, Berkeley | 50 | 2026-11-01 | 2026-10-26 |
| Evaporative Dry Eye acoltremon 0.003%. - Dry Eye, Evaporative Dry Eye | Phase 4 | Not yet recruiting | Southern College of Optometry | 41 | 2026-10-26 | 2026-10-28 |
| Contact Lens-Wearing Dry Eye Subjects Who Are Treated With Acoltremon 0.003% acoltremon 0.003% - Dry Eye, Contact Lens Discomfort | Phase 4 | Not yet recruiting | Eye Research Associates, LLC | 50 | 2026-10-10 | 2026-10-08 |
| Switching From Preserved Glaucoma Therapy to Preservative-Free ZOLYMBUS preservative free ZOLYMBUS™ 0.01%. - Eye Drops Self-instillation, Glaucoma | Phase 4 | Not yet recruiting | Southern College of Optometry | 40 | 2026-10-05 | 2026-09-28 |
| Effect of Acoltremon Ophthalmic Solution 0.003% on Tear Production and Symptoms in Patients With Tear Deficiency and Concurrent Neuropathic Corneal Pain acoltremon ophthalmic solution 0.003% - Ocular Pain, Dry Eye | Phase 4 | Not yet recruiting | University of South Florida | 28 | 2026-10-01 | 2026-10-06 |
| Temporary Tear Duct Filling With Hyaluronic Acid Gel and Assessment of Dry Eye Disease (DED) After Bilateral Cataract Surgery LACRIFILL® Canalicular Gel administration, Sham lacrimal canalicular procedure - Dry Eye, Dry Eye Disease (DED) | Phase 4 | Not yet recruiting | Medical University of Vienna | 25 | 2026-09-15 | 2026-09-09 |
| Evaluation of Lacrifill Lacrifill, Saline - Dry Eye, Ocular Surface Disease | Phase 4 | Recruiting | Eye Research Associates, LLC | 40 | 2026-09-02 | 2026-09-25 |
| BL-RX01-TFSTAB-1402 Determine the ability of the iTrace™, BOSA™, OPD-Scan III, and IDRA to detect tear film stability utilizing Miebo® - Dry Eye | Phase 4 | Recruiting | Vance Thompson Vision | 20 | 2026-08-01 | 2026-08-27 |
| Perfluorohexyloctane Eye Drops vs. Sodium Hyaluronate for Video Display Terminal-Associated Dry Eye 0.1% Sodium Hyaluronate Eye Drops, Perfluorohexyloctane Eye Drops (PFHO) - Dry Eye | Phase 4 | Not yet recruiting | Beijing Tongren Hospital | 159 | 2026-06-30 | 2026-07-01 |
| A Single Center, Open-Label Study to Evaluate the Ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to Detect Tear Film Stability Utilizing Miebo® Determine the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo® - Dry Eye | Phase 4 | Active not recruiting | The Eye Care Institute | 20 | 2026-06-26 | 2026-07-29 |
| Vevye + Flarex Combination Therapy for Dry Eye Vevye(Cyclosporine 0.1% Ophthalmic Solution), Flarex - Dry Eye | Phase 4 | Enrolling by invitation | Canyon City Eyecare | 60 | 2026-04-03 | 2026-04-28 |
| Clinical Evaluation of Lifitegrast Ophthalmic Solution 5.0% in Dry Eye Disease Using In Vivo Confocal Microscopy Lifitegrast Ophthalmic Solution 5.0% (Xiidra) - Dry Eye | Phase 4 | Not yet recruiting | Toyos Clinic | 30 | 2026-04-01 | 2026-05-01 |
| Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment Varenicline 0.03Mg/Spray Nasal Soln - Dry Eye, Meibomian Gland Dysfunction | Phase 4 | Recruiting | University of California, Berkeley | 65 | 2026-03-06 | 2026-05-27 |
| Switching From Xiidra to TRYPTYR acoltremon 0.003% - Dry Eye, Dry Eyes Chronic | Phase 4 | Not yet recruiting | Southern College of Optometry | 100 | 2025-12-15 | 2025-12-05 |
| Single-Arm Study of a Treatment for Dry Eye in People Who Struggle to Wear Contact Lenses Lacrifill - Dry Eye | Phase 4 | Recruiting | Vision Innovation Centers of Pennsylvania, LLC d/b/a Eye Care Specialists | 30 | 2025-12-12 | 2026-04-03 |
| Switching From Restasis to TRYPTYR acoltremon 0.003% - Dry Eye, Eye Diseases | Phase 4 | Not yet recruiting | Southern College of Optometry | 100 | 2025-12-01 | 2025-12-05 |
| Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work Acoltremon - Dry Eye, Eye Diseases | Phase 4 | Recruiting | Southern College of Optometry | 40 | 2025-11-01 | 2025-12-05 |
| Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK Kera Sol Eye Drops - Dry Eye | Phase 4 | Recruiting | Vance Thompson Vision | 60 | 2025-08-01 | 2026-07-13 |
| Quality of Life in Presbyopic Patients Who Are Treated With Qlosi pilocarpine HCL ophthalmic solution - Presbyopia, Glasses | Phase 4 | Recruiting | Southern College of Optometry | 36 | 2025-07-18 | 2025-08-12 |
| A Study to Evaluate Concomitant Perfluorohexyloctane Use With Contact Lens Wear Perfluorohexyloctane ophthalmic solution - Dry Eye | Phase 4 | Completed | Bausch & Lomb Incorporated | 104 | 2025-07-02 | 2025-12-18 |
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Dry Eye Syndromes (107) · Cataract (4) · Eye Diseases (3) · Glaucoma (3) · Meibomian Gland Dysfunction (3) · Insulin Resistance (2) · Keratoconjunctivitis Sicca (2) · Sjogren's Syndrome (2) · Anxiety Disorders (1) · Autoimmune Diseases (1) · Breast Neoplasms (1) · Corneal Diseases (1) · Depression (1) · Diabetes Mellitus (1) · Eye Pain (1)
Lacrimal Apparatus Diseases (107) · Eye Diseases (104) · Immune System Diseases (4) · Lens Diseases (4) · Conjunctival Diseases (3) · Corneal Diseases (3) · Eyelid Diseases (3) · Glucose Metabolism Disorders (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Ocular Hypertension (3) · Skin and Connective Tissue Diseases (3) · Arthritis (2) · Arthritis, Rheumatoid (2) · Autoimmune Diseases (2)
Cyclosporins (10) · Ophthalmic Solutions (9) · lifitegrast (9) · Lubricant Eye Drops (7) · Calcium Dobesilate (4) · Cyclosporine (4) · Hyaluronic Acid (4) · perfluorohexyl-octan (4) · Insulin (3) · Sodium Chloride (3) · Punctal Plugs (2) · Standard of Care (2) · Varenicline (2) · Azithromycin (1) · Carboxymethylcellulose Sodium (1)
Innovative Medical (10) · Southern College of Optometry (7) · Alcon Research (5) · University of Alabama at Birmingham (5) · Bausch & Lomb Incorporated (4) · Toyos Clinic (4) · Research Insight LLC (3) · University of California, Berkeley (3) · Barbara Burgos Blasco (2) · Center for Ophthalmic and Vision Research, LLC (2) · Eye Research Associates, LLC (2) · Medical University of Vienna (2) · Oyster Point Pharma, Inc. (2) · Peking University Third Hospital (2) · Scripps Poway Eyecare and Optometry (2)
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John Hovanesian, MD (3) · Barbara Burgos Blasco, MD, PhD (2) · Hong Qi (2) · Jay Mashouf, OD (2) · Lyndon Jones, PhD, FCOptom (2) · Pedram Hamrah, MD (2) · Ana Hervas Ontiveros, Dr (1) · Andrew Hopkinson, PhD (1) · Barry Schechter, MD (1) · Christopher Starr, MD (1) · Dan Terveen, MD (1) · Daniel S. Durrie, MD (1) · Danielle Iacono, OD (1) · David Hardten, MD (1)
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