43 completed, 12 unknown, 5 terminated, 3 recruiting. 20 Not applicable, 15 Phase 2, 11 Phase 3, 11 Phase 4, 2 Phase 1.
Follow Blepharitis: new trials by email Literature Review of Blepharitis trials Research Report on Blepharitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 2 Study to Compare Efficacy and Safety of a Novel Topical Therapy (APT-001, Spinosad 1.8%) in Patients With Blepharitis APT-001 topical ophthalmic ointment (spinosad), Placebo control for APT-001 topical ophthalmic ointment - Blepharitis | Phase 2 | Not yet recruiting | Aperta Biosciences, LLC | 15 | 2026-12-01 | 2026-10-30 |
| Demodex Blepharitis in Scleral Lens Wearers Xdemvy - Demodex Blepharitis | Phase 4 | Completed | Boston Sight | 6 | 2026-04-27 | 2026-10-22 |
| A Phase 2, Controlled, Double Blind, Randomized and Multicenter Study to Compare Efficacy and Safety of a Novel Topical Therapy (APT-001, Spinosad 1.8%) in Patients With Blepharitis. APT-001 topical ophthalmic ointment (spinosad), Vehicle control for APT-001 topical ophthalmic ointment - Blepharitis | Phase 2 | Completed | Aperta Biosciences, LLC | 66 | 2025-11-01 | 2026-10-27 |
| Performance and Safety of IRIDIUM GARZE in Blepharitis or Blepharconjunctivitis Adjuvant Treatment IRIDIUM GARZE - Blepharitis, Blepharoconjunctivitis | Not applicable | Completed | Fidia Farmaceutici s.p.a. | 80 | 2025-09-17 | 2026-09-25 |
| Study of the Safety and Efficacy of Moxidectin Tablets for the Reduction of Demodex Eyelash Infestation Moxidectin 2 MG Oral Tablet, Placebo - Blepharitis | Phase 4 | Completed | Eye Research Foundation, Inc. | 24 | 2025-02-02 | 2025-08-12 |
| Treatment of Blepharitis Induced by Demodex Folliculorum Through Eyelid Cleansing With Wipes Containing Topical Chlorhexidine Eyelid Cleansing with Wipes Containing Topical Chlorhexidine - Blepharitis | Phase 4 | Completed | Instituto de Oftalmología Fundación Conde de Valenciana | 39 | 2024-07-01 | 2026-07-08 |
| Photobiomodulation With REd vs BluE Light (REBEL) Red LLLT, Blue LLLT, Sham Red LLLT - Dry Eye Syndromes, Meibomian Gland Dysfunction | Not applicable | Recruiting | Aston University | 36 | 2024-05-01 | 2026-01-21 |
| A Phase 3 Study to Evaluate the Efficacy and Safety of Pimecrolimus 0.3% Ophthalmic Ointment Pimecrolimus 0.3% Ophthalmic Ointment, Placebo Ophthalmic Ointment - Blepharitis | Phase 3 | Terminated | Famy Life Sciences, a Viatris Company | 477 | 2024-04-22 | 2026-01-07 |
| BroadBand Light for the Treatment of Dry Eye Disease Broadband Light treatment, Sham broadband light treatment - Dry Eye Syndromes, Meibomian Gland Dysfunction | Not applicable | Unknown | University of Southern California | 60 | 2024-02-01 | 2023-12-18 |
| A Usability Study of iTEAR100 For Combined EyeLid Microblepharoexfoliation and Neurostimulation iLIDS100 - MicroBlepharoexfoliation, NuLids, iTEAR100, iLIDS100, Blepharitis, Dry Eye Syndrome | Phase 1 | Unknown | Olympic Ophthalmics, Inc. | 200 | 2024-01-19 | 2024-02-01 |
| Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening - Artifical Intelligence, Cataract | Recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 3000 | 2023-12-12 | 2026-06-09 | |
| Effect of an Exploratory Vehicle on Meibomian Gland Dysfunction in Patients With Demodex Vehicle of TP-03 - Meibomian Gland Dysfunction, Demodex Infestation of Eyelid | Phase 2 | Unknown | Tarsus Pharmaceuticals, Inc. | 36 | 2023-08-01 | 2024-04-09 |
| Comparison Between Continuous and Pulsed Oral Doxycycline Treatment Protocols for Refractory Meibomian Gland Dysfunction Doxycyclin - Meibomian Gland Dysfunction, Blepharitis | Completed | University of Milan | 65 | 2023-03-01 | 2024-07-25 | |
| Sterile Plant-Based Gauze for Eyelid Hygiene in Anterior Blepharitis Plant-Based Sterile Eyelid Gauze, Sterile Cotton Gauze Moistened with Saline Solution - Blepharitis | Not applicable | Completed | Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona | 38 | 2023-02-02 | 2026-08-12 |
| Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study Lotilaner, Vehicle Control - Blepharitis | Phase 3 | Completed | LianBio LLC | 163 | 2022-10-23 | 2024-05-21 |
| Pilot Study Comparing the Safety and Efficacy of Two Dosing Regimens of TP-03 for the Treatment of MGD TP-03, TP-03 Vehicle - Meibomian Gland Dysfunction, Blepharitis | Phase 2 | Completed | Tarsus Pharmaceuticals, Inc. | 39 | 2022-08-03 | 2025-10-01 |
| 0.01% Hypochlorous Acid in the Treatment of Blepharitis 0.01% hypochlorous acid, Placebo - Blepharitis | Not applicable | Unknown | Eye & ENT Hospital of Fudan University | 100 | 2022-07-01 | 2022-11-08 |
| Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Maskin Probe - Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses | Not applicable | Unknown | Massachusetts Eye and Ear Infirmary | 30 | 2021-12-01 | 2021-12-06 |
| Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye LipiFlow Thermal pulsation system, Eyelid warm compresses plus massages - Meibomian Gland Dysfunction, Cataract | Not applicable | Completed | Azienda Ospedaliero-Universitaria Careggi | 46 | 2021-09-07 | 2022-07-21 |
| Trial to Evaluate the Safety and Efficacy of TP-03 for the Treatment of Demodex Blepharitis TP-03, TP-03 Vehicle - Blepharitis | Phase 3 | Completed | Tarsus Pharmaceuticals, Inc. | 412 | 2021-04-29 | 2023-12-21 |
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Meibomian Gland Dysfunction (16) · Dry Eye Syndromes (11) · Conjunctivitis (5) · Keratitis (4) · Meibomitis (4) · Corneal Diseases (3) · Cataract (2) · Xerophthalmia (2) · Conjunctivitis, Bacterial (1) · Dacryocystitis (1) · Dyslipidemias (1) · Ectropion (1) · Entropion (1) · Exophthalmos (1)
Eyelid Diseases (65) · Eye Diseases (64) · Lacrimal Apparatus Diseases (14) · Conjunctival Diseases (8) · Pathological Conditions, Signs and Symptoms (5) · Corneal Diseases (4) · Infections (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Dry Eye Syndromes (2) · Eye Infections (2) · Eye Infections, Bacterial (2)
Azithromycin (10) · Dexamethasone (3) · Doxycycline (3) · Loteprednol Etabonate (3) · Intense Pulsed Light Therapy (2) · Moxifloxacin (2) · Tea Tree Oil (2) · Tobramycin (2) · Tobramycin, Dexamethasone Drug Combination (2) · spinosad (2) · 22,23-dihydroavermectin B(1)a (1) · Capsules (1) · Control Groups (1) · Erythromycin (1) · Fluticasone (1)
Merck Sharp & Dohme LLC (7) · Tarsus Pharmaceuticals, Inc. (4) · Alcon Research (2) · Aperta Biosciences, LLC (2) · Federal University of São Paulo (2) · Massachusetts Eye and Ear Infirmary (2) · National Taiwan University Hospital (2) · Nicox Ophthalmics, Inc. (2) · University of Texas Southwestern Medical Center (2) · Adapt Produtos Oftalmológicos Ltda. (1) · Aston University (1) · Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona (1) · Azienda Ospedaliero-Universitaria Careggi (1) · Bausch & Lomb Incorporated (1) · BioTissue Holdings, Inc (1)
United States (35) · Italy (5) · Brazil (3) · China (3) · United Kingdom (3) · France (2) · Guatemala (2) · Singapore (2) · Taiwan (2) · Canada (1) · Colombia (1) · Germany (1) · Mexico (1) · New Zealand (1) · Spain (1)
Reza Haque, MD (3) · Josue Moran, Ph.D. (2) · Nicox Ophthalmics (2) · Ahmad M Fahmy, OD (1) · Alejandra Rodriguez, MSc, PhD (1) · Charles Johnson, MBChB (1) · Chia-Yu Chu, M.D., Ph.D. (1) · Christy Stevens, OD, MPH (1) · Damien Goldberg, MD (1) · Daniel Brocks, MD (1) · David W. Stroman, Ph.D. (1) · David Wirta, MD (1) · Esther Chu (1) · Gary N Foulks, MD (1)
PMID 35965392, PMID 37285925, PMID 11097583, PMID 11311627, PMID 17216074, PMID 20489573, PMID 20689407, PMID 20712970, PMID 21138337, PMID 21398284, PMID 22256909, PMID 22527308, PMID 22668581, PMID 23748846, PMID 24470662, PMID 25902082, PMID 26989003, PMID 27345733, PMID 27399954, PMID 27519147, PMID 27698616, PMID 28902017, PMID 29325546, PMID 29688838, PMID 30120003, PMID 30481814, PMID 30950926, PMID 31125783, PMID 31612399, PMID 31806355, PMID 32059038, PMID 32182637, PMID 32188437, PMID 32589270, PMID 32617914, PMID 32885484, PMID 33182758, PMID 33226501, PMID 33972176, PMID 34743107, PMID 36729441, PMID 36875531, PMID 37272680
2009 (1), R44EY019586 (1)