71 completed, 14 unknown, 7 terminated, 3 active not recruiting. 34 Not applicable, 33 Phase 4, 20 Phase 2, 17 Phase 3, 6 Phase 1.
Follow Lubricant Eye Drops: new trials by email Literature Review of Lubricant Eye Drops trials Research Report on Lubricant Eye Drops
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial Baduanjin, Laughter exercise, Artificial tears - Dry Eye Disease (DED) | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 540 | 2027-01-01 | 2026-04-13 |
| Evaluation of Ophtholic Ultra for Ocular Surface Protection After Cataract Surgery Ophtholic Ultra, Standard postoperative therapy without lubricating eye drops - Dry Eye Disease (DED) | Phase 4 | Active not recruiting | Kazakh Eye Research Institute | 60 | 2026-08-24 | 2026-10-09 |
| Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular Hypertension Netarsudil Ophthalmic Solution (Rhopressa), Artificial Tears (AT) - Glaucoma, Ocular Hypertension | Phase 4 | Recruiting | Indiana University | 50 | 2026-06-05 | 2026-06-11 |
| Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection Hypoallergenic Eyelid Taping, Hypoallergenic Eyelid Taping With Lubricant Eye Drops - Corneal Injury, Exposure Keratopathy | Not applicable | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 200 | 2026-06-01 | 2026-05-07 |
| Surabgene Lomparvovec Administered in the Suprachoroidal Space in Adult Participants With Diabetic Retinopathy Without Center-Involved Diabetic Macular Edema Surabgene Lomparvovec, Sham, Topical Steroid - Diabetic Retinopathy | Phase 2 / Phase 3 | Recruiting | AbbVie | 576 | 2026-06-01 | 2026-10-16 |
| 0.01% and 0.025% Atropine Eye Drops Combined Auricular Acupoint Stimulation on Myopia Control and Corneal Endothelium Change Auricular acupoint stimulation, 0.01% concentration atropine drops, 0.025% atropine eye drops - Acupressure | Not applicable | Enrolling by invitation | China Medical University Hospital | 420 | 2026-04-11 | 2026-06-04 |
| A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease BRM421 Ophthalmic Solution, 0.03%, Artificial Tear, BRM421 Ophthalmic Solution, 0.06% - Dry Eye Disease (DED), Keratoconjunctivitis Sicca | Phase 2 | Not yet recruiting | BRIM Biotechnology Inc. | 99 | 2025-12-01 | 2025-10-20 |
| Effect of Rhopressa on Intraocular Pressure (IOP) in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension Post-SLT Netarsudil ophthalmic solution 0.02%, Artificial tears - Primary Open Angle Glaucoma or Ocular Hypertension | Phase 4 | Active not recruiting | East Coast Institute for Research | 70 | 2025-06-27 | 2026-06-10 |
| Topical Insulin for Ocular Surface Interface in Dry Eye Disease Artificial tear, insulin human - Dry Eye, Insulin Sensitivity | Phase 4 | Completed | Khyber Teaching Hospital | 128 | 2025-04-14 | 2026-08-14 |
| Evaluation of the Effectiveness of Auricular Acupuncture in Improving Dry Eye Symptoms in University Students Auricular acupuncture, Sham auricular acupuncture, Artificial Tears (AT) - Dry Eye Symptoms | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 50 | 2025-03-15 | 2025-09-24 |
| A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes 0.003% AR-15512 ophthalmic solution, Artificial tears - Dry Eye Disease | Phase 3 | Completed | Alcon Research | 55 | 2025-01-15 | 2026-03-17 |
| The Effect of Eye Care With Artificial Tears and Normal Saline on Ocular Surface Disease in Mechanically Ventilated Pediatric Patients Eye Care with Artificial Tears, Eye Care with Normal Saline - Ocular Surface Disease | Not applicable | Completed | Marmara University | 42 | 2024-11-01 | 2025-06-03 |
| A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease 0.003% AR-15512 ophthalmic solution, Artificial Tears - Dry Eye Disease | Phase 3 | Completed | Alcon Research | 80 | 2024-10-08 | 2026-03-27 |
| Treating Meibomian Gland Disease in a Pediatric Population Low level light treatment, warm compress and artificial tear - Dry Eye Disease, Meibomian Gland Disease | Not applicable | Enrolling by invitation | Illinois College of Optometry | 15 | 2024-10-01 | 2025-11-14 |
| Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye Pilocarpine, artificial tears - Dry Eye Disease (DED) | Not applicable | Completed | Al-Azhar University | 40 | 2024-10-01 | 2024-12-30 |
| A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression Mirvetuximab Soravtansine, Lubricating Eye Drops, Prednisolone acetate ophthalmic suspension 1% eye drops - Recurrent Ovarian Cancer, Folate Receptor-Alpha Positive | Phase 2 | Active not recruiting | AbbVie | 108 | 2024-07-29 | 2026-08-21 |
| Traditional Chinese Medicine Ultrasonic Atomization Treatment for Dry Eye Disease TCM ultrasonic atomization treatment with herbal Compound Decoction (CD), TCM ultrasonic atomization treatment with Dendrobii Caulis (DC), TCM ultrasonic atomization treatment with Houttuynia Cordata (HC) - Dry Eye Syndromes | Not applicable | Completed | Chinese University of Hong Kong | 200 | 2024-07-28 | 2026-03-19 |
| YM-101 Eye Drops in the Treatment of Dry Eye Syndrome YM-101 high dose + artificial tear, YM-101 low dose + artificial tear, placebo + artificial tear - Dry Eye | Early Phase 1 | Completed | Eye & ENT Hospital of Fudan University | 30 | 2024-04-23 | 2026-03-16 |
| Medical vs Acupuncture for Dry Eye Artificial tears, Traditional Chinese Medicine Acupuncture - Dry Eye, Acupuncture | Not applicable | Completed | Nadide Koca | 90 | 2024-01-15 | 2025-09-22 |
| Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution NCX 470, Placebo - Open Angle Glaucoma | Phase 2 / Phase 3 | Completed | Nicox Ophthalmics, Inc. | 18 | 2023-12-12 | 2025-09-08 |
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Dry Eye Syndromes (43) · Glaucoma (9) · Ocular Hypertension (7) · Conjunctivitis, Allergic (6) · Glaucoma, Open-Angle (6) · Keratoconjunctivitis Sicca (6) · Conjunctivitis (5) · Pain (5) · Meibomian Gland Dysfunction (4) · Adenoviridae Infections (3) · Cataract (2) · Conjunctivitis, Viral (2) · Corneal Ulcer (2) · Exfoliation Syndrome (2) · Eye Diseases (2)
Alcon Research (8) · Allergan (8) · University Hospital of Patras (4) · Aristotle University Of Thessaloniki (3) · Massachusetts Eye and Ear Infirmary (3) · AbbVie (2) · Barbara Burgos Blasco (2) · Baylor College of Medicine (2) · He Eye Hospital (2) · Peschke GmbH (2) · Wills Eye (2) · Aciex Therapeutics, Inc. (1) · Adapt Produtos Oftalmológicos Ltda. (1) · Al-Azhar University (1) · Alexandria University (1)
United States (53) · Greece (7) · Canada (5) · China (5) · Spain (4) · Turkey (Türkiye) (3) · Belgium (2) · Brazil (2) · Egypt (2) · Ethiopia (2) · Hong Kong (2) · Mexico (2) · Pakistan (2) · Taiwan (2) · United Kingdom (2)
Bala Ambati (2) · Barbara Burgos Blasco, MD, PhD (2) · Emmanuel Eric Pazo (2) · Reza Dana, MD, MPH, MSc (2) · Yvette Viscuso (2) · Ahmad M Fahmy, O.D. (1) · Anastasios GP Konstas, MD, PhD (1) · Bita Esmaeli, MD (1) · Bushra Kanwal, MPO (1) · Buys M Yvonne, MD FRCSC (1) · Carol B Toris, PhD (1)
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