244 completed, 81 unknown, 25 recruiting, 17 terminated. 197 Not applicable, 53 Phase 2, 49 Phase 4, 33 Phase 3, 10 Phase 1.
Follow Eyelid Diseases: new trials by email Literature Review of Eyelid Diseases trials Research Report on Eyelid Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution - Glaucoma, Glaucoma, Open-Angle | Phase 4 | Not yet recruiting | Tulane University | 60 | 2027-11-01 | 2026-10-13 |
| Upneeq vs. Lumify Ptosis Oxymetazoline 0.1% (Upneeq), Brimonidine 0.025% (Lumify) - Acquired Ptosis | Phase 4 | Not yet recruiting | Duke University | 50 | 2026-12-01 | 2026-05-22 |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| Effect of Suture Material on Eyelid Height Stability After Anterior White-Line Advancement for Aponeurotic Ptosis. Anterior white-line advancement using an ABSORBABLE suture (POLYSORB 5-0). RED CODE., Anterior white-line advancement using a NON-ABSORBABLE suture (POLYPROPYLENE 5-0). BLUE CODE. - Blepharoptosis | Not applicable | Not yet recruiting | Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz | 58 | 2026-10-01 | 2026-10-01 |
| Omega-3 Supplementation vs Demodex vs Eyelid Cleanser for Pediatric Chalazia Omega-3 supplement, Warm compress, Standard eyelid cleanser - Pediatric Chalazia | Phase 2 | Not yet recruiting | Jaeb Center for Health Research | 168 | 2026-10-01 | 2026-08-25 |
| Blepharoptosis After Repeated Intravitreal Anti-VEGF Injections: A Prospective Study Repeated intravitreal anti-VEGF injection with eyelid speculum - Blepharoptosis, Age-Related Macular Degeneration | Recruiting | Abdulkadir Küçük | 60 | 2026-09-25 | 2026-10-22 | |
| DaxibotulinumtoxinA for Blepharospasm Botulinum Neurotoxin Type A - Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid | Phase 2 | Recruiting | University of Pennsylvania | 20 | 2026-09-24 | 2026-09-29 |
| A Trial to Evaluate Two Ectropion Preventive Measures Using the Subciliary Approach in Orbital Fracture Surgery. Subciliary Approach, Lateral Canthopexy, Orbicularis Oculi Suspension - Orbital Fractures, Orbital Floor Fractures | Not applicable | Not yet recruiting | Minia University | 30 | 2026-09-01 | 2026-08-20 |
| A Real-Time Magnetic Device Prototype for Temporary Management of Paralytic Lagophthalmos Magnetic device prototype - Paralytic Lagophthalmos | Not applicable | Suspended | E-DA Hospital | 12 | 2026-08-01 | 2025-08-14 |
| TearCare in Young Adults TearCare® - Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-08-01 | 2026-05-11 |
| The Effect of Eyelid Support Plate Assisted Eyelid Massage on Meibomian Gland Dysfunction: a Randomized Controlled Trial eyelid support plate assisted eyelid massage, glass rod assisted eyelid massage - Dry Eye Disease (DED), MGD-Meibomian Gland Dysfunction | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 142 | 2026-07-01 | 2026-06-11 |
| Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction Vevye(Cyclosporine 0.1% Ophthalmic Solution) - Meibomian Gland Dysfunction (MGD) | Phase 4 | Recruiting | University of Alabama at Birmingham | 48 | 2026-06-01 | 2026-06-09 |
| Demodex Blepharitis in Scleral Lens Wearers Xdemvy - Demodex Blepharitis | Phase 4 | Completed | Boston Sight | 6 | 2026-04-27 | 2026-10-22 |
| TearCare MGX™ System With and Without Warming Hold localized heat therapy - Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Sight Sciences, Inc. | 21 | 2026-03-17 | 2026-06-05 |
| Is the Use of a Steam Mask an Effective Treatment for Paediatric Chalazion in Comparison to Traditional Warm Compresses? Steam device, Warm Compress - Chalazion | Not applicable | Recruiting | University of Sheffield | 28 | 2026-03-10 | 2026-07-23 |
| Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment Varenicline 0.03Mg/Spray Nasal Soln - Dry Eye, Meibomian Gland Dysfunction | Phase 4 | Recruiting | University of California, Berkeley | 65 | 2026-03-06 | 2026-05-27 |
| Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction Dietary Supplement: Microbiome-targeted oral supplement, Placebo - Dry Eye, Evaporative Dry Eye Disease | Not applicable | Enrolling by invitation | Varol TUNALI | 130 | 2026-03-01 | 2026-07-28 |
| Blink Reminders and Meibomian Gland Loss in Digital Screen Users Digital Blink Reminder Software (BlinkEasy), Visual Hygiene Education (20-20-20 Rule). - Dry Eye Syndromes, Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | Asociación para Evitar la Ceguera en México | 28 | 2026-02-19 | 2026-02-27 |
| Evaluation of Effectiveness and Safety of Intense Pulsed Light Treatment for Chalazion Sham IPL, Active IPL - Chalazion | Not applicable | Not yet recruiting | Lumenis Be Ltd. | 40 | 2026-02-04 | 2026-02-19 |
| RESTORE: Comparing Two Approaches to Repeat TT Surgery Performed by Integrated Eye Care Workers (IECWs) B-RAP, BLTR - Trachoma, Eye Diseases | Not applicable | Recruiting | University of North Carolina, Chapel Hill | 1000 | 2026-01-13 | 2026-04-13 |
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Meibomian Gland Dysfunction (169) · Dry Eye Syndromes (107) · Blepharoptosis (72) · Blepharitis (62) · Blepharospasm (41) · Chalazion (16) · Entropion (15) · Dystonia (14) · Ectropion (13) · Trichiasis (13) · Torticollis (10) · Cutis Laxa (9) · Lagophthalmos (8) · Eyelid Neoplasms (7)
Eye Diseases (400) · Lacrimal Apparatus Diseases (112) · Pathological Conditions, Signs and Symptoms (49) · Nervous System Diseases (41) · Signs and Symptoms (38) · Neurologic Manifestations (37) · Neoplasms (30) · Skin and Connective Tissue Diseases (26) · Dyskinesias (22) · Skin Diseases (21) · Conjunctival Diseases (18) · Infections (18) · Mouth Diseases (18) · Stomatognathic Diseases (18)
Azithromycin (14) · Botulinum Toxins, Type A (13) · Intense Pulsed Light Therapy (12) · Lubricant Eye Drops (7) · Brimonidine Tartrate (5) · Doxycycline (5) · Ophthalmic Solutions (5) · Dexamethasone (4) · Lidocaine (4) · Loteprednol Etabonate (4) · Low-Level Light Therapy (4) · Saline Solution (4) · Sodium Chloride (4) · Therapeutics (4) · incobotulinumtoxinA (4)
Benha University (9) · Lumenis Be Ltd. (8) · National Institute of Neurological Disorders and Stroke (NINDS) (8) · Alcon Research (7) · Massachusetts Eye and Ear Infirmary (7) · Merck Sharp & Dohme LLC (7) · Second Affiliated Hospital, Zhejiang University, School of Medicine (7) · University of Miami (7) · Chulalongkorn University (6) · Laboratoires Thea (6) · Allergan (5) · Sheba Medical Center (5) · TearScience, Inc. (5) · University of California, San Francisco (5) · University of the Incarnate Word (5)
United States (161) · China (37) · United Kingdom (19) · Canada (15) · Israel (14) · France (12) · Spain (11) · Germany (10) · Italy (9) · Brazil (8) · Egypt (8) · United Arab Emirates (8) · Ethiopia (7) · South Korea (7) · Thailand (7)
Emily Gower, PhD (4) · James Chelnis, MD (4) · Srihari Narayanan, OD, PhD (4) · Jaime Dickerson, PhD (3) · Reza Haque, MD (3) · Rolando Toyos, MD (3) · Christy Stevens, OD (2) · Ciro Costagliola, Full Professor (2) · David Zadok, MD (2) · James S Wolffsohn, PhD (2) · Louis Tong, PhD (2) · Lyndon Jones, PhD (2) · Mark Hallett, M.D. (2)
PMID 31589610, PMID 21450914, PMID 21450915, PMID 21450918, PMID 22953007, PMID 27096755, PMID 27698616, PMID 31125783, PMID 35965392, PMID 37285925, PMID 11097583, PMID 11311627, PMID 11861988, PMID 12063480, PMID 12786773, PMID 12888056, PMID 12930337, PMID 14762403, PMID 15029042, PMID 15871316, PMID 15878075, PMID 16534049, PMID 17106406, PMID 17172891, PMID 17216074, PMID 17394642, PMID 18040708, PMID 18412605, PMID 19085290, PMID 19458801, PMID 19668387, PMID 19744718, PMID 19794937, PMID 19901217, PMID 19941140, PMID 20126486, PMID 20489573, PMID 20689407, PMID 20712970, PMID 21051704, PMID 21138337, PMID 21257145, PMID 21398284, PMID 21450917, PMID 21520284, PMID 21993469, PMID 22159169, PMID 22180731, PMID 22180732, PMID 22256909
1UG1EY036891 (1), 2009 (1), 2015 (1), 2019 (1), R01EY029437 (1), R44EY019586 (1), U54TR001456 (1), UG1EY025992 (1), UG1EY025992-04S1 (1)