17 completed, 4 unknown, 3 terminated, 2 not yet recruiting. 26 Phase 1, 13 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 26 | Completed 17, Unknown 4, Terminated 3, Not yet recruiting 2 |
| Phase 2 | 13 | Completed 8, Terminated 3, Unknown 2 |
Follow Dry Eye: new trials by email Literature Review of Dry Eye trials Research Report on Dry Eye
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of RC017 Ophthalmic Ointment Following Single and Multiple Doses in Healthy Adult Participants RC017 Ophthalmic Ointment, RC017 Ophthalmic Ointment placebo - Dry Eye | Phase 1 | Not yet recruiting | Nanjing Reju Therapeutics Co., Ltd | 24 | 2026-04-01 | 2026-04-13 |
| Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface. PRO-190, Systane Ultra® - Dry Eye, Dry Eyes Chronic | Phase 1 | Not yet recruiting | Laboratorios Sophia S.A de C.V. | 32 | 2025-12-30 | 2025-03-19 |
| Preliminary Clinical Study of the Effectiveness and Safety of Ocular Surface Microbiota Transplantation in the Treatment of Dry Eye Disease Ocular surface microbiota transplantation, placebo transplantation - Dry Eye | Phase 1 / Phase 2 | Completed | Second Affiliated Hospital of Nanchang University | 30 | 2025-12-26 | 2026-10-16 |
| Comparing Efficacy of Tea Tree Oil Versus Topical Azithromycin in Treating Dry Eye Tea Tree Oil Topical Application Oil, Azithromycin Ophthalmic Solution - Dry Eye | Phase 1 / Phase 2 | Completed | Ehab Mohamed Elsayed Mohamed Saad | 50 | 2025-03-01 | 2026-09-30 |
| RCI001 Eye Drops 0.25% in Healthy Adult Male Participants RCI001 Eye Drops 0.25%, Placebo Eye Drops - Dry Eye | Phase 1 | Completed | Rudacure | 40 | 2024-10-28 | 2026-06-11 |
| Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B punctum plug insertion, Eye Drops, Lubricant - Dry Eye, Keratoconjunctivitis Sicca | Phase 1 | Unknown | Eximore Ltd. | 20 | 2022-09-29 | 2023-09-07 |
| Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease With Meibomian Gland Dysfunction taVNS, Hyaluronic acid eye drops - Dry Eye | Phase 1 / Phase 2 | Unknown | Beijing Tongren Hospital | 135 | 2021-06-01 | 2024-08-09 |
| Clinical Trial to Compare the Safety and Efficacy of Nanodrop® Nanodrop®, Systane Balance - Dry Eye | Phase 1 / Phase 2 | Completed | Laboratorios Sophia S.A de C.V. | 126 | 2020-12-01 | 2025-07-16 |
| Effects of Topical Insulin on Levels of Tear Inflammatory Mediators Topical Insulin - Dry Eye | Phase 1 | Unknown | Universiti Kebangsaan Malaysia Medical Centre | 60 | 2020-10-22 | 2021-05-11 |
| Effect of UMSCs Derived Exosomes on Dry Eye in Patients With cGVHD Umbilical Mesenchymal Stem Cells derived Exosomes - Dry Eye | Phase 1 / Phase 2 | Unknown | Zhongshan Ophthalmic Center, Sun Yat-sen University | 27 | 2020-02-21 | 2022-02-11 |
| Clinical Trial to Evaluate the Safety and Tolerability of Lagricel® Ofteno Multi-dose Ophthalmic Solution lagricel ofteno multidose, lagricel ofteno single dose - Dry Eye | Phase 1 | Completed | Laboratorios Sophia S.A de C.V. | 34 | 2019-09-09 | 2021-05-03 |
| IVIG-eye Drops Treatment for Dry Eye Disease Intravenous Immune Globulin (IVIG), Placebo - Dry Eye | Phase 1 / Phase 2 | Completed | Sandeep Jain, MD | 27 | 2019-05-01 | 2020-04-10 |
| Efficacy and Safety of Ocudox Lid Wipes Compared to Traditional Lid Cleaning Eyelid cleaning - Dry Eye | Phase 1 | Completed | Singapore National Eye Centre | 7 | 2018-10-01 | 2019-05-13 |
| Topical Fibrinogen-Depleted Human Platelet Lysate in Patients With Dry Eye Secondary to Graft vs. Host Disease CAM-101 10%, Vehicle Control, CAM-101 30% - Dry Eye, Graft-versus-host-disease | Phase 1 / Phase 2 | Completed | Cambium Bio Limited | 64 | 2018-05-01 | 2026-06-12 |
| Safety and Tolerability of the Ophthalmic Gel PRO-167 Versus Corneregel® on Healthy Subjects. PRO-167, Corneregel - Dry Eye, Dry Eye Syndrome of Unspecified Lacrimal Gland | Phase 1 | Completed | Laboratorios Sophia S.A de C.V. | 24 | 2017-10-04 | 2019-07-19 |
| Lacripep™ in Subjects With Dry Eye Associated With Primary Sjögren's Syndrome 0.005% Lacripep, 0.01% Lacripep, Placebo - Primary Sjögren Syndrome, Dry Eye | Phase 1 / Phase 2 | Completed | TearSolutions, Inc. | 204 | 2017-06-30 | 2020-01-22 |
| Brimonidine Eye Drops for Treatment of Ocular Graft-vs-Host Disease (oGVHD) Brimonidine 0.15%, Brimonidine 0.075%, Placebo - Dry Eye, Ocular Graft vs Host Disease | Phase 1 / Phase 2 | Terminated | Sandeep Jain, MD | 15 | 2016-05-01 | 2019-11-08 |
| rhDNase Eye Drops in Patients With Ocular Graft-Vs.-Host Disease rhDNase I, Vehicle - Ocular Graft vs Host Disease, Dry Eye | Phase 1 / Phase 2 | Terminated | University of Illinois at Chicago | 58 | 2016-04-01 | 2021-09-05 |
| Phase 1 Study for Safety and Tolerability of HL036 HL036, Vehicle - Dry Eye | Phase 1 | Completed | HanAll BioPharma Co., Ltd. | 20 | 2016-02-01 | 2016-12-09 |
| DNase Treatment for Dry Eyes DNase, Vehicle - Dry Eye | Phase 1 / Phase 2 | Terminated | University of Illinois at Chicago | 47 | 2014-07-01 | 2020-01-18 |
Showing 20 of 26. Sign in to see all of them.
Dry Eye Syndromes (26) · Eye Pain (1) · Graft vs Host Disease (1) · Keratoconjunctivitis Sicca (1) · Meibomian Gland Dysfunction (1) · Sjogren's Syndrome (1)
Eye Diseases (26) · Lacrimal Apparatus Diseases (26) · Immune System Diseases (2) · Arthritis (1) · Arthritis, Rheumatoid (1) · Autoimmune Diseases (1) · Conjunctival Diseases (1) · Conjunctivitis (1) · Connective Tissue Diseases (1) · Corneal Diseases (1) · Eye Manifestations (1) · Eyelid Diseases (1) · Joint Diseases (1) · Keratitis (1) · Keratoconjunctivitis (1)
Lubricant Eye Drops (2) · dornase alfa (2) · Brimonidine Tartrate (1) · Deoxyribonucleases (1) · Dexamethasone (1) · Immunoglobulins, Intravenous (1) · Insulin (1) · Ophthalmic Solutions (1) · Propylene Glycol (1) · Ruthenium-101 (1) · Tobramycin (1) · dexpanthenol (1)
Laboratorios Sophia S.A de C.V. (4) · Sandeep Jain, MD (2) · University of Illinois at Chicago (2) · Alcon Research (1) · Beijing Tongren Hospital (1) · Cambium Bio Limited (1) · Ehab Mohamed Elsayed Mohamed Saad (1) · Eleven Biotherapeutics (1) · Eximore Ltd. (1) · HanAll BioPharma Co., Ltd. (1) · Laurantis Pharma, Ltd. (1) · Nanjing Reju Therapeutics Co., Ltd (1) · R-Tech Ueno, Ltd. (1) · Rudacure (1) · Santen Inc. (1)
United States (10) · Mexico (4) · China (3) · South Korea (2) · Egypt (1) · Finland (1) · Malaysia (1) · Singapore (1) · Spain (1)
Sandeep Jain, MD (4) · Belen Sadaba, MD, PhD (1) · Edmund K Waller, MD PhD (1) · John Sheppard, MD (1) · Kai Kaarniranta, Professor (1) · Louis Tong, PhD (1) · Mae-Lynn C. Bastion (1) · Marc Odrich, MD (1) · Michael Goldstein, MD (1) · Nallely Ramos Betancourt, Dr. (1) · SeungHwan Lee, M.D., Ph.D. (1) · Xialin Liu, Prof. (1)
PMID 34707360, PMID 15948994, PMID 16021174, PMID 17054241, PMID 22511024, PMID 23169882, PMID 24255046, PMID 24695688, PMID 26783543, PMID 27893109, PMID 37077305, PMID 38407974, PMID 39839752, PMID 42764009
R01EY024966 (1)