104 completed, 37 unknown, 9 withdrawn, 8 recruiting. 104 Not applicable, 19 Phase 2, 17 Phase 4, 5 Phase 3, 2 Phase 1.
Follow Meibomian Gland Dysfunction: new trials by email Literature Review of Meibomian Gland Dysfunction trials Research Report on Meibomian Gland Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| TearCare in Young Adults TearCare® - Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-11-01 | 2026-10-29 |
| Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients Meibomian Gland Dysfunction, Dry Eye Syndromes | Not yet recruiting | Assiut University | 150 | 2026-10-01 | 2026-09-09 | |
| A Multi Center Evaluation of TearCare on Surgical Measurements Before Cataract Surgery Manual expression of meibomian glands after thermal eyelid therapy - Dry Eye Syndrome (DES), Meibomian Gland Dysfunction (Disorder) | Recruiting | Cleveland Eye Clinic | 36 | 2026-09-22 | 2026-11-10 | |
| The Effect of Eyelid Support Plate Assisted Eyelid Massage on Meibomian Gland Dysfunction: a Randomized Controlled Trial eyelid support plate assisted eyelid massage, glass rod assisted eyelid massage - Dry Eye Disease (DED), MGD-Meibomian Gland Dysfunction | Not applicable | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 142 | 2026-07-01 | 2026-06-11 |
| Efficacy of Vevye Ophthalmic Solution for the Treatment of Meibomian Gland Dysfunction Vevye(Cyclosporine 0.1% Ophthalmic Solution) - Meibomian Gland Dysfunction (MGD) | Phase 4 | Recruiting | University of Alabama at Birmingham | 48 | 2026-06-01 | 2026-06-09 |
| TearCare MGX™ System With and Without Warming Hold localized heat therapy - Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Sight Sciences, Inc. | 21 | 2026-03-17 | 2026-11-13 |
| Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment Varenicline 0.03Mg/Spray Nasal Soln - Dry Eye, Meibomian Gland Dysfunction | Phase 4 | Recruiting | University of California, Berkeley | 65 | 2026-03-06 | 2026-05-27 |
| Microbiome-Focused Food Supplement for Evaporative Dry Eye Due to Meibomian Gland Dysfunction Dietary Supplement: Microbiome-targeted oral supplement, Placebo - Dry Eye, Evaporative Dry Eye Disease | Not applicable | Enrolling by invitation | Varol TUNALI | 130 | 2026-03-01 | 2026-11-10 |
| Blink Reminders and Meibomian Gland Loss in Digital Screen Users Digital Blink Reminder Software (BlinkEasy), Visual Hygiene Education (20-20-20 Rule). - Dry Eye Syndromes, Meibomian Gland Dysfunction (Disorder) | Not applicable | Not yet recruiting | Asociación para Evitar la Ceguera en México | 28 | 2026-02-19 | 2026-02-27 |
| Comparing Tear Proteomics Profile in Dry Eye Disease pre-and Post-treatment With Low Level Light Therapy Dry Eye, Meibomian Gland Dysfunction (Disorder) | Recruiting | Singapore National Eye Centre | 30 | 2025-11-05 | 2026-01-09 | |
| Effect of a Dietary Supplement on Gut Microbiota and Ocular Surface Outcomes in Dry Eye Disease Dietary Supplement Product - Dry Eye, Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Varol TUNALI | 20 | 2025-10-01 | 2026-10-06 |
| Autologous Serum Obtained by a Closed-Circuit Collection Device Autologous Serum 20% - GVHD, Meibomian Gland Dysfunction (Disorder) | Phase 2 | Active not recruiting | GIANCARLO FATOBENE | 16 | 2025-06-20 | 2026-10-21 |
| Low Level Light Therapy & Skin Pigmentation Three 15-minute low-level light therapy sessions using Light Emitting Diodes of wavelength 633nm (Essilor epi-c plus). - Dry Eye, Meibomian Gland Dysfunction (Disorder) | Not applicable | Recruiting | University of Houston | 40 | 2025-06-11 | 2025-09-15 |
| Effectiveness of Low Level Light Therapy and Intense Pulse Light on Mite Count as Adjuntive Therapies in Demodex Blepharitis Using Artificial Intelligent Program (Ai-Demodex) The blue MY MASK-E, IPL, Mechanical with pharmacological treatment - Demodex Blepharitis, Meibomian Gland Dysfunction (MGD) | Not applicable | Completed | Chulalongkorn University | 88 | 2025-02-01 | 2026-07-13 |
| Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Cataract Surgery Low-Level Light Therapy, Sham (No Treatment) - Dry Eye, Meibomian Gland Dysfunction (Disorder) | Not applicable | Completed | Grigore T. Popa University of Medicine and Pharmacy | 98 | 2025-01-08 | 2026-01-02 |
| Comparative Effects of USB-Powered Warm Compress and Self-Heating Eye Mask in the Management of Meibomian Gland Dysfunction USB-Powered Warm Compress, Self-Heating Eye Mask - Dry Eye, MGD-Meibomian Gland Dysfunction | Not applicable | Completed | King Saud University | 15 | 2025-01-05 | 2026-06-01 |
| Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye I-DROP MGD, Theloze Duo, Systane Complete PF - Evaporative Dry Eye Disease | Phase 4 | Not yet recruiting | I-MED Pharma | 60 | 2024-11-15 | 2024-11-13 |
| Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD The Thermage FLX System, Sham treatment - Dry Eye Syndromes, Meibomian Gland Dysfunction | Not applicable | Recruiting | The University of Hong Kong | 112 | 2024-10-22 | 2026-11-09 |
| The Effect of Gland Expression on the Regeneration of Meibomian Gland Meibomian gland expression (MGX) - Meibomian Gland Dysfunction | Not applicable | Completed | Chulalongkorn University | 64 | 2024-10-03 | 2025-03-17 |
| Efficacy of Adjunctive Low-Level Light Therapy to Intense Pulsed Light for Meibomian Gland Dysfunction Low-level light therapy (LLLT), Intense pulsed light (IPL) - MGD-Meibomian Gland Dysfunction | Not applicable | Unknown | Chulalongkorn University | 58 | 2024-10-02 | 2024-11-05 |
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Dry Eye Syndromes (97) · Blepharitis (14) · Cataract (4) · Sjogren's Syndrome (4) · Eyelid Diseases (3) · Rosacea (3) · Lacerations (2) · Meibomitis (2) · Stevens-Johnson Syndrome (2) · cyclopia sequence (2) · Acanthamoeba Keratitis (1) · Acne Vulgaris (1) · Aniridia (1) · Arthritis, Psoriatic (1)
Eye Diseases (169) · Eyelid Diseases (167) · Lacrimal Apparatus Diseases (97) · Skin and Connective Tissue Diseases (11) · Skin Diseases (8) · Immune System Diseases (7) · Mouth Diseases (6) · Stomatognathic Diseases (6) · Connective Tissue Diseases (5) · Arthritis (4) · Autoimmune Diseases (4) · Joint Diseases (4) · Lens Diseases (4) · Musculoskeletal Diseases (4) · Rheumatic Diseases (4)
Intense Pulsed Light Therapy (12) · Azithromycin (4) · Doxycycline (4) · Low-Level Light Therapy (4) · Lubricant Eye Drops (4) · Therapeutics (4) · Dextrans (2) · Loteprednol Etabonate (2) · Ophthalmic Solutions (2) · carbomer (2) · Brimonidine Tartrate (1) · Calcium Dobesilate (1) · Cataract Extraction (1) · Control Groups (1) · Cyclosporins (1)
Chulalongkorn University (5) · Lumenis Be Ltd. (5) · University of the Incarnate Word (5) · Yonsei University (5) · Aston University (4) · Azura Ophthalmics (4) · Alcon Research (3) · Laboratoires Thea (3) · Sight Sciences, Inc. (3) · Singapore National Eye Centre (3) · Tear Film Innovations, Inc. (3) · University of Alabama at Birmingham (3) · Zhongnan Hospital (3) · Zhongshan Ophthalmic Center, Sun Yat-sen University (3) · Chinese University of Hong Kong (2)
United States (63) · China (18) · Spain (7) · Canada (6) · Thailand (6) · United Kingdom (6) · Australia (4) · Austria (4) · France (4) · Israel (4) · South Korea (4) · Turkey (Türkiye) (4) · Hong Kong (3) · New Zealand (3) · Singapore (3)
Srihari Narayanan, OD, PhD (4) · Jaime Dickerson, PhD (3) · Rolando Toyos, MD (3) · David Zadok, MD (2) · James S Wolffsohn, PhD (2) · Louis Tong, PhD (2) · Lyndon Jones, PhD (2) · Reza Dana, MD, MPH, MSc (2) · Thomas Chester, OD (2) · Alejandra Rodriguez, MSc, PhD (1) · Ana Hervas Ontiveros, Dr (1) · Ana Mercedes Garcia Albisua, MD (1)
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