417 completed, 70 recruiting, 59 terminated, 45 unknown. 652 Phase 2, 71 Phase 3, 70 Phase 1.
Follow Depressive Disorder: new trials by email Literature Review of Depressive Disorder trials Research Report on Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder | Phase 1 / Phase 2 | Not yet recruiting | BioLite, Inc. | 12 | 2027-01-15 | 2026-04-20 |
| Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression | Phase 2 | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-01 | 2026-10-26 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| A Randomized, Double-Blind Controlled Comparison of NRX-101 vs. Placebo for Adults Being Treated With Robotic Transcranial Magnetic Stimulation for Treatment Resistant Depression: The SPARC-TMS Trial Neuronavigated robotic-enabled TMS, NRX-101, Sham TMS - Treatment Resistant Depression, Treatment Resistant Depression (TRD) | Phase 2 / Phase 3 | Recruiting | NeuroRx, Inc. | 240 | 2026-12-01 | 2026-10-21 |
| A Mechanistic Study to Assess a Single Dose of CYB003 in Participants With Depression and Anxiety CYB003, Placebo - Depression, Anxiety | Phase 2 | Recruiting | Ohio State University | 40 | 2026-11-01 | 2026-10-20 |
| A Study to Evaluate BMS-986511 in Adults With Major Depressive Disorder BMS-986511, Placebo - Major Depressive Disorder | Phase 2 | Not yet recruiting | Bristol-Myers Squibb | 200 | 2026-10-30 | 2026-09-04 |
| Oral Thiamine (Vitamin B1) for Depression in Children and Adolescents thiamine hydrochloride 100 mg - Major Depressive Disorder (MDD), Thiamine | Phase 2 | Not yet recruiting | Massachusetts General Hospital | 40 | 2026-10-01 | 2026-08-28 |
| The BAARD Study : Evaluating a Computerized Approach to Treatment Selection in Older Adults With Treatment Resistant Depression. Aripiprazole Augmentation, Bupropion Augmentation - Late Life Treatment Resistant Depression, Depression - Major Depressive Disorder | Phase 2 | Not yet recruiting | Washington University School of Medicine | 300 | 2026-10-01 | 2026-10-16 |
| Pregnenolone Treatment for Alcohol Use Disorder and Major Depressive Disorder Pregnenolone, Placebo - Alcohol Use Disorder (AUD), Major Depressive Disorder (MDD) | Phase 2 | Not yet recruiting | Sherwood Brown, MD, PhD | 100 | 2026-10-01 | 2026-08-24 |
| Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression Sertraline - Major Depressive Disorder (MDD), Probiotic Intervention | Phase 2 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 120 | 2026-10-01 | 2026-06-12 |
| A Study to Evaluate the Safety and Efficacy of ALKS 7290 as an Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder ALKS 7290 Dose, Placebo - Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Alkermes, Inc. | 180 | 2026-10-01 | 2026-10-28 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 100 | 2026-10-01 | 2026-10-30 |
| Behavioural Activation Therapy and Ketamine for Treatment-Resistant Depression Ketamine (0.5 mg/kg), Behavioural Activation Therapy - Treatment Resistant Depression, Major Depressive Disorder (MDD) | Phase 2 / Phase 3 | Not yet recruiting | The Royal's Institute of Mental Health Research | 60 | 2026-09-01 | 2026-09-03 |
| Precision Depression Adalimumab Trial Adalimumab Biosimilars Injection, Placebo - Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Daniel Moriarity | 60 | 2026-09-01 | 2026-09-29 |
| Pregnenolone for Cannabis Use Disorder and Depression Pregnenolone - Cannabis Use Disorder, Major Depressive Disorder (MDD) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 20 | 2026-09-01 | 2026-07-06 |
| Inhaled DMT for Major Depressive Disorder N,N-Dimethyltryptamine (15 mg + 60 mg), N,N-Dimethyltryptamine (1 mg + 4 mg) - MDD, Major Depressive Disorder (MDD) | Phase 2 | Recruiting | Universidade Federal do Rio Grande do Norte | 140 | 2026-08-01 | 2026-07-13 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
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Depressive Disorder, Major (506) · Depression (253) · Depressive Disorder, Treatment-Resistant (93) · Mood Disorders (43) · Depression, Postpartum (34) · Bipolar Disorder (29) · Anxiety Disorders (27) · Mental Disorders (20) · Dysthymic Disorder (14) · Suicidal Ideation (13) · Alcoholism (12) · Inflammation (12) · Anhedonia (10) · Suicide (9)
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Ketamine (48) · Psilocybin (42) · Escitalopram (24) · Sertraline (18) · Cognitive Behavioral Therapy (14) · Transcranial Direct Current Stimulation (14) · Fluoxetine (13) · Therapeutics (12) · Transcranial Magnetic Stimulation (12) · Venlafaxine Hydrochloride (12) · Bupropion (10) · Citalopram (10) · Vortioxetine (9) · Duloxetine Hydrochloride (8) · Midazolam (8)
National Institute of Mental Health (NIMH) (23) · GlaxoSmithKline (17) · Massachusetts General Hospital (17) · Janssen Research & Development, LLC (16) · Washington University School of Medicine (10) · Alto Neuroscience (8) · H. Lundbeck A/S (8) · Icahn School of Medicine at Mount Sinai (8) · New York State Psychiatric Institute (8) · The University of New South Wales (8) · University of Pittsburgh (8) · AstraZeneca (7) · Centre for Addiction and Mental Health (7) · Otsuka Pharmaceutical Development & Commercialization, Inc. (7) · Shanghai Mental Health Center (7)
United States (395) · Canada (62) · Germany (37) · China (28) · United Kingdom (26) · Australia (25) · Poland (24) · Russia (24) · Bulgaria (18) · Japan (18) · Brazil (16) · Czechia (15) · Spain (14) · Sweden (14) · Belgium (13)
Carlos A Zarate, M.D. (8) · Maurizio Fava, MD (7) · Andre R Brunoni, MD (3) · Ishrat Husain, MBBS, MD (3) · Jessica Harder, MD (3) · Peter Nagele, MD, MSc (3)
PMID 34510411, PMID 23146246, PMID 34817851, PMID 42171126, PMID 22215866, PMID 25150403, PMID 27685842, PMID 28086004, PMID 29111077, PMID 30508090, PMID 31270774, PMID 33128208, PMID 33146667, PMID 35092868, PMID 36322843, PMID 37585253, PMID 37651119, PMID 39955416, PMID 40398609, PMID 42304135, PMID 42521762, PMID 10197825, PMID 10990547, PMID 11063978, PMID 11723286, PMID 12113998, PMID 12217271, PMID 12244081, PMID 12949224, PMID 14557145, PMID 14677403, PMID 15147306, PMID 15351385, PMID 15365580, PMID 15580167, PMID 15583115, PMID 15982444, PMID 15987799, PMID 16002441, PMID 16319710, PMID 16390366, PMID 16491981, PMID 16794566, PMID 16894061, PMID 17215046, PMID 17591596, PMID 17690799, PMID 18061147, PMID 18295436, PMID 18314433
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