10 not yet recruiting, 8 completed, 4 recruiting, 2 withdrawn. 27 Phase 2, 4 Phase 3, 3 Phase 1.
Follow Combat Disorders: new trials by email Literature Review of Combat Disorders trials Research Report on Combat Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD Written Exposure Therapy (WET), methylphenidate (MPH), placebo (PBO) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | VA Office of Research and Development | 138 | 2027-07-01 | 2026-10-29 |
| Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | Multidisciplinary Association for Psychedelic Studies | 320 | 2027-02-01 | 2026-08-11 |
| Assessing of Behavioral Risk and Response to Electromagnetic and Psychedelic Therapies Transcranial Magnetic Stimulation, Psilocybin (drug), Neurofeedback - PTSD, PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University of New Mexico | 150 | 2026-12-31 | 2026-10-30 |
| ONE-P TMS Military Veterans D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-20 |
| ONE-P TMS First Responders D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-19 |
| Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder TREATMENT ARM: Full dose, CONTROL ARM: Active-controlled - PTSD, Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | U.S. Army Medical Research and Development Command | 86 | 2026-10-01 | 2026-07-15 |
| Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence Psilocybin - Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV) | Phase 2 | Not yet recruiting | University of Calgary | 76 | 2026-10-01 | 2026-09-08 |
| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder COMP360 psilocybin - PTSD - Post Traumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Recruiting | COMPASS Pathways | 300 | 2026-09-14 | 2026-11-05 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence Propranolol, 120mg, Placebo - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University Hospital, Tours | 34 | 2026-09-01 | 2026-03-05 |
| Initial Study Sesting Efficacy and Tolerability of PT150 for PTSD in Veterans PT150, Placebo - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | San Diego Veterans Healthcare System | 120 | 2026-04-01 | 2025-12-23 |
| Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy - TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2025-10-01 | 2025-10-09 |
| Trifecta Research Study Hormone Replacement Therapy (HRT), Magnetic Resonance Therapy (MeRT), ibogaine with magnesium treatment - PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction | Phase 2 | Withdrawn | Johns Hopkins University | 2025-09-01 | 2025-08-22 | |
| MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents MDMA, Psychotherapy - PTSD, Post Traumatic Stress Disorder, Adolescents | Phase 2 | Withdrawn | University of California, Los Angeles | 2025-07-01 | 2025-04-10 | |
| Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder) Esketamine (Intranasal Spray), Massed Prolonged Exposure (PE) - Post Traumatic Stress Disorder PTSD | Phase 1 / Phase 2 | Completed | The University of Texas Health Science Center at San Antonio | 4 | 2025-06-09 | 2026-01-28 |
| Neuromodulation of the Hippocampus to Reduce Intrusive Re-Experiencing in PTSD: A Randomized Controlled Trial Hippocampal stimulation using repetitive transcranial magnetic stimulation (rTMS), Sham stimulation using repetitive transcranial magnetic stimulation (rTMS) - PTSD - Post Traumatic Stress Disorder, Intrusive Memories of Traumatic Event(s) | Phase 2 | Recruiting | Tel Aviv University | 60 | 2024-11-01 | 2024-11-01 |
| Software as a Medical Device for the Treatment of Patients With PTSD Software as a Medical Device - Post-Traumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Active not recruiting | Otsuka Medical Devices Co., Ltd. Japan | 52 | 2024-09-01 | 2026-10-19 |
| Ketamine Treatment for PTSD and MDD in TBI IV ketamine, Midazolam - PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder | Phase 2 | Not yet recruiting | Minneapolis Veterans Affairs Medical Center | 40 | 2024-03-01 | 2024-01-29 |
| MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD 3,4-methylenedioxymethamphetamine - Post Traumatic Stress Disorder, Combat Stress Disorders | Phase 2 | Completed | VA Loma Linda Health Care System | 5 | 2021-07-29 | 2025-07-20 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
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Stress Disorders, Post-Traumatic (19) · Brain Injuries, Traumatic (4) · Wounds and Injuries (4) · Depression (3) · Post-Concussion Syndrome (3) · Depressive Disorder, Major (2) · Anxiety Disorders (1) · Behavior, Addictive (1) · Brain Concussion (1) · Brain Injuries (1) · Cognitive Dysfunction (1) · Headache (1) · Marijuana Abuse (1) · Mental Disorders (1)
Trauma and Stressor Related Disorders (27) · Mental Disorders (26) · Stress Disorders, Traumatic (26) · Behavior (5) · Brain Diseases (5) · Central Nervous System Diseases (5) · Craniocerebral Trauma (5) · Nervous System Diseases (5) · Trauma, Nervous System (5) · Wounds and Injuries (5) · Behavioral Symptoms (4) · Brain Injuries (4) · Head Injuries, Closed (3) · Wounds, Nonpenetrating (3) · Brain Concussion (2)
Cycloserine (2) · Hyperbaric Oxygenation (2) · N-Methyl-3,4-methylenedioxyamphetamine (2) · Propranolol (2) · Psilocybin (2) · Transcranial Magnetic Stimulation (2) · (11R,13S,17S)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta(a)phenanthren-3-one (1) · Cognitive Behavioral Therapy (1) · Corn Oil (1) · Esketamine (1) · Exercise (1) · Hormone Replacement Therapy (1) · Ibogaine (1) · Implosive Therapy (1) · Ketamine (1)
VA Office of Research and Development (3) · Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA (2) · Minneapolis Veterans Affairs Medical Center (2) · Summit Hyperbarics and Wellness (2) · COMPASS Pathways (1) · Dartmouth-Hitchcock Medical Center (1) · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium (1) · Johns Hopkins University (1) · Multidisciplinary Association for Psychedelic Studies (1) · Otsuka Medical Devices Co., Ltd. Japan (1) · San Diego Veterans Healthcare System (1) · Tel Aviv University (1) · The University of Texas Health Science Center at San Antonio (1) · U.S. Army Medical Research and Development Command (1) · United States Department of Defense (1)
United States (16) · Canada (4) · France (1) · Iraq (1) · Israel (1) · Japan (1)
Fidel Vila-Rodriguez, M.D., PhD, FRCPC, DFAPA (2) · Andrea Townsend, PhD (1) · Casey Straud, PsyD (1) · Cynthia L Mayer, DO (1) · Daniel T Johnston, MD, MPH (1) · Davin Quinn, MD (1) · Deborah C Beidel, Ph.D., ABPP (1) · Leah Mayo, PhD (1) · Mark P. McGovern, Ph.D. (1) · Nina A Sayer, PhD (1) · Pamela Kryskow, MD, CCFP (1) · Paul van Donkelaar, PhD (1) · Sandeep Nayak, MD (1) · Sandy Shultz, PhD (1)
PMID 23696427, PMID 24913102, PMID 28102979, PMID 35950709
1IK2RX001136-01A2 (1), 2023 (1), K23DA016574 (1)