180 completed, 74 recruiting, 68 unknown, 38 active not recruiting. 254 Not applicable, 24 Phase 2, 12 Phase 3, 5 Phase 1, 5 Phase 4.
Follow Cognitive Decline: new trials by email Literature Review of Cognitive Decline trials Research Report on Cognitive Decline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The CDAC Study - Cerebral Dysfunction After Coronary Revascularization Neurocognitive testing - CABG, PCI | Not yet recruiting | The Scripps Research Institute | 600 | 2027-01-01 | 2026-03-24 | |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-05-14 |
| Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study utmbHealthyBrain Smartphone App - Aging, Dementia | Not applicable | Not yet recruiting | The University of Texas Medical Branch, Galveston | 40 | 2026-10-01 | 2026-03-27 |
| The BASIC-S Feasibility Study for Vascular Risk Reduction BASIC-S Intervention, Standard / Usual Care - Hypertension (HTN), Vascular Diseases | Not applicable | Not yet recruiting | Andrew Appleton | 120 | 2026-10-01 | 2026-08-25 |
| Predictors of Cognitive Decline and Delirium in Older Women With Ovarian Cancer Ovarian Cancer, Cognitive Decline | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 205 | 2026-09-01 | 2026-07-21 | |
| Using Artificial Intelligence to Detect Early Signs of Alzheimer's Disease in People With Memory Concerns High-frequency Transcranial Magnetic Stimulation (TMS), Digital Cognitive Training, Structured Physical Exercise - Subjective Cognitive Decline, Alzheimer Disease | Not applicable | Not yet recruiting | IRCCS San Raffaele | 300 | 2026-08-01 | 2026-06-17 |
| Vivifrail Exercise Program in Nonagenarians: Effects on Function, Muscle, and Cognition Vivifrail multicomponent exercise program - Frailty, Aging | Not applicable | Enrolling by invitation | Federal University of Rio Grande do Sul | 54 | 2026-07-29 | 2026-09-03 |
| AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions High intensity cycling, Low-intensity cycling, Health education session - Stroke, Chronic, Aging | Not applicable | Active not recruiting | University of Alabama at Birmingham | 48 | 2026-07-15 | 2026-07-17 |
| Effects of Accelerated rTMS on Cognitive Function TMS - Cognitive Decline, Cognitive Impairment | Not applicable | Recruiting | San Francisco Neurology and Sleep Center | 80 | 2026-07-15 | 2026-07-17 |
| Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline Fitness app for self-efficacy, Social network via app for social support, Health education app targeting outcome expectations - Older Adults With Cognitive Decline, Older Adults | Not applicable | Recruiting | The University of Tennessee, Knoxville | 64 | 2026-06-08 | 2026-06-15 |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health Social Connection Intervention Program (SCIP): Community activities, peer-support groups, and home-based coaching to reduce social isolation and loneliness. - Social Isolation in Older Adults, Loneliness | Not applicable | Active not recruiting | Universidad de Especialidades Espiritu Santo | 500 | 2026-06-01 | 2026-07-09 |
| Effects of Comprehensive Community Support Programs on Cognitive Function and Quality of Life in Older Adults Multidomain Community Support Program - Cognitive Decline, Aging | Recruiting | Istanbul Medipol University Hospital | 120 | 2026-05-20 | 2026-05-27 | |
| Algal Lutein Against Decline of Intellectual Nimbleness Lutein, Placebo - Menopausal Syndrome, Cognitive Decline | Not applicable | Not yet recruiting | Poznan University of Life Sciences | 300 | 2026-05-01 | 2026-05-20 |
| Psychological and Lifestyle Factors That Predict Adherence of Multi-domain Interventions for Promoting Brain Health Generic Lifestyle Education, ToBrainHealth Personalised Digital Intervention, ToBrainHealth Personalised Digital Intervention with Coaching - Brain Health Activities, Cognition | Not applicable | Completed | Institut Guttmann | 120 | 2026-02-15 | 2026-07-07 |
| Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairment and Insulin Resistance Sabroxy®, Placebo - Insulin Resistance, Mild Cognitive Impairment | Not applicable | Recruiting | SF Research Institute, Inc. | 140 | 2026-01-29 | 2026-01-28 |
| Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping - MCI, Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Fondazione Don Carlo Gnocchi ETS | 384 | 2026-01-20 | 2026-08-10 |
| Microbiota Mediated Flavonoid Metabolites for Cognitive Health Polyphenol Supplement, Placebo Supplement - Cognitive Decline, Cognitive Dysfunction | Not applicable | Recruiting | University of Ulster | 100 | 2025-11-25 | 2025-11-24 |
| Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Neuropathy Turning Based Dual Task Training, Dual-Task Training - Diabetic Neuropathy, Balance | Not applicable | Completed | Foundation University Islamabad | 50 | 2025-11-20 | 2026-05-14 |
| Exercise Adherence and Cognitive Decline: Phase 2 Goal Setting and Exercise Intensity Intervention - Cognitive Decline | Not applicable | Recruiting | University of Colorado, Boulder | 226 | 2025-11-05 | 2026-06-11 |
Showing 20 of 396. Sign in to see all of them.
Cognitive Dysfunction (396) · Dementia (81) · Alzheimer Disease (61) · Motor Activity (32) · Memory Disorders (22) · Depression (17) · Delirium (16) · Neurocognitive Disorders (15) · Stroke (14) · Hypertension (13) · Cardiovascular Diseases (11) · Dementia, Vascular (11) · Frailty (11) · Cognition Disorders (9) · Inflammation (9)
Mental Disorders (394) · Cognition Disorders (387) · Neurocognitive Disorders (381) · Nervous System Diseases (195) · Central Nervous System Diseases (141) · Brain Diseases (136) · Pathological Conditions, Signs and Symptoms (115) · Signs and Symptoms (83) · Behavior (73) · Neurologic Manifestations (72) · Neurodegenerative Diseases (64) · Tauopathies (61) · Pathologic Processes (57) · Cardiovascular Diseases (47) · Vascular Diseases (45)
Exercise (14) · Cognitive Training (8) · Cholecalciferol (4) · Neuropsychological Tests (4) · Transcranial Direct Current Stimulation (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (3) · Blood Specimen Collection (3) · Control Groups (3) · Fish Oils (3) · Vitamin B 12 (3) · Amlodipine (2) · Curcumin (2) · Dexmedetomidine (2) · Folic Acid (2) · Hematologic Tests (2)
Rsocialform - Geriatria, Lda (5) · University of California, San Francisco (5) · Wageningen University (5) · Massachusetts General Hospital (4) · The University of Texas at Arlington (4) · Brigham and Women's Hospital (3) · Chinese University of Hong Kong (3) · Cognito Therapeutics, Inc. (3) · Dingqun Bai (3) · Duke University (3) · Foundation University Islamabad (3) · Indiana University (3) · Johns Hopkins University (3) · LuciLab (3) · National Taiwan Normal University (3)
United States (145) · China (21) · Canada (17) · Netherlands (16) · United Kingdom (15) · Spain (14) · Taiwan (14) · Italy (13) · France (11) · Portugal (10) · Israel (8) · Sweden (8) · Singapore (7) · Switzerland (6) · Australia (5)
Susana I Justo Henriques, PhD (5) · Robert M Brothers, PhD (4) · Robin C Hilsabeck, PhD (3) · Aprinda I Queen, PhD (2) · Frank R Lin, MD, PhD (2) · Jong-Long Guo, PhD (2) · Mikel Tainta, MD (2) · Nicolai Goettel, MD (2) · Olivier Beauchet, MD (2) · Riley Bove, MD (2) · Robert Petrella, MD, PhD (2) · Sandrine Thuret, PhD (2) · Sylvie Belleville, PhD (2) · Aarno Dietz, prof. (1)
PMID 10125443, PMID 11556941, PMID 1535198, PMID 15368607, PMID 15536110, PMID 15616043, PMID 15797159, PMID 16460376, PMID 16541455, PMID 16594782, PMID 16632311, PMID 16804371, PMID 16925881, PMID 17179457, PMID 17200216, PMID 17240287, PMID 17565164, PMID 17998490, PMID 18221549, PMID 18243244, PMID 18245764, PMID 18400101, PMID 18482293, PMID 18511736, PMID 18768414, PMID 18842201, PMID 18997197, PMID 19021673, PMID 19066368, PMID 19173101, PMID 19966535, PMID 20065132, PMID 20418350, PMID 20643703, PMID 20929341, PMID 21034202, PMID 21060040, PMID 21072603, PMID 21283646, PMID 21391767, PMID 21430116, PMID 21791146, PMID 21966393, PMID 22136405, PMID 22136481, PMID 22156335, PMID 22262124, PMID 22263004, PMID 22289240, PMID 2229948
P30AG022849 (2), R01AG081768 (2), 2017 (1), 2018 (1), 2023 (1), 2025 (1), 2SB1AG037357-04A1 (1), 3UG1CA189824-04S1 (1), K12HD001441 (1), K23AG078448 (1), K23AG086604 (1), K23NS097625 (1), K25AG086592 (1), K99AG056670 (1), KL2TR002370 (1)