4 completed, 4 unknown, 2 recruiting. 4 Not applicable, 3 Phase 4, 1 Early Phase 1, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 4 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
Follow Central Nervous System Depressants: new trials by email Literature Review of Central Nervous System Depressants trials Research Report on Central Nervous System Depressants
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Natural History of Depression, Bipolar Disorder and Suicide Risk Behavioral Symptoms, Suicide | Recruiting | National Institute of Mental Health (NIMH) | 500 | 2024-09-09 | 2026-10-01 | |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression VTS-K - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Theresa Jacob, PhD, MPH | 15 | 2022-12-06 | 2026-04-21 |
| Opioid-free Anesthesia in Laparoscopic Cholecystectomies ketamine-lidocaine-dexmedetomidine, fentanyl - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 70 | 2021-10-11 | 2023-02-24 |
| Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine ketamine-lidocaine-dexmedetomidine, fentanyl - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 60 | 2021-04-01 | 2022-10-24 |
| Comparison Between Natural Sleep Endoscopy and Drug-induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea Drug-induced sleep endoscopy, Natural sleep endoscopy - Sleep Apnea, Obstructive, Sleep Apnea | Not applicable | Unknown | ethisch.comite@uza.be | 40 | 2021-03-30 | 2021-07-26 |
| Relative Bioavailability of LY03010 Compared to Listed Drug LY03010; paliperidone palmitate, INVEGA SUSTENNA - Schizophrenia, Psychotic Disorders | Phase 1 | Completed | Luye Pharma Group Ltd. | 281 | 2021-01-13 | 2023-04-25 |
| Lidocaine and Magnesium and Ketamine in Gynecological Surgery lidocaine-magnesium infusion, lidocaine-ketamine infusion, lidocaine infusion - Pain, Postoperative, Pain, Acute | Not applicable | Unknown | Aretaieion University Hospital | 90 | 2020-11-14 | 2022-10-27 |
| Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine - Physiological Effect of Drugs, Morphine | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 44 | 2020-05-11 | 2022-05-26 |
| Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients Dexmedetomidine Hydrochloride Group - Delirium, Cognitive Dysfunction | Phase 4 | Recruiting | Sunnybrook Health Sciences Centre | 2400 | 2019-12-01 | 2025-12-01 |
| Alcohol, Behavior, and Brain Imaging Ethanol, Placebo - Alcohol Drinking, Binge Drinking | Early Phase 1 | Completed | University of Chicago | 80 | 2016-01-01 | 2022-04-25 |
Pain, Postoperative (4) · Acute Pain (3) · Agnosia (3) · Chronic Pain (3) · Depression (2) · Depressive Disorder, Major (2) · Depressive Disorder, Treatment-Resistant (2) · Mental Disorders (2) · Nervous System Diseases (2) · Neuralgia (2) · Alcohol Drinking (1) · Apnea (1) · Behavioral Symptoms (1) · Binge Drinking (1) · Bipolar Disorder (1)
Pathological Conditions, Signs and Symptoms (7) · Neurologic Manifestations (6) · Signs and Symptoms (6) · Mental Disorders (4) · Nervous System Diseases (4) · Pain (4) · Pathologic Processes (4) · Postoperative Complications (4) · Behavior (3) · Neurobehavioral Manifestations (3) · Perceptual Disorders (3) · Mood Disorders (2) · Neuromuscular Diseases (2) · Peripheral Nervous System Diseases (2) · Alcohol-Related Disorders (1)
Control Groups (2) · Fentanyl (2) · Aspirin (1) · Dexmedetomidine (1) · Epinephrine (1) · Ethanol (1) · Ketamine (1) · Lidocaine (1) · Paliperidone Palmitate (1) · chloroprocaine (1)
Aretaieion University Hospital (3) · Luye Pharma Group Ltd. (1) · National Institute of Mental Health (NIMH) (1) · Sunnybrook Health Sciences Centre (1) · The University of Texas Health Science Center, Houston (1) · Theresa Jacob, PhD, MPH (1) · University of Chicago (1) · ethisch.comite@uza.be (1)
United States (4) · Greece (3) · Belgium (1) · Canada (1)
Elizabeth D Ballard, Ph.D. (1) · Jessica Weafer (1) · Kassiani Theodoraki (1) · Kassiani Theodoraki, PhD, DESA (1) · Kassiani Theodoraki, phD, DESA (1) · Linden Lee, MD (1) · Olivier Vanderveken, MD, PhD (1) · Rui Li, MD (1) · Stephen Choi, MD,MSc,FRCPC (1) · Theresa Jacob, PhD, MPH (1)
PMID 33201577, PMID 33849856, PMID 34950101, PMID 36534717, PMID 42752599