19 completed, 3 not yet recruiting, 3 recruiting, 3 terminated. 14 Phase 4, 4 Not applicable, 4 Phase 2, 4 Phase 3, 2 Early Phase 1.
Follow chloroprocaine: new trials by email Literature Review of chloroprocaine trials Research Report on chloroprocaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted Nerve Injection to the Knee (Nerve to Vastus Medialis): Comparing Two Adductor Canal Block Approaches Traditional adductor canal block, NVM (nerve to vastus medialis) targeted adductor canal block, Chloroprocaine Injection - Anesthesia, Local | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-08-27 |
| Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy Sodium Chloride 0.9%, Dexamethasone, Chloroprocaine Injection [Clorotekal] - Knee Arthroscopy | Phase 3 | Not yet recruiting | CMC Ambroise Paré | 60 | 2026-09-01 | 2026-06-29 |
| Flex Appeal: Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia Spinal Anesthesia, General Anesthesia, Propofol - Knee Stiffness After Total Knee Arthroplasty | Phase 4 | Recruiting | Duke University | 128 | 2026-06-01 | 2026-06-03 |
| Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty Mepivacaine Injection, Chloroprocaine Injection - Recovery Period, Anesthesia | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 170 | 2026-03-31 | 2026-02-06 |
| Local Anesthetic Clinical Trial Lidocaine, Bupivacaine Hydrochloride, Mepivacaine Hydrochloride - Mohs Micrographic Surgery, Anesthesia, Local | Phase 4 | Enrolling by invitation | Baylor Research Institute | 400 | 2025-01-07 | 2026-05-22 |
| Multicenter Study of Chloroprocaine Versus Ropivacaine for Epidural Labor Analgesia Chloroprocaine - Obstetric Labor | Phase 4 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 356 | 2024-06-18 | 2024-06-25 |
| Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population Chloroprocaine 3% eye gel, Oxybuprocaine Hydrochloride 4 Mg/mL Eye Drops - Local Anesthetic | Phase 3 | Completed | Sintetica SA | 74 | 2024-05-23 | 2026-03-09 |
| Pain Selective Anesthesia for Labor Mobility (PSALM Study): a Randomized Controlled Trial of Combined Lidocaine - Chlorprocaine for Labor Epidural Analgesia Chlorprocaine, Lidocaine, Lidocaine-chlorprocaine combination - Labor Pain | Phase 4 | Recruiting | Hadassah Medical Organization | 303 | 2024-03-12 | 2026-09-25 |
| Chloroprocaine 1% Versus Ropivacaine 0,75% During Cesarean Section Chloroprocaine 1% Injectable Solution, Ropivacaine 0.75% Injectable Solution - Cesarean Section, Local Anesthetic | Not applicable | Recruiting | Aretaieion University Hospital | 60 | 2024-01-10 | 2025-07-22 |
| Intraabdominal Chloroprocaine During Cesarean Delivery for Pain Control Chloroprocaine Hcl 2% Inj, Normal saline - Cesarean Section Complications, Pain | Phase 3 | Withdrawn | Johns Hopkins University | 2021-06-01 | 2021-09-29 | |
| Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine - Physiological Effect of Drugs, Morphine | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 44 | 2020-05-11 | 2022-05-26 |
| Intrathecal Chloroprocaine for Lower Limb Arthroplasty Chloroprocaine Injection - Lower Limb Arthroplasty Under Chloroprocaine Spinal Anesthesia | Completed | Hôpital de la Croix-Rousse | 65 | 2020-01-01 | 2022-05-09 | |
| Comparison of Clorotekal and Bupivacaine for Short Obstetric Surgery Chloroprocaine Injection [Clorotekal], Bupivacaine Hydrochloride 0.75% Injection Solution - Anesthesia, Spinal | Phase 4 | Suspended | Oregon Health and Science University | 27 | 2019-10-24 | 2024-06-21 |
| Chloroprocaine Lavage to Improve Outcomes Related to Operative Cesarean Delivery Preservative free 1% Chloroprocaine, Preservative free 2% Chloroprocaine, Preservative free 3% Chloroprocaine - Cesarean Section | Early Phase 1 | Completed | Oregon Health and Science University | 15 | 2019-09-30 | 2024-09-19 |
| 1% Chloroprocaine(PF) vs. Bupivacaine Spinals 1% chloroprocaine, 0.75% bupivacaine - Return of Motor and Sensory Blockade, Anesthesia, Spinal | Phase 2 | Completed | Montefiore Medical Center | 110 | 2019-09-11 | 2025-02-28 |
| Optimizing Anesthesia for Post Partum Tubal Ligations Chloroprocaine, Bupivacaine - Pregnancy Related | Phase 2 | Terminated | University of Alabama at Birmingham | 15 | 2019-08-13 | 2021-12-17 |
| The Efficacy and Safety of Chloroprocaine 1% and 2% in Pediatric Population Chloroprocaine 1% Injectable Solution, Chloroprocaine 2% Injectable Solution - Hernia, Inguinal, Flat Foot | Phase 2 | Completed | Sintetica SA | 164 | 2019-02-14 | 2026-03-23 |
| ED90 of 3% Chloroprocaine for Cervical Cerclage Chloroprocaine Hcl 3% Inj - Cerclage, Cervical | Phase 4 | Completed | Duke University | 47 | 2019-02-07 | 2021-10-12 |
| Chloroprocaine Spinal for Outpatient Knee Surgery Chloroprocaine, Mepivacaine, General Anesthetics - Knee Arthroscopy | Phase 2 | Terminated | Hospital for Special Surgery, New York | 39 | 2018-06-24 | 2022-04-20 |
| Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery 2% Lidocaine, 3% Chloroprocaine - Surgical Anesthesia, Cesarean Section | Early Phase 1 | Completed | University of Arkansas | 70 | 2018-02-15 | 2020-04-13 |
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Pain (4) · Agnosia (2) · Hernia, Inguinal (2) · Acute Kidney Injury (1) · Flatfoot (1) · Hernia, Umbilical (1) · Hypotension (1) · Labor Pain (1) · Pain, Postoperative (1) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (1) · Uterine Cervical Incompetence (1)
Duke University (4) · Sintetica SA (3) · Oregon Health and Science University (2) · AZ St.-Dimpna Geel (1) · Aretaieion University Hospital (1) · Astes (1) · Baylor Research Institute (1) · CMC Ambroise Paré (1) · Columbia University (1) · Hadassah Medical Organization (1) · Hospital for Special Surgery, New York (1) · Hôpital de la Croix-Rousse (1) · Jinling Hospital, China (1) · Johns Hopkins University (1) · Joseph D. Tobias (1)
United States (15) · Belgium (2) · France (2) · Italy (2) · Canada (1) · Greece (1) · Israel (1) · Spain (1)
Brandon M Togioka, MD (2) · Ahizechukwu Eke, MD MPH (1) · Aliaksandra Parashchanka, MD (1) · Ashraf Habib, MBBS (1) · Ben Gys, md (1) · Brian Mendelson (1) · Dan Drzymalski, MD (1) · David Kim (1) · Elilary Montilla Medrano, MD (1) · Emily Hall (1) · Eric P Deflandre, MD, FCCP (1) · Jean-Denis Roy, MD (1) · Jeff Gadsden, MD (1) · Jonathan P Wanderer, MD, MPhil (1)
PMID 21203878, PMID 11812697, PMID 15155349, PMID 16480471, PMID 17377114, PMID 18931242, PMID 20529983, PMID 23176984, PMID 23320599, PMID 25211156, PMID 32852294, PMID 34153006, PMID 35139044, PMID 35544759, PMID 36534717, PMID 39740957
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