6 completed, 4 terminated, 3 recruiting. 13 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 6, Terminated 4, Recruiting 3 |
| Phase 2 | 1 | Terminated 1 |
Follow Cardiac Disease: new trials by email Literature Review of Cardiac Disease trials Research Report on Cardiac Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Sivelestat in Preventing Postoperative Acute Lung Injury or Acute Respiratory Distress Syndrome After Cardiac Surgery Sivelestat, placebo - Cardiac Disease | Phase 3 | Completed | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 382 | 2024-02-18 | 2025-08-06 |
| Effect of Colchicine on Perioperative Anti-inflammatory Organ Injury in Cardiac Surgery Colchicine 0.5 MG, Placebo - Inflammatory Response, Cardiac Disease | Phase 3 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 768 | 2024-01-28 | 2025-11-17 |
| Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis Colchicine 0.5 MG, Ticagrelor 90mg, Aspirin 75-300mg - Stroke, Stroke, Ischemic | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2800 | 2023-05-17 | 2025-09-08 |
| ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE Placebo, Ravulizumab - Chronic Kidney Disease, CKD | Phase 3 | Terminated | Alexion Pharmaceuticals, Inc. | 555 | 2023-04-06 | 2026-10-29 |
| Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients: Vasopressin, Norepinephrine - Cardiac Disease | Phase 3 | Completed | The Cleveland Clinic | 153 | 2020-11-05 | 2026-10-27 |
| Heparin vs Placebo for Cardiac Catheterization Heparin, Placebos - Cardiac Disease | Phase 3 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1623 | 2020-10-05 | 2026-02-20 |
| DEF-315 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY DEFINITY® - Cardiac Disease | Phase 3 | Completed | Lantheus Medical Imaging | 160 | 2018-12-28 | 2021-01-28 |
| DEF-314 Better Accuracy in Ejection Fraction (EF) Assessment With DEFINITY DEFINITY - Cardiac Disease | Phase 3 | Completed | Lantheus Medical Imaging | 153 | 2018-10-24 | 2020-12-17 |
| Edoxaban for Prevention of Blood Vessels Being Blocked by Clots (Thrombotic Events) in Children at Risk Because of Cardiac Disease Edoxaban, Standard of Care (SOC) - Cardiac Disease | Phase 3 | Completed | Daiichi Sankyo | 168 | 2018-05-15 | 2022-07-26 |
| Beta Blockers and Angiotensin Receptor Blockers in Bicuspid Aortic Valve Disease Aortopathy (BAV Study) Atenolol, Telmisartan - Cardiac Disease | Phase 3 | Terminated | Hamilton Health Sciences Corporation | 85 | 2011-06-01 | 2019-09-18 |
| Angiomax in Patients With HIT/HITTS Type II Undergoing Off-Pump Coronary Artery Bypass Grafting (CABG) (CHOOSE) Angiomax (bivalirudin) anticoagulant - Thrombocytopenia, Thrombosis | Phase 3 | Completed | The Medicines Company | 88 | 2003-10-01 | 2018-11-30 |
| Moxonidine in Patients Undergoing Vascular Surgery moxonidine - Cardiac Disease, Vascular Surgery | Phase 3 | Terminated | University Hospital, Basel, Switzerland | 141 | 2002-11-01 | 2009-11-10 |
| Attenuation Corrected Cardiac SPECT Using the GE Hawkeye Camera System GE Attenuation Corrected Hawkeye Camera - Cardiac Disease | Phase 2 / Phase 3 | Terminated | Mayo Clinic | 608 | 2001-07-01 | 2015-04-23 |
Heart Diseases (13) · Myocardial Infarction (2) · Angina, Unstable (1) · Atherosclerosis (1) · Bicuspid Aortic Valve Disease (1) · Cerebral Infarction (1) · Chest Pain (1) · Ischemic Stroke (1) · Renal Insufficiency, Chronic (1) · Stroke (1) · Thrombocytopenia (1) · Thrombosis (1)
Cardiovascular Diseases (13) · Pathologic Processes (3) · Pathological Conditions, Signs and Symptoms (3) · Vascular Diseases (3) · Infarction (2) · Ischemia (2) · Myocardial Ischemia (2) · Necrosis (2) · Neurologic Manifestations (2) · Pain (2) · Signs and Symptoms (2) · Angina Pectoris (1) · Aortic Valve Disease (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1)
Colchicine (2) · Heparin (2) · perflutren (2) · Anticoagulants (1) · Aspirin (1) · Atenolol (1) · Enoxaparin (1) · Norepinephrine (1) · Standard of Care (1) · Telmisartan (1) · Ticagrelor (1) · Vasopressins (1) · Warfarin (1) · bivalirudin (1) · edoxaban (1)
Lantheus Medical Imaging (2) · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School (2) · Alexion Pharmaceuticals, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Daiichi Sankyo (1) · Hamilton Health Sciences Corporation (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Mayo Clinic (1) · The Cleveland Clinic (1) · The Medicines Company (1) · University Hospital, Basel, Switzerland (1)
United States (7) · Canada (4) · China (3) · France (3) · India (2) · Israel (2) · Spain (2) · Turkey (Türkiye) (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Austria (1) · Brazil (1) · Croatia (1) · Egypt (1)
DongJin Wang, M.D (1) · Judith Therrien, MD (1) · Mariya Geube, MD (1) · Miodrag Filipovic, PD Dr. (1) · Todd D Miller, MD (1) · Tolga Baykal, MD, PhD (1) · Toval Rothschild, Ph.D. (1) · Tuo Pan, M.D (1) · Tuo Pan, MD (1)
PMID 17968979, PMID 36328157, PMID 39266309, PMID 40448185, PMID 41811317, PMID 41985829
2017 (1)