48 completed, 16 recruiting, 9 terminated, 5 unknown. 21 Phase 2, 20 Not applicable, 14 Phase 1, 10 Phase 3, 10 Phase 4.
Follow perflutren: new trials by email Literature Review of perflutren trials Research Report on perflutren
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multiparametric Ultrasound for the Diagnosis of Clinically Significant Prostate Cancer ultiparametric Magnetic Resonance Imaging, Perflutren lipid microsphere, Transrectal Ultrasound - Prostate Carcinoma | Phase 3 | Not yet recruiting | Thomas Jefferson University | 300 | 2026-10-01 | 2026-08-25 |
| Microvasculature Ultrasound Super-resolution in Transplant Delayed Graft Function Ultrasound contrast agent (Contrast-enhanced ultrasound), Optison (Perflutren Protein-Type A Microspheres Injectable Suspension), Lumason® contrast agent - End Stage Chronic Renal Failure, Renal Transplant | Not yet recruiting | Roderick Tan | 40 | 2026-06-01 | 2026-06-12 | |
| Application of Contrast-enhanced Ultrasound in Monitoring Soft Tissue Sarcoma Response to Neoadjuvant Radiotherapy Definity, Contrast-Enhanced Ultrasound - Soft Tissue Sarcoma | Early Phase 1 | Recruiting | Thomas Jefferson University | 10 | 2026-03-23 | 2026-04-14 |
| Pembrolizumab Plus Ultrasound-Induced Microbubble Cavitation in Head and Neck Cancer Pembrolizumab, Definity, Ultrasound-Induced Microbubble Cavitation - Head and Neck Cancer, Head and Neck Small Cell Carcinoma | Phase 1 | Recruiting | Thomas Jefferson University | 6 | 2026-03-18 | 2026-10-28 |
| Ultrasound With Subharmonic Imaging and Subharmonic Aided Pressure Estimation (SHAPE) to Identify Portal Hypertension Electronic Health Record Review, Liver Biopsy, Medical Device Usage and Evaluation - Portal Hypertension | Not applicable | Recruiting | Mayo Clinic | 60 | 2025-03-13 | 2026-08-14 |
| SHAPE for ICP Assessment Perflutren lipid microsphere - Lumbar Puncture | Phase 2 | Completed | Thomas Jefferson University | 19 | 2024-12-15 | 2025-09-04 |
| Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer Definity, Sonalleve Focused Ultrasound Device - Breast Cancer | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 200 | 2024-07-25 | 2024-09-27 |
| Contrast-enhanced Ultrasound in the Treatment of Acute Spinal Cord Injury Perflutren lipid - Acute Spinal Cord Injury | Phase 4 | Recruiting | University of Washington | 50 | 2023-09-28 | 2025-04-27 |
| REtinal Detachment Outcomes Study Pars plana vitrectomy, Pars plana vitrectomy with scleral buckle, Sulfur hexafluoride gas tamponade - Retinal Detachment | Not applicable | Recruiting | CHU de Quebec-Universite Laval | 560 | 2023-09-26 | 2026-11-09 |
| A Study of Renal Microvessel Imaging for Chronic Kidney Disease Definity, Super-resolution ultrasound imaging - Healthy, Chronic Kidney Diseases | Phase 2 | Enrolling by invitation | Mayo Clinic | 186 | 2023-08-09 | 2026-09-11 |
| Pancreas Ultrasound Imaging in type1 Diabetes Definity Suspension for Injection - Type1diabetes, Insulitis | Recruiting | University of Colorado, Denver | 50 | 2023-02-27 | 2026-05-06 | |
| Contrast-Enhanced Ultrasound and Shear Wave Elastography for the Treatment of Lymphedema Lumason, Optison, Definity - Lymphedema Arm | Phase 1 | Completed | Mayo Clinic | 10 | 2022-12-15 | 2024-08-21 |
| Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension; Renewal SHAPE measurement (Sonazoid ultrasoud contrast agent), SHAPE measurement (Definity ultrasoud contrast agent) - Liver Diseases, Portal Hypertension | Phase 3 | Recruiting | Thomas Jefferson University | 660 | 2022-11-28 | 2026-10-02 |
| Prostate Cancer Diagnosis by Multiparametric Ultrasound (Wholemount) Perflutren Lipid Microspheres, Ultrasound - Prostate Carcinoma | Phase 3 | Active not recruiting | Thomas Jefferson University | 70 | 2022-06-15 | 2025-09-04 |
| MRI-Guided Focused Ultrasound Radiosensitization for Patients With Malignant Melanoma and Non Melanoma Skin Cancer Definity, Sonalleve Focused Ultrasound Device - Melanoma | Phase 1 | Recruiting | Sunnybrook Health Sciences Centre | 20 | 2022-06-15 | 2023-12-15 |
| 3-D Super Resolution Ultrasound Microvascular Imaging Definity, Acoustic Angiography - Breast Cancer, Thyroid Cancer | Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 27 | 2022-05-26 | 2025-10-06 |
| Medical Imaging and Focused Ultrasound Treatment for Breast Tumors Using Harmonic Motion Imaging (HMI) Harmonic motion imaging guided focused ultrasound (HMIgFUS), Microbubble-mediated Low Intensity Focused Ultrasound (LIFU), Microbubbles - Fibroadenoma, Breast Cancer Stage I | Phase 1 | Recruiting | Columbia University | 82 | 2022-01-19 | 2026-08-13 |
| Carotid Intraplaque Neovascularization Combined With Stress Echo Carotid Contrast Enhanced Ultrasound - Atherosclerosis, Cardiovascular Diseases | Recruiting | Dr. Amer Johri | 1500 | 2021-08-16 | 2025-02-06 | |
| SHAPE Neoadjuvant Chemotherapy Response Contrast-Enhanced Ultrasound, Perflutren Lipid Microspheres, Ultrasound - Anatomic Stage III Breast Cancer AJCC v8, Locally Advanced Breast Carcinoma | Phase 2 / Phase 3 | Active not recruiting | Kibo Nam | 122 | 2021-04-19 | 2026-09-23 |
| SONOthrombolysis in Patients With an ST-segment Elevation Myocardial Infarction With fibrinoLYSIS (SONOSTEMI-LYSIS) Trial Definity® with High Mechanical Index Ultrasound - ST Elevation Myocardial Infarction | Phase 2 | Terminated | University of Alberta | 41 | 2021-02-23 | 2026-03-04 |
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Breast Neoplasms (8) · Carcinoma, Hepatocellular (5) · Renal Insufficiency, Chronic (5) · Heart Diseases (4) · Coronary Artery Disease (3) · Cystic Fibrosis (3) · Kidney Neoplasms (3) · Liver Neoplasms (3) · Prostatic Neoplasms (3) · Retinal Detachment (3) · ST Elevation Myocardial Infarction (3) · Asthma (2) · Cardiovascular Diseases (2) · Carotid Artery Diseases (2) · Head and Neck Neoplasms (2)
Thomas Jefferson University (12) · Mayo Clinic (6) · University of Nebraska (6) · Lantheus Medical Imaging (5) · UNC Lineberger Comprehensive Cancer Center (5) · University of Virginia (5) · Sunnybrook Health Sciences Centre (4) · University of Southern California (4) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (3) · University of North Carolina, Chapel Hill (3) · Columbia University (2) · Stanford University (2) · University of Alabama at Birmingham (2) · University of Washington (2) · CHU de Quebec-Universite Laval (1)
United States (65) · Canada (11) · Netherlands (3) · Brazil (1) · Colombia (1) · Germany (1) · Norway (1) · Switzerland (1) · United Kingdom (1)
Thomas R Porter, MD (6) · Flemming Forsberg, PhD (5) · Dr. Gregory Czarnota, MD, Ph.D. (2) · Emily Chang, M.D. (2) · Emily Chang, MD (2) · Kambiz Kalantarinia, MD (2) · Kibo Nam, PhD (2) · Veronica Lee, MD (2) · Yueh Lee, MD, PhD (2) · Ali Dirani, MD MSc MPH (1) · Amer Johri, MD (1) · Ananda Basu, MBBS, M.D. (1) · Andrei Alexandrov, MD (1) · Arthur C. Fleischer, MD (1) · Aya Kamaya (1)
PMID 18395321, PMID 18947918, PMID 21693401, PMID 22275808, PMID 22562290, PMID 22619674, PMID 22752464, PMID 23180239, PMID 24158005, PMID 24932797, PMID 25692527, PMID 26109588, PMID 28245140, PMID 28793871, PMID 29672210, PMID 30468761, PMID 32408387, PMID 32739607, PMID 33303537, PMID 33855814, PMID 33885738, PMID 34783716, PMID 34815790, PMID 35079778, PMID 35469453, PMID 35584850, PMID 35762891, PMID 36648035, PMID 36717526, PMID 37554284, PMID 37847138, PMID 38000699, PMID 38124155, PMID 38364771, PMID 39014314, PMID 39418015
P30CA014089 (3), R37CA234428 (2), K23DK074616 (1), K23HL138257 (1), P30CA068485 (1), R01AG038961 (1), R01CA140338 (1), R01CA189479 (1), R01CA194307 (1), R01CA195443 (1), R01CA220681 (1), R01CA228275 (1), R01CA252311 (1), R01CA301199 (1), R01DK098526 (1)