47 completed. 47 Phase 3, 11 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 47 | Completed 47 |
| Phase 2 | 11 | Completed 11 |
Follow Brain Injuries: new trials by email Literature Review of Brain Injuries trials Research Report on Brain Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury Memantine Hydrochloride - Treatment of Cognitive Deficits After Traumatic Brain Injury | Phase 3 | Completed | Assiut University | 60 | 2024-01-01 | 2024-08-07 |
| The Effect of Mannitol Volume With Changes in Osmolarity in Traumatic Brain Injury Mannitol - Anesthesia, Traumatic Brain Injury | Phase 3 | Completed | Universitas Diponegoro | 64 | 2023-11-01 | 2026-06-11 |
| Combined Cerebrolysin and Amantadine Sulfate Administration for Patients With Traumatic Brain Injury in the ICU Cerebrolysin, amantadine sulfate - Traumatic Brain Injury | Phase 3 | Completed | Ain Shams University | 150 | 2023-09-01 | 2025-11-19 |
| Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients Routine labs - Hemorrhagic Shock, Acute Blood Loss Anemia | Phase 3 | Completed | Loma Linda University | 199 | 2022-03-05 | 2025-08-08 |
| NeuroAiD II™ (MLC901) in Mild Traumatic Brain Injury Traditional Chinese Medicine (NeuroAiD II™ (MLC901), Placebo - Traumatic Brain Injury | Phase 3 | Completed | Moleac Pte Ltd. | 182 | 2021-08-23 | 2023-03-15 |
| Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury Vitamin B3, Vitamin B12 - Traumatic Brain Injury | Phase 3 | Completed | KRL Hospital, Islamabad | 300 | 2021-06-01 | 2023-07-24 |
| International Trial of Efficacy of Cytoflavin in Head Trauma Cytoflavin ((Inosine + Nicotinamide + Riboflavin + Succinic Acid), Placebo - Head Trauma,Closed | Phase 3 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 166 | 2020-11-22 | 2025-04-18 |
| RECONsolidation of Traumatic Memories to ResOLve Post Traumatic Stress Disorder (RECONTROLPTSD) Reconsolidation of Traumatic Memories (RTM), Prolonged Exposure (PE) - Posttraumatic Stress Disorder, Traumatic Brain Injury | Phase 2 / Phase 3 | Completed | Uniformed Services University of the Health Sciences | 94 | 2019-06-12 | 2025-07-15 |
| Mgso4 as Neuroprotective in Post Traumatic Brain Injury Magnesium Sulfate, Placebo - Magnesium Sulphate, Traumatic Brain Injury | Phase 3 | Completed | Osama Mohamed Abdelwahab | 60 | 2019-05-02 | 2020-11-30 |
| Inhaled Nitric Oxide in Brain Injury Inhaled Nitric Oxide, Placebo - Traumatic Brain Injury | Phase 3 | Completed | University of Cincinnati | 13 | 2018-12-12 | 2025-04-30 |
| Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Somatropin - Traumatic Brain Injury, Fatigue | Phase 3 | Completed | The University of Texas Medical Branch, Galveston | 72 | 2018-08-06 | 2025-03-05 |
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol Melatonin 10 MG Oral Tablet, Propofol, Placebo oral tablet - TBI (Traumatic Brain Injury) | Phase 3 | Completed | Cairo University | 38 | 2018-01-01 | 2019-07-26 |
| Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Salovum, Placebo - Brain Trauma | Phase 3 | Completed | Peter Siesjö | 100 | 2017-09-17 | 2022-10-12 |
| Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury VAS203, Saline - Traumatic Brain Injury | Phase 3 | Completed | veriNOS operations GmbH | 224 | 2016-06-01 | 2021-10-11 |
| Erigo®Pro Coma Outcome Study - Study on the Effectiveness of a Robotic Tilt Table Device for Recovery of Consciousness Standard physiotherapy, Erigo®Pro group without FES, Erigo®Pro group with FES - Brain Injuries, Disorders of Consciousness | Phase 3 | Completed | Ludwig-Maximilians - University of Munich | 47 | 2016-01-01 | 2019-08-13 |
| Effect of Epigallocatechin -3-gallate Supplementation in Traumatic Brain Injury Patients EGCG, Placebo (deionized water) - Traumatic Brain Injury | Phase 2 / Phase 3 | Completed | National Nutrition and Food Technology Institute | 30 | 2015-03-01 | 2016-06-07 |
| Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disability NT 201 Placebo, NT 201 - Chronic Troublesome Sialorrhea, Cerebral Palsy | Phase 3 | Completed | Merz Pharmaceuticals GmbH | 256 | 2015-02-09 | 2021-08-10 |
| Safety and Efficacy of Wendan Decoction in Acute Moderated to Severe Brain Injury Wendan decoction combination in acute brain injury - Acute Brain Injury | Phase 2 / Phase 3 | Completed | Taichung Tzu Chi Hospital | 60 | 2014-06-01 | 2019-02-22 |
| Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions IncobotulinumtoxinA (100 Units), IncobotulinumtoxinA (75 Units), Placebo - Chronic Troublesome Sialorrhea, Parkinson's Disease | Phase 3 | Completed | Merz Pharmaceuticals GmbH | 184 | 2014-04-01 | 2018-03-27 |
| Multicenter Evaluation of Memory Remediation After TBI With Donepezil Donepezil, Placebo - Traumatic Brain Injury, Memory Deficits | Phase 3 | Completed | Baylor College of Medicine | 75 | 2013-09-01 | 2025-01-15 |
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Brain Injuries, Traumatic (41) · Craniocerebral Trauma (5) · Wounds and Injuries (5) · Cognitive Dysfunction (4) · Stroke (4) · Brain Concussion (3) · Hypothermia (3) · Anxiety Disorders (2) · Consciousness Disorders (2) · Head Injuries, Closed (2) · Parkinson Disease (2) · Adrenal Insufficiency (1) · Alcoholism (1) · Alzheimer Disease (1)
Brain Diseases (47) · Central Nervous System Diseases (47) · Nervous System Diseases (47) · Trauma, Nervous System (46) · Craniocerebral Trauma (41) · Wounds and Injuries (41) · Pathological Conditions, Signs and Symptoms (14) · Mental Disorders (11) · Signs and Symptoms (10) · Neurocognitive Disorders (7) · Cardiovascular Diseases (6) · Vascular Diseases (6) · Cerebrovascular Disorders (5) · Neurologic Manifestations (5)
Sodium Chloride (4) · Saline Solution (3) · Amantadine (2) · Botulinum Toxins, Type A (2) · Magnesium Sulfate (2) · Niacinamide (2) · Tranexamic Acid (2) · Valproic Acid (2) · incobotulinumtoxinA (2) · 4-amino-tetrahydrobiopterin (1) · Acupuncture Therapy (1) · Cardiopulmonary Resuscitation (1) · Cholinesterase Inhibitors (1) · Cyclosporine (1) · Dextrans (1)
Baylor College of Medicine (2) · Merz Pharmaceuticals GmbH (2) · VA Office of Research and Development (2) · Ain Shams University (1) · Assiut University (1) · Australia and New Zealand Intensive Care Society (1) · Australian and New Zealand Intensive Care Research Centre (1) · Avanir Pharmaceuticals (1) · BHR Pharma, LLC (1) · Cairo University (1) · Claudia Sue Robertson (1) · Columbia University (1) · Emory University (1) · Hospices Civils de Lyon (1) · JFK Medical Center (1)
United States (19) · Germany (6) · France (5) · Egypt (4) · Russia (4) · Australia (3) · New Zealand (3) · Austria (2) · Canada (2) · Finland (2) · Georgia (2) · Hungary (2) · Poland (2) · Spain (2) · Thailand (2)
Adriaan J Vlok, Professor (1) · Alexander V Savello, Prof (1) · Alistair D Nichol, MD (1) · Allen W Brown, MD (1) · Andreas Bender, Prof.Dr. (1) · Andrew Maas, M.D. (1) · Angelle Sander, PhD (1) · Aria P Hayanto, Sp.An-TI (1) · Avroy A. Fanaroff, MD (1) · Barbara J. Stoll, MD (1) · Barry Willer, Ph.D. (1) · Claudia Robertson, MD (1)
PMID 10625862, PMID 12114906, PMID 16361021, PMID 17166799, PMID 19930566, PMID 20082712, PMID 21675055, PMID 22375973, PMID 22446155, PMID 22721545, PMID 23895556, PMID 24686108, PMID 24701988, PMID 24842590, PMID 25058216, PMID 25062507, PMID 25066331, PMID 25493978, PMID 25528574, PMID 25884605, PMID 26452709, PMID 26491799, PMID 26496111, PMID 27433815, PMID 27626622, PMID 27630085, PMID 28716153, PMID 30132785, PMID 30175246, PMID 30184559, PMID 30583957, PMID 30918101, PMID 31623894, PMID 31794936, PMID 31937347, PMID 32711551, PMID 33172504, PMID 33514274, PMID 33566466, PMID 33928903, PMID 34116828, PMID 34213962, PMID 34341153, PMID 35418437, PMID 35461285, PMID 36136523, PMID 36536249, PMID 38325012, PMID 38894576, PMID 39301879
2009 (1), M01RR000070 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR008084 (1), P01NS038660 (1), R01NS055827 (1), U01HD019897 (1), U10HD021364 (1), U10HD021385 (1), U10HD021415 (1), U10HD027851 (1), U10HD027853 (1), U10HD027856 (1)