698 completed, 182 recruiting, 153 unknown, 80 terminated. 491 Not applicable, 217 Phase 2, 115 Phase 3, 94 Phase 1, 29 Phase 4.
Follow Intellectual Disability: new trials by email Literature Review of Intellectual Disability trials Research Report on Intellectual Disability
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Regulating Together for Intellectual Disability and Autism: A Group Behavioral Therapy for for Emotion Dysregulation Regulating Together group therapy - Autism, Intellectual Disabilities With Other Behavioral Symptoms | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 10 | 2027-10-01 | 2026-09-03 |
| Efficacy and Safety of NTI164 in Children and Young Adults With Rett Syndrome NTI164, Placebo - RETT Syndrome With Proven MECP2 Mutation, Rett Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Fenix Innovation Group | 40 | 2027-07-01 | 2026-09-09 |
| IT and IV Lentiviral Gene Therapy for X-ALD Intrathecal and intravenous LV gene therapy - X-linked Adrenoleukodystrophy | Not applicable | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-01 | 2026-11-02 |
| A Study to Assess Safety, Tolerability, Pharmacokinetics, and Efficacy of S247240 in Adult Male Participants With Fragile X Syndrome S247240 Low dose, S247240 Middle dose, S247240 High dose - Fragile X Syndrome (FXS) | Phase 2 | Not yet recruiting | Institut de Recherches Internationales Servier (I.R.I.S.) | 100 | 2027-01-25 | 2026-11-12 |
| Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation Regulating Together group therapy - Prader-Willi Syndrome | Not applicable | Recruiting | Children's Mercy Hospital Kansas City | 10 | 2027-01-01 | 2026-09-02 |
| Creating Mobility-supported Home Play Environments to Enhance Development in Infants With Down Syndrome PUMA - Down Syndrome | Not applicable | Not yet recruiting | Boston University Charles River Campus | 60 | 2027-01-01 | 2026-11-13 |
| A Study to Investigate the Effects and Safety of Codabakalner for the Treatment of FXS in Male Participants and Adult Participants With ADS Codabakalner, Placebo - Fragile X Syndrome (FXS), Autism Spectrum Disorder (ASD) | Phase 2 / Phase 3 | Not yet recruiting | Spinogenix | 120 | 2026-12-01 | 2026-10-09 |
| Executive Function Play Opportunities for Children With Down Syndrome EXPO, EXPO Extended, EXPO Foundations - Down Syndrome, Trisomy 21 | Not applicable | Not yet recruiting | Colorado State University | 150 | 2026-12-01 | 2026-10-30 |
| Inhibition of Aggressive Behavior in Participants With Fragile X Syndrome SRX246, Placebo - Aggressive Behavior in Fragile X Syndome | Phase 2 | Not yet recruiting | Azevan Pharmaceuticals | 80 | 2026-12-01 | 2026-10-30 |
| Advancing Cardiovascular Health Among Adolescents With Intellectual Disabilities: Co-Development of Technology Interventions to Enhance Physical Activity Virtual reality physical activity health promotion intervention - Physical Activity, Intellectual Disabilities | Not applicable | Not yet recruiting | Michigan State University | 77 | 2026-11-30 | 2026-11-05 |
| Evaluating ICF-Based Case Management in Adults With Intellectual Disabilities ICF-Based Interdisciplinary Case Management, Conventional Multidisciplinary Rehabilitation Care - Intellectual Disabilities (F70-F79) | Not applicable | Not yet recruiting | Po Leung Kuk | 84 | 2026-11-26 | 2026-11-12 |
| Effects of Exercise Snacks on Physical Health and Cognitive Function in Individuals With Intellectual Disabilities High-Intensity Interval Training, Exercise Snacks - Intellectual Disability | Not applicable | Not yet recruiting | University of Macau | 24 | 2026-11-16 | 2026-08-12 |
| Effects of a Pacifier on Obstructive Sleep Apnea and Its Repercussions in Infants With Down Syndrome CURAPROX pacifier use, Pacifier diary, Polysomnography (PSG) to explore OSA - Obstructive Sleep Apnea, Down Syndrome (Trisomy 21) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 50 | 2026-11-02 | 2026-10-07 |
| Hematological Profile in Children With Numerical Chromosomal Disorders Down Syndrome, Turner Syndrome | Not yet recruiting | Assiut University | 158 | 2026-11-02 | 2026-10-29 | |
| Nature and Frequency of Genetic Abnormalities and Associated Phenotypes in a Cohort of Adults With Intellectual Disability Intellectual Disabilities | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2026-11-01 | 2025-07-03 | |
| Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome N-acetyl cysteine, Placebo - Cornelia de Lange Syndrome | Phase 2 | Not yet recruiting | Johns Hopkins University | 10 | 2026-11-01 | 2026-08-14 |
| Single Session Support for Parents of Children With Neurodevelopmental Disabilities Struggling With Anxious Avoidance EMPOWER-ND - Neurodevelopmental Disorders, Autism Spectrum Disorder (ASD) | Not applicable | Not yet recruiting | Boston University Charles River Campus | 50 | 2026-11-01 | 2026-10-27 |
| Escalating Doses of Memantine in Down Syndrome (MEDS-123) Memantine - Down Syndrome, Intellectual Disability | Phase 1 | Not yet recruiting | University Hospitals Cleveland Medical Center | 25 | 2026-10-14 | 2026-10-05 |
| Examining the Effectiveness of an Intervention Protocol Based on CO-OP for Children and Adolescents With IDD: A Pilot Study The CO-OP approach (Cognitive Orientation to daily Occupational Performance) - Intellectual Developmental Disorder | Not applicable | Not yet recruiting | Miri Tal-Saban | 10 | 2026-10-01 | 2026-08-11 |
| ICF-Based Interdisciplinary Case Management for Individuals With Disabilities ICF-Based Interdisciplinary Case Management (Rehab-Cycle®), Conventional Care Management - Intellectual Disability, Mild to Moderate, Developmental Disability | Not applicable | Recruiting | The Hong Kong Polytechnic University | 120 | 2026-10-01 | 2026-09-10 |
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Down Syndrome (434) · Prader-Willi Syndrome (140) · Fragile X Syndrome (115) · Rett Syndrome (95) · Autism Spectrum Disorder (87) · Mucopolysaccharidosis II (77) · Adrenoleukodystrophy (63) · Developmental Disabilities (61) · Autistic Disorder (54) · Obesity (44) · Motor Activity (37) · Learning Disabilities (36) · Cerebral Palsy (34) · Sudden Infant Death (34)
Neurobehavioral Manifestations (1284) · Nervous System Diseases (1282) · Neurologic Manifestations (1280) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (996) · Genetic Diseases, Inborn (957) · Congenital Abnormalities (737) · Chromosome Disorders (705) · Abnormalities, Multiple (598) · Pathological Conditions, Signs and Symptoms (578) · Signs and Symptoms (483) · Mental Disorders (481) · Neurodevelopmental Disorders (403) · Heredodegenerative Disorders, Nervous System (372) · X-Linked Intellectual Disability (361)
Blood Specimen Collection (19) · idursulfase (14) · Exercise (12) · Oxytocin (12) · Control Groups (9) · Donepezil (8) · trofinetide (8) · Human Growth Hormone (7) · Metformin (7) · Cytarabine (6) · Growth Hormone (6) · Sodium Chloride (6) · Surveys and Questionnaires (6) · mavoglurant (6) · Alemtuzumab (5)
Riphah International University (50) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (21) · University Hospital, Toulouse (18) · Assistance Publique - Hôpitaux de Paris (17) · Children's Hospital Medical Center, Cincinnati (15) · Shire (15) · Cairo University (13) · University of Colorado, Denver (13) · Boston Children's Hospital (11) · Hospices Civils de Lyon (11) · Stanford University (11) · Duke University (10) · Hoffmann-La Roche (10) · Institut Jerome Lejeune (10) · Massachusetts General Hospital (10)
United States (606) · France (144) · Spain (90) · United Kingdom (85) · Canada (75) · Italy (70) · Pakistan (56) · Turkey (Türkiye) (52) · Australia (42) · Germany (38) · Netherlands (33) · China (31) · Brazil (29) · Egypt (28) · Belgium (21)
Alexander Kolevzon, MD (6) · Elizabeth Berry-Kravis, MD, PhD (5) · Paul Orchard, MD (5) · Alan Percy, MD (4) · Joanne Kurtzberg, MD (4) · Joaquin Espinosa, PhD (4) · Randi J Hagerman, MD (4) · Allan L Reiss (3) · Barbara B Biesecker (3) · Bryan King, MD, PhD (3)
PMID 37460385, PMID 33395098, PMID 38363467, PMID 38671361, PMID 39383458, PMID 19772971, PMID 21586746, PMID 22005709, PMID 22281937, PMID 23035069, PMID 24399845, PMID 25071871, PMID 25283752, PMID 25801175, PMID 25834952, PMID 26764156, PMID 26855682, PMID 29718281, PMID 33232306, PMID 35568815, PMID 35794169, PMID 35961250, PMID 37915038, PMID 37919617, PMID 38723617, PMID 39383459, PMID 10331611, PMID 10417280, PMID 10517635, PMID 10586155, PMID 10595921, PMID 10797443, PMID 11231629, PMID 11241498, PMID 11399225, PMID 12103288, PMID 12520259, PMID 12820840, PMID 12889762, PMID 14605787, PMID 14662594, PMID 15368082, PMID 15492353, PMID 15521982, PMID 15551335, PMID 15923132, PMID 16275846, PMID 16278898, PMID 16411192, PMID 16509530
2023 (6), 2025 (6), U10CA180886 (4), 2019 (3), U54HD061222 (3), U54NS065768 (3), U54NS092090 (3), 2009 (2), 2014 (2), 2018 (2), K23HD109375 (2), KL2TR002367 (2), R01AG016381 (2), R01HD071981 (2), R61HL151253 (2)