362 completed, 92 unknown, 71 recruiting, 32 terminated. 321 Not applicable, 64 Phase 3, 51 Phase 2, 31 Phase 4, 25 Phase 1.
Follow Muscle Spasticity: new trials by email Literature Review of Muscle Spasticity trials Research Report on Muscle Spasticity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy Lateral spinal cord surgical implant of electrodes - Cerebral Palsy, Spasticity | Not applicable | Not yet recruiting | Juan Carlos M. Andreani MD | 40 | 2027-06-01 | 2026-04-28 |
| A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Sclerosis Arbaclofen, Placebo - Spasticity | Phase 3 | Not yet recruiting | RVL Pharmaceuticals, Inc. | 442 | 2027-01-01 | 2025-12-03 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Evaluating the Effects of the EXOPULSE Suit on Mobility, Walking Ability, and Balance in People With Multiple Sclerosis Electrostimulation suit - Multiple Sclerosis | Not applicable | Not yet recruiting | Otto Bock Healthcare Products GmbH | 100 | 2026-11-01 | 2026-10-27 |
| Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation Epidural implant stimulation device - SCI - Spinal Cord Injury, Spasticity | Not applicable | Recruiting | Kessler Foundation | 8 | 2026-10-01 | 2026-10-22 |
| Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury Focused extracorporeal shockwave therapy, Botulinum toxin, Sham - Spinal Cord Injury, Spasticity | Phase 2 | Recruiting | Kessler Foundation | 30 | 2026-09-21 | 2026-10-28 |
| Spinal Cord Stimulation for Poststroke Spasticity Active spinal cord stimulation, Sham spinal cord stimulation - Spasticity Post Stroke | Not applicable | Recruiting | Beijing Pins Medical Co., Ltd | 92 | 2026-09-09 | 2026-09-21 |
| A Pilot Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368, a FAAH/MAGL Inhibitor, in Participants With Post-Stroke Spasticity (The STIPS Study) Administration of BMS-986368, Placebo - Post-Stroke Spasticity | Phase 2 | Recruiting | Alberto Esquenazi | 42 | 2026-09-02 | 2026-10-01 |
| Collagenase Injection for Spasticity Management XIAFLEX Collagenase injection - Spasticity | Early Phase 1 | Not yet recruiting | The University of Texas Health Science Center, Houston | 15 | 2026-09-01 | 2026-07-09 |
| The Use of Photobiomodulation in the Treatment of Spasticity After Stroke. Photobiomodulation Therapy, Placebo PBM, Standard Multidisciplinary Rehabilitation Program for Spasticity - Stroke, Spasticity | Phase 1 / Phase 2 | Recruiting | University of Nove de Julho | 42 | 2026-08-28 | 2026-09-01 |
| Intermittent Theta-Burst Stimulation for Lower-Limb Spasticity and Pain in Multiple Sclerosis Active Intermittent Theta-Burst Stimulation (iTBS), Sham Intermittent Theta-Burst Stimulation - Multiple Sclerosis, Muscle Spasticity | Not applicable | Not yet recruiting | Comenius University | 40 | 2026-08-10 | 2026-08-26 |
| Orthosis to Improve Trunk Control in Infants Age 6-18 Months SPIO® Core-MAX® Expedition thoracolumbosacral orthosis, Standard Care Therapy option - Cerebral Palsy | Completed | Medical College of Wisconsin | 21 | 2026-08-06 | 2026-10-08 | |
| Co-contraction and Corticoreticular Excitability in Spinal Cord Injury Corticoreticular excitability and co-contraction measurement - Spinal Cord Injury, Spasticity | Not applicable | Enrolling by invitation | Taipei Veterans General Hospital, Taiwan | 20 | 2026-07-27 | 2026-10-14 |
| Extracorporeal Shock Wave Therapy in Botulinum Toxin-Treated Patients With Post-Stroke Ankle Plantar Flexor Spasticity Radial Extracorporeal Shock Wave Therapy (rESWT), Conventional Physical Therapy and Rehabilitation - Stroke, Post-stroke Spasticity of the Lower Limb | Not applicable | Not yet recruiting | Pamukkale University | 32 | 2026-07-20 | 2026-07-10 |
| Dorsal Root Electrical Stimulation in Children With Cerebral Palsy Constant Current Stimulator, Cadwell Guardian System - Cerebral Palsy (CP), Cerebral Palsy | Not applicable | Recruiting | Martin Piazza | 15 | 2026-07-16 | 2026-08-11 |
| Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain Chronic Pain, PERIPHERAL NEUROPATHY | Recruiting | Yale University | 80 | 2026-06-20 | 2026-08-21 | |
| Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity Selective dorsal rhizotomy with neuromonitoring - Post Traumatic Induced Spasticity | Not applicable | Not yet recruiting | Assiut University | 32 | 2026-06-01 | 2026-05-13 |
| Constraint-induced Movement Therapy Combined With Functional Electrical Stimulation in Children With Cerebral Palsy Constraint-Induced Movement Therapy Combined with Functional Electrical Stimulation, Constraint-Induced Movement Therapy - Cerebral Palsy (CP) | Not applicable | Completed | Montiha Azeem | 46 | 2026-05-18 | 2026-07-06 |
| Effects of Functional Electrical Stimulation on Spasticity, Quadriceps Muscle Strength and Functional Mobility in Individuals With Paraplegia Conventional Neurorehabilitation, Functional Electrical Stimulation (FES) of Quadriceps Muscle, Sham FES group: Conventional neurorehabilitation + sham/placebo FES - Spinal Cord Injury, Paraplegia | Not applicable | Withdrawn | Istanbul Medipol University Hospital | 2026-05-10 | 2026-10-28 | |
| Trial to Test the Effectiveness of Vibrotactile Stimulation for Lower Limb Spasticity Vibrotactile Stimulation (Static Use), Vibrotactile Stimulation (Dynamic Use), Vibrotactile Stimulation (Neurophysiological Mechanism) - Lower Limb Spasticity | Not applicable | Recruiting | Weill Medical College of Cornell University | 25 | 2026-04-30 | 2026-06-17 |
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Stroke (215) · Cerebral Palsy (144) · Multiple Sclerosis (76) · Spinal Cord Injuries (65) · Hemiplegia (44) · Pain (25) · Paresis (22) · Muscle Hypertonia (17) · Brain Injuries, Traumatic (14) · Dystonia (13) · Brain Injuries (12) · Gait Disorders, Neurologic (9) · Ischemic Stroke (9) · Motor Activity (9)
Pathological Conditions, Signs and Symptoms (621) · Neuromuscular Manifestations (618) · Signs and Symptoms (618) · Muscular Diseases (617) · Musculoskeletal Diseases (617) · Neurologic Manifestations (615) · Nervous System Diseases (614) · Muscle Hypertonia (604) · Central Nervous System Diseases (428) · Brain Diseases (368) · Cardiovascular Diseases (221) · Vascular Diseases (220) · Cerebrovascular Disorders (219) · Brain Damage, Chronic (146) · Wounds and Injuries (83)
Botulinum Toxins, Type A (73) · Dry Needling (17) · nabiximols (17) · Extracorporeal Shockwave Therapy (14) · Botulinum Toxins (13) · Baclofen (11) · Physical Therapy Modalities (11) · abobotulinumtoxinA (10) · incobotulinumtoxinA (10) · Rehabilitation (7) · Transcranial Direct Current Stimulation (7) · Control Groups (6) · Muscle Stretching Exercises (6) · Saline Solution (6) · Transcranial Magnetic Stimulation (6)
Riphah International University (19) · Allergan (17) · Ipsen (15) · Chang Gung Memorial Hospital (12) · Jazz Pharmaceuticals (10) · Kessler Foundation (8) · Shirley Ryan AbilityLab (7) · Vanderbilt University (7) · Assistance Publique - Hôpitaux de Paris (6) · GlaxoSmithKline (6) · Marmara University (6) · Medy-Tox (6) · Universitaire Ziekenhuizen KU Leuven (6) · Cairo University (5) · Hacettepe University (5)
United States (164) · Turkey (Türkiye) (76) · France (39) · Spain (37) · Pakistan (34) · Canada (30) · United Kingdom (27) · Italy (26) · Taiwan (24) · Poland (19) · South Korea (19) · Belgium (17) · Russia (17) · Germany (16) · Brazil (15)
David Charles, M.D. (5) · Pong Ya-Ping, MD (4) · Jen-Wen Hung (3) · Mirza Obaid Baig, MSPT (3) · Monica A Gorassini, PhD (3) · William Z Rymer, MD, PhD (3) · Aiko K Thompson, PhD (2)
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